WO2001030345A1 - Clonidine preparations - Google Patents
Clonidine preparations Download PDFInfo
- Publication number
- WO2001030345A1 WO2001030345A1 PCT/US2000/028776 US0028776W WO0130345A1 WO 2001030345 A1 WO2001030345 A1 WO 2001030345A1 US 0028776 W US0028776 W US 0028776W WO 0130345 A1 WO0130345 A1 WO 0130345A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- clonidine
- accordance
- aqueous gel
- gel
- topical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Bending Of Plates, Rods, And Pipes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60045691T DE60045691D1 (en) | 1999-10-26 | 2000-10-18 | CLONDINZUBEREITUNGEN |
AT00973624T ATE499935T1 (en) | 1999-10-26 | 2000-10-18 | CLONED PREPARATIONS |
JP2001532765A JP4901042B2 (en) | 1999-10-26 | 2000-10-18 | Clonidine preparation |
EP00973624A EP1248613B1 (en) | 1999-10-26 | 2000-10-18 | Clonidine preparations |
DK00973624.0T DK1248613T3 (en) | 1999-10-26 | 2000-10-18 | Clonidine preparations |
AU12119/01A AU1211901A (en) | 1999-10-26 | 2000-10-18 | Clonidine preparations |
HK03102665.7A HK1050484A1 (en) | 1999-10-26 | 2003-04-11 | Clonidine preparations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/427,367 | 1999-10-26 | ||
US09/427,367 US6147102A (en) | 1999-10-26 | 1999-10-26 | Clonidine preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001030345A1 true WO2001030345A1 (en) | 2001-05-03 |
Family
ID=23694569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/028776 WO2001030345A1 (en) | 1999-10-26 | 2000-10-18 | Clonidine preparations |
Country Status (13)
Country | Link |
---|---|
US (2) | US6147102A (en) |
EP (1) | EP1248613B1 (en) |
JP (1) | JP4901042B2 (en) |
CN (1) | CN1148186C (en) |
AT (1) | ATE499935T1 (en) |
AU (1) | AU1211901A (en) |
CY (1) | CY1111463T1 (en) |
DE (1) | DE60045691D1 (en) |
DK (1) | DK1248613T3 (en) |
ES (1) | ES2359787T3 (en) |
HK (1) | HK1050484A1 (en) |
PT (1) | PT1248613E (en) |
WO (1) | WO2001030345A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7887842B2 (en) | 2003-02-07 | 2011-02-15 | Teikoku Pharma Usa, Inc. | Methods of administering a dermatological agent to a subject |
EP4122450A1 (en) * | 2021-07-20 | 2023-01-25 | Rosemont Pharmaceuticals Ltd | Liquid pharmaceutical composition of clonidine |
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US6559186B1 (en) | 1990-02-26 | 2003-05-06 | Arc 1, Inc. | Compositions and methods of treatment of sympathetically maintained pain |
US20030104041A1 (en) * | 1999-12-16 | 2003-06-05 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
US20050074487A1 (en) * | 1999-12-16 | 2005-04-07 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
US6544927B2 (en) | 2001-04-28 | 2003-04-08 | University Of Florida | Use of α2-adrenergic receptor agonists and adrenergic inhibitors in reducing defoliation |
US20030124174A1 (en) * | 2001-10-25 | 2003-07-03 | Endo Pharmaceuticals, Inc | Method for treating non-neuropathic pain |
US7687080B2 (en) * | 2002-11-25 | 2010-03-30 | Taraxos Inc. | Treatment of neuropathy |
US7276246B2 (en) * | 2003-05-09 | 2007-10-02 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
US7306812B2 (en) | 2003-05-09 | 2007-12-11 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
US20050020600A1 (en) | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
US20050112183A1 (en) * | 2003-11-25 | 2005-05-26 | Galer Bradley S. | Compositions and methods for treating neuropathic sensory loss |
US8026266B2 (en) | 2005-11-08 | 2011-09-27 | Arcion Therapeutics, Inc. | Treatment of length dependent neuropathy |
WO2007056460A2 (en) | 2005-11-08 | 2007-05-18 | Arcion Therapeutics, Inc. | Treatment of length dependent neuropathy |
US8536445B2 (en) * | 2006-06-02 | 2013-09-17 | Emcore Solar Power, Inc. | Inverted metamorphic multijunction solar cells |
US20080102097A1 (en) * | 2006-10-31 | 2008-05-01 | Zanella John M | Device and method for treating osteolysis using a drug depot to deliver an anti-inflammatory agent |
CN101190183B (en) * | 2006-11-29 | 2010-05-12 | 上海医药工业研究院 | Clonidine hydrochloride multi-vesicular liposome and preparation method thereof |
US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
CN101536981B (en) * | 2008-03-19 | 2010-11-17 | 上海医药工业研究院 | Clonidine hydrochloride multivesicular liposome and preparation method thereof |
US9610243B2 (en) | 2008-04-18 | 2017-04-04 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
US20090264489A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Method for Treating Acute Pain with a Formulated Drug Depot in Combination with a Liquid Formulation |
US9132085B2 (en) * | 2008-04-18 | 2015-09-15 | Warsaw Orthopedic, Inc. | Compositions and methods for treating post-operative pain using clonidine and bupivacaine |
US8883768B2 (en) * | 2008-04-18 | 2014-11-11 | Warsaw Orthopedic, Inc. | Fluocinolone implants to protect against undesirable bone and cartilage destruction |
US8889173B2 (en) * | 2008-04-18 | 2014-11-18 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of pain and/or inflammation |
US8946277B2 (en) | 2008-04-18 | 2015-02-03 | Warsaw Orthopedic, Inc. | Clonidine formulations in a biodegradable polymer carrier |
US8420114B2 (en) * | 2008-04-18 | 2013-04-16 | Warsaw Orthopedic, Inc. | Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation |
US9132119B2 (en) | 2008-04-18 | 2015-09-15 | Medtronic, Inc. | Clonidine formulation in a polyorthoester carrier |
US8629172B2 (en) * | 2008-04-18 | 2014-01-14 | Warsaw Orthopedic, Inc. | Methods and compositions for treating post-operative pain comprising clonidine |
US9072727B2 (en) * | 2008-04-18 | 2015-07-07 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of degenerative disc disease |
US20090263489A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Analgesic and anti-inflammatory compositions and methods for reducing, preventing or treating pain and inflammation |
US20090263451A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain |
US20090264477A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc., An Indiana Corporation | Beta adrenergic receptor agonists for treatment of pain and/or inflammation |
US8557273B2 (en) * | 2008-04-18 | 2013-10-15 | Medtronic, Inc. | Medical devices and methods including polymers having biologically active agents therein |
US8722079B2 (en) * | 2008-04-18 | 2014-05-13 | Warsaw Orthopedic, Inc. | Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine |
USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
US8956641B2 (en) * | 2008-04-18 | 2015-02-17 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of inflammatory diseases |
US20110003823A1 (en) * | 2008-08-01 | 2011-01-06 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage |
US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
US8283350B2 (en) * | 2008-08-01 | 2012-10-09 | Alpha Synergy Development, Inc. | Compositions and methods for reducing capillary permeability |
US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
WO2010036937A1 (en) * | 2008-09-27 | 2010-04-01 | Taraxos Inc. | Topical formulations for treatment of neuropathy |
US20100098746A1 (en) * | 2008-10-20 | 2010-04-22 | Warsaw Orthopedic, Inc. | Compositions and methods for treating periodontal disease comprising clonidine, sulindac and/or fluocinolone |
US8822546B2 (en) * | 2008-12-01 | 2014-09-02 | Medtronic, Inc. | Flowable pharmaceutical depot |
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US8617583B2 (en) * | 2009-07-17 | 2013-12-31 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for prevention or treatment of a hematoma, edema, and/or deep vein thrombosis |
US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
US8231891B2 (en) * | 2009-07-31 | 2012-07-31 | Warsaw Orthopedic, Inc. | Implantable drug depot for weight control |
US20110097375A1 (en) | 2009-10-26 | 2011-04-28 | Warsaw Orthopedic, Inc. | Formulation for preventing or reducing bleeding at a surgical site |
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CA2792646C (en) | 2010-03-26 | 2018-11-20 | Galderma Research & Development | Improved uses and compositions for safe and effective treatment of erythema |
WO2011127586A1 (en) * | 2010-04-15 | 2011-10-20 | The Royal Institution For The Advancement Of Learning / Mcgill University | Topical treatments for pain |
WO2012012319A1 (en) | 2010-07-19 | 2012-01-26 | 3M Innovative Properties Company | Hand tool with replaceable knife cartridge |
WO2012012333A1 (en) * | 2010-07-19 | 2012-01-26 | Arcion Therapeutics, Inc. | Topical treatment of neuropathic pain and methods of diagnosis |
US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
US20130261126A1 (en) | 2010-10-21 | 2013-10-03 | Galderma S.A. | Brimonidiine gel compositions and methods of use |
FR2977493B1 (en) * | 2011-07-05 | 2014-02-14 | Galderma Res & Dev | NOVEL STABLE ANESTHETIC COMPOSITION FOR REDUCING SKIN REACTIONS |
US9012486B2 (en) * | 2011-11-14 | 2015-04-21 | Alex Chervinsky | Topical composition for pain relief |
US20220142209A1 (en) * | 2019-02-20 | 2022-05-12 | Gregory Aharonian | Methods and compositions for improving the taste of diet cola sodas and other beverages |
WO2020222192A1 (en) | 2019-05-01 | 2020-11-05 | Clexio Biosciences Ltd. | Methods of treating pruritus |
KR20220002950A (en) | 2019-05-01 | 2022-01-07 | 클렉시오 바이오사이언시스 리미티드 | How to treat pruritus |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5447947A (en) | 1990-02-26 | 1995-09-05 | Arc 1 | Compositions and methods of treatment of sympathetically maintained pain |
US5605911A (en) * | 1995-01-31 | 1997-02-25 | Washington University | Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH) |
US5780049A (en) * | 1991-10-16 | 1998-07-14 | Richardson-Vicks Inc. | Enhanced skin penetration system for improved topical delivery of drugs |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4801586A (en) * | 1986-04-23 | 1989-01-31 | Nelson Research & Development Co. | Penetration enhancers for transdermal delivery of systemic agents |
IE60941B1 (en) * | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
US4808414A (en) * | 1986-09-29 | 1989-02-28 | Nelson Research & Development Co. | Amide penetration enhancers for transdermal delivery of systemic agents |
DE3778833D1 (en) * | 1986-11-19 | 1992-06-11 | Whitby Research Inc | PENETRATION IMPROVERS FOR THE TRANSDERMAL ADMINISTRATION OF SYSTEMICALLY EFFECTIVE MEDICINAL PRODUCTS. |
US5462744A (en) * | 1989-12-01 | 1995-10-31 | Boehringer Ingelheim Kg | Transdermal system for the administration of pharmacological compounds under pH-controlled conditions |
US5070084A (en) * | 1990-02-26 | 1991-12-03 | Campbell James N | Treatment of sympathetically maintained pain |
EP0516026A1 (en) * | 1991-05-28 | 1992-12-02 | Takeda Chemical Industries, Ltd. | Hydrogel and method of producing same |
US6365178B1 (en) * | 1996-09-06 | 2002-04-02 | Watson Pharmaceuticals, Inc. | Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions |
-
1999
- 1999-10-26 US US09/427,367 patent/US6147102A/en not_active Expired - Lifetime
-
2000
- 2000-08-07 CN CNB001209450A patent/CN1148186C/en not_active Expired - Fee Related
- 2000-10-18 ES ES00973624T patent/ES2359787T3/en not_active Expired - Lifetime
- 2000-10-18 JP JP2001532765A patent/JP4901042B2/en not_active Expired - Fee Related
- 2000-10-18 AU AU12119/01A patent/AU1211901A/en not_active Abandoned
- 2000-10-18 DK DK00973624.0T patent/DK1248613T3/en active
- 2000-10-18 AT AT00973624T patent/ATE499935T1/en active
- 2000-10-18 DE DE60045691T patent/DE60045691D1/en not_active Expired - Lifetime
- 2000-10-18 WO PCT/US2000/028776 patent/WO2001030345A1/en active Application Filing
- 2000-10-18 PT PT00973624T patent/PT1248613E/en unknown
- 2000-10-18 EP EP00973624A patent/EP1248613B1/en not_active Expired - Lifetime
- 2000-11-10 US US09/710,138 patent/US6534048B1/en not_active Expired - Lifetime
-
2003
- 2003-04-11 HK HK03102665.7A patent/HK1050484A1/en not_active IP Right Cessation
-
2011
- 2011-05-06 CY CY20111100439T patent/CY1111463T1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5447947A (en) | 1990-02-26 | 1995-09-05 | Arc 1 | Compositions and methods of treatment of sympathetically maintained pain |
US5780049A (en) * | 1991-10-16 | 1998-07-14 | Richardson-Vicks Inc. | Enhanced skin penetration system for improved topical delivery of drugs |
US5605911A (en) * | 1995-01-31 | 1997-02-25 | Washington University | Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH) |
Non-Patent Citations (10)
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7887842B2 (en) | 2003-02-07 | 2011-02-15 | Teikoku Pharma Usa, Inc. | Methods of administering a dermatological agent to a subject |
US8449913B2 (en) | 2003-02-07 | 2013-05-28 | Teikoku Pharma Usa, Inc. | Methods of administering a dermatological agent to a subject |
US9023392B2 (en) | 2003-02-07 | 2015-05-05 | Teikoku Pharma Usa, Inc. | Methods of administering a dermatological agent to a subject |
EP4122450A1 (en) * | 2021-07-20 | 2023-01-25 | Rosemont Pharmaceuticals Ltd | Liquid pharmaceutical composition of clonidine |
Also Published As
Publication number | Publication date |
---|---|
DK1248613T3 (en) | 2011-05-16 |
EP1248613A4 (en) | 2006-03-22 |
EP1248613A1 (en) | 2002-10-16 |
EP1248613B1 (en) | 2011-03-02 |
CN1148186C (en) | 2004-05-05 |
HK1050484A1 (en) | 2003-06-27 |
CN1302608A (en) | 2001-07-11 |
ATE499935T1 (en) | 2011-03-15 |
US6534048B1 (en) | 2003-03-18 |
ES2359787T3 (en) | 2011-05-26 |
PT1248613E (en) | 2011-05-05 |
DE60045691D1 (en) | 2011-04-14 |
CY1111463T1 (en) | 2015-08-05 |
JP2003512427A (en) | 2003-04-02 |
JP4901042B2 (en) | 2012-03-21 |
US6147102A (en) | 2000-11-14 |
AU1211901A (en) | 2001-05-08 |
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