WO2000067801A2 - Prodrugs of chemotherapeutic agents with oxaalkanoic acids - Google Patents
Prodrugs of chemotherapeutic agents with oxaalkanoic acids Download PDFInfo
- Publication number
- WO2000067801A2 WO2000067801A2 PCT/US2000/012322 US0012322W WO0067801A2 WO 2000067801 A2 WO2000067801 A2 WO 2000067801A2 US 0012322 W US0012322 W US 0012322W WO 0067801 A2 WO0067801 A2 WO 0067801A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- och
- prodrug
- acid
- stirred
- room temperature
- Prior art date
Links
- 0 CC(*)C=CN**C1OC1C(*)(*)**C(*)(*)C(*)(*)** Chemical compound CC(*)C=CN**C1OC1C(*)(*)**C(*)(*)C(*)(*)** 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002368831A CA2368831A1 (en) | 1999-05-06 | 2000-05-05 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
KR1020017014077A KR20020031334A (en) | 1999-05-06 | 2000-05-05 | Permeable, Water Soluble, Non-irritating Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids |
EP00928867A EP1233789A2 (en) | 1999-05-06 | 2000-05-05 | Prodrugs of chemotherapeutic agents with oxaalkanoic acids |
AU47037/00A AU4703700A (en) | 1999-05-06 | 2000-05-05 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
JP2000616826A JP2003513884A (en) | 1999-05-06 | 2000-05-05 | Prodrugs of permeable, water-soluble, non-inflammatory chemotherapeutic agents and oxaalkanoic acids |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13280399P | 1999-05-06 | 1999-05-06 | |
US60/132,803 | 1999-05-06 | ||
US09/565,079 | 2000-05-04 | ||
US09/565,079 US6765019B1 (en) | 1999-05-06 | 2000-05-04 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000067801A2 true WO2000067801A2 (en) | 2000-11-16 |
WO2000067801A3 WO2000067801A3 (en) | 2001-08-02 |
Family
ID=26830748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/012322 WO2000067801A2 (en) | 1999-05-06 | 2000-05-05 | Prodrugs of chemotherapeutic agents with oxaalkanoic acids |
Country Status (7)
Country | Link |
---|---|
US (2) | US6765019B1 (en) |
EP (1) | EP1233789A2 (en) |
JP (1) | JP2003513884A (en) |
KR (1) | KR20020031334A (en) |
AU (1) | AU4703700A (en) |
CA (1) | CA2368831A1 (en) |
WO (1) | WO2000067801A2 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
US6403604B1 (en) | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
WO2002085928A2 (en) * | 2001-04-20 | 2002-10-31 | Debiopharm S.A. | Modified cyclosporine which can be used as a pro-drug and use thereof |
WO2003106429A1 (en) * | 2002-06-14 | 2003-12-24 | 武田薬品工業株式会社 | Prodrug and process for producing the same |
US6855720B2 (en) | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
US6933302B2 (en) | 2002-06-03 | 2005-08-23 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
WO2006030217A2 (en) * | 2004-09-15 | 2006-03-23 | Drug Discovery Laboratory As | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
US7033583B2 (en) | 2001-11-09 | 2006-04-25 | Enzon Pharmaceuticals, Inc. | Polymeric thiol-linked prodrugs |
WO2007059118A1 (en) * | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Combretastatin derivatives and related therapeutic methods |
US7262164B2 (en) | 2001-11-09 | 2007-08-28 | Enzon, Inc. | Polymeric thiol-linked prodrugs employing benzyl elimination systems |
US20100227865A1 (en) * | 2007-03-12 | 2010-09-09 | Jennifer Riggs-Sauthier | Oligomer-Beta Blocker Conjugates |
US7875602B2 (en) | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
CN103965208A (en) * | 2013-02-06 | 2014-08-06 | 南京美西宁医药科技有限责任公司 | Lipid-soluble camptothecin anticancer pharmaceutical compound modified by lipophilic alcohol or phenol, and preparation, preparing method and application thereof |
CN106242972A (en) * | 2016-07-29 | 2016-12-21 | 浙江大学 | Combretastatin prodrug, pharmaceutical preparation and preparation method |
US11021430B2 (en) | 2016-04-05 | 2021-06-01 | Moresco Corporation | Oxa acid compound |
EP3723750A4 (en) * | 2017-12-14 | 2021-08-18 | Graybug Vision, Inc. | Drugs and compositions for ocular delivery |
WO2024037644A1 (en) * | 2022-08-19 | 2024-02-22 | 津药生物科技(天津)有限公司 | Peg-modified glucocorticoid medicament and use thereof |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7193065B2 (en) * | 2001-07-13 | 2007-03-20 | Roche Diagnostics Operations, Inc. | Protease inhibitor conjugates and antibodies useful in immunoassay |
AU2008226823B2 (en) | 2007-03-12 | 2014-03-13 | Nektar Therapeutics | Oligomer-protease inhibitor conjugates |
US9095620B2 (en) * | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
EP2624869A4 (en) * | 2010-10-08 | 2015-11-04 | Univ Virginia Commonwealth | Prodrugs utilizing a transporter directed uptake mechanism |
MX2018003462A (en) | 2015-09-22 | 2018-09-06 | Graybug Vision Inc | Compounds and compositions for the treatment of ocular disorders. |
BR112019019452A2 (en) | 2017-03-23 | 2020-04-14 | Graybug Vision Inc | compound, and, use of a compound |
CN111201040A (en) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | Sustained release microparticles and suspensions thereof for medical therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0357495A2 (en) * | 1988-08-26 | 1990-03-07 | Ire-Celltarg S.A. | 3'Azido-3'-deoxythymidine (AZT) derivatives active against the AIDS virus |
WO1996022303A1 (en) * | 1995-01-16 | 1996-07-25 | Commonwealth Scientific And Industrial Research Organisation | Therapeutic compound - fatty acid conjugates |
WO2000077020A1 (en) * | 1999-06-11 | 2000-12-21 | Laboratoires Laphal S.A. | Novel compounds derived from nucleosides, preparation methods and pharmaceutical compositions containing same |
Family Cites Families (35)
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US4053638A (en) * | 1970-05-06 | 1977-10-11 | William Wrigley Jr. Company | Anticaries confectioneries and oral health products |
US4009283A (en) | 1973-11-07 | 1977-02-22 | The Upjohn Company | Antiinflammatory and antithrombotic compositions and method of use |
US4083974A (en) * | 1977-03-07 | 1978-04-11 | The Upjohn Company | Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether |
US4206220A (en) | 1978-07-13 | 1980-06-03 | Interx Research Corporation | Prodrugs for the improved delivery of non-steroidal anti-inflammatory agents |
US4412994A (en) | 1980-04-24 | 1983-11-01 | Interx Research Corporation | Mannich-base hydroxamic acid prodrugs, compositions and use |
CA1148165A (en) | 1981-03-04 | 1983-06-14 | Paolo Ferruti | Esters of arylpropionic acids endowed with an anti- inflammatory activity, process for their preparation, and related pharmaceutical compositions |
US4489080A (en) | 1981-06-26 | 1984-12-18 | The Upjohn Company | Process for analgesic treatment |
US4443476A (en) | 1981-07-20 | 1984-04-17 | The Upjohn Company | Treatment of adult respiratory distress syndrome |
US4477468A (en) | 1982-12-06 | 1984-10-16 | The Upjohn Company | Treatment of type II herpes virus with flurbiprofen |
US4473584A (en) | 1982-12-06 | 1984-09-25 | The Upjohn Company | Treatment of Type I Herpes virus with flurbiprofen |
JPS601122A (en) | 1983-06-20 | 1985-01-07 | Green Cross Corp:The | Fat emulsion of biphenylylpropionic acid derivative |
US4439451A (en) | 1983-06-30 | 1984-03-27 | The Upjohn Company | Treatment of the blood-brain barrier with flurbiprofen |
GB8401965D0 (en) | 1984-01-25 | 1984-02-29 | Beecham Group Plc | Composition |
US4937253A (en) | 1985-04-19 | 1990-06-26 | Smithkline Beecham Corporation | Ester prodrugs |
GB8524421D0 (en) | 1985-10-03 | 1985-11-06 | Boots Co Plc | Therapeutic agents |
US5650510A (en) | 1986-11-18 | 1997-07-22 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives |
US4935508A (en) | 1988-08-23 | 1990-06-19 | Bristol-Myers Company | Process for cephem prodrug esters |
US4897417A (en) | 1988-12-15 | 1990-01-30 | E. I. Du Pont De Nemours & Co. | Prodrugs of 3,4-hydroxy benzoyloxypropanolamines |
CA1321786C (en) | 1989-09-29 | 1993-08-31 | University Of Saskatchewan | Nucleosides with anti-herpes simplex virus activity |
GB8927913D0 (en) | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
DE4004430A1 (en) | 1990-02-09 | 1991-08-14 | Schering Ag | CONSTRUCTED POLYALDEHYDE CONSTITUENTS |
US5681964A (en) | 1990-10-23 | 1997-10-28 | University Of Kentucky Research Foundation | Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents |
US5208221A (en) | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
JPH06509559A (en) | 1991-03-19 | 1994-10-27 | セラピューティック パッチ リサーチ エヌ.ブイ. | Amino alcohol derivative compositions and methods as membrane permeation enhancers |
CA2087452A1 (en) | 1991-05-20 | 1992-11-21 | Toshiro Tsuda | Steriod compound combined with polysaccharide |
GB9314960D0 (en) | 1992-07-23 | 1993-09-01 | Zeneca Ltd | Chemical compounds |
US5614549A (en) | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5491253A (en) | 1993-10-22 | 1996-02-13 | Abbott Laboratories | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane |
MX9703766A (en) | 1994-11-22 | 1997-08-30 | Abbott Lab | Process for preparation of 5-hydroxymethylthiazole. |
ZA962455B (en) * | 1995-03-31 | 1996-10-02 | B Eugene Guthery | Fast acting and persistent topical antiseptic |
US5578637A (en) | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
US5707984A (en) | 1995-12-08 | 1998-01-13 | G. D. Searle & Co. | Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs |
US5847003A (en) * | 1996-06-04 | 1998-12-08 | Avon Products, Inc. | Oxa acids and related compounds for treating skin conditions |
US5842441A (en) * | 1996-08-26 | 1998-12-01 | Pharmalett Denmark A/S | Medicated and individualized treatment shampoo for dermatological disturbances of companion animals |
-
2000
- 2000-05-04 US US09/565,079 patent/US6765019B1/en not_active Expired - Fee Related
- 2000-05-05 AU AU47037/00A patent/AU4703700A/en not_active Abandoned
- 2000-05-05 CA CA002368831A patent/CA2368831A1/en not_active Abandoned
- 2000-05-05 JP JP2000616826A patent/JP2003513884A/en active Pending
- 2000-05-05 KR KR1020017014077A patent/KR20020031334A/en not_active Application Discontinuation
- 2000-05-05 EP EP00928867A patent/EP1233789A2/en not_active Withdrawn
- 2000-05-05 WO PCT/US2000/012322 patent/WO2000067801A2/en not_active Application Discontinuation
-
2004
- 2004-05-24 US US10/851,096 patent/US7214710B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0357495A2 (en) * | 1988-08-26 | 1990-03-07 | Ire-Celltarg S.A. | 3'Azido-3'-deoxythymidine (AZT) derivatives active against the AIDS virus |
WO1996022303A1 (en) * | 1995-01-16 | 1996-07-25 | Commonwealth Scientific And Industrial Research Organisation | Therapeutic compound - fatty acid conjugates |
WO2000077020A1 (en) * | 1999-06-11 | 2000-12-21 | Laboratoires Laphal S.A. | Novel compounds derived from nucleosides, preparation methods and pharmaceutical compositions containing same |
Non-Patent Citations (6)
Title |
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DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; CYNKOWSKA, G. ET AL: "Synthesis and properties of biolabile prodrugs of zidovudine with polyoxa acids and short chain polyethylene glycols." retrieved from STN XP002157082 & ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, (1998) VOL. 215, NO. 1-2, PP. MEDI 36. MEETING INFO.: 215TH AMERICAN CHEMICAL SOCIETY NATIONAL MEETING DALLAS, TEXAS, USA MARCH 29-APRIL 2, 1998 AMERICAN CHEMICAL SOCIETY. , * |
DATABASE CHEMABS [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CYNKOWSKA, G. ET AL: "Structure-stability study of novel anti-HIV prodrugs of zalcitabine with acids, oxa acids and aminooxa acid derivatives" retrieved from STN XP002157079 & BOOK OF ABSTRACTS, 217TH ACS NATIONAL MEETING, ANAHEIM, CALIF., MARCH 21-25 (1999), MEDI-170 PUBLISHER: AMERICAN CHEMICAL SOCIETY, WASHINGTON, D. C. , * |
DATABASE CHEMABS [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CYNKOWSKA, G. ET AL: "Synthesis and properties of biolabile prodrugs of didanosine with polyoxa acids, amino acids and short chain polyethylene glycols." retrieved from STN XP002157084 & BOOK OF ABSTRACTS, 216TH ACS NATIONAL MEETING, BOSTON, AUGUST 23-27 (1998), MEDI-347 PUBLISHER: AMERICAN CHEMICAL SOCIETY, WASHINGTON, D. C. , * |
DATABASE CHEMABS [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CYNKOWSKI, T. ET AL: "Novel prodrug ester forms of hydroxyl-containing drugs. Mono- and dicarboxylic oxa acids conjugates." retrieved from STN XP002157085 & BOOK OF ABSTRACTS, 211TH ACS NATIONAL MEETING, NEW ORLEANS, LA, MARCH 24-28 (1996), MEDI-029 PUBLISHER: AMERICAN CHEMICAL SOCIETY, WASHINGTON, D. C. , * |
DATABASE CHEMABS [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CYNKOWSKI, T. ET AL: "Synthesis and properties of novel codrugs of protease inhibitors with reverse transcriptase inhibitors" retrieved from STN XP002157080 & BOOK OF ABSTRACTS, 217TH ACS NATIONAL MEETING, ANAHEIM, CALIF., MARCH 21-25 (1999), MEDI-171 PUBLISHER: AMERICAN CHEMICAL SOCIETY, WASHINGTON, D. C. , * |
DATABASE CHEMABS [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GREENWALD, RICHARD B. ET AL: "Camptothecin-20-PEG ester transport forms: the effect of spacer groups on antitumor activity" retrieved from STN Database accession no. 129:122786 XP002157081 & BIOORG. MED. CHEM. (1998), 6(5), 551-562 , * |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100879489B1 (en) * | 2001-01-18 | 2009-01-20 | 캘리포니아 퍼시픽 메디컬 센터 | Camptothecin derivatives |
USRE39707E1 (en) | 2001-01-18 | 2007-06-26 | Catholic Healthcare West | Camptothecin derivatives |
US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
US6855720B2 (en) | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
US6403604B1 (en) | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
US6995139B2 (en) * | 2001-04-20 | 2006-02-07 | Debiopharm S.A. | Cyclic undecapeptide pro-drugs and uses thereof |
WO2002085928A3 (en) * | 2001-04-20 | 2003-04-17 | Debiopharm Sa | Modified cyclosporine which can be used as a pro-drug and use thereof |
WO2002085928A2 (en) * | 2001-04-20 | 2002-10-31 | Debiopharm S.A. | Modified cyclosporine which can be used as a pro-drug and use thereof |
US7033583B2 (en) | 2001-11-09 | 2006-04-25 | Enzon Pharmaceuticals, Inc. | Polymeric thiol-linked prodrugs |
US7262164B2 (en) | 2001-11-09 | 2007-08-28 | Enzon, Inc. | Polymeric thiol-linked prodrugs employing benzyl elimination systems |
US6933302B2 (en) | 2002-06-03 | 2005-08-23 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
WO2003106429A1 (en) * | 2002-06-14 | 2003-12-24 | 武田薬品工業株式会社 | Prodrug and process for producing the same |
WO2006030217A2 (en) * | 2004-09-15 | 2006-03-23 | Drug Discovery Laboratory As | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
WO2006030217A3 (en) * | 2004-09-15 | 2007-03-22 | Drug Discovery Lab As | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
US8563537B2 (en) | 2005-10-21 | 2013-10-22 | Sutter West Bay Hospital | Camptothecin derivatives as chemoradiosensitizing agents |
US8779138B2 (en) | 2005-10-21 | 2014-07-15 | Sutter West Bay Hospital | Camptothecin derivatives as chemoradiosensitizing agents |
US7875602B2 (en) | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
WO2007059118A1 (en) * | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Combretastatin derivatives and related therapeutic methods |
US20100227865A1 (en) * | 2007-03-12 | 2010-09-09 | Jennifer Riggs-Sauthier | Oligomer-Beta Blocker Conjugates |
US9782488B2 (en) * | 2007-03-12 | 2017-10-10 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
US10251959B2 (en) | 2007-03-12 | 2019-04-09 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
US10881738B2 (en) | 2007-03-12 | 2021-01-05 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
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US11021430B2 (en) | 2016-04-05 | 2021-06-01 | Moresco Corporation | Oxa acid compound |
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CN106242972B (en) * | 2016-07-29 | 2019-02-26 | 浙江大学 | Combretastatin prodrug, pharmaceutical preparation and preparation method |
EP3723750A4 (en) * | 2017-12-14 | 2021-08-18 | Graybug Vision, Inc. | Drugs and compositions for ocular delivery |
WO2024037644A1 (en) * | 2022-08-19 | 2024-02-22 | 津药生物科技(天津)有限公司 | Peg-modified glucocorticoid medicament and use thereof |
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US20040214784A1 (en) | 2004-10-28 |
US7214710B2 (en) | 2007-05-08 |
EP1233789A2 (en) | 2002-08-28 |
KR20020031334A (en) | 2002-05-01 |
JP2003513884A (en) | 2003-04-15 |
US6765019B1 (en) | 2004-07-20 |
AU4703700A (en) | 2000-11-21 |
WO2000067801A3 (en) | 2001-08-02 |
CA2368831A1 (en) | 2000-11-16 |
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