WO2001051083A3 - Innate immunity-stimulating compositions of cpg and saponin and methods thereof - Google Patents

Innate immunity-stimulating compositions of cpg and saponin and methods thereof Download PDF

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Publication number
WO2001051083A3
WO2001051083A3 PCT/US2001/001046 US0101046W WO0151083A3 WO 2001051083 A3 WO2001051083 A3 WO 2001051083A3 US 0101046 W US0101046 W US 0101046W WO 0151083 A3 WO0151083 A3 WO 0151083A3
Authority
WO
WIPO (PCT)
Prior art keywords
saponin
innate immunity
cpg
methods
stimulating compositions
Prior art date
Application number
PCT/US2001/001046
Other languages
French (fr)
Other versions
WO2001051083A2 (en
Inventor
Charlotte R Kensil
Original Assignee
Aquila Biopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquila Biopharm Inc filed Critical Aquila Biopharm Inc
Priority to JP2001551506A priority Critical patent/JP2003527352A/en
Priority to EP01902032A priority patent/EP1250150A2/en
Priority to AU27877/01A priority patent/AU781812B2/en
Priority to CA002397374A priority patent/CA2397374A1/en
Publication of WO2001051083A2 publication Critical patent/WO2001051083A2/en
Publication of WO2001051083A3 publication Critical patent/WO2001051083A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions comprising oligonucleotides comprising at least one unmethylated CpG dinucleotide and saponin and the use thereof for stimulating innate immunity and enhancing natural killer cell activity are disclosed.
PCT/US2001/001046 2000-01-13 2001-01-12 Innate immunity-stimulating compositions of cpg and saponin and methods thereof WO2001051083A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001551506A JP2003527352A (en) 2000-01-13 2001-01-12 Innate immune stimulating compounds of CPG and saponin and methods thereof
EP01902032A EP1250150A2 (en) 2000-01-13 2001-01-12 Innate immunity-stimulating compositions of cpg and saponin and methods thereof
AU27877/01A AU781812B2 (en) 2000-01-13 2001-01-12 Innate immunity-stimulating compositions of CPG and saponin and methods thereof
CA002397374A CA2397374A1 (en) 2000-01-13 2001-01-12 Innate immunity-stimulating compositions of cpg and saponin and methods thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US17584000P 2000-01-13 2000-01-13
US60/175,840 2000-01-13
US20085300P 2000-05-01 2000-05-01
US60/200,853 2000-05-01
US36994100A 2000-08-06 2000-08-06
US09/369,941 2000-08-06

Publications (2)

Publication Number Publication Date
WO2001051083A2 WO2001051083A2 (en) 2001-07-19
WO2001051083A3 true WO2001051083A3 (en) 2002-01-03

Family

ID=27390599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/001046 WO2001051083A2 (en) 2000-01-13 2001-01-12 Innate immunity-stimulating compositions of cpg and saponin and methods thereof

Country Status (4)

Country Link
JP (1) JP2003527352A (en)
AU (1) AU781812B2 (en)
CA (1) CA2397374A1 (en)
WO (1) WO2001051083A2 (en)

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US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US7776343B1 (en) 1999-02-17 2010-08-17 Csl Limited Immunogenic complexes and methods relating thereto
GB9908885D0 (en) * 1999-04-19 1999-06-16 Smithkline Beecham Biolog Vccine
EP2322210A1 (en) 1999-04-19 2011-05-18 GlaxoSmithKline Biologicals S.A. Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide
US20020098199A1 (en) * 2000-03-10 2002-07-25 Gary Van Nest Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
AU5697001A (en) 2000-03-31 2001-10-15 Purdue Research Foundation Method of treatment using ligand-immunogen conjugates
KR100860893B1 (en) * 2000-10-18 2008-09-29 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccines
JP4516748B2 (en) 2001-09-14 2010-08-04 サイトス バイオテクノロジー アーゲー Packaging immunostimulatory substances in virus-like particles: preparation and use
ATE451935T1 (en) * 2001-09-28 2010-01-15 Purdue Research Foundation TREATMENT METHODS USING LIGAND-IMMUNOGEN CONJUGATES
WO2003055514A1 (en) 2001-12-21 2003-07-10 Antigenics Inc. Compositions comprising immunoreactive reagents and saponins, and methods of use thereof
CA2388049A1 (en) 2002-05-30 2003-11-30 Immunotech S.A. Immunostimulatory oligonucleotides and uses thereof
ATE489969T1 (en) * 2002-06-20 2010-12-15 Cytos Biotechnology Ag PACKAGED VIRUS-LIKE PARTICLES IN COMBINATION WITH CPG FOR USE AS ADJUVANTS WITH ALLERGENS. MANUFACTURING PROCESS AND USE
CA2502015A1 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5' cpg nucleic acids and methods of use
ES2385933T3 (en) 2003-02-20 2012-08-03 University Of Connecticut Health Center METHODS FOR THE PRODUCTION OF ALFA ANTIGEN MOLECULES COMPLEXES (2) MACROGLOBULIN.
EP1670507A4 (en) 2003-09-12 2007-10-17 Antigenics Inc Vaccine for treatment and prevention of herpes simplex virus infection
WO2007092299A2 (en) 2006-02-03 2007-08-16 Purdue Research Foundation Targeted conjugates and radiation
WO2010115118A2 (en) 2009-04-03 2010-10-07 Antigenics, Inc. Methods for preparing and using multichaperone-antigen complexes
JP6045895B2 (en) 2012-10-01 2016-12-14 株式会社トプコン Ophthalmic observation device
CA2984643A1 (en) 2015-05-13 2016-11-17 Agenus Inc. Vaccines for treatment and prevention of cancer
US20180325971A1 (en) 2016-07-29 2018-11-15 Saponin Research Center S.A. Use of quillaja saponaria extracts for the prevention and control of viral infections in fish
WO2018018170A1 (en) 2016-07-29 2018-02-01 Saponin Research Center S.A. Use of extracts of quillaja saponaria for the prevention and control of bacterial infections in fish
US11541274B2 (en) 2019-03-11 2023-01-03 Rom Technologies, Inc. System, method and apparatus for electrically actuated pedal for an exercise or rehabilitation machine
US20200289889A1 (en) 2019-03-11 2020-09-17 Rom Technologies, Inc. Bendable sensor device for monitoring joint extension and flexion
US11185735B2 (en) 2019-03-11 2021-11-30 Rom Technologies, Inc. System, method and apparatus for adjustable pedal crank
US11957960B2 (en) 2019-05-10 2024-04-16 Rehab2Fit Technologies Inc. Method and system for using artificial intelligence to adjust pedal resistance
US11801423B2 (en) 2019-05-10 2023-10-31 Rehab2Fit Technologies, Inc. Method and system for using artificial intelligence to interact with a user of an exercise device during an exercise session
US11904207B2 (en) 2019-05-10 2024-02-20 Rehab2Fit Technologies, Inc. Method and system for using artificial intelligence to present a user interface representing a user's progress in various domains
US11071597B2 (en) 2019-10-03 2021-07-27 Rom Technologies, Inc. Telemedicine for orthopedic treatment
US11701548B2 (en) 2019-10-07 2023-07-18 Rom Technologies, Inc. Computer-implemented questionnaire for orthopedic treatment
US11756666B2 (en) 2019-10-03 2023-09-12 Rom Technologies, Inc. Systems and methods to enable communication detection between devices and performance of a preventative action
US11955220B2 (en) 2019-10-03 2024-04-09 Rom Technologies, Inc. System and method for using AI/ML and telemedicine for invasive surgical treatment to determine a cardiac treatment plan that uses an electromechanical machine
US11101028B2 (en) 2019-10-03 2021-08-24 Rom Technologies, Inc. Method and system using artificial intelligence to monitor user characteristics during a telemedicine session
US11923065B2 (en) 2019-10-03 2024-03-05 Rom Technologies, Inc. Systems and methods for using artificial intelligence and machine learning to detect abnormal heart rhythms of a user performing a treatment plan with an electromechanical machine
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US11955221B2 (en) 2019-10-03 2024-04-09 Rom Technologies, Inc. System and method for using AI/ML to generate treatment plans to stimulate preferred angiogenesis
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US11069436B2 (en) 2019-10-03 2021-07-20 Rom Technologies, Inc. System and method for use of telemedicine-enabled rehabilitative hardware and for encouraging rehabilitative compliance through patient-based virtual shared sessions with patient-enabled mutual encouragement across simulated social networks
US11826613B2 (en) 2019-10-21 2023-11-28 Rom Technologies, Inc. Persuasive motivation for orthopedic treatment
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Citations (4)

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WO1998037919A1 (en) * 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
WO1999061056A2 (en) * 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methods and products for inducing mucosal immunity
WO2000009159A1 (en) * 1998-08-10 2000-02-24 Aquila Biopharmaceuticals, Inc. Compositions of cpg and saponin adjuvants and methods thereof
WO2000062800A2 (en) * 1999-04-19 2000-10-26 Smithkline Beecham Biologicals Sa Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1998037919A1 (en) * 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
WO1999061056A2 (en) * 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methods and products for inducing mucosal immunity
WO2000009159A1 (en) * 1998-08-10 2000-02-24 Aquila Biopharmaceuticals, Inc. Compositions of cpg and saponin adjuvants and methods thereof
WO2000062800A2 (en) * 1999-04-19 2000-10-26 Smithkline Beecham Biologicals Sa Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide

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Title
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Also Published As

Publication number Publication date
AU781812B2 (en) 2005-06-16
AU2787701A (en) 2001-07-24
JP2003527352A (en) 2003-09-16
CA2397374A1 (en) 2001-07-19
WO2001051083A2 (en) 2001-07-19

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