WO2001042774A3 - Potentiometric sensor - Google Patents

Potentiometric sensor Download PDF

Info

Publication number
WO2001042774A3
WO2001042774A3 PCT/GB2000/004711 GB0004711W WO0142774A3 WO 2001042774 A3 WO2001042774 A3 WO 2001042774A3 GB 0004711 W GB0004711 W GB 0004711W WO 0142774 A3 WO0142774 A3 WO 0142774A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
flow channel
analyte ions
sample solution
substrate chip
Prior art date
Application number
PCT/GB2000/004711
Other languages
French (fr)
Other versions
WO2001042774A2 (en
Inventor
Andreas Manz
Ratna Tantra
Original Assignee
Imperial College
Andreas Manz
Ratna Tantra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College, Andreas Manz, Ratna Tantra filed Critical Imperial College
Priority to EP00985509A priority Critical patent/EP1238269A2/en
Priority to US10/148,969 priority patent/US20030112013A1/en
Publication of WO2001042774A2 publication Critical patent/WO2001042774A2/en
Publication of WO2001042774A3 publication Critical patent/WO2001042774A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/4035—Combination of a single ion-sensing electrode and a single reference electrode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A microfabricated potentiometric sensor and a method of measuring the activity of analyte ions in a sample solution, the sensor comprising: a substrate chip; a flow channel defined by the substrate chip through which analyte ions of a sample solution are in use driven; at least one ion-selective electrode comprising a chamber defined by the substrate chip and including a port in communication with the flow channel, an ion-selective membrane disposed in the chamber, and a conductive element configured such as in use to be in electrical connection with the ion-selective membrane; a reference electrode configured such as in use to be in electrical connection with the flow channel; whereby, on driving analyte ions of a sample solution through the flow channel, an electromotive force is developed between the at least one ion-selective electrode and the reference electrode which is representative of the activity of the analyte ions.
PCT/GB2000/004711 1999-12-08 2000-12-08 Potentiometric sensor WO2001042774A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00985509A EP1238269A2 (en) 1999-12-08 2000-12-08 Potentiometric sensor
US10/148,969 US20030112013A1 (en) 1999-12-08 2000-12-08 Potentiometric sensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9929069.4A GB9929069D0 (en) 1999-12-08 1999-12-08 Potentiometric sensor
GB9929069.4 1999-12-08

Publications (2)

Publication Number Publication Date
WO2001042774A2 WO2001042774A2 (en) 2001-06-14
WO2001042774A3 true WO2001042774A3 (en) 2001-12-27

Family

ID=10865966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004711 WO2001042774A2 (en) 1999-12-08 2000-12-08 Potentiometric sensor

Country Status (3)

Country Link
EP (1) EP1238269A2 (en)
GB (1) GB9929069D0 (en)
WO (1) WO2001042774A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE50105368D1 (en) * 2001-06-28 2005-03-24 Agilent Technologies Inc Microfluidic system with regulator
NL1021269C2 (en) * 2002-08-14 2004-02-17 Lionix B V Electrode system, for electro hydraulic microsystems, used for chemical analysis, includes hydraulic constriction filled with second electrically conductive liquid
DE102017109225A1 (en) * 2017-04-28 2018-10-31 Testo SE & Co. KGaA Measuring arrangement for measuring liquids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4314755A1 (en) * 1993-05-05 1994-11-10 Meinhard Prof Dr Knoll Capillary-electrophoresis separation method and device for carrying out chemical and biochemical analyses
DE4408352A1 (en) * 1994-03-12 1995-09-14 Meinhard Prof Dr Knoll Miniaturized flow measuring chamber with integrated chemical and biosensor elements as well as processes for their production
WO1998032008A1 (en) * 1997-01-20 1998-07-23 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Electrochemical flow cell
WO1998049549A1 (en) * 1997-04-30 1998-11-05 Orion Research, Inc. Capillary electrophoretic separation system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4314755A1 (en) * 1993-05-05 1994-11-10 Meinhard Prof Dr Knoll Capillary-electrophoresis separation method and device for carrying out chemical and biochemical analyses
DE4408352A1 (en) * 1994-03-12 1995-09-14 Meinhard Prof Dr Knoll Miniaturized flow measuring chamber with integrated chemical and biosensor elements as well as processes for their production
WO1998032008A1 (en) * 1997-01-20 1998-07-23 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Electrochemical flow cell
WO1998049549A1 (en) * 1997-04-30 1998-11-05 Orion Research, Inc. Capillary electrophoretic separation system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARQUINT P ET AL: "MICROMACHINED ANALYZERS ON A SILICON CHIP", CLINICAL CHEMISTRY,US,AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY. WINSTON, vol. 40, no. 9, 1 September 1994 (1994-09-01), pages 1805 - 1809, XP000444697, ISSN: 0009-9147 *
SHUICHI SHOJI ET AL: "MICRO FLOW CELL FOR BLOOD GAS ANALYSIS REALIZING VERY SMALL SAMPLE VOLUME*", SENSORS AND ACTUATORS B,CH,ELSEVIER SEQUOIA S.A., LAUSANNE, vol. B08, no. 2, 1 May 1992 (1992-05-01), pages 205 - 208, XP000286957, ISSN: 0925-4005 *

Also Published As

Publication number Publication date
EP1238269A2 (en) 2002-09-11
GB9929069D0 (en) 2000-02-02
WO2001042774A2 (en) 2001-06-14

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