WO2000071080A3 - Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1 - Google Patents

Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1 Download PDF

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Publication number
WO2000071080A3
WO2000071080A3 PCT/US2000/013961 US0013961W WO0071080A3 WO 2000071080 A3 WO2000071080 A3 WO 2000071080A3 US 0013961 W US0013961 W US 0013961W WO 0071080 A3 WO0071080 A3 WO 0071080A3
Authority
WO
WIPO (PCT)
Prior art keywords
rack1
interaction
pde4d5
cyclic
specific phosphodiesterase
Prior art date
Application number
PCT/US2000/013961
Other languages
French (fr)
Other versions
WO2000071080A9 (en
WO2000071080A2 (en
Inventor
Graeme B Bolger
Miles D Houslay
Michael R Steele
Stephen J Yarwood
Original Assignee
Univ Utah Res Found
Graeme B Bolger
Miles D Houslay
Michael R Steele
Stephen J Yarwood
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found, Graeme B Bolger, Miles D Houslay, Michael R Steele, Stephen J Yarwood filed Critical Univ Utah Res Found
Priority to AU52786/00A priority Critical patent/AU5278600A/en
Priority to EP00937642A priority patent/EP1183391A2/en
Publication of WO2000071080A2 publication Critical patent/WO2000071080A2/en
Publication of WO2000071080A3 publication Critical patent/WO2000071080A3/en
Publication of WO2000071080A9 publication Critical patent/WO2000071080A9/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

It has been discovered that the cAMP-specific phosphodiesterase, PDE4D5, interacts specifically and with high affinity with the Receptor for Activated C-Kinase (RACK1). The region of PDE4D5 that interacts with RACK1 was determined, and it was shown that peptides spanning this region inhibit the specific interaction of PDE4D5 and RACK1. Drugs that inhibit or stimulate this interaction should be therapeutically important for treating various conditions. A method for screening candidate drugs involves detecting inhibition or stimulation of this interaction of the peptide and RACK1. Peptides that modulate this interaction and methods of making thereof are also disclosed.
PCT/US2000/013961 1999-05-20 2000-05-20 Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1 WO2000071080A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU52786/00A AU5278600A (en) 1999-05-20 2000-05-20 Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1
EP00937642A EP1183391A2 (en) 1999-05-20 2000-05-20 Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13503599P 1999-05-20 1999-05-20
US60/135,035 1999-05-20

Publications (3)

Publication Number Publication Date
WO2000071080A2 WO2000071080A2 (en) 2000-11-30
WO2000071080A3 true WO2000071080A3 (en) 2001-03-15
WO2000071080A9 WO2000071080A9 (en) 2001-12-20

Family

ID=22466200

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/013961 WO2000071080A2 (en) 1999-05-20 2000-05-20 Interaction of the cyclic-amp-specific phosphodiesterase pde4d5 with rack1

Country Status (3)

Country Link
EP (1) EP1183391A2 (en)
AU (1) AU5278600A (en)
WO (1) WO2000071080A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851784A (en) * 1994-12-23 1998-12-22 Celltech Therapeutics, Limited Human phosphodiesterase type IVC, and its production and use
US5922557A (en) * 1997-01-09 1999-07-13 Merck & Co., Inc. System for stably expressing a high-affinity camp phosphodiesterase and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851784A (en) * 1994-12-23 1998-12-22 Celltech Therapeutics, Limited Human phosphodiesterase type IVC, and its production and use
US5922557A (en) * 1997-01-09 1999-07-13 Merck & Co., Inc. System for stably expressing a high-affinity camp phosphodiesterase and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YARWOOD ET AL.: "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 21, 21 May 1999 (1999-05-21), pages 14909 - 14917, XP002933884 *

Also Published As

Publication number Publication date
WO2000071080A9 (en) 2001-12-20
AU5278600A (en) 2000-12-12
EP1183391A2 (en) 2002-03-06
WO2000071080A2 (en) 2000-11-30

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