WO2001044465A3 - Therapeutically useful synthetic oligonucleotides - Google Patents

Therapeutically useful synthetic oligonucleotides Download PDF

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Publication number
WO2001044465A3
WO2001044465A3 PCT/CA2000/001467 CA0001467W WO0144465A3 WO 2001044465 A3 WO2001044465 A3 WO 2001044465A3 CA 0001467 W CA0001467 W CA 0001467W WO 0144465 A3 WO0144465 A3 WO 0144465A3
Authority
WO
WIPO (PCT)
Prior art keywords
gxty
tygx
synthetic oligonucleotides
therapeutically useful
useful synthetic
Prior art date
Application number
PCT/CA2000/001467
Other languages
French (fr)
Other versions
WO2001044465A2 (en
Inventor
Nigel C Phillips
Mario C Filion
Original Assignee
Bioniche Life Sciences Inc
Nigel C Phillips
Mario C Filion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioniche Life Sciences Inc, Nigel C Phillips, Mario C Filion filed Critical Bioniche Life Sciences Inc
Priority to DK00981117T priority Critical patent/DK1238070T3/en
Priority to DE60036019T priority patent/DE60036019T2/en
Priority to PL00355868A priority patent/PL355868A1/en
Priority to MXPA02005842A priority patent/MXPA02005842A/en
Priority to AU18479/01A priority patent/AU785212B2/en
Priority to JP2001545542A priority patent/JP4772245B2/en
Priority to IL15019600A priority patent/IL150196A0/en
Priority to CA002393808A priority patent/CA2393808A1/en
Priority to EP00981117A priority patent/EP1238070B1/en
Priority to HU0300627A priority patent/HUP0300627A3/en
Priority to MXPA03001812A priority patent/MXPA03001812A/en
Priority to EP01947067A priority patent/EP1313853B1/en
Priority to ES01947067T priority patent/ES2383671T3/en
Priority to DK01947067.3T priority patent/DK1313853T3/en
Priority to JP2002522500A priority patent/JP2004507469A/en
Priority to PCT/CA2001/000845 priority patent/WO2002018593A2/en
Priority to CA002420103A priority patent/CA2420103A1/en
Priority to US09/879,668 priority patent/US20020091095A1/en
Priority to PT01947067T priority patent/PT1313853E/en
Priority to AU2001268863A priority patent/AU2001268863B2/en
Priority to AT01947067T priority patent/ATE550428T1/en
Priority to AU6886301A priority patent/AU6886301A/en
Publication of WO2001044465A2 publication Critical patent/WO2001044465A2/en
Publication of WO2001044465A3 publication Critical patent/WO2001044465A3/en
Priority to IL150196A priority patent/IL150196A/en
Priority to NO20022820A priority patent/NO330508B1/en
Priority to US10/280,274 priority patent/US7662792B2/en
Priority to AU2007200536A priority patent/AU2007200536A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides a composition and method comprising a 2-20 base 3'-OH, 5'-OH synthetic oligonucleotide (sequence) selected from the group consisting of (GxTy)n, (TyGx)n, a(GxTy)n, a(TyGx)n, (GxTy)nb, (TyGx)nb, a(GxTy)nb, a(TyGx)nb, wherein x and y is an integer between 1 and 7, n is an integer between 1 and 12, a and b are one or more As, Cs, Gs or Ts and wherein the sequence induces a response selected from the group consisting of induction of cell cycle arrest, inhibition of proliferation, activation of caspases and induction of apoptosis in cancer cells and production of cytokines by immune system cells.
PCT/CA2000/001467 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides WO2001044465A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
DK00981117T DK1238070T3 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides
DE60036019T DE60036019T2 (en) 1999-12-13 2000-12-12 SYNTHETIC OLIGONUCLEOTIDES THAT ARE THERAPEUTICALLY USEFUL
PL00355868A PL355868A1 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides
MXPA02005842A MXPA02005842A (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides.
AU18479/01A AU785212B2 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides
JP2001545542A JP4772245B2 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides
IL15019600A IL150196A0 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides
CA002393808A CA2393808A1 (en) 1999-12-13 2000-12-12 Anti-cancer synthetic oligonucleotides
EP00981117A EP1238070B1 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides
HU0300627A HUP0300627A3 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides
DK01947067.3T DK1313853T3 (en) 2000-08-29 2001-06-12 Modulation of Fas and Fasl expression with a synthetic phosphodiester oligonucleotide and an anti-Fas antibody
AU2001268863A AU2001268863B2 (en) 1999-12-13 2001-06-12 Modulation of FAS and FASL expression
ES01947067T ES2383671T3 (en) 2000-08-29 2001-06-12 Modulation of Fas and FasL expression by a synthetic oligonucleotide phosphodiester and an anti-Fas antibody
MXPA03001812A MXPA03001812A (en) 2000-08-29 2001-06-12 Modulation of fas and fasl expression.
JP2002522500A JP2004507469A (en) 2000-08-29 2001-06-12 Regulation of FAS and FASL expression
PCT/CA2001/000845 WO2002018593A2 (en) 2000-08-29 2001-06-12 Modulation of fas and fasl expression
CA002420103A CA2420103A1 (en) 2000-08-29 2001-06-12 Modulation of fas and fasl expression
US09/879,668 US20020091095A1 (en) 1999-12-13 2001-06-12 Modulation of Fas and FasL expression
PT01947067T PT1313853E (en) 2000-08-29 2001-06-12 Modulation of fas and fasl expression by a synthetic phosphodiester oligonucleotide and an anti-fas antibody
EP01947067A EP1313853B1 (en) 2000-08-29 2001-06-12 Modulation of fas and fasl expression by a synthetic phosphodiester oligonucleotide and an anti-fas antibody
AT01947067T ATE550428T1 (en) 2000-08-29 2001-06-12 MODULATION OF FAS AND FASL EXPRESSION BY A SYNTHETIC OLIGONUCLEOTIDE AND AN ANTI-FAS ANTIBODY
AU6886301A AU6886301A (en) 2000-08-29 2001-06-12 Modulation of fas and fasl expression
IL150196A IL150196A (en) 1999-12-13 2002-06-12 Compositions comprising therapeutic synthetic phosphodiester oligonucleotides and chemotherapeutic agent
NO20022820A NO330508B1 (en) 1999-12-13 2002-06-13 Mixture consisting of synthetic phosphodiester nucleotide sequence and use thereof.
US10/280,274 US7662792B2 (en) 1999-12-13 2002-10-25 Modulation of Fas and FasL expression
AU2007200536A AU2007200536A1 (en) 1999-12-13 2007-02-07 Therapeutically useful synthetic oligonucleotides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17032599P 1999-12-13 1999-12-13
US60/170,325 1999-12-13
US22892500P 2000-08-29 2000-08-29
US60/228,925 2000-08-29

Publications (2)

Publication Number Publication Date
WO2001044465A2 WO2001044465A2 (en) 2001-06-21
WO2001044465A3 true WO2001044465A3 (en) 2001-11-29

Family

ID=26865979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001467 WO2001044465A2 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides

Country Status (18)

Country Link
US (2) US7157436B2 (en)
EP (2) EP1238070B1 (en)
JP (1) JP4772245B2 (en)
KR (1) KR100829646B1 (en)
CN (2) CN100445380C (en)
AT (2) ATE455851T1 (en)
AU (1) AU785212B2 (en)
CA (1) CA2393808A1 (en)
CZ (1) CZ20022372A3 (en)
DE (2) DE60036019T2 (en)
DK (2) DK1867718T3 (en)
ES (2) ES2288883T3 (en)
HU (1) HUP0300627A3 (en)
IL (2) IL150196A0 (en)
MX (1) MXPA02005842A (en)
NO (1) NO330508B1 (en)
PT (1) PT1238070E (en)
WO (1) WO2001044465A2 (en)

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