WO2001029269A3 - Gene expression profiling of inflammatory bowel disease - Google Patents

Gene expression profiling of inflammatory bowel disease Download PDF

Info

Publication number
WO2001029269A3
WO2001029269A3 PCT/US2000/041457 US0041457W WO0129269A3 WO 2001029269 A3 WO2001029269 A3 WO 2001029269A3 US 0041457 W US0041457 W US 0041457W WO 0129269 A3 WO0129269 A3 WO 0129269A3
Authority
WO
WIPO (PCT)
Prior art keywords
inflammatory bowel
ibd
gene expression
cells
expression profiling
Prior art date
Application number
PCT/US2000/041457
Other languages
French (fr)
Other versions
WO2001029269A2 (en
Inventor
Shukti Chakravarti
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Priority to EP00988479A priority Critical patent/EP1287162A2/en
Priority to IL14393600A priority patent/IL143936A0/en
Priority to CA2356207A priority patent/CA2356207C/en
Priority to AU24685/01A priority patent/AU784861B2/en
Publication of WO2001029269A2 publication Critical patent/WO2001029269A2/en
Publication of WO2001029269A3 publication Critical patent/WO2001029269A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to methods for identifying and/or classifying patients with inflammatory bowel diseases (IBD), particularly patients with Crohn's disease or ulcerative colitis. Gene expression profiling shows broad and fundamental differences in the pathogenic mechanism of UC and CD. The subject method is based on the findings that certain genes are differentially expressed in intestinal tissue of IBD patients compared with related normal cells, such as normal colon cells. That change can be used to identify or classify IBD cells by the upregulation and/or downregulation of expression of particular genes, alterations in protein levels or modification, or changes at the genomic level (such as mutation, methylation, etc), e.g., an event which is implicated in the pathology of inflammatory bowel diseases.
PCT/US2000/041457 1999-10-21 2000-10-23 Gene expression profiling of inflammatory bowel disease WO2001029269A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00988479A EP1287162A2 (en) 1999-10-21 2000-10-23 Gene expression profiling of inflammatory bowel disease
IL14393600A IL143936A0 (en) 1999-10-21 2000-10-23 Gene expression profiling of inflammatory bowel disease
CA2356207A CA2356207C (en) 1999-10-21 2000-10-23 Gene expression profiling of inflammatory bowel disease
AU24685/01A AU784861B2 (en) 1999-10-21 2000-10-23 Gene expression profiling of inflammatory bowel disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16083599P 1999-10-21 1999-10-21
US60/160,835 1999-10-21

Publications (2)

Publication Number Publication Date
WO2001029269A2 WO2001029269A2 (en) 2001-04-26
WO2001029269A3 true WO2001029269A3 (en) 2002-12-05

Family

ID=22578660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041457 WO2001029269A2 (en) 1999-10-21 2000-10-23 Gene expression profiling of inflammatory bowel disease

Country Status (5)

Country Link
EP (2) EP1287162A2 (en)
AU (1) AU784861B2 (en)
CA (1) CA2356207C (en)
IL (1) IL143936A0 (en)
WO (1) WO2001029269A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877192B2 (en) 2004-08-03 2014-11-04 Transtech Pharma, Llc Rage fusion proteins and methods of use
US9034341B2 (en) 2009-04-20 2015-05-19 Transtech Pharma, Llc Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
CA2842429A1 (en) * 2001-10-19 2003-05-01 Genentech, Inc. Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
JP5236856B2 (en) 2001-11-09 2013-07-17 ライフ テクノロジーズ コーポレーション Identification, observation and treatment of diseases and identification of biological states using gene expression profiles
JP4437193B2 (en) * 2002-03-29 2010-03-24 独立行政法人産業技術総合研究所 Nucleic acid library and protein library
AU2003247303A1 (en) * 2002-07-17 2004-02-02 Index Pharmaceuticals Ab Antisense compounds, methods and compositions for treating ngal-related inflammatory disorders
JP2006500073A (en) * 2002-07-18 2006-01-05 インデックス・ファーマシューティカルズ・アクチエボラーグ Antisense compounds, methods and compositions for treating MMP-12 related inflammatory disorders
DE10328813B4 (en) * 2003-06-20 2006-04-13 Epigenomics Ag Method for the investigation of cytosine methylations in DNA sequences using triplex-forming oligomers
ES2326708B1 (en) * 2005-10-05 2010-09-30 Progenika Biopharma, S.A. METHODS AND PRODUCTS FOR GENOTIPADO IN VITRO.
CA2594730A1 (en) * 2005-01-13 2006-07-20 Progenika Biopharma, S.A. Methods and products for in vitro genotyping
US8153363B2 (en) 2005-01-13 2012-04-10 Progenika Biopharma S.A. Methods and products for in vitro genotyping
WO2006133287A2 (en) * 2005-06-06 2006-12-14 Wyeth Expression profiles of peripheral blood mononuclear cells for inflammatory bowel diseases
EP2380983A3 (en) 2006-05-05 2012-12-05 TransTech Pharma Inc. RAGE fusion proteins, formulations, and methods of use thereof
US20100267575A1 (en) * 2006-10-17 2010-10-21 Childrens Hospital Medical Center Gene array technique for predicting response in inflammatory bowel diseases
WO2008147869A2 (en) 2007-05-22 2008-12-04 Centocor, Inc. Markers and methods for assessing and treating crohn's disease and related disorders
RU2513695C2 (en) 2007-06-14 2014-04-20 Гэлэктика Фармасьютикалс, Инк. Fused rage proteins
MX2010005893A (en) * 2007-11-29 2011-03-04 Genentech Inc Star Gene expression markers for inflammatory bowel disease.
US7833720B2 (en) 2008-03-14 2010-11-16 Exagen Diagnostics, Inc. Biomarkers for inflammatory bowel disease and irritable bowel syndrome
ES2356458B1 (en) * 2009-09-11 2012-01-23 Progenika Biopharma, S.A. METHODS AND PRODUCTS FOR IN VITRO GENOTIPATE OF HUMAN GENETIC VARIATIONS ASSOCIATED WITH REACTIONS ADVERSE TO DRUGS.
WO2014205507A1 (en) * 2013-06-28 2014-12-31 Newsouth Innovations Pty Limited Diagnostic method
WO2019008093A1 (en) * 2017-07-07 2019-01-10 University Of Copenhagen Markers for diagnosing inflammatory bowel diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014283A2 (en) * 1998-09-04 2000-03-16 Washington University Gene markers for chronic mucosal injury

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
CA1319101C (en) 1986-09-03 1993-06-15 Marta Iris Sabara Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US5254678A (en) 1987-12-15 1993-10-19 Gene Shears Pty. Limited Ribozymes
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5256775A (en) 1989-06-05 1993-10-26 Gilead Sciences, Inc. Exonuclease-resistant oligonucleotides
US5144019A (en) 1989-06-21 1992-09-01 City Of Hope Ribozyme cleavage of HIV-I RNA
US5225337A (en) 1989-09-25 1993-07-06 Innovir Laboratories, Inc. Ribozyme compositions and methods for use
US5264564A (en) 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5498531A (en) 1993-09-10 1996-03-12 President And Fellows Of Harvard College Intron-mediated recombinant techniques and reagents
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
AU700952B2 (en) 1995-06-07 1999-01-14 Pioneer Hi-Bred International, Inc. PCR-based cDNA subtractive cloning method
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5654173A (en) 1996-08-23 1997-08-05 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
AU707636C (en) 1995-11-23 2003-01-16 Cancer Research Campaign Technology Limited Materials and methods relating to the identification and sequencing of the BRCA2 cancer susceptibility gene and uses thereof
AU2189397A (en) 1996-02-08 1997-08-28 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014283A2 (en) * 1998-09-04 2000-03-16 Washington University Gene markers for chronic mucosal injury

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ALEXANDER RICHARD J ET AL: "Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease.", DIGESTIVE DISEASES AND SCIENCES, vol. 41, no. 4, 1996, pages 660 - 669, XP001064180, ISSN: 0163-2116 *
CAMACHO F I ET AL: "CD44v6 expression in inflammatory bowel disease is associated with activity detected by endoscopy and pathological features.", HISTOPATHOLOGY (OXFORD), vol. 35, no. 2, August 1999 (1999-08-01), pages 144 - 149, XP002207657, ISSN: 0309-0167 *
DIECKGRAEFE B ET AL: "Characterization of mucosal gene expression in inflammatory bowel disease by direct hybridization to massively parallel oligonucleotide arrays", DIGESTIVE DISEASES AND SCIENCES, PLENUM PUBLISHING CO, US, vol. 114, no. 4, PART 2, 1998, pages ABSTG3954, XP000877256, ISSN: 0163-2116 *
DIECKGRAEFE B K ET AL: "Expression of the regenerating gene family in inflammatory bowel disease: potential role as an injury-induced tissue mitogen", GASTROENTEROLOGY, SAUNDERS, PHILADELPHIA, PA,, US, vol. 116, no. 4, PART 2, April 1999 (1999-04-01), pages A601, XP000876959, ISSN: 0016-5085 *
FUNAKOSHI K ET AL: "Spectrum of cytokine gene expression in intestinal mucosal lesions of Crohn's disease and ulcerative colitis.", DIGESTION, vol. 59, no. 1, January 1998 (1998-01-01), pages 73 - 78, XP001064174, ISSN: 0012-2823 *
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring.", SCIENCE (WASHINGTON D C), vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075 *
HOSOKAWA TAKEHIKO ET AL: "Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease.", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 14, no. 10, October 1999 (1999-10-01), pages 987 - 996, XP001064163, ISSN: 0815-9319 *
MAZZUCCHELLI LUCA ET AL: "Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease.", JOURNAL OF PATHOLOGY, vol. 178, no. 2, 1996, pages 201 - 206, XP001064186, ISSN: 0022-3417 *
PALLONE F ET AL: "Hla-d region antigens on isolated human colonic epithelial cells enhanced expression in inflammatory bowel disease and in-vitro induction by different stimuli", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 74, no. 1, 1988, pages 75 - 79, XP001064184, ISSN: 0009-9104 *
SATSANGI J ET AL: "GENETIC MARKERS IN INFLAMMATORY BOWEL DISEASE", CURRENT OPINION IN GASTROENTEROLOGY, GOWER ACADEMIC JOURNALS, LONDON, GB, vol. 12, no. 4, 1 July 1996 (1996-07-01), pages 322 - 326, XP000619908, ISSN: 0267-1379 *
WILD G E ET AL: "ANALYSIS OF GENE EXPRESSION IN INFLAMMATORY BOWEL DISEASE BY DIFFERENTIAL DISPLAY PCR OF COLONOCYTE MRNA", GASTROENTEROLOGY, SAUNDERS, PHILADELPHIA, PA,, US, vol. 112, no. 4, SUPPL, 1997, pages A1118, XP000877180, ISSN: 0016-5085 *
ZUO LI ET AL: "mRNA differential display of colonic mucosa cells in ulcerative colitis.", JOURNAL OF SURGICAL RESEARCH, vol. 69, no. 1, 1997, pages 119 - 127, XP000877187, ISSN: 0022-4804 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877192B2 (en) 2004-08-03 2014-11-04 Transtech Pharma, Llc Rage fusion proteins and methods of use
US9034341B2 (en) 2009-04-20 2015-05-19 Transtech Pharma, Llc Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions

Also Published As

Publication number Publication date
EP1287162A2 (en) 2003-03-05
IL143936A0 (en) 2002-04-21
CA2356207C (en) 2012-10-09
AU2468501A (en) 2001-04-30
CA2356207A1 (en) 2001-04-26
WO2001029269A2 (en) 2001-04-26
AU784861B2 (en) 2006-07-06
EP2319939A3 (en) 2012-09-26
EP2319939A2 (en) 2011-05-11

Similar Documents

Publication Publication Date Title
WO2001029269A3 (en) Gene expression profiling of inflammatory bowel disease
Goodrich et al. The relationship between the human genome and microbiome comes into view
Langefeld et al. Transancestral mapping and genetic load in systemic lupus erythematosus
Castillo-Fernandez et al. Epigenetics of discordant monozygotic twins: implications for disease
Gibbons Alpha thalassaemia-mental retardation, X linked
Zoetendal et al. Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces
Gertz et al. Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation
Cavailles et al. A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage
CN104561016B (en) New mutation of congenital cataract PITX3 gene
WO2005024603A3 (en) Methods for detecting, diagnosing and treating human renal cell carcinoma
Logue et al. The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity
Ji et al. Association of host genetics with intestinal microbial relevant to body weight in a chicken F2 resource population
Hempelmann et al. Exploration of the genetic architecture of idiopathic generalized epilepsies
Kellermayer Challenges for epigenetic research in inflammatory bowel diseases
Winkler et al. Fuchs' endothelial corneal dystrophy in patients with myotonic dystrophy, type 1
del Carmen Plaza-Serón et al. Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema
Zhao et al. The effects of gene duplication modes on the evolution of regulatory divergence in wild and cultivated soybean
CN104745592A (en) CYP4V2 gene mutant and application thereof
CN104073499B (en) TMC1 gene mutation body and its application
Wang et al. Comparison of different normalization assumptions for analyses of DNA methylation data from the cancer genome
Lewitus et al. Neocortical development as an evolutionary platform for intragenomic conflict
CN104745594A (en) CYP4V2 gene mutant and application thereof
Kwabi-Addo Health Outcomes in a Foreign Land
Adam et al. Hepatocarcinogenesis in non‐cirrhotic liver is associated with a reduced number of clonal hepatocellular patches in non‐tumorous liver parenchyma
Ma et al. Use of high-throughput targeted exome sequencing in genetic diagnosis of Chinese family with congenital cataract

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA IL JP NZ

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2356207

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2356207

WWE Wipo information: entry into national phase

Ref document number: 143936

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 513088

Country of ref document: NZ

Ref document number: 24685/01

Country of ref document: AU

Ref document number: 2000988479

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA IL JP NZ

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WWP Wipo information: published in national office

Ref document number: 2000988479

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP