WO2001030339A1 - Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder - Google Patents
Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder Download PDFInfo
- Publication number
- WO2001030339A1 WO2001030339A1 PCT/US2000/029618 US0029618W WO0130339A1 WO 2001030339 A1 WO2001030339 A1 WO 2001030339A1 US 0029618 W US0029618 W US 0029618W WO 0130339 A1 WO0130339 A1 WO 0130339A1
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- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- hydrogen
- salt
- ammomdan
- rats
- Prior art date
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- 0 C*1(C)*(*)CC2=C*(*)C=C*(*)C=C2C1N(*)C(*)=O Chemical compound C*1(C)*(*)CC2=C*(*)C=C*(*)C=C2C1N(*)C(*)=O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Definitions
- Bipolar mood disorder commonly begins with depression and is characterized by at least one elated period sometime during the course of the illness.
- bipolar I disorder full blown manic and major depressive episodes alternate.
- bipolar II disorder depressive episodes alternate with hypomanias (i.e., mild, nonpsychotic periods of excitement) of relatively short duration.
- insomnia and poor appetite do occur during the depressive phase of bipolar illness, such atypical depressive signs as hypersomnia and overeating are more characteristic and may recur on a seasonal basis (e.g., in the autumn or winter) .
- HCA heterocyclic antidepressants
- MAOI monoamine oxidase inhibitors
- lithium salts Merck, p. 1603
- HCA and MAOI drugs are indicated for the depressive phase of the bipolar disorder, lithium is known to attenuate the bipolar mood swings.
- rodent models relevant to the manic phase like amphetamine, amphetamine with chlordiazepoxide, morphine or desmethylimipramme induced hyperactivity or to the depression phase like immobilizations, are usually used (D.L. Murphy, Anim. Mod. Psych. Neur., 1977, pp. 211-225).
- a variety of substituted 1-am ⁇ nomdans have been proposed to have some activity m the central nervous system (CNS) .
- This group of compounds has a wide range of activities, for example, U.S. Patent No. 4,096,173 discloses 1-am ⁇ nomdans with ring chloro substituents as having anti-allergic, anti- spasmodic and local anesthetic activities, whereas U.S Patent No. 3,886,168 discloses the antl-inflammatory and vasodilatory activity of certain 1-ammomdans .
- U.S. Patent No. 3,637,740 discloses dl - l -N, N- dimethylammo- 4 -met oxy-7-chloromdane as an antidepressant and/or an antianxiety agent. However, no clear evidence is provided of either activity.
- the subject mvention describes a method of treating mania the bipolar mood disorder in a subject comprising administering to the subject a therapeutically effective amount of derivatives of 1-ammomdan, their racemic mixtures, enantiomers, and salts thereof, of the general formula :
- n is 0 or 1; each of R 1 and R 2 are hydrogen, C 1 -C 4 alkyl , halogen; R 3 is hydrogen, C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy;
- R 4 is hydrogen, Ci-C 4 alkyl
- R 6 is hydrogen, substituted or unsubstituted alkyl, C 6 - C 12 aryl, C 7 -C 12 aralkyl or A-N-R 9 R 10 , provided that R 6 is not methyl when R 1 , R 2 , R 3 and R 4 are hydrogen atoms, wherein A is substituted or unsubstituted C 1 -C 12 alkyl, substituted or unsubstituted C 6 -C 12 aryl, substituted or unsubstituted C 7 -C 12 aralkyl, and each of R 9 and R 10 are independently hydrogen, C 1 -C 12 alkyl, C 6 -C 12 aryl, C 7 -C 12 aralkyl, COOtBu, or danyl ; and racemic mixtures, enantiomers, and salts thereof. Description of the Figures
- FIG. 1 shows four specific compounds discussed m the experiments: (R) -N-acetyl ammomdan (1), (S)-N-mdanyl glycinamide HC1 (2), (rac) -N- (2-ammoacetyl) -1 -ammomdan HC1 (3), (S) -N-formyl ammomdan (4).
- FIG. 2A-5B hereinafter describe the means ⁇ SE for activity counts measured for each group for 30 minutes, at 10 minute time intervals.
- the asterisk "*" denotes a significant difference from the control.
- Drug administration is mterpe ⁇ toneal (IP) .
- FIG. 2A shows the locomotor activity level for rats which have been administered (R) -N-acetyl ammomdan (1) as compared to the control .
- FIG. 2B shows the vertical activity level for rats which have been administered (R) -N-acetyl ammomdan (1) as compared to the control.
- FIG. 3A shows the locomotor activity level for rats which have been administered (S) -N-mdanyl glycinamide HC1 (2) as compared to the control .
- FIG. 3B shows the vertical activity level for rats which have been administered (S) -N-mdanyl glycinamide HC1 (2) as compared to the control .
- FIG. 4A shows the locomotor activity level for rats which have been administered (rac) -N- (2-ammoacetyl) -1-ammomdan (3) as compared to the control.
- FIG. 4B shows the vertical activity level for rats which have been administered (rac) -N- (2 -ammoacetyl) -1-ammomdan (3) as compared to the control.
- FIG. 5A shows the locomotor activity level for rats which have been administered (S) -N-formyl ammomdan (4) as compared to the control .
- FIG. 5B shows the vertical activity level for rats which have been administered (S) -N-formyl ammomdan (4) as compared to the control .
- This invention provides a method for the treatment of mania bipolar mood disorder using derivatives of 1-ammomdan or their racemic mixtures, enantiomers, and salts thereof.
- the present invention discloses a method of treating mania m bipolar mood disorder m a subject comprising administering to the subject a therapeutically effective amount of a compound of the formula:
- n is 0 or 1; each of R 1 and R 2 are hydrogen, C 1 -C 4 alkyl, halogen; R 3 is hydrogen, C x -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy; R 4 is hydrogen, C x -C 4 alkyl; R 6 is hydrogen, substituted or unsubstituted C ⁇ - C 12 alkyl, C 6 -C 12 aryl, C 7 -C 12 aralkyl or A-N-R 9 R 10 , provided that R 6 is not methyl when R 1 , R 2 , R 3 and R 4 are hydrogen atoms, wherein A is substituted or unsubstituted alkyl, substituted or unsubstituted C 6 -C 12 aryl, substituted or unsubstituted C 7 -C 12 aralkyl, and each of R 9 and R 10 are independently hydrogen, C 1 -C 12 alkyl, C 6 -C 2 aryl, C 7
- the compound is selected from the group consisting of (R) -N-acetyl ammomdan, (rac) -N-2-ammoacetyl -1-am ⁇ no ⁇ ndan HC1 and (S) -
- the subject is a human sub ect .
- the salt is selected from the group consisting of a hydrochloride salt, a mesylate salt, an ethylsulfonate salt, and a sulfate salt.
- the salt is a hydrochloride salt.
- the administration is selected from the group consisting of oral, mtrape ⁇ toneal , parenteral, topical, transdermal, rectal, nasal, and buccal administration.
- the therapeutically effective amount is an amount from 30 mg/kg to 150 mg/kg .
- the therapeutically effective amount is an amount from 30 mg/kg to 100 mg/kg. In a preferred embodiment of the invention, the therapeutically effective amount is an amount from 30 mg/kg to 75 mg/kg.
- Cohen et al disclose the preparation of the (R) -l- am omdan starting material, and certain novel representatives of ammomdan (U.S. Patents 5,877,221; 5,880,159; 5,877,218).
- the R- and S- enantiomers of each compound may be obtained by optical resolution of the corresponding racemic mixtures. Such a resolution can be accomplished by any conventional resolution method also disclosed in Cohen et al .
- IP mtrape ⁇ toneally
- Amphetamine (0.5 mg/kg, sub-cutaneous (s.c.), diluted in de- ionized water) was injected into all rats (both groups of each experiment) immediately prior to behavioral testing.
- compounds (R) -N-acetyl aminoindan (1); (S) -N-indanyl glycinamide HC1 (2); (rac)-N-(2- aminoacetyl) -1-aminoindan HC1 (3); and (S) -N-formyl aminoindan (4) were injected twice intraperitoneally (IP) at a dose of 75 mg/kg, 19 h and 3 h prior to behavioral testing in experiments. All compounds were suspended in a 5% methyl cellulose solution. The vehicle solution was administered to the control animals.
- Tables 1 and 2 The results of the experiment employing (R) -N-acetyl aminoindan (1) are shown in Tables 1 and 2, as well as FIG. 2A and 2B.
- Table 1 compares the activity counts for rats which have been administered intraperitoneal (R) -N-acetyl aminoindan (1) to control rats for three 10 minute intervals.
- FIG. 2A shows the locomotor activity level for rats which have been administered intraperitoneally (R) -N- acetyl-aminoindan (1) as compared to the control.
- FIG. 2B shows the vertical activity level for rats which have been administered intraperitoneally (R) -N-acetyl -aminoindan (1) as compared to the control .
- FIG. 3A shows the results of the experiment employing (S) -N-mdanyl glycinamide HCl (2) as compared to the control.
- Table 2 compares the activity counts for rats which have been administered (S) -N-indanyl glycinamide HCl (2) to control rats for three 10 minute intervals.
- FIG. 3A shows the locomotor activity level for rats which have been administered (S) -N-mdanyl glycinamide HCl (2) as compared to the control.
- FIG. 3B shows the vertical activity level for rats which have been administered (S) -N-mdanyl glycinamide HCl (2) as compared to the control.
- FIG. 4A shows the results of the experiment employing (rac)-N-(2- am oacetyl) -1-ammomdan HCl (3) to control rats for three 10 mmute intervals.
- FIG. 4A shows the locomotor activity level for rats which have been administered (rac) -N- (2-ammoacetyl) -1- ammomdan HCl (3) as compared to the control.
- FIG. 4B shows the vertical activity level for rats which have been administered (rac) -N- (2-ammoacetyl) -1-ammomdan HCl (3) as compared to the control .
- Table 4 compares the activity counts for rats which have been administered (S) -N-formyl aminoindan (4) to control rats for three 10 minute intervals.
- FIG. 5A shows the locomotor activity level for rats which have been administered (S) -N-formyl aminoindan (4) as compared to the control.
- FIG. 5B shows the vertical activity level for rats which have been administered (S) -N-formyl aminoindan (4) as compared to the control .
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- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60029131T DE60029131T2 (en) | 1999-10-27 | 2000-10-27 | USE OF 1-AMINOINDANE DERIVATIVES FOR THE TREATMENT OF MANIE IN CONNECTION WITH MANIC-DEPRESSIVE DISEASE |
AU14402/01A AU775885B2 (en) | 1999-10-27 | 2000-10-27 | Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder |
JP2001532759A JP2003512426A (en) | 1999-10-27 | 2000-10-27 | Use of 1-aminoindan for the treatment of mania in bipolar mood disorder. |
CA002387394A CA2387394C (en) | 1999-10-27 | 2000-10-27 | Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder |
EP00976661A EP1242066B1 (en) | 1999-10-27 | 2000-10-27 | Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder |
IL14930800A IL149308A0 (en) | 1999-10-27 | 2000-10-27 | Use of 1-aminoindan derivatives for treatment of manic disorders |
IL149308A IL149308A (en) | 1999-10-27 | 2002-04-23 | Use of 1-aminoindan derivatives for the manufacture of a medicament for the treatment of mania in bipolar disorder |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16181799P | 1999-10-27 | 1999-10-27 | |
US60/161,817 | 1999-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001030339A1 true WO2001030339A1 (en) | 2001-05-03 |
Family
ID=22582876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/029618 WO2001030339A1 (en) | 1999-10-27 | 2000-10-27 | Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder |
Country Status (9)
Country | Link |
---|---|
US (1) | US6492426B1 (en) |
EP (1) | EP1242066B1 (en) |
JP (1) | JP2003512426A (en) |
AT (1) | ATE331508T1 (en) |
AU (1) | AU775885B2 (en) |
CA (1) | CA2387394C (en) |
DE (1) | DE60029131T2 (en) |
IL (2) | IL149308A0 (en) |
WO (1) | WO2001030339A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9181026B2 (en) | 2013-10-03 | 2015-11-10 | Custom Chemical Solutions, LLC | Containment berm with internal “L” braces |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140090996A (en) * | 2011-10-10 | 2014-07-18 | 테바 파마슈티컬 인더스트리즈 리미티드 | R(+)-n-formyl-propargyl-aminoindan |
Citations (3)
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US3637740A (en) * | 1969-04-21 | 1972-01-25 | Pfizer | Aminobenzocycloalkane compounds |
US3886168A (en) * | 1971-07-26 | 1975-05-27 | Basf Ag | N-substituted 1-aminomethylindanes |
US4096173A (en) * | 1977-03-28 | 1978-06-20 | Eli Lilly And Company | Chlorinated 1-aminoindane N-methyl transferase inhibitors |
Family Cites Families (25)
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GB852735A (en) | 1956-04-13 | 1960-11-02 | Schering Ag | Manufacture of 1-aminoindanes |
JPS5824433A (en) * | 1981-08-06 | 1983-02-14 | Takehiro Mokuzai Kogyo Kk | Method for decorating surface of fiber material molded product |
DE3407842A1 (en) | 1983-03-04 | 1984-09-06 | Otsuka Pharmaceutical Co. Ltd., Tokyo | INDANDERIVATES AND THEIR SALTS, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS AND ANTIOXIDISM, WHICH CONTAIN THEM |
DE3583780D1 (en) | 1984-08-31 | 1991-09-19 | Otsuka Pharma Co Ltd | 2,3-DIHYDRO-1H-INDENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
JPS6169747A (en) | 1984-08-31 | 1986-04-10 | Otsuka Pharmaceut Co Ltd | 2,3-dihydro-1h-indene derivative |
US5242919A (en) | 1984-08-31 | 1993-09-07 | Otsuka Pharmaceutical Co., Ltd. | 2,3-dihydro-1H-indene derivatives |
US4882339A (en) | 1987-07-10 | 1989-11-21 | Ciba-Geigy Corporation | 4-Amino-substituted 1,2-dihydroxynaphthalene derivatives useful in inhibiting 5-lipoxygenase activity in mammals |
US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
IL92952A (en) | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
IL99759A (en) | 1991-10-16 | 1997-06-10 | Teva Pharma | Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them |
US5344836A (en) | 1991-11-11 | 1994-09-06 | Ono Pharmaceutical Co., Ltd. | Fused benzeneoxyacetic acid derivatives |
CH683996A5 (en) | 1992-03-05 | 1994-06-30 | Symphar Sa | aminophosphonates substituted derivatives, process for their preparation and pharmaceutical compositions containing them. |
CA2136999C (en) | 1993-04-07 | 2004-05-11 | Takafumi Fujioka | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
IL111240A (en) | 1993-10-18 | 2001-10-31 | Teva Pharma | Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them |
DE69535315T2 (en) * | 1994-01-10 | 2007-06-28 | Teva Pharmaceutical Industries Ltd. | 1-AMINOINDANDERIVATE AND COMPOSITIONS HEREVON |
US5877218A (en) | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
CH690264A5 (en) | 1995-06-30 | 2000-06-30 | Symphar Sa | aminophosphonates substituted derivatives, their preparation process and their use for preparing pharmaceutical compositions. |
US5646188A (en) | 1995-07-05 | 1997-07-08 | Teva Pharmaceutical Industries, Ltd. | Polyamine derivatives of 1-aminoindan |
IL115357A (en) | 1995-09-20 | 2000-01-31 | Teva Pharma | Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols |
US5887218A (en) | 1996-06-10 | 1999-03-23 | Ricoh Co., Ltd. | Color image forming apparatus having toner and transfer sheet bearing members and image forming method thereof |
CA2275425C (en) | 1996-12-18 | 2009-08-04 | Michael Chorev | Aminoindan derivatives |
US6251938B1 (en) | 1996-12-18 | 2001-06-26 | Teva Pharmaceutical Industries, Ltd., | Phenylethylamine derivatives |
WO1998055447A1 (en) | 1997-06-05 | 1998-12-10 | Venantius Limited | 3-aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them |
US5887221A (en) | 1997-10-20 | 1999-03-23 | Xerox Corporation | Signature sensing for optimum toner control with donor roll |
US6227886B1 (en) | 1999-04-16 | 2001-05-08 | Avaya Technology Corp. | Snag-resistant patchcord plug latch and cover |
-
2000
- 2000-10-27 AU AU14402/01A patent/AU775885B2/en not_active Ceased
- 2000-10-27 WO PCT/US2000/029618 patent/WO2001030339A1/en active IP Right Grant
- 2000-10-27 IL IL14930800A patent/IL149308A0/en active IP Right Grant
- 2000-10-27 US US09/699,127 patent/US6492426B1/en not_active Expired - Fee Related
- 2000-10-27 CA CA002387394A patent/CA2387394C/en not_active Expired - Fee Related
- 2000-10-27 EP EP00976661A patent/EP1242066B1/en not_active Expired - Lifetime
- 2000-10-27 AT AT00976661T patent/ATE331508T1/en not_active IP Right Cessation
- 2000-10-27 JP JP2001532759A patent/JP2003512426A/en active Pending
- 2000-10-27 DE DE60029131T patent/DE60029131T2/en not_active Expired - Lifetime
-
2002
- 2002-04-23 IL IL149308A patent/IL149308A/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3637740A (en) * | 1969-04-21 | 1972-01-25 | Pfizer | Aminobenzocycloalkane compounds |
US3886168A (en) * | 1971-07-26 | 1975-05-27 | Basf Ag | N-substituted 1-aminomethylindanes |
US4096173A (en) * | 1977-03-28 | 1978-06-20 | Eli Lilly And Company | Chlorinated 1-aminoindane N-methyl transferase inhibitors |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9181026B2 (en) | 2013-10-03 | 2015-11-10 | Custom Chemical Solutions, LLC | Containment berm with internal “L” braces |
Also Published As
Publication number | Publication date |
---|---|
US6492426B1 (en) | 2002-12-10 |
IL149308A (en) | 2007-07-24 |
EP1242066B1 (en) | 2006-06-28 |
DE60029131T2 (en) | 2007-01-18 |
ATE331508T1 (en) | 2006-07-15 |
AU775885B2 (en) | 2004-08-19 |
CA2387394A1 (en) | 2001-05-03 |
EP1242066A1 (en) | 2002-09-25 |
EP1242066A4 (en) | 2004-09-01 |
DE60029131D1 (en) | 2006-08-10 |
IL149308A0 (en) | 2002-11-10 |
JP2003512426A (en) | 2003-04-02 |
CA2387394C (en) | 2009-08-18 |
AU1440201A (en) | 2001-05-08 |
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