WO2000052153A3 - Method to identify ligands for orphan receptors - Google Patents

Method to identify ligands for orphan receptors

Info

Publication number
WO2000052153A3
WO2000052153A3 PCT/US2000/005764 US0005764W WO2000052153A3 WO 2000052153 A3 WO2000052153 A3 WO 2000052153A3 US 0005764 W US0005764 W US 0005764W WO 2000052153 A3 WO2000052153 A3 WO 2000052153A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
receptors
ligands
method
orphan receptors
orphan
Prior art date
Application number
PCT/US2000/005764
Other languages
French (fr)
Other versions
WO2000052153A2 (en )
Inventor
Russell J Howard
Phillip A Patten
Original Assignee
Maxygen Inc
Russell J Howard
Phillip A Patten
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries

Abstract

This invention provides methods for obtaining surrogate ligands for orphan receptors, as well as surrogate receptors for orphan ligands. Themethods are also useful for obtaining optimized ligands and/or receptors that exhibit an enhanced ability to modulate a biological activity compared to a naturally occurring cognate receptor or cognate ligand.
PCT/US2000/005764 1999-03-02 2000-03-01 Method to identify ligands for orphan receptors WO2000052153A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12256999 true 1999-03-02 1999-03-02
US60/122,569 1999-03-02

Publications (2)

Publication Number Publication Date
WO2000052153A2 true WO2000052153A2 (en) 2000-09-08
WO2000052153A3 true true WO2000052153A3 (en) 2002-07-25

Family

ID=22403479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005764 WO2000052153A3 (en) 1999-03-02 2000-03-01 Method to identify ligands for orphan receptors

Country Status (1)

Country Link
WO (1) WO2000052153A3 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
JP2003511031A (en) * 1999-10-07 2003-03-25 マキシジェン, インコーポレイテッド IFN-α homologs
US6586190B2 (en) 2000-08-18 2003-07-01 Syngenta Participations Ag Parallel high throughput method and kit
DE10060959A1 (en) * 2000-12-06 2002-06-20 Aventis Res & Tech Gmbh & Co A process for the isolation and identification of effectors
US7314613B2 (en) 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
US7285392B2 (en) 2003-06-30 2007-10-23 Biovitrum Ab Methods for identifying active compounds
EP1753779A2 (en) 2004-05-19 2007-02-21 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
EP1888633A4 (en) 2005-05-18 2010-01-27 Maxygen Inc Evolved interferon-alpha polypeptides
CA2764729A1 (en) 2009-06-26 2010-12-29 Sea Lane Biotechnologies, Llc Expression of surrogate light chains

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018626A1 (en) * 1991-04-17 1992-10-29 Laboratoire Europeen De Biotechnologie WATER-SOLUBLE POLYPEPTIDES HAVING HIGH AFFINITY FOR INTERFERONS α AND $g(b)
WO1995018380A1 (en) * 1993-12-30 1995-07-06 The Salk Institute For Biological Studies Novel uses for gal4-receptor constructs
WO1998034948A1 (en) * 1997-02-06 1998-08-13 Cornell Research Foundation, Inc. Library screening as a strategy to clone drugs for g protein coupled receptors
WO1999023107A1 (en) * 1997-10-31 1999-05-14 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
WO2000009727A2 (en) * 1998-08-12 2000-02-24 Maxygen, Inc. Dna shuffling to produce herbicide selective crops
WO2000031261A2 (en) * 1998-11-25 2000-06-02 Cadus Pharmaceutical Corporation Methods and compositions for identifying effectors of the formyl peptide receptor like-1 (fprl-1) receptor

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018626A1 (en) * 1991-04-17 1992-10-29 Laboratoire Europeen De Biotechnologie WATER-SOLUBLE POLYPEPTIDES HAVING HIGH AFFINITY FOR INTERFERONS α AND $g(b)
WO1995018380A1 (en) * 1993-12-30 1995-07-06 The Salk Institute For Biological Studies Novel uses for gal4-receptor constructs
WO1998034948A1 (en) * 1997-02-06 1998-08-13 Cornell Research Foundation, Inc. Library screening as a strategy to clone drugs for g protein coupled receptors
WO1999023107A1 (en) * 1997-10-31 1999-05-14 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
WO2000009727A2 (en) * 1998-08-12 2000-02-24 Maxygen, Inc. Dna shuffling to produce herbicide selective crops
WO2000031261A2 (en) * 1998-11-25 2000-06-02 Cadus Pharmaceutical Corporation Methods and compositions for identifying effectors of the formyl peptide receptor like-1 (fprl-1) receptor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHANG CHIA-CHUN J ET AL: "Evolution of a cytokine using DNA family shuffling.", NATURE BIOTECHNOLOGY, vol. 17, no. 8, August 1999 (1999-08-01), pages 793 - 797, XP000946490, ISSN: 1087-0156 *
CRAMERI A ET AL: "DNA SHUFFLING OF A FAMILY OF GENES FROM DIVERSE SPECIES ACCELERATESDIRECTED EVOLUTION", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 391, 15 January 1998 (1998-01-15), pages 288 - 291, XP000775869, ISSN: 0028-0836 *
HAMANN J ET AL: "STRUCTURE OF THE HUMAN CD97 GENE: EXON SHUFFLING HAS GENERATED A NEW TYPE OF SEVEN-SPAN TRANSMEMBRANE MOLECULE RELATED TO THE SECRETIN RECEPTOR SUPERFAMILY", GENOMICS,US,ACADEMIC PRESS, SAN DIEGO, vol. 32, no. 1, 15 February 1996 (1996-02-15), pages 144 - 147, XP002061688, ISSN: 0888-7543 *
PATTEN P A ET AL: "APPLICATIONS OF DNA SHUFFLING TO PHARMACEUTICALS AND VACCINES", CURRENT OPINION IN BIOTECHNOLOGY,GB,LONDON, vol. 8, 1997, pages 724 - 733, XP002916609, ISSN: 0958-1669 *
SCARLATTI G ET AL: "IN VIVO EVOLUTION OF HIV-1 CO-RECEPTOR USAGE AND SENSITIVITY TO CHEMOKINE-MEDIATED SUPPRESSION", NATURE MEDICINE,US,NATURE PUBLISHING, CO, vol. 3, no. 11, November 1997 (1997-11-01), pages 1259 - 1265, XP002914269, ISSN: 1078-8956 *
STEMMER W P C: "DIRECTED EVOLUTION OF PROTEINS, PATHWAYS, EPISOMES AND VIRUSES BY DNA SHUFFLING", FASEB JOURNAL,US,FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, vol. 12, 24 April 1998 (1998-04-24), pages A1303, XP000877379, ISSN: 0892-6638 *
STEMMER W: "DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 91, 1 October 1994 (1994-10-01), pages 10747 - 10751, XP002087463, ISSN: 0027-8424 *

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Publication number Publication date Type
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