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WO2000042994A3 - Inhibition of bacterial dissemination - Google Patents

Inhibition of bacterial dissemination Download PDF

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Publication number
WO2000042994A3
WO2000042994A3 PCT/US2000/001340 US0001340W WO0042994A3 WO 2000042994 A3 WO2000042994 A3 WO 2000042994A3 US 0001340 W US0001340 W US 0001340W WO 0042994 A3 WO0042994 A3 WO 0042994A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial dissemination
inhibition
peritoneal cavity
dissemination
bacterial
Prior art date
Application number
PCT/US2000/001340
Other languages
French (fr)
Other versions
WO2000042994A2 (en
Inventor
Sanna M Goyert
Alain Haizot
Jack Silver
Original Assignee
Sanna M Goyert
Alain Haizot
Long Island Jewish Res Inst
Jack Silver
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US11667199P priority Critical
Priority to US60/116,671 priority
Application filed by Sanna M Goyert, Alain Haizot, Long Island Jewish Res Inst, Jack Silver filed Critical Sanna M Goyert
Publication of WO2000042994A2 publication Critical patent/WO2000042994A2/en
Publication of WO2000042994A3 publication Critical patent/WO2000042994A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024Esters of saccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Abstract

Bacterial dissemination is inhibited by administering a substance which accelerates recruitment of neutrophils to the peritoneal cavity and thereby inhibits bacterial dissemination from the peritoneal cavity lipids are of particular interest. Substances are preferably screened in normal and/or CDN deficient mice.
PCT/US2000/001340 1999-01-21 2000-01-21 Inhibition of bacterial dissemination WO2000042994A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11667199P true 1999-01-21 1999-01-21
US60/116,671 1999-01-21

Publications (2)

Publication Number Publication Date
WO2000042994A2 WO2000042994A2 (en) 2000-07-27
WO2000042994A3 true WO2000042994A3 (en) 2003-08-28

Family

ID=22368549

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001340 WO2000042994A2 (en) 1999-01-21 2000-01-21 Inhibition of bacterial dissemination

Country Status (1)

Country Link
WO (1) WO2000042994A2 (en)

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* Cited by examiner, † Cited by third party
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HUE037808T2 (en) 2006-09-26 2018-09-28 Infectious Disease Res Institute Vaccine composition containing synthetic adjuvant
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
EP3124491A1 (en) 2009-06-05 2017-02-01 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them
EA027236B1 (en) 2011-04-08 2017-07-31 Иммьюн Дизайн Корп. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
LT2850431T (en) 2012-05-16 2018-06-25 Immune Design Corp. Vaccines for hsv-2
CN105209047A (en) 2013-04-18 2015-12-30 免疫设计股份有限公司 GLA monotherapy for use in cancer treatment
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
WO2018056150A1 (en) * 2016-09-23 2018-03-29 ティーエフケイ株式会社 Compound or salt thereof, anti-inflammatory agent, anticancer agent for lung cancer, method for producing compound or salt thereof, method for treating inflammatory disease, and method for treating lung cancer

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WO1995003067A1 (en) * 1993-07-21 1995-02-02 Khavinson Vladimir Khatskelevi Pharmaceutical with immunomodulating activity
WO1996008272A1 (en) * 1994-09-16 1996-03-21 The Scripps Research Institute Use of antibodies to block the effects of gram-positive bacteria and mycobacteria
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Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005555A1 (en) * 1984-05-30 1985-12-19 Baxter Travenol Laboratories, Inc. Dialysis with monophosphoryl lipid a
JPS6168497A (en) * 1984-09-11 1986-04-08 Terumo Corp Sugaralcohol ester derivative and neutrophils activator containing same
GB2220211A (en) * 1988-06-29 1990-01-04 Ribi Immunochem Research Inc Modified lipopolysaccharides
US5234912A (en) * 1989-02-14 1993-08-10 Incyte Pharmaceuticals, Inc. Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof
EP0536969A2 (en) * 1991-10-11 1993-04-14 Eisai Co., Ltd. Anti-endotoxin compounds
WO1993019087A1 (en) * 1992-03-19 1993-09-30 Emory University School Of Medicine Chemotactic, antibiotic and lipopolysaccharide-binding peptide fragments of cap37
US5622939A (en) * 1992-08-21 1997-04-22 Alpha-Beta Technology, Inc. Glucan preparation
WO1994021280A1 (en) * 1993-03-22 1994-09-29 Incyte Pharmaceuticals, Inc. Use of bactericidal/permeability increasing protein and lipopolysaccharide binding protein levels and ratios thereof in diagnosis
WO1995003067A1 (en) * 1993-07-21 1995-02-02 Khavinson Vladimir Khatskelevi Pharmaceutical with immunomodulating activity
WO1996008272A1 (en) * 1994-09-16 1996-03-21 The Scripps Research Institute Use of antibodies to block the effects of gram-positive bacteria and mycobacteria
WO1997000081A1 (en) * 1995-06-19 1997-01-03 Goyert Sanna M A method for inhibiting bacteremia and bacterial dissemination
WO2000018411A1 (en) * 1998-09-25 2000-04-06 The Collaborative Group, Ltd. VERY HIGH MOLECULAR WEIGHT β-GLUCANS

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