WO2000033080A3 - New assay - Google Patents

New assay Download PDF

Info

Publication number
WO2000033080A3
WO2000033080A3 PCT/SE1999/002252 SE9902252W WO0033080A3 WO 2000033080 A3 WO2000033080 A3 WO 2000033080A3 SE 9902252 W SE9902252 W SE 9902252W WO 0033080 A3 WO0033080 A3 WO 0033080A3
Authority
WO
WIPO (PCT)
Prior art keywords
new assay
assay
new
p2yadp
detecting
Prior art date
Application number
PCT/SE1999/002252
Other languages
French (fr)
Other versions
WO2000033080A2 (en
Inventor
Ian Kirk
Original Assignee
Astrazeneca Ab
Ian Kirk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Ian Kirk filed Critical Astrazeneca Ab
Priority to AU20161/00A priority Critical patent/AU2016100A/en
Priority to JP2000585665A priority patent/JP2002531831A/en
Priority to US09/462,294 priority patent/US6455322B1/en
Priority to EP99963792A priority patent/EP1135683A2/en
Publication of WO2000033080A2 publication Critical patent/WO2000033080A2/en
Publication of WO2000033080A3 publication Critical patent/WO2000033080A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Abstract

The invention provides a competition binding assay for detecting P2YADP receptor ligands.
PCT/SE1999/002252 1998-12-02 1999-12-01 New assay WO2000033080A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU20161/00A AU2016100A (en) 1998-12-02 1999-12-01 New assay
JP2000585665A JP2002531831A (en) 1998-12-02 1999-12-01 New assay method
US09/462,294 US6455322B1 (en) 1998-12-02 1999-12-01 Competition binding assay for detecting P2YADP receptor ligands
EP99963792A EP1135683A2 (en) 1998-12-02 1999-12-01 New assay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9804175-9 1998-12-02
SE9804175A SE9804175D0 (en) 1998-12-02 1998-12-02 New assay

Publications (2)

Publication Number Publication Date
WO2000033080A2 WO2000033080A2 (en) 2000-06-08
WO2000033080A3 true WO2000033080A3 (en) 2000-08-10

Family

ID=20413527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1999/002252 WO2000033080A2 (en) 1998-12-02 1999-12-01 New assay

Country Status (6)

Country Link
US (1) US6455322B1 (en)
EP (1) EP1135683A2 (en)
JP (1) JP2002531831A (en)
AU (1) AU2016100A (en)
SE (1) SE9804175D0 (en)
WO (1) WO2000033080A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7115585B2 (en) 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
US7335648B2 (en) 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
WO2005040174A1 (en) * 2003-10-21 2005-05-06 Inspire Pharmaceuticals, Inc. Tetrahydro-furo`3,4-d!dioxole compounds and compositions and method for inhibiting platelet aggregation
US7749981B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
JP2010508350A (en) 2006-10-31 2010-03-18 ヤンセン ファーマシューティカ エヌ．ベー． Triazolopyrimidine derivatives as ADPP2Y12 receptor antagonists
US8140768B2 (en) * 2008-02-01 2012-03-20 International Business Machines Corporation Jump starting prefetch streams across page boundaries
US20110236907A1 (en) * 2008-06-17 2011-09-29 Wei Chen Radiolabled cyclopamine assay for the smoothened receptor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
WO1997019170A1 (en) * 1995-11-21 1997-05-29 Euroscreen S.A. Receptor and nucleic acid molecule encoding said receptor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5441883A (en) * 1992-03-03 1995-08-15 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A3 adenosine receptor, DNA, and uses
US5942416A (en) * 1997-03-19 1999-08-24 Smithkline Beecham Corporation CDNA clone HNFDY20 that encodes a human 7-transmembrane receptor
US5981223A (en) * 1998-01-20 1999-11-09 Smithkline Beecham Corporation HDPXU17 encodes a novel 7-transmembrane receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents
WO1997019170A1 (en) * 1995-11-21 1997-05-29 Euroscreen S.A. Receptor and nucleic acid molecule encoding said receptor

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ARCH. BIOCHEM. BIOPHYS., vol. 343, no. 1, 1997, pages 140 - 145 *
BIOCHEM J., vol. 336, no. PT.3, 15 December 1998 (1998-12-15), pages 513 - 523 *
BLOOD, vol. 92, no. 1, 1 July 1998 (1998-07-01), pages 152 - 159 *
CHEMICAL ABSTRACTS, vol. 127, no. 10, 1997, Columbus, Ohio, US; abstract no. 133782U, PURI, RAJINDER N. ET. AL.: "Modulation of platelet responses by 2-(3-(Bromo-2-oxopropylthio)adenosine-5'-diphosphate involves its binding to as well as covalent modification of an ADP-aggregin" XP002947831 *
CHEMICAL ABSTRACTS, vol. 128, no. 17, 1998, Columbus, Ohio, US; abstract no. 203373H, JIN, JIANGUO ET. AL.: "Molecular basis for ADP-induced platelet activation, II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets" XP002947830 *
DATABASE DIALOG INF. SERVICES FILE MEDLINE; HECHLER B. ET. AL.: "The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation", XP002947818 *
DATABASE DIALOG INF. SERVICES FILE MEDLINE; KUNAPULI SP. ET. AL.: "P2 receptor subtypes in the cardiovascular system", XP002947819 *
J. BIOL. CHEM., vol. 273, no. 4, 1998, pages 2030 - 2034 *

Also Published As

Publication number Publication date
EP1135683A2 (en) 2001-09-26
SE9804175D0 (en) 1998-12-02
JP2002531831A (en) 2002-09-24
AU2016100A (en) 2000-06-19
US6455322B1 (en) 2002-09-24
WO2000033080A2 (en) 2000-06-08

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