WO2001045637A2 - Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides - Google Patents
Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides Download PDFInfo
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- WO2001045637A2 WO2001045637A2 PCT/SE2000/002559 SE0002559W WO0145637A2 WO 2001045637 A2 WO2001045637 A2 WO 2001045637A2 SE 0002559 W SE0002559 W SE 0002559W WO 0145637 A2 WO0145637 A2 WO 0145637A2
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- Prior art keywords
- compound
- quinolinyl
- piperazinyl
- methyl
- diethyl
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- 0 CCN(C*)C(c1ccc(C(c2c3ncccc3ccc2)N2CCN(Cc3ccc(C(C)(C)S)cc3)CC2)cc1)=O Chemical compound CCN(C*)C(c1ccc(C(c2c3ncccc3ccc2)N2CCN(Cc3ccc(C(C)(C)S)cc3)CC2)cc1)=O 0.000 description 2
- XLADLHOGPMXYHT-UHFFFAOYSA-N CCN(CC)C(c1ccc(C(c2c3ncccc3ccc2)N2CCNCC2)cc1)=O Chemical compound CCN(CC)C(c1ccc(C(c2c3ncccc3ccc2)N2CCNCC2)cc1)=O XLADLHOGPMXYHT-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the present invention is directed to novel compounds, to a process for their preparation, their use and pharmaceutical compositions comprising the novel compounds.
- the novel compounds are useful in therapy, and in particular for the treatment of pain.
- the ⁇ receptor has been identified as having a role in many bodily functions such as circulatory and pain systems. Ligands for the ⁇ receptor may therefore find potential use as analgesics, and/or as antihypertensive agents. Ligands for the ⁇ receptor have also been shown to possess immunomodulatory activities.
- the problem underlying the present invention was to find new analgesics having improved analgesic effects, but also with an improved side-effect profile over current ⁇ agonists, as well as having improved systemic efficacy.
- Analgesics that have been identified and are existing in the prior art have many disadvantages in that they suffer from poor pharmacokinetics and are not analgesic when administered by systemic routes. Also, it has been documented that preferred ⁇ agonist compounds, described within the prior art, show significant convulsive effects when administered systemically.
- novel compounds according to the present invention are defined by the formula I
- R is selected from
- each R phenyl ring and R heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched Ci-C ⁇ alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo.
- the substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems.
- the compounds of formula I are present as the (+)-enantiomer, or as the (-)-enantiomer.
- isomers we mean compounds of the formula I, which differ by the position of their functional group and/or orientation.
- orientation we mean stereoisomers, diastereoisomers, regioisomers and enantiomers.
- novel compounds of the present invention are useful in therapy, especially for the treatment of various pain conditions such as chronic pain, neuropathic pain, acute pain, cancer pain, pain caused by rheumatoid arthritis, migraine, visceral pain etc. This list should however not be interpreted as exhaustive.
- Compounds of the invention are useful as immunomodulators, especially for autoimmune diseases, such as arthritis, for skin grafts, organ transplants and similar surgical needs, for collagen diseases, various allergies, for use as anti-tumour agents and anti viral agents.
- Compounds of the invention are useful in disease states where degeneration or dysfunction of opioid receptors is present or implicated in that paradigm. This may involve the use of isotopically labelled versions of the compounds of the invention in diagnostic techniques and imaging applications such as positron emission tomography (PET).
- Compounds of the invention are useful for the treatment of diarrhoea, depression, anxiety, urinary incontinence, various mental illnesses, cough, lung oedema, various gastrointestinal disorders, spinal injury and drug addiction, including the treatment of alcohol, nicotine, opioid and other drug abuse and for disorders of the sympathetic nervous system for example hypertension.
- Compounds of the invention are useful as an analgesic agent for use during general anaesthesia and monitored anaesthesia care.
- Combinations of agents with different properties are often used to achieve a balance of effects needed to maintain the anaesthetic state (eg. amnesia, analgesia, muscle relaxation and sedation). Included in this combination are inhaled anaesthetics, hypnotica, anxiolytics, neuromuscular blockers and opioids.
- a further aspect of the invention is a method for the treatment of a subject suffering from any of the conditions discussed above, whereby an effective amount of a compound according to the formula I above, is administered to a patient in need of such treatment.
- an effective amount of a compound according to the formula I above is administered to a patient in need of such treatment.
- the compounds according to the present invention may be prepared by following any one of the procedures described in Schemes I, II, III, and IV. These known procedures are described in J. March, Advanced Organic Chemistry, 4' ' Edition, John Wiley and sons (1992); Katritsky, A.R., Lan, X. Chem. Soc. Rev., pp. 363-373 (1994), which are hereby incorporated by reference. SCHEME I
- R 1 as defined in formula (I) above SCHEME II
- R 1 as defined in formula (I) above SCHEME IV
- 8-Bromoquinoline (3.0 g, 14.4 mmol) was dissolved in dry THF (150 mL) and cooled to -78 °C under nitrogen.
- s-BuLi (11.1 mL, 1.3 M in pentane, 14.4 mmol) was added dropwise during 5 min (Preparation and reactions with 8-lithioquinoline: Suggs, J. Org. Chem. 1980, 45, 1514.).
- ⁇ /V-diethyl-4-formylbenzamide (3.5 g, 17.0 mmol) was added dissolved in THF (5 mL). The solution was stirred 1 h, then NH CI (aq.) was added.
- novel compounds according to the present invention may be administered orally, intramuscularly, subcutaneously, topically, intranasally, intraperitoneally, intrathoracially, intravenously, epidurally, intrathecally, intracerebroventricularly and by injection into the joints.
- a preferred route of administration is orally, intravenously or intramuscularly.
- the dosage will depend on the route of administration, the severity of the disease, age and weight of the patient and other factors normally considered by the attending physician, when determining the individual regimen and dosage level as the most appropriate for a particular patient.
- inert, pharmaceutically acceptable carriers can be either solid or liquid.
- Solid form preparations include powders, tablets, dispersible granules, capsules, cachets, and suppositories.
- a solid carrier can be one or more substances which may also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders, or tablet disintegrating agents; it can also be an encapsulating material.
- the carrier is a finely divided solid which is in a mixture with the finely divided active component.
- the active component is mixed with the carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired.
- a low-melting wax such as a mixture of fatty acid glycerides and cocoa butter is first melted and the active ingredient is dispersed therein by, for example, stirring. The molten homogeneous mixture is then poured into convenient sized molds and allowed to cool and solidify.
- Suitable carriers are magnesium carbonate, magnesium stearate, talc, lactose, sugar, pectin, dextrin, starch, tragacanth, methyl cellulose, sodium carboxymethyl cellulose, a low- melting wax, cocoa butter, and the like.
- salts are acetate, benzenesulfonate, benzoate, bicarbonate, bitartrate, bromide, calcium acetate, camsylate, carbonate, chloride, citrate, dihydrochloride, edetate, edisylate, estolate, esylate, fumarate, glucaptate, gluconate, glutamate, glycollylarsanilate, hexylresorcinate, hydrabamine, hydrobromide, hydrochloride, hydroxynaphthoate, iodide, isethionate, lactate, lactobionate, malate, maleate, mandelate mesylate, methylbromide, methylnitrate, methylsulfate, mucate, napsylate, nitrate, pamoate (embonate), pantothenate, phosphate/diphosphate, polygalacturonate, salicylate, stearate, sub
- composition is intended to include the formulation of the active component with encapsulating material as a carrier providing a capsule in which the active component (with or without other carriers) is surrounded by a carrier which is thus in association with it. Similarly, cachets are included.
- Tablets, powders, cachets, and capsules can be used as solid dosage forms suitable for oral administration.
- Liquid from compositions include solutions, suspensions, and emulsions.
- Sterile water or water-propylene glycol solutions of the active compounds may be mentioned as an example of liquid preparations suitable for parenteral administration.
- Liquid compositions can also be formulated in solution in aqueous polyethylene glycol solution.
- Aqueous solutions for oral administration can be prepared by dissolving the active component in water and adding suitable colorants, flavoring agents, stabilizers, and thickening agents as desired.
- Aqueous suspensions for oral use can be made by dispersing the finely divided active component in water together with a viscous material such as natural synthetic gums, resins, methyl cellulose, sodium carboxymethyl cellulose, and other suspending agents known to the pharmaceutical formulation art.
- the pharmaceutical compositions is in unit dosage form.
- the composition is divided into unit doses containing appropriate quantities of the active component.
- the unit dosage form can be a packaged preparation, the package containing discrete quantities of the preparations, for example, packeted tablets, capsules, and powders in vials or ampoules.
- the unit dosage form can also be a capsule, cachet, or tablet itself, or it can be the appropriate number of any of these packaged forms.
- Cells were pelleted and resuspended in lysis buffer (50 mM Tris, pH 7.0, 2.5 mM EDTA, with PMSF added just prior to use to 0.1 mM from a 0.1 M stock in ethanol), incubated on ice for 15 min, then homogenized with a polytron for 30 sec. The suspension was spun at lOOOg (max) for 10 min at 4°C. The supernatant was saved on ice and the pellets resuspended and spun as before. The supernatants from both spins were combined and spun at 46,000 g(max) for 30 min. The pellets were resuspended in cold Tris buffer (50 mM Tris/Cl, pH 7.0) and spun again.
- lysis buffer 50 mM Tris, pH 7.0, 2.5 mM EDTA, with PMSF added just prior to use to 0.1 mM from a 0.1 M stock in ethanol
- the final pellets were resuspended in membrane buffer ( 50 mM Tris, 0.32 M sucrose, pH 7.0). Aliquots (1 ml) in polypropylene tubes were frozen in dry ice/ethanol and stored at -70°C until use. The protein concentrations were determined by a modified Lowry assay with SDS.
- Membranes were thawed at 37°C, cooled on ice, passed 3 times through a 25-gauge needle, and diluted into binding buffer (50 mM Tris, 3 mM MgCl 2 , 1 mg/ml BSA (Sigma A-7888), pH 7.4, which was stored at 4°C after filtration through a 0.22 m filter, and to which had been freshly added 5 ⁇ g/ml aprotinin, 10 ⁇ Mbestatin, 10 ⁇ M diprotin A, no DTT).
- binding buffer 50 mM Tris, 3 mM MgCl 2 , 1 mg/ml BSA (Sigma A-7888), pH 7.4
- the radioactivity (dpm) retained on the filters was measured with a beta counter after soaking the filters for at least 12h in mini vials containing 6-7 ml scintillation fluid. If the assay is set up in 96-place deep well plates, the filtration is over 96-place PEI-soaked unifilters, which were washed with 3 x 1 ml wash buffer, and dried in an oven at 55°C for 2h. The filter plates were counted in a TopCount (Packard) after adding 50 ⁇ l MS-20 scintillation fluid/well.
- TopCount Packard
- the specific binding (SB) was calculated as TB-NS, and the SB in the presence of various test peptides was expressed as percentage of control SB.
- Values of IC50 and Hill coefficient (njj) for ligands in displacing specifically bound radioligand were calculated from logit plots or curve fitting programs such as Ligand, GraphPad Prism, SigmaPlot, or ReceptorFit.
- Values of Kj were calculated from the Cheng-Prussoff equation. Mean ⁇ S.E.M. values of IC50, Kj and n ⁇ were reported for ligands tested in at least three displacement curves. Biological data are reported below in Table 1.
- Radioligand K ⁇ values were determined by performing the binding assays on cell membranes with the appropriate radiohgands at concentrations ranging from 0.2 to 5 times the estimated K ⁇ (up to 10 times if amounts of radioligand required are feasable). The specific radioligand binding was expressed as pmole/mg membrane protein. Values of K ⁇ and B max from individual expe ⁇ ments were obtained from nonlinear fits of specifically bound (B) vs. nM free (F) radioligand from individual according to a one-site model.
- Rats were placed in Plexiglas cages on top of a wire mesh bottom which allowed access to the paw, and were left to habituate for 10-15 min. The area tested was the mid-plantar left hind paw, avoiding the less sensitive foot pads. The paw was touched with a series of 8 Von Frey hairs with logarithmically incremental stiffness (0.41, 0.69, 1.20, 2.04, 3.63, 5.50, 8.51, and 15.14 grams; Stoelting, 111, USA).
- the von Frey hair was applied from underneath the mesh floor pe ⁇ endicular to the plantar surface with sufficient force to cause a slight buckling against the paw, and held for approximately 6-8 seconds. A positive response was noted if the paw was sharply withdrawn. Flinching immediately upon removal of the hair was also considered a positive response. Ambulation was considered an ambiguous response, and in such cases the stimulus was repeated.
- the animals were tested on postoperative day 1 for the FCA-treated group.
- the 50% withdrawal threshold was determined using the up-down method of Dixon (1980). Testing was started with the 2.04 g hair, in the middle of the series. Stimuli were always presented in a consecutive way, whether ascending or descending. In the absence of a paw withdrawal response to the initially selected hair, a stronger stimulus was presented; in the event of paw withdrawal, the next weaker stimulus was chosen.
- Optimal threshold calculation by this method requires 6 responses in the immediate vicinity of the 50% threshold, and counting of these 6 responses began when the first change in response occurred, e.g. the threshold was first crossed.
- ⁇ 0.224.
- Von Frey thresholds were converted to percent of maximum possible effect (% MPE), according to Chaplan et al. 1994. The following equation was used to compute % MPE:
- % MPE Drug treated threshold (g) - allodvnia threshold (g) X 100 Control threshold (g) - allodynia threshold (g)
- Rats were injected (subcutaneously, intraperitoneally, intravenously or orally) with a test substance prior to von Frey testing, the time between administration of test compound and the von Frey test varied depending upon the nature of the test compound.
- Acetic acid will bring abdominal contractions when administered intraperitoneally in mice. These will then extend their body in a typical pattern. When analgesic drugs are administered, this described movement is less frequently observed and the drug selected as a potential good candidate.
- a complete and typical Writhing reflexe is considered only when the following elements are present: the animal is not in movement; the lower back is slightly depressed; the plantar aspect of both paws is observable.
- Acetic acid 120 ⁇ L of Acetic Acid is added to 19.88 ml of distilled water in order to obtain a final volume of 20 ml with a final concentration of 0.6% AcOH. The solution is then mixed (vortex) and ready for injection.
- the AcOH is administered intraperitoneally (i.p.) in two sites at 10 ml/kg (considering the average mice body weight) immediately prior to testing. (iii) Testing
- mice The animal (mouse) is observed for a period of 20 minutes and the number of occasions (Writhing reflex) noted and compiled at the end of the experiment. Mice are kept in individual "shoe box” cages with contact bedding. A total of 4 mice are usually observed at the same time: one control and three doses of drug.
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
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- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract
Description
Claims
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU25643/01A AU780714B2 (en) | 1999-12-20 | 2000-12-15 | Novel compounds |
JP2001546378A JP2003518022A (en) | 1999-12-20 | 2000-12-15 | New compounds |
UA2002064508A UA72945C2 (en) | 1999-12-20 | 2000-12-15 | A compound (variants), a pharmaceutical composition, a method for treatment (variants) |
MXPA02006062A MXPA02006062A (en) | 1999-12-20 | 2000-12-15 | Novel compounds. |
DE60006583T DE60006583T2 (en) | 1999-12-20 | 2000-12-15 | NEW CONNECTIONS |
HU0300298A HUP0300298A2 (en) | 1999-12-20 | 2000-12-15 | 4-[piperazinyl-(8-quinolinyl)metyl]benzamide derivatives, their use and pharmaceutical compositions containing them |
CA002393568A CA2393568C (en) | 1999-12-20 | 2000-12-15 | Diarylmethylpiperazines |
EEP200200334A EE05035B1 (en) | 1999-12-20 | 2000-12-15 | 1- [Phenyl- (8-quinolinyl) methyl] piperazine derivatives and their use in medicine |
US10/149,911 US6784181B2 (en) | 1999-12-20 | 2000-12-15 | Piperazine-containing compounds useful in the treatment of pain |
PL00356797A PL356797A1 (en) | 1999-12-20 | 2000-12-15 | Novel compounds |
EP00989096A EP1242402B1 (en) | 1999-12-20 | 2000-12-15 | Novel compounds |
SK885-2002A SK285753B6 (en) | 1999-12-20 | 2000-12-15 | Benzamide derivatives, pharmaceutical composition containing the derivatives and their use |
DK00989096T DK1242402T3 (en) | 1999-12-20 | 2000-12-15 | New connections |
BR0016578-6A BR0016578A (en) | 1999-12-20 | 2000-12-15 | Compound, use of it, pharmaceutical composition, and, methods for the treatment of pain, for the treatment of gastrointestinal disorders and for the treatment of spinal damage. |
AT00989096T ATE254120T1 (en) | 1999-12-20 | 2000-12-15 | NEW CONNECTIONS |
SI200030296T SI1242402T1 (en) | 1999-12-20 | 2000-12-15 | Novel compounds |
NZ519985A NZ519985A (en) | 1999-12-20 | 2000-12-15 | Opioid receptor ligands for treating pain and gastrointestinal disorders |
IL15012600A IL150126A0 (en) | 1999-12-20 | 2000-12-15 | Novel 4(piperazinyl(8-quinolinyl)methyl) benzamides |
IL150126A IL150126A (en) | 1999-12-20 | 2002-06-10 | 4-(piperazinyl(8-quinolinyl)methyl)benzamides, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for therapy |
BG106806A BG65456B1 (en) | 1999-12-20 | 2002-06-10 | Piperazine quinolinemethyl benzamides, a pharmaceutical composition containing them, and use thereof as medicaments |
IS6423A IS2194B (en) | 1999-12-20 | 2002-06-14 | Compounds containing piperazine that are useful for the treatment of pain |
NO20022918A NO323402B1 (en) | 1999-12-20 | 2002-06-18 | New connections |
HK03100181.6A HK1048113B (en) | 1999-12-20 | 2003-01-07 | Novel compounds |
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SE9904673A SE9904673D0 (en) | 1999-12-20 | 1999-12-20 | Novel compounds |
SE9904673-2 | 1999-12-20 |
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WO2001045637A2 true WO2001045637A2 (en) | 2001-06-28 |
WO2001045637A3 WO2001045637A3 (en) | 2001-12-13 |
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PCT/SE2000/002559 WO2001045637A2 (en) | 1999-12-20 | 2000-12-15 | Novel 4(piperazinyl (8-quinolinyl)metyl)benzamides |
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US (1) | US6784181B2 (en) |
EP (1) | EP1242402B1 (en) |
JP (1) | JP2003518022A (en) |
KR (1) | KR100807515B1 (en) |
CN (1) | CN1225465C (en) |
AT (1) | ATE254120T1 (en) |
AU (1) | AU780714B2 (en) |
BG (1) | BG65456B1 (en) |
BR (1) | BR0016578A (en) |
CA (1) | CA2393568C (en) |
CO (1) | CO5271646A1 (en) |
CZ (1) | CZ20022122A3 (en) |
DE (1) | DE60006583T2 (en) |
DK (1) | DK1242402T3 (en) |
EE (1) | EE05035B1 (en) |
ES (1) | ES2210028T3 (en) |
HK (1) | HK1048113B (en) |
HU (1) | HUP0300298A2 (en) |
IL (2) | IL150126A0 (en) |
IS (1) | IS2194B (en) |
MX (1) | MXPA02006062A (en) |
MY (1) | MY125394A (en) |
NO (1) | NO323402B1 (en) |
NZ (1) | NZ519985A (en) |
PL (1) | PL356797A1 (en) |
PT (1) | PT1242402E (en) |
RU (1) | RU2260006C2 (en) |
SE (1) | SE9904673D0 (en) |
SK (1) | SK285753B6 (en) |
TR (1) | TR200400237T4 (en) |
TW (1) | TWI238822B (en) |
UA (1) | UA72945C2 (en) |
WO (1) | WO2001045637A2 (en) |
ZA (1) | ZA200204256B (en) |
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WO2002070492A1 (en) * | 2001-03-07 | 2002-09-12 | Astrazeneca Ab | New asymmetric process for the preparation of diarylmethylpiperazines derivatives and novel asymmetric diarylmetylamines as intermediates |
JP2005508363A (en) * | 2001-10-29 | 2005-03-31 | アーデント ファーマスーティカルズ,インコーポレイテッド | Method of treating depression with delta receptor agonist compounds |
US7241764B2 (en) | 2002-11-07 | 2007-07-10 | Astrazeneca Ab | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
US7253173B2 (en) | 2002-11-07 | 2007-08-07 | Astrazeneca Ab | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain of gastrointestinal disorders |
US7396834B2 (en) | 2002-11-07 | 2008-07-08 | Astrazeneca Ab | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
US7659286B2 (en) | 2006-10-20 | 2010-02-09 | Astrazeneca Ab | N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide |
US7915413B2 (en) | 2001-05-18 | 2011-03-29 | Astrazeneca Ab | Compounds |
US8129393B2 (en) | 2004-08-02 | 2012-03-06 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
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US8987736B2 (en) * | 2000-07-10 | 2015-03-24 | Amit Goyal | [100] or [110] aligned, semiconductor-based, large-area, flexible, electronic devices |
SE0400027D0 (en) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
SE0401968D0 (en) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
US20100029681A1 (en) * | 2006-05-26 | 2010-02-04 | Hassan Pajouhesh | Heterocyclic compounds as calcium channel blockers |
AU2009249714A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Method of treating anxious major depressive disorder |
CN111465623B (en) * | 2017-12-12 | 2022-08-02 | 学校法人东京理科大学 | Active energy ray-curable composition |
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- 2000-12-15 ES ES00989096T patent/ES2210028T3/en not_active Expired - Lifetime
- 2000-12-15 HU HU0300298A patent/HUP0300298A2/en unknown
- 2000-12-15 CZ CZ20022122A patent/CZ20022122A3/en unknown
- 2000-12-15 NZ NZ519985A patent/NZ519985A/en unknown
- 2000-12-15 DK DK00989096T patent/DK1242402T3/en active
- 2000-12-15 UA UA2002064508A patent/UA72945C2/en unknown
- 2000-12-15 DE DE60006583T patent/DE60006583T2/en not_active Expired - Fee Related
- 2000-12-15 MX MXPA02006062A patent/MXPA02006062A/en active IP Right Grant
- 2000-12-15 US US10/149,911 patent/US6784181B2/en not_active Expired - Fee Related
- 2000-12-15 EE EEP200200334A patent/EE05035B1/en not_active IP Right Cessation
- 2000-12-15 PL PL00356797A patent/PL356797A1/en not_active IP Right Cessation
- 2000-12-15 IL IL15012600A patent/IL150126A0/en active IP Right Grant
- 2000-12-15 TR TR2004/00237T patent/TR200400237T4/en unknown
- 2000-12-15 PT PT00989096T patent/PT1242402E/en unknown
- 2000-12-15 KR KR1020027007835A patent/KR100807515B1/en not_active IP Right Cessation
- 2000-12-15 EP EP00989096A patent/EP1242402B1/en not_active Expired - Lifetime
- 2000-12-15 BR BR0016578-6A patent/BR0016578A/en not_active Application Discontinuation
- 2000-12-15 SK SK885-2002A patent/SK285753B6/en not_active IP Right Cessation
- 2000-12-15 JP JP2001546378A patent/JP2003518022A/en active Pending
- 2000-12-15 RU RU2002114345/04A patent/RU2260006C2/en not_active IP Right Cessation
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- 2000-12-15 WO PCT/SE2000/002559 patent/WO2001045637A2/en active IP Right Grant
- 2000-12-15 CN CNB008189765A patent/CN1225465C/en not_active Expired - Fee Related
- 2000-12-15 AT AT00989096T patent/ATE254120T1/en not_active IP Right Cessation
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Cited By (15)
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KR100856996B1 (en) * | 2001-03-07 | 2008-09-04 | 아스트라제네카 아베 | New Asymmetric Process for the Preparation of Diarylmethylpiperazines Derivatives and Novel Asymmetric Diarylmethylamines as Intermediates |
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US7960389B2 (en) | 2002-11-07 | 2011-06-14 | Astrazeneca Ab | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
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