WO2001023582A1 - Whole cell catalyst comprising a hydantoinase, a racemase and a carbamoylase - Google Patents
Whole cell catalyst comprising a hydantoinase, a racemase and a carbamoylase Download PDFInfo
- Publication number
- WO2001023582A1 WO2001023582A1 PCT/EP2000/008473 EP0008473W WO0123582A1 WO 2001023582 A1 WO2001023582 A1 WO 2001023582A1 EP 0008473 W EP0008473 W EP 0008473W WO 0123582 A1 WO0123582 A1 WO 0123582A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plasmids
- pbw34
- hydantoinase
- whole cell
- catalyst
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/227—Tryptophan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/009—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving hydantoins or carbamoylamino compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
- C12Y305/02002—Dihydropyrimidinase (3.5.2.2), i.e. hydantoinase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00960557A EP1216304B1 (en) | 1999-09-28 | 2000-08-31 | Whole cell catalyst comprising a hydantoinase, a racemase and a carbamoylase |
DE60043988T DE60043988D1 (en) | 1999-09-28 | 2000-08-31 | WHOLE-CELL CATALYST CONTAINING A HYDANTOINASE, A RACEMASE, AND A CARBAMOYLASE |
AT00960557T ATE460486T1 (en) | 1999-09-28 | 2000-08-31 | WHOLE-CELL CATALYST CONTAINING A HYDANTOINASE, A RACEMASE AND A CARBAMOYLASE |
AU72817/00A AU7281700A (en) | 1999-09-28 | 2000-08-31 | Whole cell catalyst comprising a hydantoinase, a racemase and a carbamoylase |
JP2001526964A JP2003527095A (en) | 1999-09-28 | 2000-08-31 | Whole-cell catalyst, including hydantoinase, racemase and carbamoylase |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/407,062 US6713288B1 (en) | 1999-09-28 | 1999-09-28 | Whole cell catalysts |
US09/407,062 | 1999-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001023582A1 true WO2001023582A1 (en) | 2001-04-05 |
Family
ID=23610441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/008473 WO2001023582A1 (en) | 1999-09-28 | 2000-08-31 | Whole cell catalyst comprising a hydantoinase, a racemase and a carbamoylase |
Country Status (7)
Country | Link |
---|---|
US (2) | US6713288B1 (en) |
EP (1) | EP1216304B1 (en) |
JP (1) | JP2003527095A (en) |
AT (1) | ATE460486T1 (en) |
AU (1) | AU7281700A (en) |
DE (1) | DE60043988D1 (en) |
WO (1) | WO2001023582A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002010424A1 (en) * | 2000-07-28 | 2002-02-07 | Degussa Ag | Process for the preparation of allysine acetal |
WO2002072841A1 (en) * | 2001-03-08 | 2002-09-19 | Ajinomoto Co., Inc. | Dna encoding hydantoinase, dna encoding n-carbamyl-l-amino acid hydrolase, recombinant dna, transformed cells, process for producing protein and process for producing optically active amino acid |
EP1285962A1 (en) * | 2001-08-16 | 2003-02-26 | Degussa AG | NADH oxidase from Lactobacillus |
WO2003085108A1 (en) * | 2002-04-10 | 2003-10-16 | Ajinomoto Co., Inc. | Recombinant dna having hydantoinase gene and carbamylase gene and process for producing amino acid |
DE10234764A1 (en) * | 2002-07-30 | 2004-02-19 | Degussa Ag | Racemization of 5-tert-butylhydantoin, useful as precursor of tert-leucine, using peptide with hydantoin racemase activity, also preparation of tert-leucine |
WO2004111227A2 (en) * | 2003-06-06 | 2004-12-23 | Degussa Ag | Screening process for hydantoin racemases |
WO2005038021A1 (en) * | 2003-09-08 | 2005-04-28 | Ajinomoto Co., Inc. | Novel transporter protein |
WO2008067981A2 (en) | 2006-12-04 | 2008-06-12 | Dsm Ip Assets B.V. | Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase |
ES2322418A1 (en) * | 2006-10-02 | 2009-06-19 | Universidad De Almeria | Enzymatic coexpression system for the production of d-amino acids (Machine-translation by Google Translate, not legally binding) |
US7582454B2 (en) * | 2000-09-13 | 2009-09-01 | Ajinomoto Co. Inc. | 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids |
US7713724B2 (en) | 2002-05-23 | 2010-05-11 | Dsm Ip Assets B.V. | Hydantoin racemase |
WO2011003702A1 (en) | 2009-07-09 | 2011-01-13 | Dsm Ip Assets B.V. | Stabilized enzyme compositions |
CN101098967B (en) * | 2004-06-14 | 2012-01-04 | 赢创德固赛有限公司 | Preparation of optically active alcohols with whole-cell catalysts |
US8895310B2 (en) | 2002-12-02 | 2014-11-25 | Basf Se | L-rhamnose-inducible expression systems |
WO2022248739A1 (en) | 2021-06-16 | 2022-12-01 | Evonik Operations Gmbh | Enzymatic method for the production of l-glufosinate p-alkyl esters |
WO2023174511A1 (en) | 2022-03-14 | 2023-09-21 | Evonik Operations Gmbh | Enzymatic method for the production of l-glufosinate p-esters |
WO2023232225A1 (en) | 2022-05-31 | 2023-12-07 | Evonik Operations Gmbh | Enzymatic method for the diastereoselective production of l-glufosinate p-esters |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004057966A1 (en) * | 2004-11-30 | 2006-06-01 | Degussa Ag | Method for asymmetrical enzymatic production of optically active organic compounds in microemulsion |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03251176A (en) | 1990-01-10 | 1991-11-08 | Nippon Soda Co Ltd | 5-substituted hydantoin and n-carbamylamino acid transferase |
DE4316928C2 (en) * | 1993-05-19 | 1995-03-16 | Degussa | New microorganisms, their use and process for the production of L-alpha-amino acids |
DE19519717C1 (en) | 1995-05-30 | 1996-08-22 | Degussa | New microorganism DSM 9771 for prepn of L-alpha-amino acids |
JP4445668B2 (en) | 1998-04-02 | 2010-04-07 | エボニック デグサ ゲーエムベーハー | Recombinant LN-carbamoylase from Arthrobacter aurecens and method for producing L-amino acid thereby |
-
1999
- 1999-09-28 US US09/407,062 patent/US6713288B1/en not_active Expired - Lifetime
-
2000
- 2000-08-31 AU AU72817/00A patent/AU7281700A/en not_active Abandoned
- 2000-08-31 DE DE60043988T patent/DE60043988D1/en not_active Expired - Lifetime
- 2000-08-31 EP EP00960557A patent/EP1216304B1/en not_active Expired - Lifetime
- 2000-08-31 AT AT00960557T patent/ATE460486T1/en active
- 2000-08-31 JP JP2001526964A patent/JP2003527095A/en active Pending
- 2000-08-31 WO PCT/EP2000/008473 patent/WO2001023582A1/en active Application Filing
-
2003
- 2003-01-02 US US10/334,990 patent/US7393679B2/en not_active Expired - Fee Related
Non-Patent Citations (9)
Title |
---|
BLATTNER FREDERICK R ET AL: "The complete genome sequence of Escherichia coli K-12.", SCIENCE (WASHINGTON D C), vol. 277, no. 5331, 1997, pages 1453 - 1462, XP002069950, ISSN: 0036-8075 * |
DATABASE GENBANK [online] NCBI; 8 February 1996 (1996-02-08), LEBOWITZ, J.: "Plasmid ColE1, complete genome", XP002154850, retrieved from NCBI accession no. http://www.ncbi.nlm.nih.gov:80/ Database accession no. http://www.ncbi.nlm.nih.gov:80/Genbank/index.html * |
GRIFANTINI RENATA ET AL: "Efficient conversion of 5-substituted hydantoins to D-alpha-amino acids using recombinant Escherichia coli strains.", MICROBIOLOGY (READING), vol. 144, no. 4, April 1998 (1998-04-01), pages 947 - 954, XP002154848, ISSN: 1350-0872 * |
MAY OLIVER ET AL: "Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine.", NATURE BIOTECHNOLOGY, vol. 18, no. 3, March 2000 (2000-03-01), pages 317 - 320, XP002154849, ISSN: 1087-0156 * |
SIEMANN MARTIN ET AL: "Characterization of serological properties of polyclonal antibodies produced against enzymes involved in the L-selective cleavage of hydantoin derivatives.", BIOTECHNOLOGY LETTERS, vol. 15, no. 1, 1993, pages 1 - 6, XP000944249, ISSN: 0141-5492 * |
WATABE K ET AL: "CLONING AND SEQUENCE OF THE GENES INVOLVED IN THE CONVERSION OF 5-SUBSTITUTED HYDANTOINS TO THE CORRESPONDING L AMINO ACIDS FROM THE NATIVE PLASMID OF PSEUDOMONAS-SP STRAIN NS671", JOURNAL OF BACTERIOLOGY, vol. 174, no. 3, 1992, pages 962 - 969, XP000944036, ISSN: 0021-9193 * |
WATABE K ET AL: "IDENTIFICATION AND SEQUENCING OF A GENE ENCODING A HYDANTOIN RACEMASE FROM THE NATIVE PLASMID OF PSEUDOMONAS-SP STRAIN NS671", JOURNAL OF BACTERIOLOGY, vol. 174, no. 11, 1992, pages 3461 - 3466, XP000944037, ISSN: 0021-9193 * |
WIESE ANJA ET AL: "Hydantoin racemase from Arthrobacter aurescens DSM 3747: Heterologous expression, purification and characterization.", JOURNAL OF BIOTECHNOLOGY, vol. 80, no. 3, 2000, pages 217 - 230, XP000943983, ISSN: 0168-1656 * |
WILMS BURKHARD ET AL: "Cloning, nucleotide sequence and expression of a new L-N-carbamoylase gene from Arthrobacter aurescens DSM 3747 in E. coli.", JOURNAL OF BIOTECHNOLOGY, vol. 68, no. 2-3, 19 February 1999 (1999-02-19), pages 101 - 113, XP004164275, ISSN: 0168-1656 * |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6825014B2 (en) | 2000-07-28 | 2004-11-30 | Degussa Ag | Process for the preparation of allysine acetal |
WO2002010424A1 (en) * | 2000-07-28 | 2002-02-07 | Degussa Ag | Process for the preparation of allysine acetal |
US7582454B2 (en) * | 2000-09-13 | 2009-09-01 | Ajinomoto Co. Inc. | 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids |
US7098020B2 (en) | 2001-03-08 | 2006-08-29 | Ajinomoto Co., Inc. | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein, and method of producing optically active amino acid |
WO2002072841A1 (en) * | 2001-03-08 | 2002-09-19 | Ajinomoto Co., Inc. | Dna encoding hydantoinase, dna encoding n-carbamyl-l-amino acid hydrolase, recombinant dna, transformed cells, process for producing protein and process for producing optically active amino acid |
US8460902B1 (en) | 2001-03-08 | 2013-06-11 | Ajinomoto Co., Inc. | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein, and method of producing optically active amino acid |
US7361490B2 (en) | 2001-03-08 | 2008-04-22 | Ajinomoto Co., Inc. | DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein and method of producing optically active amino acid |
EP1285962A1 (en) * | 2001-08-16 | 2003-02-26 | Degussa AG | NADH oxidase from Lactobacillus |
US6987013B2 (en) | 2001-08-16 | 2006-01-17 | Degussa Ag | NADH oxidase from lactobacillus |
WO2003085108A1 (en) * | 2002-04-10 | 2003-10-16 | Ajinomoto Co., Inc. | Recombinant dna having hydantoinase gene and carbamylase gene and process for producing amino acid |
US7713724B2 (en) | 2002-05-23 | 2010-05-11 | Dsm Ip Assets B.V. | Hydantoin racemase |
DE10234764A1 (en) * | 2002-07-30 | 2004-02-19 | Degussa Ag | Racemization of 5-tert-butylhydantoin, useful as precursor of tert-leucine, using peptide with hydantoin racemase activity, also preparation of tert-leucine |
US8895310B2 (en) | 2002-12-02 | 2014-11-25 | Basf Se | L-rhamnose-inducible expression systems |
WO2004111227A2 (en) * | 2003-06-06 | 2004-12-23 | Degussa Ag | Screening process for hydantoin racemases |
WO2004111227A3 (en) * | 2003-06-06 | 2005-06-16 | Degussa | Screening process for hydantoin racemases |
WO2005038021A1 (en) * | 2003-09-08 | 2005-04-28 | Ajinomoto Co., Inc. | Novel transporter protein |
US7320794B2 (en) | 2003-09-08 | 2008-01-22 | Ajinomoto Co., Inc. | Transporter protein |
US7851610B2 (en) | 2003-09-08 | 2010-12-14 | Ajinomoto Co., Ltd. | Transporter protein |
CN101098967B (en) * | 2004-06-14 | 2012-01-04 | 赢创德固赛有限公司 | Preparation of optically active alcohols with whole-cell catalysts |
ES2322418A1 (en) * | 2006-10-02 | 2009-06-19 | Universidad De Almeria | Enzymatic coexpression system for the production of d-amino acids (Machine-translation by Google Translate, not legally binding) |
WO2008067981A3 (en) * | 2006-12-04 | 2008-10-02 | Dsm Ip Assets Bv | Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase |
EP2267144A3 (en) * | 2006-12-04 | 2011-05-25 | DSM IP Assets B.V. | Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase |
EP2267144A2 (en) | 2006-12-04 | 2010-12-29 | DSM IP Assets B.V. | Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase |
WO2008067981A2 (en) | 2006-12-04 | 2008-06-12 | Dsm Ip Assets B.V. | Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase |
WO2011003702A1 (en) | 2009-07-09 | 2011-01-13 | Dsm Ip Assets B.V. | Stabilized enzyme compositions |
WO2022248739A1 (en) | 2021-06-16 | 2022-12-01 | Evonik Operations Gmbh | Enzymatic method for the production of l-glufosinate p-alkyl esters |
EP4105335A1 (en) | 2021-06-16 | 2022-12-21 | Evonik Operations GmbH | Enzymatic method for the production of l-glufosinate p-alkyl esters |
WO2023174511A1 (en) | 2022-03-14 | 2023-09-21 | Evonik Operations Gmbh | Enzymatic method for the production of l-glufosinate p-esters |
WO2023232225A1 (en) | 2022-05-31 | 2023-12-07 | Evonik Operations Gmbh | Enzymatic method for the diastereoselective production of l-glufosinate p-esters |
Also Published As
Publication number | Publication date |
---|---|
EP1216304A1 (en) | 2002-06-26 |
US20030175910A1 (en) | 2003-09-18 |
US6713288B1 (en) | 2004-03-30 |
ATE460486T1 (en) | 2010-03-15 |
EP1216304B1 (en) | 2010-03-10 |
JP2003527095A (en) | 2003-09-16 |
US7393679B2 (en) | 2008-07-01 |
AU7281700A (en) | 2001-04-30 |
DE60043988D1 (en) | 2010-04-22 |
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