WO2001032129A3 - Augmentation and repair of age-related soft tissue defects - Google Patents

Augmentation and repair of age-related soft tissue defects Download PDF

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Publication number
WO2001032129A3
WO2001032129A3 PCT/US2000/030623 US0030623W WO0132129A3 WO 2001032129 A3 WO2001032129 A3 WO 2001032129A3 US 0030623 W US0030623 W US 0030623W WO 0132129 A3 WO0132129 A3 WO 0132129A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
defect
augmentation
subject
extracellular matrix
Prior art date
Application number
PCT/US2000/030623
Other languages
French (fr)
Other versions
WO2001032129A2 (en
Inventor
Don A Kleinsek
Adriana Soto
Original Assignee
Gerigene Medical Corp
Don A Kleinsek
Adriana Soto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU14725/01A priority Critical patent/AU1472501A/en
Priority to CA002390053A priority patent/CA2390053A1/en
Priority to JP2001534337A priority patent/JP2003517858A/en
Priority to EP00977033A priority patent/EP1263931A4/en
Priority to BR0015367-2A priority patent/BR0015367A/en
Application filed by Gerigene Medical Corp, Don A Kleinsek, Adriana Soto filed Critical Gerigene Medical Corp
Publication of WO2001032129A2 publication Critical patent/WO2001032129A2/en
Publication of WO2001032129A3 publication Critical patent/WO2001032129A3/en
Priority to US11/175,981 priority patent/US20060039896A1/en
Priority to US11/981,668 priority patent/US20080299213A2/en
Priority to US11/981,852 priority patent/US20090074729A2/en
Priority to US11/981,657 priority patent/US20080286242A2/en
Priority to US11/981,658 priority patent/US20090130066A1/en
Priority to US11/982,321 priority patent/US7799325B2/en
Priority to US11/982,338 priority patent/US20080267923A2/en
Priority to US12/924,150 priority patent/US20110110898A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/066—Tenocytes; Tendons, Ligaments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rehabilitation Therapy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)

Abstract

The present invention discloses methods for the long-term augmentation and/or repair of skin defects (scars, skin laxness, skin thinning, and skin augmentation), cellulite, breast tissue, wounds and burns, urological and gastroesophageal sphincter structures, hernias, periodontal disease and disorders, tendon and ligament tears and baldness, by the injection or direct surgical placement/implantation of autologous cultured cells and/or cultured cell-produced extracellular matrix that is derived from connective tissue, dermis, fascia, lamina propria, stroma, adipose tissue, muscle, tendon, ligament or the hair follicle. The corrective application is done on tissue proximal or within the area of the defect. The method involves retrieving viable cells from the subject, a neonate or human fetus. Alternatively, the corrective application involves the cells placed in a matrix, preferably comprised of autologous extracellular matrix constituents as a three-dimensional structure or as a suspension, prior to placement into a position with respect to the subject's defect. In a further embodiment, the preferable autologous extracellular matrix constituents are collected from culture and placed in a position with respect to the subject's defect.
PCT/US2000/030623 1999-11-05 2000-11-06 Augmentation and repair of age-related soft tissue defects WO2001032129A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
AU14725/01A AU1472501A (en) 1999-11-05 2000-11-06 Augmentation and repair of age-related soft tissue defects
CA002390053A CA2390053A1 (en) 1999-11-05 2000-11-06 Augmentation and repair of age-related soft tissue defects
JP2001534337A JP2003517858A (en) 1999-11-05 2000-11-06 Augmentation and repair of age-related soft tissue defects
EP00977033A EP1263931A4 (en) 1999-11-05 2000-11-06 Augmentation and repair of age-related soft tissue defects
BR0015367-2A BR0015367A (en) 1999-11-05 2000-11-06 Increase and repair of age-related soft tissue defects
US11/175,981 US20060039896A1 (en) 1999-11-05 2005-07-06 Augmentation and repair of age-related soft tissue defects
US11/981,658 US20090130066A1 (en) 2000-11-06 2007-10-31 Augmentation and repair of sphincter defects with cells including muscle cells
US11/981,668 US20080299213A2 (en) 1999-11-05 2007-10-31 Augmentation and repair of spincter defects with cells including adipocytic cells
US11/981,657 US20080286242A2 (en) 1999-11-05 2007-10-31 Augmentation and repair of spincter defects with cells including mesenchymal cells
US11/981,852 US20090074729A2 (en) 1999-11-05 2007-10-31 Augmentation and repair of spincter defects with cells including fibroblasts
US11/982,321 US7799325B2 (en) 1999-11-05 2007-11-01 Removal of hypertrophic scars
US11/982,338 US20080267923A2 (en) 1999-11-05 2007-11-01 Hair undifferentiated cells
US12/924,150 US20110110898A1 (en) 1999-11-05 2010-09-22 Bioactive removal of hypertrophic scars

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16373499P 1999-11-05 1999-11-05
US60/163,734 1999-11-05

Related Child Applications (8)

Application Number Title Priority Date Filing Date
US10129180 A-371-Of-International 2000-11-06
US11/175,981 Continuation US20060039896A1 (en) 1999-11-05 2005-07-06 Augmentation and repair of age-related soft tissue defects
US11/981,852 Continuation-In-Part US20090074729A2 (en) 1999-11-05 2007-10-31 Augmentation and repair of spincter defects with cells including fibroblasts
US11/981,657 Continuation-In-Part US20080286242A2 (en) 1999-11-05 2007-10-31 Augmentation and repair of spincter defects with cells including mesenchymal cells
US11/981,658 Continuation-In-Part US20090130066A1 (en) 2000-11-06 2007-10-31 Augmentation and repair of sphincter defects with cells including muscle cells
US11/981,668 Continuation-In-Part US20080299213A2 (en) 1999-11-05 2007-10-31 Augmentation and repair of spincter defects with cells including adipocytic cells
US11/982,321 Continuation-In-Part US7799325B2 (en) 1999-11-05 2007-11-01 Removal of hypertrophic scars
US11/982,338 Continuation-In-Part US20080267923A2 (en) 1999-11-05 2007-11-01 Hair undifferentiated cells

Publications (2)

Publication Number Publication Date
WO2001032129A2 WO2001032129A2 (en) 2001-05-10
WO2001032129A3 true WO2001032129A3 (en) 2001-10-04

Family

ID=22591342

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030623 WO2001032129A2 (en) 1999-11-05 2000-11-06 Augmentation and repair of age-related soft tissue defects

Country Status (7)

Country Link
US (1) US20060039896A1 (en)
EP (1) EP1263931A4 (en)
JP (1) JP2003517858A (en)
AU (1) AU1472501A (en)
BR (1) BR0015367A (en)
CA (1) CA2390053A1 (en)
WO (1) WO2001032129A2 (en)

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