WO2001009154A3 - USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN - Google Patents

USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN Download PDF

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Publication number
WO2001009154A3
WO2001009154A3 PCT/US2000/020735 US0020735W WO0109154A3 WO 2001009154 A3 WO2001009154 A3 WO 2001009154A3 US 0020735 W US0020735 W US 0020735W WO 0109154 A3 WO0109154 A3 WO 0109154A3
Authority
WO
WIPO (PCT)
Prior art keywords
isoleucyl
staphylococcus aureus
trna synthetase
crystal structure
present
Prior art date
Application number
PCT/US2000/020735
Other languages
French (fr)
Other versions
WO2001009154A2 (en
Inventor
Jimin Wang
Laura F Silvian
Thomas A Steitz
Original Assignee
Univ Yale
Jimin Wang
Laura F Silvian
Thomas A Steitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Jimin Wang, Laura F Silvian, Thomas A Steitz filed Critical Univ Yale
Priority to CA002380335A priority Critical patent/CA2380335A1/en
Priority to AU63915/00A priority patent/AU6391500A/en
Priority to EP00950881A priority patent/EP1200564A2/en
Publication of WO2001009154A2 publication Critical patent/WO2001009154A2/en
Publication of WO2001009154A3 publication Critical patent/WO2001009154A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides the atomic coordinates derived from high resolution x-ray diffraction of the cocrystal complex comprising mupirocin with its target enzyme, isoleucyl-tRNA synthetase form Staphylococcus aureus, and the cognate tRNAile from Escherichia coli. The present invention further provides methods of using the atomic coordinates to identify and design new agents which modulate protein synthesis as well as the agents themselves.
PCT/US2000/020735 1999-07-29 2000-07-31 USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN WO2001009154A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002380335A CA2380335A1 (en) 1999-07-29 2000-07-31 Use of the crystal structure of staphylococcus aureus isoleucyl-trna synthetase in antibiotic design
AU63915/00A AU6391500A (en) 1999-07-29 2000-07-31 Use of the crystal structure of staphylococcus aureus isoleucyl-trna synthetase in antibiotic design
EP00950881A EP1200564A2 (en) 1999-07-29 2000-07-31 USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14617699P 1999-07-29 1999-07-29
US60/146,176 1999-07-29

Publications (2)

Publication Number Publication Date
WO2001009154A2 WO2001009154A2 (en) 2001-02-08
WO2001009154A3 true WO2001009154A3 (en) 2001-07-26

Family

ID=22516158

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/020735 WO2001009154A2 (en) 1999-07-29 2000-07-31 USE OF THE CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ISOLEUCYL-tRNA SYNTHETASE IN ANTIBIOTIC DESIGN

Country Status (5)

Country Link
US (1) US6631329B1 (en)
EP (1) EP1200564A2 (en)
AU (1) AU6391500A (en)
CA (1) CA2380335A1 (en)
WO (1) WO2001009154A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004013167A2 (en) * 2002-08-01 2004-02-12 Affinium Pharmaceuticals, Inc. Purified polypeptides from enterococcus faecalis
US20070118296A1 (en) * 2003-11-07 2007-05-24 Dna Software Inc. System and methods for three dimensional molecular structural analysis
WO2008070257A2 (en) * 2006-09-29 2008-06-12 Anacor Pharmaceuticals, Inc. Crystal structure of a trna synthetase
CN112933243B (en) * 2021-01-25 2023-06-27 中山大学 Complex crystal of isoleucyl tRNA synthetase and Lei Fumei element A, and preparation method and application thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
L F SILVIAN ET AL.: "Insights into editing from an Ile-t RNAS synthetase structure with tRNA and mupirocin", SCIENCE., vol. 285, 13 August 1999 (1999-08-13), AAAS. LANCASTER, PA., US, pages 1074 - 1077, XP002160175 *
O NUREKI ET AL.: "Enzyme structure with two catalytic sites for double-sieve selection of substrates", SCIENCE., vol. 280, 24 April 1998 (1998-04-24), AAAS. LANCASTER, PA., US, pages 578 - 582, XP002160173 *
S P HALE ET AL.: "Discrete determinants in transfer RNA for editing and aminoacylation", SCIENCE., vol. 276, 23 May 1997 (1997-05-23), AAAS. LANCASTER, PA., US, pages 1250 - 1252, XP002160174 *

Also Published As

Publication number Publication date
CA2380335A1 (en) 2001-02-08
AU6391500A (en) 2001-02-19
EP1200564A2 (en) 2002-05-02
WO2001009154A2 (en) 2001-02-08
US6631329B1 (en) 2003-10-07

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