WO2001038381A1 - Nouveau polypeptide phosphodiesterase 17 humaine inhibee par gmpc et polynucleotide le codant - Google Patents
Nouveau polypeptide phosphodiesterase 17 humaine inhibee par gmpc et polynucleotide le codant Download PDFInfo
- Publication number
- WO2001038381A1 WO2001038381A1 PCT/CN2000/000451 CN0000451W WO0138381A1 WO 2001038381 A1 WO2001038381 A1 WO 2001038381A1 CN 0000451 W CN0000451 W CN 0000451W WO 0138381 A1 WO0138381 A1 WO 0138381A1
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- WIPO (PCT)
- Prior art keywords
- polypeptide
- polynucleotide
- phosphodiesterase
- guanine
- human
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La présente invention concerne un nouveau polypeptide phosphodiestérase 17 humaine inhibée par GMPc ainsi qu'un polynucléotide le codant, de même qu'une méthode de production du polypeptide par génie génétique. La présente invention concerne également des méthodes d'utilisation du polypeptide dans le traitement de diverses maladies, telles que des tumeurs malignes, des maladies du sang, des infections à VIH, des maladies immunologiques et diverses inflammations. La présente invention concerne également un antagoniste contre le polypeptide et l'utilisation thérapeutique de celui-ci. En outre, la présente invention concerne l'utilisation de ce polynucléotide codant la phosphodiestérase 17 humaine inhibée par GMPc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU15097/01A AU1509701A (en) | 1999-11-23 | 2000-11-20 | A novel polypeptide - human cgmp-inhibited phosphodiesterase 17 and a polynucleotide encoding the same |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99124077.4 | 1999-11-23 | ||
| CN99124077A CN1297049A (zh) | 1999-11-23 | 1999-11-23 | 一种新的多肽——人环磷酸鸟嘌呤抑制的磷酸二酯酶17和编码这种多肽的多核苷酸 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001038381A1 true WO2001038381A1 (fr) | 2001-05-31 |
Family
ID=5283170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2000/000451 WO2001038381A1 (fr) | 1999-11-23 | 2000-11-20 | Nouveau polypeptide phosphodiesterase 17 humaine inhibee par gmpc et polynucleotide le codant |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1297049A (fr) |
| AU (1) | AU1509701A (fr) |
| WO (1) | WO2001038381A1 (fr) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672509A (en) * | 1993-08-25 | 1997-09-30 | Pfizer Inc. | hPDE IV-C: a human phosphodiesterase IV isozyme |
| US5702936A (en) * | 1993-05-27 | 1997-12-30 | Icos Corporation | Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
| US5798246A (en) * | 1996-03-25 | 1998-08-25 | Incyte Pharmaceuticals, Inc. | Cyclic nucleotide phosphodiesterase |
| WO1999019495A1 (fr) * | 1997-10-16 | 1999-04-22 | Icos Corporation | Phosphodiesterase 8a |
-
1999
- 1999-11-23 CN CN99124077A patent/CN1297049A/zh active Pending
-
2000
- 2000-11-20 AU AU15097/01A patent/AU1509701A/en not_active Abandoned
- 2000-11-20 WO PCT/CN2000/000451 patent/WO2001038381A1/fr active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5702936A (en) * | 1993-05-27 | 1997-12-30 | Icos Corporation | Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
| US5672509A (en) * | 1993-08-25 | 1997-09-30 | Pfizer Inc. | hPDE IV-C: a human phosphodiesterase IV isozyme |
| US5798246A (en) * | 1996-03-25 | 1998-08-25 | Incyte Pharmaceuticals, Inc. | Cyclic nucleotide phosphodiesterase |
| WO1999019495A1 (fr) * | 1997-10-16 | 1999-04-22 | Icos Corporation | Phosphodiesterase 8a |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1297049A (zh) | 2001-05-30 |
| AU1509701A (en) | 2001-06-04 |
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