WO2001036587A3 - Gene for encoding merozoite surface protein of plasmodium vivax and use thereof - Google Patents

Gene for encoding merozoite surface protein of plasmodium vivax and use thereof Download PDF

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Publication number
WO2001036587A3
WO2001036587A3 PCT/KR2000/001302 KR0001302W WO0136587A3 WO 2001036587 A3 WO2001036587 A3 WO 2001036587A3 KR 0001302 W KR0001302 W KR 0001302W WO 0136587 A3 WO0136587 A3 WO 0136587A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
surface protein
merozoite surface
provides
protein
Prior art date
Application number
PCT/KR2000/001302
Other languages
French (fr)
Other versions
WO2001036587A2 (en
Inventor
Hyun Park
Original Assignee
Humanbio Co Ltd
Hyun Park
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019990050616A external-priority patent/KR20010046731A/en
Priority claimed from KR1020000022041A external-priority patent/KR20010097729A/en
Priority claimed from KR1020000027305A external-priority patent/KR20010106041A/en
Application filed by Humanbio Co Ltd, Hyun Park filed Critical Humanbio Co Ltd
Priority to AU14209/01A priority Critical patent/AU1420901A/en
Publication of WO2001036587A2 publication Critical patent/WO2001036587A2/en
Publication of WO2001036587A3 publication Critical patent/WO2001036587A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a gene encoding merozoite surface protein of Plasmodium and a method for preparing 27.5 kDa recombinant antigen protein by expressing the above gene in E. coli expression vector. The invention also provides a method of using the gene encoding C-terminal of prior known merozoite surface protein of Plasmodium in determining and/or diagnosing the malarial infection, comprising to clone the gene and to produce about 27 kDa recombinant protein from such gene. More particularly, the invention provides the more simple and convenient method for diagnosing the malarial infection having improvements in higher sensitivity and specificity, compared with conventional diagnosis methods, by applying the enzyme-linked immunosorbent assay(ELISA) method.
PCT/KR2000/001302 1999-11-15 2000-11-15 Gene for encoding merozoite surface protein of plasmodium vivax and use thereof WO2001036587A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14209/01A AU1420901A (en) 1999-11-15 2000-11-15 Gene for encoding merozoite surface protein of plasmodium vivax and use thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR1999/50616 1999-11-15
KR1019990050616A KR20010046731A (en) 1999-11-15 1999-11-15 DNA sequence of merozoite surface protein of Plasmodium vivax
KR2000/22041 2000-04-25
KR1020000022041A KR20010097729A (en) 2000-04-25 2000-04-25 Malaria antibody diagnostic kits and methods for the same
KR1020000027305A KR20010106041A (en) 2000-05-20 2000-05-20 Malaria antibody-diagnostic kits and methods for manufacturing the same
KR2000/27305 2000-05-20

Publications (2)

Publication Number Publication Date
WO2001036587A2 WO2001036587A2 (en) 2001-05-25
WO2001036587A3 true WO2001036587A3 (en) 2002-02-28

Family

ID=27350093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2000/001302 WO2001036587A2 (en) 1999-11-15 2000-11-15 Gene for encoding merozoite surface protein of plasmodium vivax and use thereof

Country Status (2)

Country Link
AU (1) AU1420901A (en)
WO (1) WO2001036587A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2378949B (en) * 2001-08-16 2005-09-07 Morten Steen Hanefeld Dziegiel Recombinant anti-plasmodium falciparum antibodies
US8268981B2 (en) * 2008-03-06 2012-09-18 Abbott Laboratories Plasmodium malariae and plasmodium ovale genes and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MANCILLA LI ET AL.: "Plasmodium vivax: dimorphic DNA sequences from the MSP-1 gene code for regions that are immunogenic in natural infections", EXP. PARASITO., vol. 79, no. 2, September 1994 (1994-09-01), pages 148 - 158 *
PAN W. ET AL.: "Vaccine candidate MSP-1 from plasmodium falciparum: a redesigned 4917 bp polynucleotide enables synthesis and isolation of full-length protein from escherichia coli and mammalian cells", NUCLEIC ACIDS RES., vol. 27, no. 4, February 1999 (1999-02-01), pages 1094 - 1103, XP002348256, DOI: doi:10.1093/nar/27.4.1094 *

Also Published As

Publication number Publication date
WO2001036587A2 (en) 2001-05-25
AU1420901A (en) 2001-05-30

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