WO2001002360A1 - Process for preparing amlodipine benzenesulphonate - Google Patents
Process for preparing amlodipine benzenesulphonate Download PDFInfo
- Publication number
- WO2001002360A1 WO2001002360A1 PCT/HU1999/000050 HU9900050W WO0102360A1 WO 2001002360 A1 WO2001002360 A1 WO 2001002360A1 HU 9900050 W HU9900050 W HU 9900050W WO 0102360 A1 WO0102360 A1 WO 0102360A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amiodipine
- methyl
- acid
- benzenesulphonate
- general formula
- Prior art date
Links
- 0 C*(C)C1=C([*+]OC)*C(C)=C(*)C1c1ccccc1Cl Chemical compound C*(C)C1=C([*+]OC)*C(C)=C(*)C1c1ccccc1Cl 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N OS(c1ccccc1)(=O)=O Chemical compound OS(c1ccccc1)(=O)=O SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Definitions
- the invention relates also to the novel phthalamidic acid derivatives of general formula II - wherein X represents hydrogen or alkali metal or alkali earth metal or quaternary ammonium - per se and the process for producing the same. These compounds are new final key intermediates (precursors) in the synthesis of amiodipine benzenesulphonate.
- the invention relates also to a process for preparing a pharmaceutical composition containing amiodipine benzenesulphonate when prepared according to the process of this invention.
- Amiodipine and the salts thereof were reported first in the European Patent Specification No. 89167 as one of the claimed novel 1 ,4-dihydropyridines and pharmaceutically acceptable salts thereof.
- the maleate is disclosed as being particularly preferred.
- 1,4- dihydropyridines including amiodipine and the salts thereof are produced from a precursor which can be the corresponding azido derivatives being converted to the amino group by reduction, e.g. with triphenylphosphine or zinc and hydrochloric acid or by hydrogenation over palladium catalyst.
- the disadvantage of this process is the relatively poor yield of the process for preparing the corresponding azide precursor, moreover the manipulation of azide compounds is less convenient due to the well-known explosiveness of the azidic structures.
- amino 1,4-dihydropyridine including amiodipine can be obtained by removal of the protecting group, then the obtained 1,4-dihydropyridine bases including amiodipine were isolated as an oil, and then were treated with acid.
- the protecting group is benzyl
- it is removed by catalytic hydrogenation over palladium catalyst in a solvent such as methanol at room temperature.
- the protecting group is 2,2,2-trichloroethoxycarbonyl
- it is removed by reduction with zinc in either formic or acetic acid.
- the protecting group is phthaloyl
- it can be removed by reaction with a primary amine. such as methylamine.
- the phthaloyl group can be removed also with hydrazine hydrate at reflux temperature in a solvent, such as ethanol.
- the phthaloyl group can be removed also with two equivalents of an alkali metal hydroxide, such as potassium hydroxide at room temperature, followed by refluxing the mixture with an excess of hydrochloric acid or sulphuric acid in tetrahydrofuran and water solution.
- amiodipine base was reacted with nearly stoichiometric amount of benzenesulphonic acid in a methanolic suspension and the amiodipine besylate was obtained in a yield of 83,8 %.
- amiodipine base was reacted with ammonium benzene sulphonate in methanol, then after a short heating under reflux the amiodipine besylate was isolated in a yield of 70 %.
- the European Patent Specification No. 599 220 describes a process for the preparation of amiodipine benzenesulphonate by reacting a novel trityl-protected amiodipine base with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature range from 20 °C to the reflux temperature and then the amiodipine benzenesulphonic acid was isolated and purified.
- amiodipine benzenesulphonate salt can be prepared directly without preparing amiodipine base contrary to as described in the above European Patents Nos 89 167 and 244 944, by reacting an easily preparable, new, stable and pure crystalhne phthalamidic acid derivative of general formula II - wherein X represents hydrogen or alkali metal or alkali earth metal or quaternary ammonium - with benzenesulphonic acid in a one-step synthesis
- the amount of benzenesulphonic acid is at least a stoichiomet ⁇ c amount or a small excess of benzenesulphonic acid is to be used
- the reaction time is 3 to 4 hours
- the new phthalamidic acid derivatives of general formula II - wherein X represents hydrogen or alkali metal or alkali earth metal or quaternary ammonium - can be prepared selectively by reacting 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2- (2-phthal ⁇ m ⁇ doethoxy)methyl-l,4-d ⁇ hydropy ⁇ d ⁇ ne with a strong base
- the thus obtained compound of general formula 11 - wherein ⁇ represents alkali metal or alkali earth metal or quaternary ammonium group - can be isolated or without isolation, if desired, can be reacted with an acid to obtain phthalamidic acid derivative of general formula 11, wherein X represents hydrogen
- the starting material of this process can be obtained conventionallv by Hantzsch reaction
- Acceptable strong bases can be alkali metal hydroxides, e g potassium hydroxide, sodium hydroxide, lithium hydroxide, etc or alkali earth metal oxides e g , calcium oxide, etc , or hydroxides or quaternary ammonium bases, e g , tetramethylammonium hydroxide, etc
- the quantity of the strong bases is not decisive, however, practically at least a stoichiomet ⁇ c amount of strong base or more conveniently a slight excess of strong base is required
- reaction with a strong base is carried out at room temperature and the neutralisation step with the acid is carried out during ice-cooling
- the new phthalamidic acid or its basic salt of general formula II - wherein X represents hvdrogen or alkali metal or alkali earth metal or quaternary ammonium - was reacted with at least a stoichiomet ⁇ c amount of the aqueous solution of benzenesulphonic acid under inert atmosphere, conveniently under nitrogen or argon in a mixture of an organic solvent and water conveniently in a 2 1 mixture of water and acetomt ⁇ l under heating
- the reaction temperature amounts to 70-80 °C and the reaction time is about 3 to 4 hours
- the amiodipine benzenesulphonate of the formula I can be obtained in a good yield (80-90 %) and in a high purity (> 99 5 % by HPLC)
- This method was used to make tablets containing different concentrations of the amiodipine benzenesulphonate salt.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA2002020897A UA72768C2 (en) | 1999-07-05 | 1999-05-07 | A method for obtaining amilodipine benzenesulphonate |
AU49237/99A AU777565B2 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
PCT/HU1999/000050 WO2001002360A1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
PT99933061T PT1196383E (en) | 1999-07-05 | 1999-07-05 | PROCESS FOR PREPARING AMLODIPINE BENZENOSULFONATE |
DE69922417T DE69922417T2 (en) | 1999-07-05 | 1999-07-05 | Process for the preparation of amlodipine benzene sulphonate |
NZ517013A NZ517013A (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate from phthalamidic acid derivatives |
DK99933061T DK1196383T3 (en) | 1999-07-05 | 1999-07-05 | Process for the preparation of amlodipine benzenesulfonate |
CZ20014690A CZ300509B6 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulfonate, intermediate product and method for preparing thereof |
PL99352493A PL194193B1 (en) | 1999-07-05 | 1999-07-05 | Method of obtaining amlodipin benzenesulphonate |
ES99933061T ES2234272T3 (en) | 1999-07-05 | 1999-07-05 | PROCESS TO PREPARE AMLODIPINE BENCENOSULFONATE. |
JP2001507800A JP3764386B2 (en) | 1999-07-05 | 1999-07-05 | Method for producing amlodipine benzenesulfonate |
MXPA01013407A MXPA01013407A (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate. |
KR1020027000052A KR100585442B1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
CA002376540A CA2376540C (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
EEP200100686A EE05398B1 (en) | 1999-07-05 | 1999-07-05 | Method for the preparation of amlodipine benzenesulfonate |
CNB998167746A CN1141297C (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
US10/019,424 US6596874B1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
EP99933061A EP1196383B1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
EA200200125A EA004208B1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
SK2-2002A SK285611B6 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate, intermediate and process for its preparation |
AT99933061T ATE283841T1 (en) | 1999-07-05 | 1999-07-05 | METHOD FOR PRODUCING AMLODIPINE BENZENESULFONATE |
BG106164A BG65657B1 (en) | 1999-07-05 | 2001-12-03 | Process for preparing amlodipine benzenesulphonate |
NO20020029A NO321714B1 (en) | 1999-07-05 | 2002-01-04 | Process for the preparation of amlodipine benzenesulfonate and pharmaceutical composition comprising this, phthalamidic acid derivative, compound and process for the preparation of novel phthalamidic acid derivatives. |
HK02105733.9A HK1044151B (en) | 1999-07-05 | 2002-08-06 | Process for preparing amlodipine benzenesulphonate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/HU1999/000050 WO2001002360A1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001002360A1 true WO2001002360A1 (en) | 2001-01-11 |
Family
ID=10991279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/HU1999/000050 WO2001002360A1 (en) | 1999-07-05 | 1999-07-05 | Process for preparing amlodipine benzenesulphonate |
Country Status (24)
Country | Link |
---|---|
US (1) | US6596874B1 (en) |
EP (1) | EP1196383B1 (en) |
JP (1) | JP3764386B2 (en) |
KR (1) | KR100585442B1 (en) |
CN (1) | CN1141297C (en) |
AT (1) | ATE283841T1 (en) |
AU (1) | AU777565B2 (en) |
BG (1) | BG65657B1 (en) |
CA (1) | CA2376540C (en) |
CZ (1) | CZ300509B6 (en) |
DE (1) | DE69922417T2 (en) |
DK (1) | DK1196383T3 (en) |
EA (1) | EA004208B1 (en) |
EE (1) | EE05398B1 (en) |
ES (1) | ES2234272T3 (en) |
HK (1) | HK1044151B (en) |
MX (1) | MXPA01013407A (en) |
NO (1) | NO321714B1 (en) |
NZ (1) | NZ517013A (en) |
PL (1) | PL194193B1 (en) |
PT (1) | PT1196383E (en) |
SK (1) | SK285611B6 (en) |
UA (1) | UA72768C2 (en) |
WO (1) | WO2001002360A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100354806B1 (en) * | 2000-06-21 | 2002-10-05 | 한국유나이티드제약 주식회사 | New intermediate for the preparation of amlodipine besylate and its process |
WO2003004025A1 (en) * | 2001-07-06 | 2003-01-16 | Lek Pharmaceutical And Chemical Company D.D. | High purity amlodipine benzenesulfonate and a process for its preparation |
WO2003043635A1 (en) * | 2001-11-21 | 2003-05-30 | Synthon B.V. | Amlodipine salt forms and processes for preparing them |
US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
KR100462304B1 (en) * | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | An organic acid salt of amlodipine |
KR100496436B1 (en) * | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | An organic acid salt of amlodipine |
US7671208B2 (en) | 2007-03-30 | 2010-03-02 | Esteve Quimica, S.A. | Acetone solvate of phthaloyl amlodipine |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100467669B1 (en) * | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | An organic acid salt of amlodipine |
JP2008013489A (en) * | 2006-07-06 | 2008-01-24 | Ohara Yakuhin Kogyo Kk | Tablet comprising amlodipine besylate |
CN101812014B (en) * | 2010-04-28 | 2011-08-24 | 王明 | Amlodipine besylate compound and novel preparation method thereof |
CN102993083A (en) * | 2012-12-21 | 2013-03-27 | 王学军 | Preparation method of amlodipine besylate |
CN104262237A (en) * | 2014-09-28 | 2015-01-07 | 常州瑞明药业有限公司 | Synthesis method of amlodipine free alkali |
US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0089167A2 (en) * | 1982-03-11 | 1983-09-21 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them |
EP0244944A2 (en) * | 1986-04-04 | 1987-11-11 | Pfizer Limited | Salts of amlodipine |
EP0599220A1 (en) * | 1992-11-26 | 1994-06-01 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | A process for the preparation of amlodipine benzenesulphonate |
EP0902016A1 (en) * | 1997-08-12 | 1999-03-17 | Egis Gyogyszergyar | A process and intermediate compounds for the preparation of amlodipine benzene sulphonate |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19738943B4 (en) | 1997-09-05 | 2008-01-03 | Siemens Ag | Method and device for determining properties of a steel |
-
1999
- 1999-05-07 UA UA2002020897A patent/UA72768C2/en unknown
- 1999-07-05 KR KR1020027000052A patent/KR100585442B1/en not_active IP Right Cessation
- 1999-07-05 MX MXPA01013407A patent/MXPA01013407A/en not_active IP Right Cessation
- 1999-07-05 US US10/019,424 patent/US6596874B1/en not_active Expired - Lifetime
- 1999-07-05 AU AU49237/99A patent/AU777565B2/en not_active Expired
- 1999-07-05 SK SK2-2002A patent/SK285611B6/en not_active IP Right Cessation
- 1999-07-05 EE EEP200100686A patent/EE05398B1/en unknown
- 1999-07-05 CA CA002376540A patent/CA2376540C/en not_active Expired - Lifetime
- 1999-07-05 CZ CZ20014690A patent/CZ300509B6/en unknown
- 1999-07-05 WO PCT/HU1999/000050 patent/WO2001002360A1/en active IP Right Grant
- 1999-07-05 DK DK99933061T patent/DK1196383T3/en active
- 1999-07-05 ES ES99933061T patent/ES2234272T3/en not_active Expired - Lifetime
- 1999-07-05 EP EP99933061A patent/EP1196383B1/en not_active Expired - Lifetime
- 1999-07-05 NZ NZ517013A patent/NZ517013A/en not_active IP Right Cessation
- 1999-07-05 PT PT99933061T patent/PT1196383E/en unknown
- 1999-07-05 CN CNB998167746A patent/CN1141297C/en not_active Expired - Lifetime
- 1999-07-05 JP JP2001507800A patent/JP3764386B2/en not_active Expired - Lifetime
- 1999-07-05 AT AT99933061T patent/ATE283841T1/en active
- 1999-07-05 EA EA200200125A patent/EA004208B1/en not_active IP Right Cessation
- 1999-07-05 DE DE69922417T patent/DE69922417T2/en not_active Expired - Lifetime
- 1999-07-05 PL PL99352493A patent/PL194193B1/en unknown
-
2001
- 2001-12-03 BG BG106164A patent/BG65657B1/en unknown
-
2002
- 2002-01-04 NO NO20020029A patent/NO321714B1/en not_active IP Right Cessation
- 2002-08-06 HK HK02105733.9A patent/HK1044151B/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0089167A2 (en) * | 1982-03-11 | 1983-09-21 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them |
EP0244944A2 (en) * | 1986-04-04 | 1987-11-11 | Pfizer Limited | Salts of amlodipine |
EP0599220A1 (en) * | 1992-11-26 | 1994-06-01 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | A process for the preparation of amlodipine benzenesulphonate |
EP0902016A1 (en) * | 1997-08-12 | 1999-03-17 | Egis Gyogyszergyar | A process and intermediate compounds for the preparation of amlodipine benzene sulphonate |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100354806B1 (en) * | 2000-06-21 | 2002-10-05 | 한국유나이티드제약 주식회사 | New intermediate for the preparation of amlodipine besylate and its process |
WO2003004025A1 (en) * | 2001-07-06 | 2003-01-16 | Lek Pharmaceutical And Chemical Company D.D. | High purity amlodipine benzenesulfonate and a process for its preparation |
US7153970B2 (en) | 2001-07-06 | 2006-12-26 | Lek Pharmaceuticals D.D. | High purity amlodipine benzenesulfonate and a process for its preparation |
US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
WO2003043635A1 (en) * | 2001-11-21 | 2003-05-30 | Synthon B.V. | Amlodipine salt forms and processes for preparing them |
KR100462304B1 (en) * | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | An organic acid salt of amlodipine |
KR100496436B1 (en) * | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | An organic acid salt of amlodipine |
US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
US7671208B2 (en) | 2007-03-30 | 2010-03-02 | Esteve Quimica, S.A. | Acetone solvate of phthaloyl amlodipine |
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