WO2000044274A2 - Personal physiological monitor - Google Patents
Personal physiological monitor Download PDFInfo
- Publication number
- WO2000044274A2 WO2000044274A2 PCT/US2000/002418 US0002418W WO0044274A2 WO 2000044274 A2 WO2000044274 A2 WO 2000044274A2 US 0002418 W US0002418 W US 0002418W WO 0044274 A2 WO0044274 A2 WO 0044274A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sensors
- data
- raw
- sensor
- processing unit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0531—Measuring skin impedance
- A61B5/0533—Measuring galvanic skin response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02405—Determining heart rate variability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
- A61B5/4035—Evaluating the autonomic nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6825—Hand
- A61B5/6826—Finger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6838—Clamps or clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
Definitions
- TECHNICAL FIELD This invention is related to the subject of the monitoring and assessment of the specific physiological conditions reflecting the functions of the autonomic nervous system (ANS) - heart rate variability, blood volume pulse, galvanic skin reactions (GSR) and peripheral skin temperature (TMP) .
- ANS autonomic nervous system
- GSR galvanic skin reactions
- TMP peripheral skin temperature
- the ANS has two antagonistic branches - the sympathetic and parasympathetic nervous systems. Every organ is activated by one branch and inhibited by the other. Generally when the organism is in a calm state (relaxation, sleep, etc.) several organs, including the heart, lungs and blood vessels, are under the dominance of parasympathetic control. When the organism is activated by physical activity, psycho-emotional arousal or stress, the organs are under dominant control of the sympathetic nervous system. A healthy organism is capable of adjusting to any outer influence by means of a quick and adequate sympathetic response. Once that factor disappears the parasympathetic activity increases balancing the organism's overall autonomic regulation.
- Heart rate variability analysis It is known that the time intervals between each two consecutive heartbeats vary and are under control of the autonomic nervous system. When the parasympathetic system is dominant the heart interbeat intervals (IBI) are oscillating with higher frequencies (0.15 - 0.4 Hz). When sympathetic arousal occurs, lower frequency oscillations take place.
- IBI heart interbeat intervals
- GSR galvanic skin response
- peripheral skin temperature reflects changes in sweat gland activity driven by involuntary arousal of the sympathetic nervous system. These changes are rapid and varied as a reaction of the organism to outer events and slower changes reflecting variations of overall tonus of the sympathetic system.
- the skin temperature reflects a degree of vasoconstriction or dilation of the peripheral blood vessels, which also reflects a long-term process of the interaction of both branches of autonomic nervous systems.
- Another physiological measure - blood volume pulse reflects the level of peripheral blood vessels constriction / dilation. Blood volume pulse is affected by the same autonomic function activity.
- HRV evaluation There is a standard mathematical procedure for short- term HRV evaluation, suggested by the Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) . It provides both time and frequency domain analysis of the IBI time series. There are three important parameters of frequency domain analysis of HRV that reflect the levels of sympathetic and parasympathetic activities and their balance.
- the high frequency range (0.15 Hz- 0.4 Hz) of the IBI power spectrum (HF) reflects parasympathetic influence on heart rate.
- the low frequency range (0.04 Hz -0.15 Hz) of the IBI power spectrum (LF) has a considerable input of the both branches of the autonomic nervous system.
- ECG ECG signal
- the IBI are derived from the ECG as the intervals between consecutive R-peaks .
- This method is very accurate and reliable but has a serious disadvantage - it requires the use of complex ECG equipment with the inconvenience of multiple site electrode placement.
- An alternative is to use a photoplethysmograph (PPG) measurement, which is a portable and convenient optical sensor that can be applied in many places to pick up peripheral blood flow changes (e.g. fingers, ear lobe, etc.).
- the PPG emits an infrared (IR) light on the skin.
- the emitted light is partially consumed by the blood flow.
- the degree of light consumption / reflection is proportional to the changes in blood flow.
- the PPG signal has periodic peaks that represent flow pulsation in blood vessels. It can be used to derive the IBI by measuring the time between two PPG peaks. Blood volume pulse information can be derived as well.
- the personal physiological monitoring method of the present invention includes several possible hardware configurations of the physiological monitoring apparatus. Generally a physiological monitor continuously carries out any of the following functions depending on the particular hardware configuration:
- the present invention may be embodied in either a standalone physiological monitoring device or in a computer-based unit.
- Fig. lb shows the LCD module and wireless IR or RF module of the standalone embodiment transmitting a signal to a remote computer
- Fig. 2a shows a finger sensor unit as held by a user
- Fig. 2b shows detail of the finger sensor pad that may be secured to the finger of a user
- Fig. 3a illustrates the use of a physiological monitoring system having sensors integrated into a typical computer mouse
- Fig. 3b shows details of the mouse of the embodiment of Fig. 3a
- Fig. 4 is a schematic block diagram showing the structural and functional elements of the invention.
- Fig. 5 is a schematic block diagram of the 3 -channel physiological monitor
- Fig. 6 illustrates how PPG sensor electronic circuitry of the present invention operates; and Fig. 7 illustrates the procedure of IBI computation carried out by the micro-controller.
- Figs, la and lb depict a first preferred embodiment 10 of the personal physiological monitoring apparatus of the present invention, particularly illustrating the standalone unit concept. It can be implemented in the form of a glove combined with a flexible wristband.
- the soft glove 11 supports embedded sensors in any combination of PPG 12, GSR 14 and temperature 16, all of which are well known in the art. Collectively, these elements comprise the sensor unit.
- the sensors are wired to a main processing unit 18 embedded in a flexible wristband 20, which also supports an LCD module 22.
- the main processing unit includes a battery unit 24, which powers the main processing unit and which is also connected to the sensors via sensor circuits 17 to provide power to the sensors sufficient to conduct their respective measurements.
- a flash memory module 28 to collect physiological data and a wireless infrared (IR) or radio frequency (RF) module 30 capable of transmitting a signal 32 for downloading of the data to a remote computer 34.
- IR infrared
- RF radio frequency
- Figs. 2a, 2b, 3a, and 3b depict a computer-based unit concept.
- Fig. 2a shows a finger sensor unit 40 in use
- Fig. 2b shows detail of the finger sensor pad 42 that may be placed on a finger and secured, for example, with a strip of hook and loop fastening material (not shown) .
- Fig. 2a there are up to three sensors located on top of the pad: PPG optical sensor window 44, two GSR electrodes 46 and a temperature sensor 48. All physiological signals are sent to the data processing unit 50 that processes the signals and transmits digital information to the computer 52 via serial interface 54.
- Fig. 3a illustrates the use of a mouse-based physiological monitoring system 60 having sensors integrated into a typical computer mouse; and Fig. 3b shows details of the mouse of this embodiment.
- a PPG sensor 62 and/or a temperature sensor 64 can be placed on the lateral side of the mouse 66 where a thumb is normally situated when mouse is in a grip.
- Two GSR electrodes (metal plates or conductive rubber patches) 68 can be placed either on the left and right mouse buttons where two fingers are typically situated or can be placed on the top of the mouse body to maintain contact with the palm surface when mouse is in a grip. All physiological signals are sent to the data processing unit 70 that processes the signals and transmits digital information to the computer 72 via the serial interface 74.
- Fig. 4 is a schematic block diagram showing the structural and functional elements of the invention.
- the device measures any combination of the physiological signals of PPG 80, GSR 82 and temperature 84 by means of the respective sensors that are combined in one device.
- the device has a built-in microprocessor 86 that controls all of the functions and processing of the PPG signal to derive the IBIs.
- the computer-based design finger pad or mouse-integrated device
- all physiological data is transmitted to the computer via serial interface (RS232 port, USB port, wireless infrared (IR) or radio (RF) port) 88.
- serial interface RS232 port, USB port, wireless infrared (IR) or radio (RF) port
- IR infrared
- RF radio
- physiological data is displayed on built-in LCD display 90 and can be stored in the flash memory module 92. Data collected in the flash memory 92 can be downloaded to the computer via the serial port 88.
- the device can be powered from the power supply 94 built into device (standalone or wireless models) or from the computer via USB port. It can also be powered via RS232 port if the model does not include the GSR sensor.
- the specific software could collect physiological data via the specific device driver 96 to perform certain tasks like physiological monitoring, evaluation or training
- Fig. 5 is a schematic block diagram of the 3 -channel physiological monitor 100.
- This particular design describes a mouse-integrated version of the monitor as an example.
- a standalone device is equivalent to this embodiment, excluding the mouse-specific components of X- coordinate control circuitry, Y-coordinate control circuitry, and push buttons control circuitry.
- the photo sensor 102 consists of two 880nm IR emitters 104 and one 880nm IR detector 106. Such a combination provides better movement artifact reduction.
- the micro-controller 108 carries out all the signal process functions of the device. An input signal goes to the internal sample and hold circuit 110 of the micro-controller passing an input amplifier 112 and an analog one-pole high-pass filter 114. This allows for input signal conditioning.
- the sample and hold circuit 110 is connected to the cascade of an output amplifier with built-in band-pass filter 116 and a one- pole low-pass filter 118.
- the output of this cascade is connected to the input multiplexer of the 12 -bit analog- to-digital converter 120.
- the signals from GSR electrodes and temperature sensor (thermoresistor) go to the input multiplexer of A-to-D converter 120 passing a low-pass filter 122.
- the current source 124 provides both GSR and TMP sensor circuits with the necessary power to conduct the measurements.
- the power supply 126 is preferably one of two types: (A) two AAA batteries with switching voltage regulator or (B) one 9-V battery with a linear voltage regulator.
- the apparatus may be modified to run from any of a number of other suitable power sources.
- the micro-controller 108 carries out sensor functioning, interbeat interval computing as well as standard mouse functioning along with X-coordinate 128, Y-coordinate 130 and push button 132 control circuitry. It also provides a serial interface communication with a serial port 134 of a computer 136.
- Fig. 6 demonstrates how the PPG sensor electronic circuitry operates.
- the operation of GSR and TMP is not reflected here because of its extreme simplicity.
- the micro-controller generates square 200uS-long (Tp) impulses 140 with 3.3V amplitude and 2mS periods (Te) pulse 142, sent to the IR emitter.
- the use of switch power mode provides better power consumption and eliminates an excessive sensitivity to the external lights.
- An output signal of the IR detector is a function of the intensity of the signal reflected by the skin surface.
- the output signal of the IR detector is sent to the input of the analog switch of the micro-controller through the input amplifier (current-to-voltage converter with a gain) and the high-pass filter to eliminate a signal offset 144.
- the micro-controller controls an internal analog switch in a "Sample and Hold" mode 146, switching the capacitor Ch between an output of the input amplifier and an input of the output amplifier, so Ch holds constant voltage depending on the input signal 148.
- the output amplifier is an AC amplifier with a built-in band-pass filter and gain of 70 appr. It provides an output signal in the voltage range of the A-to-D converter 150.
- the micro-controller carries out the PPG signal processing and sends data to the PC.
- Fig. 7 illustrates the procedure of IBI computation carried out by the micro-controller.
- the raw PPG signal 160 varies in the range of 0 ... 1000 units. It is filtered by a low-pass digital filter (2.5 Hz cut-off).
- the LP filter gives a filtered signal 162 that looks almost like a sine wave. Then the signal is filtered by a high-pass digital filter (0.5 Hz cut-off).
- the HP filter gives a signal 164 that is oscillating at around zero.
- IBI interbeat intervals
- IBI sequence 166 gets every new value at the moment of next crossing of the zero line.
- the sequence of the interbeat intervals also called periodogram has an irregular nature, in other words, the time intervals between its elements are not constant. This is because of the moments when next PPG peak occurs are not predictable.
- the micro-controller then does a resampling procedure to convert a periodogram into a stabilized sequence of IBI values by means of linear interpolation 168. This allows for the processing of signals to do spectral analysis of IBis to evaluate the various physiological parameters.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU29777/00A AU2977700A (en) | 1999-01-29 | 2000-01-28 | Personal physiological monitor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11796699P | 1999-01-29 | 1999-01-29 | |
US60/117,966 | 1999-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000044274A2 true WO2000044274A2 (en) | 2000-08-03 |
WO2000044274A3 WO2000044274A3 (en) | 2007-06-07 |
Family
ID=22375784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/002418 WO2000044274A2 (en) | 1999-01-29 | 2000-01-28 | Personal physiological monitor |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2977700A (en) |
WO (1) | WO2000044274A2 (en) |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002072196A3 (en) * | 2001-03-08 | 2002-12-19 | Cardiac Pacemakers Inc | Cardiac rhythm management system using time-domain heart rate variability indicia |
US6599250B2 (en) | 2000-03-17 | 2003-07-29 | Medtronic, Inc. | Heart failure monitor quicklook summary for patient management systems |
GB2389899A (en) * | 2002-05-27 | 2003-12-24 | Tatung Co Ltd | Circuit built in a computer peripheral for physiological signal processing |
US6748272B2 (en) | 2001-03-08 | 2004-06-08 | Cardiac Pacemakers, Inc. | Atrial interval based heart rate variability diagnostic for cardiac rhythm management system |
NL1020773C2 (en) * | 2002-04-26 | 2004-06-29 | Tatung Co | Mouse which is capable of detecting a physiological signal and environmental luminescence. |
WO2004093676A1 (en) * | 2003-04-23 | 2004-11-04 | Almen Adam J | Apparatus and method for monitoring heart rate variability |
US7062314B2 (en) | 1999-10-01 | 2006-06-13 | Cardiac Pacemakers, Inc. | Cardiac rhythm management device with triggered diagnostic mode |
US7260431B2 (en) | 2004-05-20 | 2007-08-21 | Cardiac Pacemakers, Inc. | Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device |
US7272442B2 (en) | 2002-12-30 | 2007-09-18 | Cardiac Pacemakers, Inc. | Automatically configurable minute ventilation sensor |
US7428436B2 (en) | 2000-11-02 | 2008-09-23 | Cardiac Pacemakers, Inc. | Method for exclusion of ectopic events from heart rate variability metrics |
US7460899B2 (en) | 2003-04-23 | 2008-12-02 | Quiescent, Inc. | Apparatus and method for monitoring heart rate variability |
EP1977688A3 (en) * | 2007-04-04 | 2008-12-17 | LG Electronics Inc. | Blood pressure monitoring apparatus and method |
US7580745B2 (en) | 2005-01-18 | 2009-08-25 | Cardiac Pacemakers, Inc. | Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy |
US7672725B2 (en) | 2005-01-18 | 2010-03-02 | Cardiac Pacemakers, Inc. | Method and apparatus for using heart rate variability as a safety check in electrical therapies |
US7672724B2 (en) | 2005-01-18 | 2010-03-02 | Cardiac Pacemakers, Inc. | Method and apparatus for optimizing electrical stimulation parameters using heart rate variability |
CN102283656A (en) * | 2011-05-23 | 2011-12-21 | 中国人民解放军空军航空医学研究所 | Integrated PPG (photoplethysmography) and GSR (galvanicskin response) signal sensor structure |
US8634591B2 (en) | 2009-08-20 | 2014-01-21 | Koninklijke Philips N.V. | Method and system for image analysis |
US8805019B2 (en) | 2009-03-06 | 2014-08-12 | Koninklijke Philips N.V. | Processing images of at least one living being |
US8818041B2 (en) | 2009-03-06 | 2014-08-26 | Koninklijke Philips N.V. | Method of controlling a function of a device and system for detecting the presence of a living being |
US8880171B2 (en) | 2003-07-02 | 2014-11-04 | Cardiac Pacemakers, Inc. | Cardiac cycle synchronized sampling of impedance signal |
US9025826B2 (en) | 2009-10-06 | 2015-05-05 | Koninklijkle Philips N.V. | Formation of a time-varying signal representative of at least variations in a value based on pixel values |
ITUB20159145A1 (en) * | 2015-12-23 | 2017-06-23 | Playaround S R L | BIOIMPEDENCE MEASUREMENT DEVICE |
US10271746B2 (en) | 2009-10-06 | 2019-04-30 | Koninklijke Philips N.V. | Method and system for carrying out photoplethysmography |
US10349844B2 (en) | 2012-01-16 | 2019-07-16 | Valencell, Inc. | Reduction of physiological metric error due to inertial cadence |
US10390762B2 (en) | 2012-01-16 | 2019-08-27 | Valencell, Inc. | Physiological metric estimation rise and fall limiting |
US10869602B2 (en) | 2002-03-25 | 2020-12-22 | Masimo Corporation | Physiological measurement communications adapter |
US11087875B2 (en) | 2009-03-04 | 2021-08-10 | Masimo Corporation | Medical monitoring system |
US11133105B2 (en) | 2009-03-04 | 2021-09-28 | Masimo Corporation | Medical monitoring system |
RU2756426C2 (en) * | 2015-11-19 | 2021-09-30 | @Хелт | Method and system for obtaining and analyzing physiological data |
US11145408B2 (en) | 2009-03-04 | 2021-10-12 | Masimo Corporation | Medical communication protocol translator |
USRE49007E1 (en) | 2010-03-01 | 2022-04-05 | Masimo Corporation | Adaptive alarm system |
CN116746900A (en) * | 2022-10-19 | 2023-09-15 | 荣耀终端有限公司 | Arrhythmia identification method and wearable device |
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- 2000-01-28 AU AU29777/00A patent/AU2977700A/en not_active Abandoned
Patent Citations (3)
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US5544661A (en) * | 1994-01-13 | 1996-08-13 | Charles L. Davis | Real time ambulatory patient monitor |
US5577510A (en) * | 1995-08-18 | 1996-11-26 | Chittum; William R. | Portable and programmable biofeedback system with switching circuit for voice-message recording and playback |
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Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7062314B2 (en) | 1999-10-01 | 2006-06-13 | Cardiac Pacemakers, Inc. | Cardiac rhythm management device with triggered diagnostic mode |
US6599250B2 (en) | 2000-03-17 | 2003-07-29 | Medtronic, Inc. | Heart failure monitor quicklook summary for patient management systems |
US7428436B2 (en) | 2000-11-02 | 2008-09-23 | Cardiac Pacemakers, Inc. | Method for exclusion of ectopic events from heart rate variability metrics |
US8280510B2 (en) | 2000-11-02 | 2012-10-02 | Cardiac Pacemakers, Inc. | Method for exclusion of ectopic events from heart rate variability metrics |
US7970467B2 (en) | 2000-11-02 | 2011-06-28 | Cardiac Pacemakers, Inc. | Method for exclusion of ectopic events from heart rate variability metrics |
US6678547B2 (en) | 2001-03-08 | 2004-01-13 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system using time-domain heart rate variability indicia |
US6748272B2 (en) | 2001-03-08 | 2004-06-08 | Cardiac Pacemakers, Inc. | Atrial interval based heart rate variability diagnostic for cardiac rhythm management system |
US7248919B2 (en) | 2001-03-08 | 2007-07-24 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system using time-domain heart rate variability indicia |
WO2002072196A3 (en) * | 2001-03-08 | 2002-12-19 | Cardiac Pacemakers Inc | Cardiac rhythm management system using time-domain heart rate variability indicia |
US11484205B2 (en) | 2002-03-25 | 2022-11-01 | Masimo Corporation | Physiological measurement device |
US10869602B2 (en) | 2002-03-25 | 2020-12-22 | Masimo Corporation | Physiological measurement communications adapter |
NL1020773C2 (en) * | 2002-04-26 | 2004-06-29 | Tatung Co | Mouse which is capable of detecting a physiological signal and environmental luminescence. |
NL1022305C2 (en) * | 2002-05-27 | 2005-12-20 | Tatung Co | Device with a circuit built into a peripheral device for a computer for detecting a physiological signal. |
GB2389899B (en) * | 2002-05-27 | 2005-11-23 | Tatung Co Ltd | Circuit apparatus built in a computer peripheral device for detecting physiological signal |
GB2389899A (en) * | 2002-05-27 | 2003-12-24 | Tatung Co Ltd | Circuit built in a computer peripheral for physiological signal processing |
US7272442B2 (en) | 2002-12-30 | 2007-09-18 | Cardiac Pacemakers, Inc. | Automatically configurable minute ventilation sensor |
WO2004093676A1 (en) * | 2003-04-23 | 2004-11-04 | Almen Adam J | Apparatus and method for monitoring heart rate variability |
US7460899B2 (en) | 2003-04-23 | 2008-12-02 | Quiescent, Inc. | Apparatus and method for monitoring heart rate variability |
US8880171B2 (en) | 2003-07-02 | 2014-11-04 | Cardiac Pacemakers, Inc. | Cardiac cycle synchronized sampling of impedance signal |
US7805193B2 (en) | 2004-05-20 | 2010-09-28 | Cardiac Pacemakers, Inc. | Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device |
US7260431B2 (en) | 2004-05-20 | 2007-08-21 | Cardiac Pacemakers, Inc. | Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device |
US8838239B2 (en) | 2004-05-20 | 2014-09-16 | Cardiac Pacemakers, Inc. | Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device |
US7672725B2 (en) | 2005-01-18 | 2010-03-02 | Cardiac Pacemakers, Inc. | Method and apparatus for using heart rate variability as a safety check in electrical therapies |
US7672724B2 (en) | 2005-01-18 | 2010-03-02 | Cardiac Pacemakers, Inc. | Method and apparatus for optimizing electrical stimulation parameters using heart rate variability |
US7580745B2 (en) | 2005-01-18 | 2009-08-25 | Cardiac Pacemakers, Inc. | Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy |
US8831724B2 (en) | 2005-01-18 | 2014-09-09 | Cardiac Pacemakers, Inc. | Method and apparatus for using heart rate variability as a safety check in electrical therapies |
US8805503B2 (en) | 2005-01-18 | 2014-08-12 | Cardiac Pacemakers, Inc. | Method and apparatus for optimizing electrical stimulation parameters using heart rate variability |
US8206309B2 (en) | 2007-04-04 | 2012-06-26 | Lg Electronics Inc. | Blood pressure monitoring apparatus and method |
EP1977688A3 (en) * | 2007-04-04 | 2008-12-17 | LG Electronics Inc. | Blood pressure monitoring apparatus and method |
US11133105B2 (en) | 2009-03-04 | 2021-09-28 | Masimo Corporation | Medical monitoring system |
US11158421B2 (en) | 2009-03-04 | 2021-10-26 | Masimo Corporation | Physiological parameter alarm delay |
US11145408B2 (en) | 2009-03-04 | 2021-10-12 | Masimo Corporation | Medical communication protocol translator |
US11087875B2 (en) | 2009-03-04 | 2021-08-10 | Masimo Corporation | Medical monitoring system |
US8805019B2 (en) | 2009-03-06 | 2014-08-12 | Koninklijke Philips N.V. | Processing images of at least one living being |
US8818041B2 (en) | 2009-03-06 | 2014-08-26 | Koninklijke Philips N.V. | Method of controlling a function of a device and system for detecting the presence of a living being |
US8634591B2 (en) | 2009-08-20 | 2014-01-21 | Koninklijke Philips N.V. | Method and system for image analysis |
US9025826B2 (en) | 2009-10-06 | 2015-05-05 | Koninklijkle Philips N.V. | Formation of a time-varying signal representative of at least variations in a value based on pixel values |
US10271746B2 (en) | 2009-10-06 | 2019-04-30 | Koninklijke Philips N.V. | Method and system for carrying out photoplethysmography |
USRE49007E1 (en) | 2010-03-01 | 2022-04-05 | Masimo Corporation | Adaptive alarm system |
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AU2977700A (en) | 2000-08-18 |
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