WO2001042425A3 - Lung stem cells and lung regeneration - Google Patents

Lung stem cells and lung regeneration Download PDF

Info

Publication number
WO2001042425A3
WO2001042425A3 PCT/US2000/042646 US0042646W WO0142425A3 WO 2001042425 A3 WO2001042425 A3 WO 2001042425A3 US 0042646 W US0042646 W US 0042646W WO 0142425 A3 WO0142425 A3 WO 0142425A3
Authority
WO
WIPO (PCT)
Prior art keywords
lung
stem cells
regeneration
alveolar surface
growth
Prior art date
Application number
PCT/US2000/042646
Other languages
French (fr)
Other versions
WO2001042425A2 (en
Inventor
Margaret Schwarz
David Warburton
Barbara Driscoll
Susan A Buckley
Original Assignee
Los Angeles Childrens Hospital
Margaret Schwarz
David Warburton
Barbara Driscoll
Susan A Buckley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Los Angeles Childrens Hospital, Margaret Schwarz, David Warburton, Barbara Driscoll, Susan A Buckley filed Critical Los Angeles Childrens Hospital
Priority to AU45201/01A priority Critical patent/AU4520101A/en
Priority to EP00992666A priority patent/EP1235485A4/en
Publication of WO2001042425A2 publication Critical patent/WO2001042425A2/en
Publication of WO2001042425A3 publication Critical patent/WO2001042425A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C12N5/0689—Stem cells; Progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Abstract

A method of stimulating the growth of lung alveolar surface in a lung comprises providing progenitor or stem cells capable of regenerating lung alveolar surface, and then administering the progenitor or stem cells to the lung in an amount sufficient to stimulate the growth of lung alveolar surface therein.
PCT/US2000/042646 1999-12-07 2000-12-07 Lung stem cells and lung regeneration WO2001042425A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU45201/01A AU4520101A (en) 1999-12-07 2000-12-07 Lung stem cells and lung regeneration
EP00992666A EP1235485A4 (en) 1999-12-07 2000-12-07 Lung stem cells and lung regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16954599P 1999-12-07 1999-12-07
US60/169,545 1999-12-07

Publications (2)

Publication Number Publication Date
WO2001042425A2 WO2001042425A2 (en) 2001-06-14
WO2001042425A3 true WO2001042425A3 (en) 2002-05-10

Family

ID=22616151

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/042646 WO2001042425A2 (en) 1999-12-07 2000-12-07 Lung stem cells and lung regeneration

Country Status (4)

Country Link
US (2) US20020164790A1 (en)
EP (1) EP1235485A4 (en)
AU (1) AU4520101A (en)
WO (1) WO2001042425A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0218332D0 (en) * 2002-08-07 2002-09-18 Imp College Innovations Ltd Preparation of type pneumocytes
GB0222276D0 (en) * 2002-09-25 2002-10-30 Inst Of Molecul & Cell Biology Methods
EP1548100A1 (en) * 2003-11-11 2005-06-29 DeltaCell B.V. Inhibition of stem cell differentiation, enhancement of proliferation and selective induction of apoptosis by Wnt factors
DE602005027557D1 (en) 2004-04-23 2011-06-01 Bioe Llc MULTIPLE LINE Progenitor Cells
US7622108B2 (en) 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
ES2308877B1 (en) 2005-11-28 2009-10-26 Consejo Superior Investig. Cientificas USE OF TYPE II NUEMOCITS IN THE TREATMENT OF PULMONARY DISEASES COURTING WITH PULMONARY FIBROSIS.
WO2007121443A2 (en) 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
JP5567476B2 (en) * 2007-05-28 2014-08-06 モナッシュ ユニバーシティ Treatment of chronic lung disease
US20120301482A1 (en) * 2009-08-25 2012-11-29 National Jewish Health Methods and compositions for treatment of lung injury
CN112522184B (en) * 2016-04-08 2023-08-04 苏州吉美瑞生医学科技有限公司 Kit and method for separating and obtaining lung stem cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859068A (en) * 1995-02-24 1999-01-12 Children's Medical Center Corporation Acceleration of tissue growth using fluorocarbon liquid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859068A (en) * 1995-02-24 1999-01-12 Children's Medical Center Corporation Acceleration of tissue growth using fluorocarbon liquid

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHAPELIER ET AL.: "Gene therapy in lung transplantation: feasibility of ex vivo adenovirus-mediated gene transfer to the graft", HUMAN GENE THERAPY, vol. 7, 1 October 1996 (1996-10-01), pages 1837 - 1845, XP002942526 *
OTTO ET AL.: "Lung stem cells", INT. J. EXP. PATHOL., vol. 78, no. 5, October 1997 (1997-10-01), pages 291 - 310, XP002942524 *
SHAABAN ET AL.: "Fetal hematopoietic stem cell transplantation", SEMINARS IN PERINATOLOGY, vol. 23, no. 6, December 1999 (1999-12-01), pages 515 - 523, XP002942525 *
WARBURTON ET AL.: "Commitment and differentiation of lung cell lineages", BIOCHEM. CELL BIOL., vol. 76, 1998, pages 971 - 995, XP002942522 *
ZEPEDA ET AL.: "Characterization of stem cells in human airway capable of reconstituting a fully differentiated epithelium", SOMATIC CELL AND MOLECULAR GENETICS, vol. 21, no. 1, 1995, pages 61 - 73, XP002942523 *

Also Published As

Publication number Publication date
US20020164790A1 (en) 2002-11-07
AU4520101A (en) 2001-06-18
EP1235485A4 (en) 2005-08-31
EP1235485A2 (en) 2002-09-04
WO2001042425A2 (en) 2001-06-14
US20040229352A1 (en) 2004-11-18

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