WO2001010383A2 - Caspase inhibitors and uses thereof - Google Patents
Caspase inhibitors and uses thereof Download PDFInfo
- Publication number
- WO2001010383A2 WO2001010383A2 PCT/US2000/021503 US0021503W WO0110383A2 WO 2001010383 A2 WO2001010383 A2 WO 2001010383A2 US 0021503 W US0021503 W US 0021503W WO 0110383 A2 WO0110383 A2 WO 0110383A2
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- disease
- dmso
- caspase
- compound
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- 0 CNC(CC(O)=O)C(C*)=O Chemical compound CNC(CC(O)=O)C(C*)=O 0.000 description 3
- DJWOMKRCQTVFQA-UHFFFAOYSA-N OC(CC(C(CF)=O)NC(c1cc(I)ccc1)=O)=O Chemical compound OC(CC(C(CF)=O)NC(c1cc(I)ccc1)=O)=O DJWOMKRCQTVFQA-UHFFFAOYSA-N 0.000 description 1
- HEMTWRDMCVLVSX-UHFFFAOYSA-N OC(CC(C(CF)=O)NC(c1cccc(-c2ccccc2)c1)=O)=O Chemical compound OC(CC(C(CF)=O)NC(c1cccc(-c2ccccc2)c1)=O)=O HEMTWRDMCVLVSX-UHFFFAOYSA-N 0.000 description 1
- VFKCEXLTSCHTLN-UHFFFAOYSA-N OC(CC(C(CF)=O)NC(c1cccc(OCCc2ccccc2)c1)=O)=O Chemical compound OC(CC(C(CF)=O)NC(c1cccc(OCCc2ccccc2)c1)=O)=O VFKCEXLTSCHTLN-UHFFFAOYSA-N 0.000 description 1
- GKLWBCDEIYOYTA-UHFFFAOYSA-N OC(CC(C(CF)=O)NC(c1cccc(OCc2ccccc2)c1)=O)=O Chemical compound OC(CC(C(CF)=O)NC(c1cccc(OCc2ccccc2)c1)=O)=O GKLWBCDEIYOYTA-UHFFFAOYSA-N 0.000 description 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00957311A EP1163208B1 (en) | 1999-08-06 | 2000-08-04 | Caspase inhibitors and uses thereof |
SI200030446T SI1163208T1 (en) | 1999-08-06 | 2000-08-04 | Caspase inhibitors and uses thereof |
AT00957311T ATE266623T1 (en) | 1999-08-06 | 2000-08-04 | CASPASE INHIBITORS AND THEIR USE |
DK00957311T DK1163208T3 (en) | 1999-08-06 | 2000-08-04 | Caspase Inhibitors and Uses thereof |
AU68948/00A AU6894800A (en) | 1999-08-06 | 2000-08-04 | Caspase inhibitors and uses thereof |
JP2001514908A JP2003506389A (en) | 1999-08-06 | 2000-08-04 | Caspase inhibitors and uses thereof |
DE60010675T DE60010675T2 (en) | 1999-08-06 | 2000-08-04 | CASPASE INHIBITORS AND THEIR USE |
US09/834,052 US6632962B2 (en) | 1999-08-06 | 2001-04-03 | Caspase inhibitors and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14770699P | 1999-08-06 | 1999-08-06 | |
US60/147,706 | 1999-08-06 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/834,052 Continuation US6632962B2 (en) | 1999-08-06 | 2001-04-03 | Caspase inhibitors and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001010383A2 true WO2001010383A2 (en) | 2001-02-15 |
WO2001010383A3 WO2001010383A3 (en) | 2001-09-07 |
Family
ID=22522602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/021503 WO2001010383A2 (en) | 1999-08-06 | 2000-08-04 | Caspase inhibitors and uses thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US6632962B2 (en) |
EP (1) | EP1163208B1 (en) |
JP (1) | JP2003506389A (en) |
AT (1) | ATE266623T1 (en) |
AU (1) | AU6894800A (en) |
DE (1) | DE60010675T2 (en) |
DK (1) | DK1163208T3 (en) |
ES (1) | ES2219381T3 (en) |
PT (1) | PT1163208E (en) |
TW (1) | TWI281910B (en) |
WO (1) | WO2001010383A2 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6355618B1 (en) | 1999-04-09 | 2002-03-12 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
US6495522B1 (en) | 1999-08-27 | 2002-12-17 | Cytovia, Inc. | Substituted alpha-hydroxy acid caspase inhibitors and the use thereof |
WO2003024955A2 (en) * | 2001-09-18 | 2003-03-27 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
US6620782B1 (en) | 1999-03-16 | 2003-09-16 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
WO2003088917A2 (en) * | 2002-04-19 | 2003-10-30 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
WO2003106402A1 (en) * | 2002-06-12 | 2003-12-24 | Bayer Aktiengesellschaft | 2-naphtamide derivatives |
WO2005039615A1 (en) * | 2003-10-26 | 2005-05-06 | Yeda Research And Development Co.Ltd. | Use of caspase-8 inhibitors for modulating hematopoiesis |
AT413485B (en) * | 2001-04-09 | 2006-03-15 | Hemoteq Gmbh | Stent for stabilizing blood vessels, useful for inhibiting restenosis after vascular intervention, is coated with peptide inhibitor of caspase |
WO2007015931A3 (en) * | 2005-07-28 | 2007-06-07 | Vertex Pharma | Caspase inhibitor prodrugs |
US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
EP2295054A1 (en) | 2004-05-27 | 2011-03-16 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
EP2399915A1 (en) | 2004-03-12 | 2011-12-28 | Vertex Pharmaceuticals Incorporated | Process and intermediates for the preparation of aspartic acetal caspase inhibitors |
US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
US9994613B2 (en) | 2000-05-19 | 2018-06-12 | Vertex Pharmaceuticals Incorporated | Prodrug of an ICE inhibitor |
US11434212B2 (en) | 2017-01-23 | 2022-09-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bicyclic compound as a caspase inhibitor |
WO2022187440A1 (en) | 2021-03-03 | 2022-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | La protien as a novel regulator of osteoclastogenesis |
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US20060217299A1 (en) * | 2003-02-24 | 2006-09-28 | Hirofumi Doi | Degradation inhibitor for hepatitis b virus x interacting protein |
CA2524882A1 (en) * | 2003-05-06 | 2004-11-25 | Cytovia, Inc. | Protease inhibitors for coronaviruses and sars-cov and the use thereof |
AU2003902704A0 (en) * | 2003-05-29 | 2003-06-19 | Crc For Waste Management And Pollution Control Limited Of Unsw | Process for producing a nanoscale zero-valent metal |
CA2557631A1 (en) * | 2004-02-18 | 2005-09-01 | Georgia Tech Research Corporation | Propenoyl hydrazides |
JP4848367B2 (en) * | 2004-05-15 | 2011-12-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | Treatment of seizures using ICE inhibitors |
FR2878522B1 (en) * | 2004-12-01 | 2008-04-18 | Merck Sante Soc Par Actions Si | NEW SPECIFIC INHIBITORS OF CASPAS-10 |
WO2008137567A1 (en) * | 2007-05-01 | 2008-11-13 | Cedars-Sinai Medical Center | Caspase inhibitors in the treatment of infection-associated preterm delivery |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
EP2916656B1 (en) | 2012-11-09 | 2017-10-25 | Cornell University | Small molecule inhibitors of malt1 |
WO2015175381A1 (en) | 2014-05-12 | 2015-11-19 | Conatus Pharmaceuticals, Inc. | Treatment of the complications of chronic liver disease with caspase inhibitors |
WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
KR20180101418A (en) | 2015-12-31 | 2018-09-12 | 코나터스 파마슈티칼스, 인크. | Methods of using caspase inhibitors in the treatment of liver disease |
CA3039283A1 (en) | 2016-10-05 | 2018-04-12 | Novartis Ag | Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder |
WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000055114A1 (en) * | 1999-03-16 | 2000-09-21 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents. |
DE69711845T2 (en) * | 1996-09-12 | 2002-10-31 | Idun Pharmaceuticals Inc | NEW TRICYCLIC COMPOUNDS WITH ICE / CED-3 PROTEASE FAMILY-INHIBITING PROPERTIES |
US6242422B1 (en) * | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
WO2001090070A2 (en) * | 2000-05-23 | 2001-11-29 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
IL152845A0 (en) * | 2000-06-07 | 2003-06-24 | Vertex Pharma | Fused heterocyclic compounds and pharmaceutical compositions containing the same |
-
2000
- 2000-08-04 AT AT00957311T patent/ATE266623T1/en not_active IP Right Cessation
- 2000-08-04 PT PT00957311T patent/PT1163208E/en unknown
- 2000-08-04 ES ES00957311T patent/ES2219381T3/en not_active Expired - Lifetime
- 2000-08-04 EP EP00957311A patent/EP1163208B1/en not_active Expired - Lifetime
- 2000-08-04 DE DE60010675T patent/DE60010675T2/en not_active Expired - Lifetime
- 2000-08-04 WO PCT/US2000/021503 patent/WO2001010383A2/en active IP Right Grant
- 2000-08-04 DK DK00957311T patent/DK1163208T3/en active
- 2000-08-04 JP JP2001514908A patent/JP2003506389A/en active Pending
- 2000-08-04 AU AU68948/00A patent/AU6894800A/en not_active Abandoned
- 2000-08-05 TW TW089115790A patent/TWI281910B/en active
-
2001
- 2001-04-03 US US09/834,052 patent/US6632962B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000055114A1 (en) * | 1999-03-16 | 2000-09-21 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
Non-Patent Citations (1)
Title |
---|
See also references of EP1163208A2 * |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6620782B1 (en) | 1999-03-16 | 2003-09-16 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
US6716818B2 (en) | 1999-04-09 | 2004-04-06 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
US6355618B1 (en) | 1999-04-09 | 2002-03-12 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
US6495522B1 (en) | 1999-08-27 | 2002-12-17 | Cytovia, Inc. | Substituted alpha-hydroxy acid caspase inhibitors and the use thereof |
US9994613B2 (en) | 2000-05-19 | 2018-06-12 | Vertex Pharmaceuticals Incorporated | Prodrug of an ICE inhibitor |
AT413485B (en) * | 2001-04-09 | 2006-03-15 | Hemoteq Gmbh | Stent for stabilizing blood vessels, useful for inhibiting restenosis after vascular intervention, is coated with peptide inhibitor of caspase |
US6878743B2 (en) | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
WO2003024955A3 (en) * | 2001-09-18 | 2003-08-14 | Sunesis Pharmaceuticals Inc | Small molecule inhibitors of caspases |
WO2003024955A2 (en) * | 2001-09-18 | 2003-03-27 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
WO2003088917A3 (en) * | 2002-04-19 | 2004-03-04 | Vertex Pharma | Regulation of tnf-alpha |
WO2003088917A2 (en) * | 2002-04-19 | 2003-10-30 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
US7960398B2 (en) | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
WO2003106402A1 (en) * | 2002-06-12 | 2003-12-24 | Bayer Aktiengesellschaft | 2-naphtamide derivatives |
JP2007509132A (en) * | 2003-10-26 | 2007-04-12 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | Use of caspase-8 inhibitors to regulate hematopoiesis |
WO2005039615A1 (en) * | 2003-10-26 | 2005-05-06 | Yeda Research And Development Co.Ltd. | Use of caspase-8 inhibitors for modulating hematopoiesis |
EP2399915A1 (en) | 2004-03-12 | 2011-12-28 | Vertex Pharmaceuticals Incorporated | Process and intermediates for the preparation of aspartic acetal caspase inhibitors |
EP2399916A1 (en) | 2004-03-12 | 2011-12-28 | Vertex Pharmaceuticals Incorporated | Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors |
EP2295054A1 (en) | 2004-05-27 | 2011-03-16 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
JP2009502922A (en) * | 2005-07-28 | 2009-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッド | Caspase inhibitor prodrug |
WO2007015931A3 (en) * | 2005-07-28 | 2007-06-07 | Vertex Pharma | Caspase inhibitor prodrugs |
US8168798B2 (en) | 2005-07-28 | 2012-05-01 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
US11434212B2 (en) | 2017-01-23 | 2022-09-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bicyclic compound as a caspase inhibitor |
WO2022187440A1 (en) | 2021-03-03 | 2022-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | La protien as a novel regulator of osteoclastogenesis |
Also Published As
Publication number | Publication date |
---|---|
WO2001010383A3 (en) | 2001-09-07 |
DE60010675T2 (en) | 2005-06-16 |
TWI281910B (en) | 2007-06-01 |
US6632962B2 (en) | 2003-10-14 |
EP1163208A2 (en) | 2001-12-19 |
ES2219381T3 (en) | 2004-12-01 |
JP2003506389A (en) | 2003-02-18 |
US20020132833A1 (en) | 2002-09-19 |
PT1163208E (en) | 2004-08-31 |
DE60010675D1 (en) | 2004-06-17 |
ATE266623T1 (en) | 2004-05-15 |
DK1163208T3 (en) | 2004-08-16 |
EP1163208A4 (en) | 2002-07-03 |
EP1163208B1 (en) | 2004-05-12 |
AU6894800A (en) | 2001-03-05 |
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