WO2001000192A3 - Method of administering an imidazole derivative to obtain analgesia - Google Patents

Method of administering an imidazole derivative to obtain analgesia Download PDF

Info

Publication number
WO2001000192A3
WO2001000192A3 PCT/FI2000/000566 FI0000566W WO0100192A3 WO 2001000192 A3 WO2001000192 A3 WO 2001000192A3 FI 0000566 W FI0000566 W FI 0000566W WO 0100192 A3 WO0100192 A3 WO 0100192A3
Authority
WO
WIPO (PCT)
Prior art keywords
administering
imidazole derivative
intraspinally
analgesia
obtain analgesia
Prior art date
Application number
PCT/FI2000/000566
Other languages
French (fr)
Other versions
WO2001000192A2 (en
Inventor
Antti Haapalinna
Jyrki Lehtimaeki
Tiina Leino
Timo Viitamaa
Raimo Virtanen
Original Assignee
Orion Corp
Antti Haapalinna
Jyrki Lehtimaeki
Tiina Leino
Timo Viitamaa
Raimo Virtanen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp, Antti Haapalinna, Jyrki Lehtimaeki, Tiina Leino, Timo Viitamaa, Raimo Virtanen filed Critical Orion Corp
Priority to EP00940441A priority Critical patent/EP1196168A2/en
Priority to AU55378/00A priority patent/AU5537800A/en
Publication of WO2001000192A2 publication Critical patent/WO2001000192A2/en
Publication of WO2001000192A3 publication Critical patent/WO2001000192A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a method for obtaining analgesia by administering 3-[1-(1H-imidazol-4-yl)-ethyl]-indan-5-ol, its enantiomer or a pharmaceutically acceptable ester or salt thereof to a mammal intraspinally. 3-[1-(1H-imidazol-4-yl)-ethyl]-indan-5-ol, its enantiomer or a pharmaceutically acceptable ester or salt thereof can be administered intraspinally to a mammal obtaining analgesia without side-effects, such as sedation. The present invention also relates to a method for using the drug as an adjunct to anaesthesia by administering it intraspinally.
PCT/FI2000/000566 1999-06-25 2000-06-22 Method of administering an imidazole derivative to obtain analgesia WO2001000192A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00940441A EP1196168A2 (en) 1999-06-25 2000-06-22 Method of admistering an imidazole derivative to obtain analgesia
AU55378/00A AU5537800A (en) 1999-06-25 2000-06-22 Method of admistering an imidazole derivative to obtain analgesia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14079599P 1999-06-25 1999-06-25
US60/140,795 1999-06-25

Publications (2)

Publication Number Publication Date
WO2001000192A2 WO2001000192A2 (en) 2001-01-04
WO2001000192A3 true WO2001000192A3 (en) 2001-06-07

Family

ID=22492822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2000/000566 WO2001000192A2 (en) 1999-06-25 2000-06-22 Method of administering an imidazole derivative to obtain analgesia

Country Status (3)

Country Link
EP (1) EP1196168A2 (en)
AU (1) AU5537800A (en)
WO (1) WO2001000192A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424059A1 (en) * 1989-10-17 1991-04-24 Orion-Yhtymà„ Oy Use of sustituted imidazoles for the manufacture of an analgesic
WO1997012874A1 (en) * 1995-10-03 1997-04-10 Orion-Yhtymä Oy Imidazole derivatives having affinity for alpha2 receptors activity
US5801188A (en) * 1997-01-08 1998-09-01 Medtronic Inc. Clonidine therapy enhancement
WO2000018400A1 (en) * 1998-09-28 2000-04-06 Orion Corporation Use of 3-(1h-imidazol-4-ylmethyl)-indan-5-ol in the manufacture of a medicament for intraspinal, intrathecal or epidural administration

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424059A1 (en) * 1989-10-17 1991-04-24 Orion-Yhtymà„ Oy Use of sustituted imidazoles for the manufacture of an analgesic
WO1997012874A1 (en) * 1995-10-03 1997-04-10 Orion-Yhtymä Oy Imidazole derivatives having affinity for alpha2 receptors activity
US5801188A (en) * 1997-01-08 1998-09-01 Medtronic Inc. Clonidine therapy enhancement
WO2000018400A1 (en) * 1998-09-28 2000-04-06 Orion Corporation Use of 3-(1h-imidazol-4-ylmethyl)-indan-5-ol in the manufacture of a medicament for intraspinal, intrathecal or epidural administration

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EISENACH J C ET AL: "Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep", ANESTHESIOLOGY, vol. 91, no. 5, November 1999 (1999-11-01), pages 1425 - 1436, XP002901419 *

Also Published As

Publication number Publication date
AU5537800A (en) 2001-01-31
EP1196168A2 (en) 2002-04-17
WO2001000192A2 (en) 2001-01-04

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