WO2001011083A3 - Methods for detecting mutations using primer extension - Google Patents

Methods for detecting mutations using primer extension Download PDF

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Publication number
WO2001011083A3
WO2001011083A3 PCT/US2000/021763 US0021763W WO0111083A3 WO 2001011083 A3 WO2001011083 A3 WO 2001011083A3 US 0021763 W US0021763 W US 0021763W WO 0111083 A3 WO0111083 A3 WO 0111083A3
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WO
WIPO (PCT)
Prior art keywords
methods
primer extension
detecting mutations
deletions
detecting
Prior art date
Application number
PCT/US2000/021763
Other languages
French (fr)
Other versions
WO2001011083A2 (en
Inventor
Anthony P Shuber
William Pierceall
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Exact Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Exact Lab Inc filed Critical Exact Lab Inc
Priority to AU66273/00A priority Critical patent/AU6627300A/en
Priority to CA002381625A priority patent/CA2381625A1/en
Priority to EP00953902A priority patent/EP1203100A2/en
Priority to JP2001515330A priority patent/JP2003521892A/en
Publication of WO2001011083A2 publication Critical patent/WO2001011083A2/en
Publication of WO2001011083A3 publication Critical patent/WO2001011083A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for detecting nucleotide deletions in biological samples are described. Methods of the invention are particularly useful for detecting deletions in regions of polynucleotide repeats. In particular, methods of the invention are useful to detect deletions at the BAT26 locus.
PCT/US2000/021763 1999-08-11 2000-08-09 Methods for detecting mutations using primer extension WO2001011083A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU66273/00A AU6627300A (en) 1999-08-11 2000-08-09 Methods for detecting mutations using primer extension
CA002381625A CA2381625A1 (en) 1999-08-11 2000-08-09 Methods for detecting mutations using primer extension
EP00953902A EP1203100A2 (en) 1999-08-11 2000-08-09 Methods for detecting mutations using primer extension
JP2001515330A JP2003521892A (en) 1999-08-11 2000-08-09 Methods for detecting mutations using primer extension

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/371,991 1999-08-11
US09/371,991 US6280947B1 (en) 1999-08-11 1999-08-11 Methods for detecting nucleotide insertion or deletion using primer extension

Publications (2)

Publication Number Publication Date
WO2001011083A2 WO2001011083A2 (en) 2001-02-15
WO2001011083A3 true WO2001011083A3 (en) 2001-08-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/021763 WO2001011083A2 (en) 1999-08-11 2000-08-09 Methods for detecting mutations using primer extension

Country Status (6)

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US (2) US6280947B1 (en)
EP (1) EP1203100A2 (en)
JP (1) JP2003521892A (en)
AU (1) AU6627300A (en)
CA (1) CA2381625A1 (en)
WO (1) WO2001011083A2 (en)

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US7981607B2 (en) 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
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WO2015066695A1 (en) 2013-11-04 2015-05-07 Exact Sciences Corporation Multiple-control calibrators for dna quantitation
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JP2021523365A (en) 2018-05-11 2021-09-02 ラボラトリー コーポレイション オブ アメリカ ホールディングス Compositions and Methods for Detecting Renal Fibrosis

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Also Published As

Publication number Publication date
US6280947B1 (en) 2001-08-28
US20020045183A1 (en) 2002-04-18
EP1203100A2 (en) 2002-05-08
JP2003521892A (en) 2003-07-22
CA2381625A1 (en) 2001-02-15
AU6627300A (en) 2001-03-05
US6482595B2 (en) 2002-11-19
WO2001011083A2 (en) 2001-02-15

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