WO2001032085A1 - Device for implanting occlusion coils - Google Patents

Device for implanting occlusion coils Download PDF

Info

Publication number
WO2001032085A1
WO2001032085A1 PCT/EP2000/010660 EP0010660W WO0132085A1 WO 2001032085 A1 WO2001032085 A1 WO 2001032085A1 EP 0010660 W EP0010660 W EP 0010660W WO 0132085 A1 WO0132085 A1 WO 0132085A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
electrolytically
characterized
device according
corrodible
occlusion
Prior art date
Application number
PCT/EP2000/010660
Other languages
German (de)
French (fr)
Inventor
Hermann Monstadt
Hans Henkes
Marion Denk
Original Assignee
Dendron Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12163Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a string of elements connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00404Blood vessels other than those in or around the heart
    • A61B2018/00416Treatment of aneurisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B2018/1405Electrodes having a specific shape
    • A61B2018/1435Spiral
    • A61B2018/1437Spiral whereby the windings of the spiral touch each other such as to create a continuous surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B2018/1495Electrodes being detachable from a support structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure

Abstract

The invention relates to a device for implanting electrolytically detachable occlusion coils in body cavities or blood vessels, comprising a voltage source, a cathode, a catheter and an occlusion coil can be moved in a longitudinal direction inside said catheter wherein said occlusion coil (3) is embodied in such a way that it can be electrolytically corroded at several interspaced points, so that when body fluids come into contact with one or more variable lengths of said occlusion coils (3), said lengths can be separated by electrolysis.

Description

A device for implanting occlusion coils

The invention relates to a device for implanting occlusion coils in cash electrolytically ablös- body cavities or blood vessels.

The use of endovascular techniques for the occlusion of body lumens or vessels such as arteries, veins, fallopian tubes or vascular malformations such. As vascular aneurysms is known in the art. The occlusion is then introduced as a rule by means of an endovascular guidewire through a catheter into the cavity to occiudierenden and deposited.

The necessary for landfill removal of the occlusion created thereby technically particularly problematic because the required for this device must on the one hand be as small as possible to be guided through the gerin- gen diameter of the catheter to the target sites to be able, on the other hand, they must have a reliable separation of the occlusion effect, since this may result in returning the catheter to an unwanted removal of the occlusion of the cavity and thus to occiudierenden injury and / or rupture of the cavity or vessel wall.

Mechanical method for separating the occlusion of the insertion aid are indeed associated with a small amount of time, however, the technical reasons rigidity of the connection of occlusion and insertion more difficult to implant placement. Moreover, due the rigidity of low strength of the joint entails a not insignificant risk of premature separation of an insertion and Occiusionsimplantat. Furthermore must transmit in the mechanical separation of the insertion wire and occlusion coil energy (usually by rotating the Einführdrahtes), whether the implant from the desired position can be displaced by the.

The electrolytic severance of stainless steel wire spikes in blood during transcatheter electro-coagulation of blood vessels or deformities of the same was for the first time in 1979 by Thompson et al and McAlister et al described (Radiology 133: 335-340, November 1979, AJR 132: 998-1000 June 1979).

Based on the EP 0484468 describes a device for implantation of an occlusion based on the electrolytically corrodible formation of the wire tip of the guide wire at the connection between the guidewire and occlusion coil. While this device uses an elegant manner, the voltage applied to Elektrothrombieruπg of serving as an anode occlusion coil voltage for the simultaneous separation of the wire tip and the occlusion coil located thereon, but it has like the aforementioned mechanical separation has the disadvantage that only implants predefined length can be separated. It must be based on the size of the cavity occiudierenden the length usually from immediate implant placement, ie longitudinal extent of the employed occlusion are vordefiπiert. However, since the irregular training to occiudierenden body cavities complicates the assessment of the need to fill the length of the employed occlusion, it may happen that your too long or too short Occlusionswen- be inserted inside the occiudierenden cavity, resulting in incomplete Occludierung one hand, and the damage or rupture of the wall of the cavity to occiudierenden or adjacent vessels may require other.

A further disadvantage of elektrolytischeπ detachment of the guidewire tip is the fact that to form the guide wire only materials can be used, which have high stability, so that the reliable guidance of the introduced Occlusionsdrahtes is possible by the guide wire. The choice of material for the formation of electrolytic Abiösestelle is therefore very limited.

For substances occurring in the prior art devices for the electrolytic detachment of occlusion coils occlusion and guide wire are not manufactured in one piece, but are mechanically connected to each other in the rule. This configuration has the disadvantage that in order to ensure sufficient stability in the proximal region of the guidewire and for the purpose of enabling the electrolytically corrosive dissolution of the wire tip in the distal region of the wire, the guide wire must be rejuvenated by means of expensive grinding process toward the tip. However, this corrodible area of ​​the wire tip of the guide wire at the connection point between the guidewire and occlusion can not be less to ensure adequate stability of the connection point a certain minimum diameter of about 0.05 mm because it is subject to high bending stress. The connection point between occlusion and Führuπgsdraht performing corrodible wire tip is therefore quite rigid and needs to electrolytically corrosive resolution relatively long times.

DE 44 45 715 C2 describes by a laser beam which is focused on the point to be split of the implant by means of an accompanying optical fiber induced separation of an occlusion of the inserter. This device makes it possible to separate the optimal for filling the cavity length of the occlusion coil by means of the filling state of the to occiudierenden cavity during the procedure. Sun can be separated optimally suitable for filling the cavity length when using uniform in length occlusion coils and deposited itself. However, the time required for application of this device technology is still very expensive.

Since the state of the art to date does not provide satisfactory from the cost and safety option for the endovascular landfilling of Occlusi- onswendeln at their ideal length, the invention has for its object to provide a device that makes it possible to cost-effective, effective and safe manner allowed to deposit occlusion coils in each of the right length in body cavities or vessels.

This object is inventively achieved by a device for implantation of peelable electrolysis occlusion coils in body cavities or blood vessels with a voltage source, a cathode, a catheter and a slidable in the catheter in the longitudinal direction serving as an anode occlusion, which is characterized in that the occlusion coil at a plurality of spaced-apart locations is formed electrolytically corrodible so that sigkeit in contact with a Körperflüs- one or more variably dimensioned lengths of the occlusion coil can be detached by electrolysis. The integration of a plurality of electrolytically corrodible points in the occlusion coil has over conventional devices for the electrolytic detachment of occlusion coils has the advantage that not only can be special the replaced several lengths thereof filament in succession and placed in the to occiudierenden cavity during an implant process. This not only saves time and money but will also help to further minimize the operational risk.

The invention is based on experiments by the inventors, which revealed that surprisingly specifically the electrolytically corrodible the distal end of the catheter closest point of the occlusion dissolved by electrolysis at investor gene of a current to a erfiπdungsgemäße device. This specificity is probably due to the fact that on the one hand located in the catheter electrolytically corrodible points of the occlusion coil that are available through the catheter from the ionic medium are isolated, which means that no electrolysis may be subject to, and on the other hand, the current density according to a result of the increasing distally resistance in the occlusion of the proximal distally decreases. Extending distally as the first adjoining the distal catheter end electrolytically corrodible point is therefore subjected to the most electrolytic processes and dissolves preferred. The inventive device for implanting occlusion coils combined than any known in the art other device the advantages of Occlusionseffektivität with operational safety and cost-effectiveness. comparable prevents the determinable during the implantation process implant length that is too short occlusion coil is introduced to the occiudierenden cavity, leading to the formation of a sufficiently large for the space to occiudierenden thrombus. Furthermore, with respect to that of the cavity to occiudierenden too long occlusion coil is inserted, which minimizes the risk of injury or rupture of the cavity to be filled, or adjacent vessels is prevented. It also falls in the electrolytic separation of occlusion coils around a proven technology whose parameters are largely determined. Ultimately, the erfiπ--making device according to implanting occlusion coils in the advantage that cheap unit lengths may be used to occlusion coils for mass production. This represents a Kostenvorteii compared to those in conventional electrolytic or mechanical separation occlusion coils of predetermined length, because it requires different lengths of occlusion coils have to be made up, then pointed at the implantation process in its entirety by separation of the wire to be installed in to occiudierenden cavity.

Since the electrolytically corrodible points of the device according to the invention form part of the occlusion coil itself, and also present in plurality, they are subject applies a substantially lower bending stresses during the implantation process compared to the conventional rigid electrolytically formed connections between the guide wire and Occlusions-. This low bending stress allows the use of electrolytically corrodible points with substantially smaller diameters than in the prior art, resulting in an improved and faster electrolytic releasability of the occlusion coil. Such small diameter of less than 0.5 mm are suitable for this purpose, such. to achieve as mechanical methods.

Another Vorteill the formation of the electrolytically corrodible points of the inventive device in the occlusion coil itself against the occurring in the prior art detachment of the guidewire tip is the much greater choice of materials which can be used for forming the release corrodible sites. In contrast to conventional replacement of the guidewire tip that settled in the Occlusions- spiral electrolytically corrodible points of the device according to the invention need not have very great stability, it is also less stable, more flexible materials are used, therefore, if they are corroded and biocompatible.

Conveniently, can connect to the proximal occlusion as a managerial formed wire insertion. Such an embodiment has the advantage that the guide wire may be formed from with respect to the occlusion expensive materials since it does not come in contact with the body tissue. Furthermore, the configuration of the guide wire is preferably determined such that it allows good control of the octyl clusionswendel through the catheter, which contributes to improved disposability.

In such an embodiment of the inventive device insertion and occlusion coil are preferably connected to each other by soldering and / or gluing and / or welding operations and / or mechanical connections. It is known in the prior art connection methods, which are characterized by simplicity and the stability of the so-induced connection.

In another embodiment, guidewire and occlusion of the device according to the invention may be trained det as parts of the same wire. This embodiment is characterized by exceptional stability and can be very cost-effective because the aforementioned connection method of the guidewire eliminated with the occlusion.

In a particularly advantageous embodiment of the device according to the invention the occlusion coil, or a portion thereof is formed as a micro-coil off. This configuration has the advantage that an increased surface area for the thrombosis is provided. For the same purpose also Toggle particular embodiments of the occlusion can be used, the same increase the surface area, so refinements are conceivable, for example, the distal end bifurcates itself.

In order to ensure as gentle as possible and effective filling of the cavity to occiudierenden, an embodiment of the device according to the invention is advantageous, wherein said occlusion or a part thereof is under elastic pretension, so that it forms turns for release from the catheter. This configuration allows a dense and careful filling of the cavity to occiudierenden without the occlusion coil must be formed through the wall of the cavity to occiudierenden for forming such windings, which reduces the risk of rupture Wandungs. It does this by the elastic bias for formation of secondary windings.

Conveniently, the electrolytically non-corrodible sections of occlusion of one or more of the following materials may include: noble metals or noble metal alloys, corrosion-resistant ceramic materials, corrosion-resistant plastics, preferably platinum metal alloys.

Also preferably, an embodiment of the apparatus of the invention, de- occlusion coil is ren contains the electrolytically corrodible points of one or more of the following materials: ceramic materials, plastics, base metals or alloys thereof, preferably stainless steel

Here, in particular the stainless steels of the types AISI 301, 303 or 316 or subgroups of these types are suitable.

The ceramic materials and plastics used in the construction of the occlusion coil are electrically conductive.

In an advantageous embodiment of the electrolytically non-corrodible sections of the transitions to the electrolytically corrodible points are chosen material combinations for the training that are suitable for forming local elements. the electrolytic releasability of the occlusion improved - in this way is - regardless of the reduction of the diameter of the corrodible points.

Here are the most suitable material combinations in which for forming the electrolytically corrodible points stainless steels, preferably of types AISI 301, 304, 316 or subgroups thereof, Ti or TiNi al- loys or Co-based alloys with one or more of the following metals or precious metal alloys: Pt, Pt metals, Pt alloys, Au alloys or Sn alloys.

The use of the aforementioned materials for forming the electrolytically non-corrodible sections and the electrolytically corrodible points of the occlusion coil ensure the specific electrolytic corrosion of the occlusion coil for the predetermined locations.

Especially advantageous is the formation of electrolytically corrodible points which constitute local elements on both sides. This embodiment of the electrolytically korrodierbareπ points is substantially corrosion joyful and therefore corrodes much faster than electrolytically corrodible points which form only one side of a local cell. therefore material combinations with the greatest possible distance in the electrochemical series are preferred. This is also an advantage of the device according to the invention compared to those found in the prior art devices which corrode the tip of the guidewire to replace the Embolisierungsdrahtes, since in this case only to one side, namely the side of the Embolisierungsdrahtes (usually a platinum wire) a local cell is formed.

The shape of the electrolytically korrodierbareπ points is expediently designed with functional aspects. It is advantageous in terms of the bending stress to adapt the shape of the electrolytically corrodible points to the shape of occlusion and these to integrate reindeer for example in the turns of a designed as a micro-coil occlusion. Has the other hand, substantially straight formation of the electrolytically corrodible points to advantage that it is technically uncomplicated. For the purpose of good slidability of the occlusion coil in the catheter while the orientation of the substantially straight electrolytically corrodible points in longitudinal axis of the occlusion coil is advantageous.

The electrolytically corrodible points of occlusion can thereby be formed for example by Formteiie that are inserted between the electrolytically non-corrodible fractions of the occlusion. This embodiment has the advantage that a particularly important variety of different materials for the training of elektroiytisch corrodible points and the electrolytically non-corrodible sections may be combined. This embodiment has the further advantage that the electrolytically corrodible points and the electrolytically non-corrodible sections can be modular and, therefore, technically uπaufwendig joined to the formation of occlusion coils of variable lengths. This is particularly simple when the electrolytically corrodible points and thus the constituent molded articles are substantially straight.

Conveniently, the electrolytically corrodible points moldings with the non-corrodible sections by solder and / or adhesive and / or Schweißvorgäπge may be connected. Likewise, the electrolytically corrodible points moldings can be mechanically joined to the electrolytically non-corrodible sections such. For example, by input voltage or obstruction, provided that the electrolytically non-corrodible sections comprise recesses for receiving the mold parts. This is for example the case with electrolytically non-corrodible sections which are formed as an interior cavity circumscribing microcoils. The moldings can be so formschiüssig inserted into this cavity and fixed. It may also be appropriate if the moldings receiving outer regions of the designed as Mikroweπdel electrolytically non-corrodible sections are reinforced.

It is particularly advantageous if the electrolytically corrodible points are pre-corroded forming moldings by etching or other method, so that their diameter is tapered towards the center. The outer and weakened portions of the mold parts with a larger diameter are then joined by welding of different materials, for example, mechanical incorporation or bonding of the electrolytically non-corrodible sections. The connection between the electrolytically corrodible points and the electrolytically non korrodierbareπ sections is very stable, therefore, while the lead is a result of the pre-corrosion toward the center of the molded part tapering diameter for good electrolytic detachment of occlusion. Here, for the material combination of platinum alloys or platinum metals as the material for the formation of the electrolytically non-corrodible sections of stainless steel as a material, the compound more preferably by welding of different materials for the electrolytically korrodierbareπ points forming moldings. Those skilled is of course also the possibility of Vorkorrodierung the electrolytically corrodible points if they are not formed from molded parts.

It is expedient here to provide the moldings with a partial coating of a material which is in the electrochemical series than the material forming the mold parts. This embodiment is particularly advantageous in electrolytic corrosivity of the electrolytically korrodierba- ren sites which are located there where the coating on the molded part is missing. Be particularly advantageous in this case coatings have been found of Zn or Sn, or alloys of these metals on molded parts made of stainless steel.

The mechanical attachment of the mold parts is particularly advantageous if the electrolytically corrodible points is substantially straight and formed to be arranged along the longitudinal axis of the occlusion coil. The Aneinanderfüguπg of the occlusion coil forming modules (not electrolytically corrodible sections and electrolytically corrodible points) in this case is associated with a particularly low technical effort.

To further secure and stabilize the concatenation of the individual, the occlusion coil forming modules, a combination of the methods mentioned can be used. The flexibility of the occlusion coil is ensured even in case of mechanical butt joint, due to the choice of material and due to the small diameter of the electrolytically korrodierbareπ points forming moldings.

In one embodiment of the device according to the invention, the electrolytically corrodible points fittings are formed as a micro-system components. This can for example be designed as an elongated micro-system components, the diameter of which tapers towards the center. The insertion of the micro-system components is carried by said current methods. The use of such tapering towards the center microsystem components in this case has the advantage that the regions of the greatest diameter are joined to the electrolytically non-corrodible sections and thus ensure a stable cohesion. Said tapered portion with a smaller diameter is exposed to the surrounding medium on the other hand and can be easily corrode electrolytically. In this way, particularly small diameter of the electrolytically corrodible points can be achieved.

The narrowing of the diameter of the electrolytically corrodible points toward the center is made on good corrodibility expedient for other designs of the electrolytically corrodible points.

In a further embodiment of the device according to the invention the occlusion or a part thereof contains a continuous wire core of electrolytically corrodible material, which is surrounded by a broken in the longitudinal axis at intervals sheath made of electrolytically corrosion resistant material. The guide wire and the core of helically Occlusions- are preferably parts of the same wire. This execution is dimensionally particularly inexpensive, because on the one hand attributable to the compound of occlusion and insertion necessary welding, soldering or gluing process and on the other hand, the wire core of generally opposite the electrolytically non-corrodible materials cheaper electrolytically corrodible material, whereas only small amounts of must be used over the wire core of electrolytically corrodible material for coating worse. The diameter of occlusion of the device according to the invention is expediently chosen so that he other hand, the electrolytically corrodible points are electrolytically corrodible good one hand ensures sufficient stability and in situ. Advantageous in this respect are off EMBODIMENTS present with the electrolytically corrodible points of the occlusion coil diameters between 0.01 to 0.05 mm, preferably 0.02 to 0.04 mm and particularly preferably 0.03 mm. The electrolytically non-corrodible sections of the occlusion, however, can also have larger diameters.

In a further advantageous Ausfühπjngsform the tip of the guide wire is insulated for example by a badly corrodible material coating or coating with a Schrumpfschiauf, so that it is not electrolytically corrodible.

The inventive apparatus is preferably fistulae for use in veterinary or human medicine, particularly in the endovascular treatment of intracranial aneurysms and arteriovenous malformations acquired or congenital and / or and / or tumor embolization determined by thrombosis.

The invention is illustrated by way of example with reference to the example illustrated in the drawings in greater detail Ausführuπgsbeispiele. , In which:

1 shows the vertical view of a neurysma positioned in a Beerena- micro-coil 3 with an associated device in much magnification;

Figure 1 b and 1 c the detail magnification of Figure 15

1 in the area of ​​the corroded eiektrolytisch point 14 of the micro-coil 3 in two different embodiments of the micro-coil 3;

2a to c stronger in comparison with FIG 1 magnification three ways of the arrangement electrolytically corrodible points 11 and electrolytically non-corrodible sections 10 in the inventive micro-coil 3;

Figure 3a-c in respect to Figure 1 higher magnification three ways of the arrangement of electrolytically corrodible points 11 and electrolytically non-corrodible

Sections 10 in the inventive micro-helix 3 3 arranged along the longitudinal axis of the electrolytically corrodible points micro-coil 11;

Figure 4 longitudinal cross-sectional view of the attachment of the

The guide wire (2) to the helical Occlusions-.

In the figure, 1 is 1 with a catheter, in particular refers to a flexible trained micro krokatheter. By the micro-catheter 1 is the made of a platinum metal alloy with electrolytically corrodible points 11 of stainless steel provided designed as a micro-coil occlusion coil 3 by means of welding technology, joined to the micro-coil 3 the guide wire 2 positioned at the entrance of the aneurysm. 6 Since these joined by non-autogenous welding connection between the guide wire 2 and micro-coil 3 is not intended for the electrolytic detachment of the micro-coil 3 and therefore need not be of particularly small diameter, it is particularly stable formed exclusively. The use of stainless steel and platinum for formation of the guide wire on the one hand and the occlusion coil on the other hand is especially advantageous because the nickel contained in steel blends during welding to a very smooth and stable connection with the platinum. Through the longitudinal axis in the microcatheter made after the distal displacement of the guiding aid 2 environment takes place the introduction of the micro-coil 3 in the aneurysmal rysma 6 forming secondary windings 1 4 due to its elastic pretension after exiting the microcatheter. Due to the displaceability longitudinal displacements of guide wire 2 and micro-coil 3 in the micro-catheter 1 individually adapted to the volume of the cavity to be filled length of the micro-coil 3 in this is introduced. of the voltage source 7, which is positioned on the body surface of the cathode 8 and the anode is then by means serving to in occiudierenden aneurysm 6 positioned micro-coil 3 a voltage over a period of 0.1 - applied 20 minutes. Thereby, the electrolytic separation of itself befin- Denden in the blood portion of the micro-coil 3 is at the closest matching the distal end of the catheter constricting electrolytically corrodible point 9 dissolved. Figure 1 illustrates a micro-coil 3, the distal end of the microcatheter 1 closest matching constricting electrolytically corrodible point 9 has already been electrolytically corroded.

Figure 1 b illustrates in enlarged detail of Figure 1, the distal end of the microcatheter 1 closest electrolytically corrodible point in corrosive diertem state 14. Further, to exploiting Dende in the blood or even in the micro-catheter 1 electrolytically corrodible points 11 are, however, still intact in front. The electrolytically corrodible points are adapted to the shape of the micro-coils 19 of the micro-coil.

Figure 1 c also provides 1 with the closest electrolytically corrodible point in corroded state 14 for a micro-coil 3 with substantially straight electrolytically korrodierbareπ represent 1 the distal end of the microcatheter 1 in Ausschnittsvergrößeruπg the figure, which are aligned with the longitudinal axis of the micro-coil. 3

2a to c illustrate a detail of three different embodiments of the micro-coil 3 according to the invention in comparison with FIG 1 higher magnification.

2a shows a micro-coil 3 with non-corrodible sections 10 made of a platinum-metal alloy, to which by welding an existing stainless steel the electrolytically corrodible point 11 forming Folrmteil is added to 17 of 0.03 mm diameter.

2b shows a detail of inventive micro-coil 3 with a micro system block 16 as electrolytically corrodible point 11, which is inserted through a bonding process between the electrolytically non-corrodible sections 10th

Figure 2c illustrates a detail of a stainless steel core 12 of 0.03 mm in diameter containing micro-coil. 3 This stainless steel core 12 is surrounded by a coating of electrolytically corrosion resistant material 13, which is provided at regular intervals with interruptions at which the Edelstahlkerπ 12 is accessible from the outside and, accordingly, an electrolytically corrodible point forms. 11

Figures 3a-c illustrate a detail of three different embodiments of the micro-coil 3 according to the invention with oriented in the longitudinal axis of the micro-coil 3 electrolytically corrodible points 11 in respect to Figure 1 higher magnification.

3a shows a micro-coil 3, with a substantially straight shape part 17 of stainless steel, which cavities form fit in the interior 18 of the micro-coils is added platinum wire 19th The modular concatenation of electrolytically non-corrodible sections 10 of platinum wire micro indungen 19 and substantially straight moldings 17 carries at regular intervals, where the substantially straight shape teiie 17 is not surrounded by the platinum-group metal micro-coils 19 and thus accessible from the outside are , for the formation of electrolytically corrodible points 11. the non-corrodible sections 10 of the micro-coil 3 other hand, are formed by the meandering in micro-coils 19 of platinum wire which joins each mechanically form-fitting manner on either side of the substantially straight formed stainless steel moldings 17th The mold part 17 is surrounded by an Sn layer 22, which is replaced in the middle due to the Vorkorrodierung. As a result of the electrolytically corrodible point 11 forming pre-corroded middle part 23 of the mold part 17 of electrolytic corrosion is particularly accessible because it has a very small diameter and forms on both sides as a result of the Sn coating local elements off. Figure 3b also illustrates a modular micro-helix 3, in which the micro-coils 19 of the platinum wire close to form-fitting to the ends of a made of stainless steel micro-system component 16 and thus form the electrolytically non-corrodible sections 10 between which the exposed portions of the micro-system component 16, the electrolytically corrodible point n form. The insertion of the portions of the micro-system component 16 with a larger diameter wire 20 micro-crinkles into the interior 18 of the platinum 19 ensures a stable fixation of the modular elements to each other. In contrast, the formation of the electrolytically corrodible point 11 by the tapered portion 21 of the micro-system component 16 with a smaller diameter 21 allows a great level of flexibility as well as good advantageous corrodibility of the electrolytically corrodible location. 11

This corrosiveness is enhanced by the structure of the micro-system component, which consists largely of an Sn alloy 22 and only in which contains tapered middle of a micro release member 24 which is made of stainless steel and forms an extremely small electrolytically corrodible location. This advantageous embodiment of extremely light corrodible and therefore particularly well suited to remove.

In figure 3c the section of an inventive Mikrowen- del 3 with a substantially straight, the electrolytically corrodible point 11 forming molding 17 shown made of stainless steel, alternatively, that is by welding to the non korrodierbareπ portions 10 forming micro turns 19 joined platinum wire.

The electronegativity differences between the corrodible points 11 forming the stainless steel and the non-corrodible sections 10 forming platinum metal alloy effected in an ionic medium such as blood, when an electrical voltage, the electrolytic dissolution of the electrolytically corrodible points. 11

Figure 4 shows a longitudinal section through the transition between the guidewire 2 and the occlusion coil 3 in magnification. In this example, the guide wire is formed of rigid stainless steel 2 and surrounded by a Beschichtuπg 25 which prevents corrosion of the steel. This coating can not be formed either conductively, in this case, the electric current for the end of the micro-catheter 1 is passed to the occlusion. 3 Or the coating is not corrodible but electrically conductive (a graphite coating, for example) may be passed in which case the electric current and over the guide wire 2 in the occlusion coil. 3 In this example, the occlusion coil 3 is formed by an array of vorkorrodierten mold parts 17 made of stainless steel, which cavities mechanically and by means of adhesive bonding in the Inneπ- 18 forming of the electrolytically non-corrodible points micro platinum wire turns are joined 19th In the middle vorkorrodierten fittings 17 particularly well corrodible sites form of electrolytically due to their small diameter.

- Claims -

Claims

claims
1. A device for implantation of peelable electrolysis occlusion coils in body cavities or blood vessels with a voltage source, a cathode, a catheter and a slidable in the catheter in the longitudinal direction serving as an anode occlusion coil, characterized in that the occlusion coil (3) at a plurality of intervals from each other spaced locations is formed electrolytically corrodible, so that in contact with a body fluid one or more variably dimensioned lengths of the occlusion coil (3) can be separated by electrolysis.
2. Device according to claim 1, characterized in that a as a guide wire (2) joined proximally to the occlusion coil (3) formed Einführhiife.
3. Device according to claim 2, characterized in that leadership wire (2) and the occlusion coil (3) by soldering and / or gluing and / or
Welding operations and / or mechanical connections are connected together.
4. Apparatus according to claim 2, characterized in that the guide wire (2) and the occlusion coil (3) is designed as parts of the same wire is.
5. Device according to one of the preceding claims, characterized in that the occlusion coil (3) or a part thereof is formed as a micro-coil.
6. Device according to one of the preceding claims, characterized in that the occlusion coil (3) or a part thereof is under elastic preload and after release from the catheter (1) turns (4) is formed.
7. Device according to one of the preceding claims, characterized in that the electrolytically non-corrodible sections (10) of the occlusion coil (3) of one or more of the following materials: noble metals or noble metal alloys, corrosion-resistant ceramic materials, corrosion-resistant plastics, preferably platinum metal al- loys.
8. Device according to one of the preceding claims, characterized in that the electrolytically corrodible points (10) of the occlusion coil (3) of one or more of the following materials: corrosion resistant ceramic materials, corrosion-resistant plastics, non-precious metals or alloys thereof, preferably stainless steel ,
9. The device according to claim 8, characterized in that stainless steel of the types AISI 301, 304 or 316 or subgroups for the formation of the electrolytically corrodible points (11) is used.
10. Device according to one of the preceding claims, characterized in that the electrolytically non-korrodierbareπ for training
Portions (10) at the transitions to the electrolytically corrodible points (11) Materiaikombinationen be selected which are suitable for forming local elements.
11. Apparatus according to claim 10, characterized in that folic constricting Materiaikombinationen be used: a) Stainless steel, preferably of the type AISI 301, 304, 316 or subgroups for the formation of the electrolytically corrodible points
(11) with noble metals or noble metal alloys, preferably Pt or Pt
Metals, Pt alloys, Au alloys or Sn alloys for the formation of the electrolytically non-corrodible sections (10); b) Ti or TiNi alloys for the formation of the electrolytically corrodible points (11) with noble metals or noble metal alloys, preferably Pt, Pt metals, Pt alloys, Au alloys or Sn alloys for the formation of the electrolytically non-corrodible sections (10 );
c) Co based alloys for the formation of the electrolytically corrodible points (11) with noble metals or noble metal alloys, preferably Pt, Pt metals, Pt alloys, Au alloys or Sn alloys for the formation of the electrolytically non-corrodible sections (10).
12. Device according to one of claims 5 to 11, characterized in that the shape of the electrolytically corrodible points (11) is adapted to the micro-windings of the micro-coil (3).
13. Device according to one of claims 1 to 11, characterized in that the electrolytically corrodible points (11) is adapted to the micro-windings of the micro-coil (3).
14. The device according to one of claims 1 to 11 or 13, characterized in that the electrolytically corrodible points of the longitudinal axis of the occlusion coil are aligned.
15. Device according to one of the preceding claims, characterized in that the electrolytically corrodible points (1 1) are formed by moldings (17) disposed between the electrolytically non-corrodible sections (10) of the occlusion coil (3) are joined.
16. The apparatus according to claim 15, characterized in that the electrolytically korrodierbareπ points (1 1) forming the mold parts (17) with the non-corrodible sections (10) by soldering and / or adhesive and / or Schweißvorgäπge and / or mechanical method are connected.
17. Device according to one of the preceding claims, characterized gkennzeichnet that the electrolytically corrodible points (11) are pre-corroded.
18. Device according to the preceding claims 1-16, characterized in that the electrolytically corrodible points (11) forming
Mold parts (17) are pre-corroded.
19. Device according to one of claims 15 to 18, characterized in that the moldings are partially coated with a material over which the mold parts forming material STE hen in the electrochemical series.
20. Device according to claim 19, characterized in that the From parts are made of stainless steel and the coating consists of Zn, Zn alloys, Sn or Sn alloys.
21. A device, characterized denotes overall according to any one of claims 15 or 20, that the electrolytically corrodible points (11) forming
Fittings (17) micro-system components (16).
22. An apparatus according to claim 21, characterized in that the micro-system components contain micro-rupture sites (24) as electrolytically corrodible points (1 1).
23. Device according to one of claims 1 to 14, characterized in that the occlusion coil (3) or a part contains the same a continuous wire core of electrolytically corrodible material, which by a repeatedly interrupted in the longitudinal axis at intervals sheath made of electrolytically corrosion resistant material (13) surrounded.
24. Device according to one of the preceding claims, characterized in that the diameter of the electrolytically corrodible STEL len (1 1) is between 0.01 to 0.05 mm, preferably 0.02 to 0.04 mm and particularly preferably 0.03 is mm.
25. The device according to any one of the preceding claims, characterized in that the wire tip of the guide wire (2) is provided with a cor- rosion the guidewire preventing coating (25).
26. The device according to any one of the preceding claims for use in animal or human medicine, preferably at the thrombosis.
PCT/EP2000/010660 1999-10-30 2000-10-30 Device for implanting occlusion coils WO2001032085A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE1999152387 DE19952387A1 (en) 1999-10-30 1999-10-30 Device to implant occlusion coil in body cavity or blood vessel; has occlusion coil that is electrolytically corrodible at several points to separate variable length of coil on contact with body fluid
DE19952387.8 1999-10-30
DE2000110840 DE10010840A1 (en) 1999-10-30 2000-03-09 Device for implanting occlusion coils uses coils electrolytically corrodable at several points at intervals so variable sized lengths can be separated by electrolysis
DE10010840.7 2000-03-09
DE2001213741 DE20113741U1 (en) 1999-10-30 2001-08-27 A device for implantation of occlusion means

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2001534297A JP2003512882A (en) 1999-10-30 2000-10-30 Embolic coil implant devices
CA 2389374 CA2389374A1 (en) 1999-10-30 2000-10-30 A device for implanting occlusion coils
EP20000977439 EP1227760B1 (en) 1999-10-30 2000-10-30 Device for implanting occlusion coils
DE2000510529 DE50010529D1 (en) 1999-10-30 2000-10-30 A device for implanting occlusion coils
US10129426 US7323000B2 (en) 1999-10-30 2000-10-30 Device for implanting of occlusion spirals
US11903311 US8048104B2 (en) 2000-10-30 2007-09-21 Device for the implantation of occlusion spirals
US13231929 US8597321B2 (en) 1999-10-30 2011-09-13 Device for the implantation of occlusion spirals

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10129426 A-371-Of-International
US11903311 Division US8048104B2 (en) 1999-10-30 2007-09-21 Device for the implantation of occlusion spirals

Publications (1)

Publication Number Publication Date
WO2001032085A1 true true WO2001032085A1 (en) 2001-05-10

Family

ID=49608197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/010660 WO2001032085A1 (en) 1999-10-30 2000-10-30 Device for implanting occlusion coils

Country Status (7)

Country Link
US (1) US7323000B2 (en)
EP (2) EP1227760B1 (en)
JP (1) JP2003512882A (en)
CA (1) CA2389374A1 (en)
DE (3) DE10010840A1 (en)
ES (1) ES2285342T3 (en)
WO (1) WO2001032085A1 (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003017852A1 (en) * 2001-08-27 2003-03-06 Dendron Gmbh Device for the implantation of occlusion means
WO2004002321A2 (en) * 2002-06-27 2004-01-08 Boston Scientific Limited Vaso-occlusive assembly with multiple detachng points
WO2004014239A1 (en) * 2001-04-10 2004-02-19 Dendron Gmbh Device for the implantation of occlusion coils
EP1638490A1 (en) * 2003-06-30 2006-03-29 Collagen Matrix, Inc. Oriented biopolymeric membrane for meningeal tissue repair
DE102007025466A1 (en) 2007-05-31 2008-12-04 Phenox Gmbh Fiber implant device for occlusion of e.g. vascular aneurysms, has fibers inserted transversely between core wires for distributing wires and twisted or interlaced with wires, so that fibers project radially outwards
DE102008050085A1 (en) 2008-10-06 2010-04-08 Phenox Gmbh implant replacement
USRE42625E1 (en) 1990-03-13 2011-08-16 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42662E1 (en) 1990-03-13 2011-08-30 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42756E1 (en) 1990-03-13 2011-09-27 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
DE102010021947A1 (en) 2010-05-28 2011-12-01 Phenox Gmbh implant replacement
CN103475872A (en) * 2013-10-02 2013-12-25 哈尔滨理工大学 Railway abnormal object detecting device based on cloud vision
US8864790B2 (en) 2006-04-17 2014-10-21 Covidien Lp System and method for mechanically positioning intravascular implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9050095B2 (en) 2004-09-22 2015-06-09 Covidien Lp Medical implant
US9198665B2 (en) 2004-09-22 2015-12-01 Covidien Lp Micro-spiral implantation device
US9254134B2 (en) 2004-01-21 2016-02-09 Dendron Gmbh Device for implanting electrically isolated occlusion helixes
US9289215B2 (en) 2007-03-13 2016-03-22 Covidien Lp Implant including a coil and a stretch-resistant member
US9326774B2 (en) 2012-08-03 2016-05-03 Covidien Lp Device for implantation of medical devices
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US9717503B2 (en) 2015-05-11 2017-08-01 Covidien Lp Electrolytic detachment for implant delivery systems
DE102004026830B4 (en) 2004-05-28 2018-06-28 Dendron Gmbh A process for the production of electrolytically corrodible detachment locations in occlusive devices, occlusive devices, and insertion of an insertion device and an occlusion

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048104B2 (en) 2000-10-30 2011-11-01 Dendron Gmbh Device for the implantation of occlusion spirals
DE10233085B4 (en) 2002-07-19 2014-02-20 Dendron Gmbh Stent with guidewire
JP2007521843A (en) 2003-05-15 2007-08-09 バイオメリクス コーポレーション Reticulated elastomeric matrix, their preparation and use in implantable devices
US20050043585A1 (en) * 2003-01-03 2005-02-24 Arindam Datta Reticulated elastomeric matrices, their manufacture and use in implantable devices
DE10301850B4 (en) * 2003-01-16 2017-05-04 Dendron Gmbh stent
US7651513B2 (en) * 2003-04-03 2010-01-26 Boston Scientific Scimed, Inc. Flexible embolic device delivery system
US20070190108A1 (en) * 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
EP1761178B1 (en) * 2004-05-21 2010-12-08 Micro Therapeutics, Inc. Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity
US20060116714A1 (en) * 2004-11-26 2006-06-01 Ivan Sepetka Coupling and release devices and methods for their assembly and use
DE102005019782A1 (en) * 2005-04-28 2006-11-09 Dendron Gmbh A device for implantation of occlusion helixes with internal securing means
US20060271097A1 (en) * 2005-05-31 2006-11-30 Kamal Ramzipoor Electrolytically detachable implantable devices
US9636115B2 (en) * 2005-06-14 2017-05-02 Stryker Corporation Vaso-occlusive delivery device with kink resistant, flexible distal end
US7722636B2 (en) * 2005-11-30 2010-05-25 Codman & Shurtleff, Inc. Embolic device delivery system with torque fracture characteristic
US9307996B2 (en) 2005-12-13 2016-04-12 DePuy Synthes Products, Inc. Detachment actuator for use with medical device deployment systems
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US8366720B2 (en) 2006-07-31 2013-02-05 Codman & Shurtleff, Inc. Interventional medical device system having an elongation retarding portion and method of using the same
US8062325B2 (en) 2006-07-31 2011-11-22 Codman & Shurtleff, Inc. Implantable medical device detachment system and methods of using the same
US20080269774A1 (en) 2006-10-26 2008-10-30 Chestnut Medical Technologies, Inc. Intracorporeal Grasping Device
US20080281350A1 (en) * 2006-12-13 2008-11-13 Biomerix Corporation Aneurysm Occlusion Devices
CN101677821B (en) 2007-03-13 2014-05-14 泰科保健集团有限合伙公司 Implant and mandrel
US8585713B2 (en) 2007-10-17 2013-11-19 Covidien Lp Expandable tip assembly for thrombus management
US8066757B2 (en) * 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
US8926680B2 (en) * 2007-11-12 2015-01-06 Covidien Lp Aneurysm neck bridging processes with revascularization systems methods and products thereby
US8088140B2 (en) * 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
US20100174309A1 (en) * 2008-05-19 2010-07-08 Mindframe, Inc. Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter
US9198687B2 (en) 2007-10-17 2015-12-01 Covidien Lp Acute stroke revascularization/recanalization systems processes and products thereby
US9220522B2 (en) * 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
US20100022951A1 (en) * 2008-05-19 2010-01-28 Luce, Forward, Hamilton 7 Scripps, Llp Detachable hub/luer device and processes
EP2234562A4 (en) 2007-12-21 2016-12-21 Microvention Inc A system and method of detecting implant detachment
EP2231030A4 (en) * 2007-12-21 2016-12-21 Microvention Inc System and method for locating detachment zone of a detachable implant
US20090192455A1 (en) * 2008-01-07 2009-07-30 David Ferrera Novel enhanced ptna rapid exchange type of catheter system
US8940003B2 (en) 2008-02-22 2015-01-27 Covidien Lp Methods and apparatus for flow restoration
US20100082056A1 (en) * 2008-04-04 2010-04-01 Akshay Mavani Implantable fistula closure device
CN101977650A (en) * 2008-04-11 2011-02-16 曼德弗雷姆公司 Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby
EP2330985A4 (en) 2008-09-04 2015-11-18 Curaseal Inc Inflatable devices for enteric fistula treatment
US20100256600A1 (en) * 2009-04-04 2010-10-07 Ferrera David A Neurovascular otw pta balloon catheter and delivery system
US9039749B2 (en) 2010-10-01 2015-05-26 Covidien Lp Methods and apparatuses for flow restoration and implanting members in the human body
JP6122424B2 (en) 2011-06-16 2017-04-26 キュラシール インコーポレイテッド Devices and related methods for fistula treatment
US9131941B2 (en) 2011-06-17 2015-09-15 Curaseal Inc. Fistula treatment devices and methods
JP6359664B2 (en) * 2013-08-20 2018-07-18 ストライカー コーポレイションStryker Corporation Vascular occlusion device delivery system
US9782186B2 (en) 2013-08-27 2017-10-10 Covidien Lp Vascular intervention system
US20150066131A1 (en) 2013-08-27 2015-03-05 Covidien Lp Delivery of medical devices
EP3041561A4 (en) * 2013-09-03 2017-05-10 Jianlu Ma Detachment mechanisms for implantable devices
US10076399B2 (en) 2013-09-13 2018-09-18 Covidien Lp Endovascular device engagement
US9808599B2 (en) 2013-12-20 2017-11-07 Microvention, Inc. Device delivery system
US9808256B2 (en) 2014-08-08 2017-11-07 Covidien Lp Electrolytic detachment elements for implant delivery systems
US9814466B2 (en) 2014-08-08 2017-11-14 Covidien Lp Electrolytic and mechanical detachment for implant delivery systems
US20160331377A1 (en) 2015-05-11 2016-11-17 Covidien Lp Electrolytic detachment with flush system for implant delivery

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013592A1 (en) * 1990-03-13 1991-09-19 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip
US5624449A (en) * 1993-11-03 1997-04-29 Target Therapeutics Electrolytically severable joint for endovascular embolic devices
US5733329A (en) * 1996-12-30 1998-03-31 Target Therapeutics, Inc. Vaso-occlusive coil with conical end
DE4445715C2 (en) 1994-12-22 1998-04-09 Hans Dr Med Henkes Arrangement for introducing an implant into a blood vessel or into a body cavity
WO1999009894A1 (en) * 1997-08-29 1999-03-04 Boston Scientific Limited Fast detaching electrically isolated implant
US5941888A (en) * 1998-02-18 1999-08-24 Target Therapeutics, Inc. Vaso-occlusive member assembly with multiple detaching points

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250071A (en) * 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US5800453A (en) * 1993-04-19 1998-09-01 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking hooks and slots
US6013084A (en) * 1995-06-30 2000-01-11 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils (II)
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013592A1 (en) * 1990-03-13 1991-09-19 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip
EP0484468A1 (en) 1990-03-13 1992-05-13 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip
US5624449A (en) * 1993-11-03 1997-04-29 Target Therapeutics Electrolytically severable joint for endovascular embolic devices
DE4445715C2 (en) 1994-12-22 1998-04-09 Hans Dr Med Henkes Arrangement for introducing an implant into a blood vessel or into a body cavity
US5733329A (en) * 1996-12-30 1998-03-31 Target Therapeutics, Inc. Vaso-occlusive coil with conical end
WO1999009894A1 (en) * 1997-08-29 1999-03-04 Boston Scientific Limited Fast detaching electrically isolated implant
US5941888A (en) * 1998-02-18 1999-08-24 Target Therapeutics, Inc. Vaso-occlusive member assembly with multiple detaching points

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE42756E1 (en) 1990-03-13 2011-09-27 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42625E1 (en) 1990-03-13 2011-08-16 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42662E1 (en) 1990-03-13 2011-08-30 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
WO2004014239A1 (en) * 2001-04-10 2004-02-19 Dendron Gmbh Device for the implantation of occlusion coils
US7238194B2 (en) 2001-04-10 2007-07-03 Dendron Gmbh Device for implanting occlusion spirals
WO2003017852A1 (en) * 2001-08-27 2003-03-06 Dendron Gmbh Device for the implantation of occlusion means
WO2004002321A3 (en) * 2002-06-27 2004-04-15 Scimed Life Systems Inc Vaso-occlusive assembly with multiple detachng points
WO2004002321A2 (en) * 2002-06-27 2004-01-08 Boston Scientific Limited Vaso-occlusive assembly with multiple detachng points
US7938845B2 (en) 2002-06-27 2011-05-10 Stryker Corporation Anchor assemblies in stretch-resistant vaso-occlusive coils
EP1638490A4 (en) * 2003-06-30 2011-11-30 Collagen Matrix Inc Oriented biopolymeric membrane for meningeal tissue repair
EP1638490A1 (en) * 2003-06-30 2006-03-29 Collagen Matrix, Inc. Oriented biopolymeric membrane for meningeal tissue repair
US9254134B2 (en) 2004-01-21 2016-02-09 Dendron Gmbh Device for implanting electrically isolated occlusion helixes
DE102004026830B4 (en) 2004-05-28 2018-06-28 Dendron Gmbh A process for the production of electrolytically corrodible detachment locations in occlusive devices, occlusive devices, and insertion of an insertion device and an occlusion
US9050095B2 (en) 2004-09-22 2015-06-09 Covidien Lp Medical implant
US9198665B2 (en) 2004-09-22 2015-12-01 Covidien Lp Micro-spiral implantation device
US8864790B2 (en) 2006-04-17 2014-10-21 Covidien Lp System and method for mechanically positioning intravascular implants
US9289215B2 (en) 2007-03-13 2016-03-22 Covidien Lp Implant including a coil and a stretch-resistant member
DE102007025466A1 (en) 2007-05-31 2008-12-04 Phenox Gmbh Fiber implant device for occlusion of e.g. vascular aneurysms, has fibers inserted transversely between core wires for distributing wires and twisted or interlaced with wires, so that fibers project radially outwards
DE102008050085A1 (en) 2008-10-06 2010-04-08 Phenox Gmbh implant replacement
WO2010040497A1 (en) 2008-10-06 2010-04-15 Phenox Gmbh Implant removal
WO2011147567A1 (en) 2010-05-28 2011-12-01 Phenox Gmbh Device for inserting an implant
DE102010021947A1 (en) 2010-05-28 2011-12-01 Phenox Gmbh implant replacement
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9326774B2 (en) 2012-08-03 2016-05-03 Covidien Lp Device for implantation of medical devices
CN103475872A (en) * 2013-10-02 2013-12-25 哈尔滨理工大学 Railway abnormal object detecting device based on cloud vision
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US9717503B2 (en) 2015-05-11 2017-08-01 Covidien Lp Electrolytic detachment for implant delivery systems

Also Published As

Publication number Publication date Type
US7323000B2 (en) 2008-01-29 grant
EP1227760B1 (en) 2005-06-08 grant
US20040078050A1 (en) 2004-04-22 application
JP2003512882A (en) 2003-04-08 application
ES2285342T3 (en) 2007-11-16 grant
CA2389374A1 (en) 2001-05-10 application
EP1523945B1 (en) 2007-02-21 grant
EP1227760A1 (en) 2002-08-07 application
DE10010840A1 (en) 2001-09-20 application
DE50014099D1 (en) 2007-04-05 grant
DE20113741U1 (en) 2001-12-06 grant
EP1523945A1 (en) 2005-04-20 application

Similar Documents

Publication Publication Date Title
US6663607B2 (en) Bioactive aneurysm closure device assembly and kit
US6159206A (en) Medical implement for depositing implanted device and method of depositing implanted device
US5690667A (en) Vasoocclusion coil having a polymer tip
US5935148A (en) Detachable, varying flexibility, aneurysm neck bridge
US5743905A (en) Partially insulated occlusion device
US5881732A (en) Intravascular method and system for treating arrhythmia
US20040199175A1 (en) Flexible embolic device delivery system
US20060106421A1 (en) Expansible neck bridge
US5980514A (en) Aneurysm closure device assembly
US5964797A (en) Electrolytically deployable braided vaso-occlusion device
US7410482B2 (en) Detachable aneurysm neck bridge
US5759161A (en) Medical wire and method for leaving implanted devices
US7128736B1 (en) Detachable aneurysm neck closure patch
US5624449A (en) Electrolytically severable joint for endovascular embolic devices
US20050021023A1 (en) System and method for electrically determining position and detachment of an implantable device
US20040002752A1 (en) Sacrificial anode stent system
US7238194B2 (en) Device for implanting occlusion spirals
US5522836A (en) Electrolytically severable coil assembly with movable detachment point
US7879064B2 (en) Medical implant
US5984929A (en) Fast detaching electronically isolated implant
US6569179B2 (en) Bioactive three loop coil
US20090177261A1 (en) Detachment mechanisms for implantable devices
US6723112B2 (en) Bioactive three loop coil
US6086577A (en) Detachable aneurysm neck bridge (III)
US6063070A (en) Detachable aneurysm neck bridge (II)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2000977439

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2389374

Country of ref document: CA

ENP Entry into the national phase in:

Ref country code: JP

Ref document number: 2001 534297

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 2000977439

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10129426

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2000977439

Country of ref document: EP