WO2000032554A1 - Process for the resolution of tramadol - Google Patents
Process for the resolution of tramadol Download PDFInfo
- Publication number
- WO2000032554A1 WO2000032554A1 PCT/GB1999/003843 GB9903843W WO0032554A1 WO 2000032554 A1 WO2000032554 A1 WO 2000032554A1 GB 9903843 W GB9903843 W GB 9903843W WO 0032554 A1 WO0032554 A1 WO 0032554A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tramadol
- single enantiomer
- substantially single
- salt
- resolution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Definitions
- the present invention relates to a process for the manufacture of single enantiomers of tramadol.
- Tramadol (cis-2-dimethylaminomethyl-l- (3-methoxy- phenyl)-l-cyclohexanol) is a chiral drug substance which is used as a high-potency analgesic agent.
- tramadol is currently marketed as the racemate only, there has been considerable interest in the physiological properties associated with its individual enantiomers, namely 1S, 2S- (-) -tramadol and lR, 2R- (+) -tramadol, the latter shown below as (1) .
- lead references to literature on this topic are highlighted in WO-A-9840053. It is possible that further investigations in this field will lead to a better understanding of the pharmacology of tramadol enantiomers, which could in turn allow for improved pharmaceutical compositions to be identified.
- This invention is based on the discovery that racemic tramadol can be resolved efficiently using the substantially single enantiomers of 0, 0-di-p- toluoyltartaric acid (DTTA) as a revolving agent.
- This resolving agent may also be used to increase the optical purity of enantio erically-enriched tramadol, i.e. tramadol which is already enriched in one of its two enantiomers.
- the process of this invention may be carried out under conditions that are generally known to those skilled in the art of classical resolution methods.
- the resolution process is extremely simple.
- dissolution of tramadol free base and 0, -di-p-toluoyl-I/- tartaric acid (1 molar equivalent) by warming in ethanol, followed by cooling gave crystallisation in 47% yield (based on racemic tramadol) of a diastereomeric salt enriched in (-) -tramadol, with a de of 97%, corresponding to 97% ee tramadol.
- This salt was reslurried in ethanol, and then filtered, washed and dried, which resulted in an enhanced de of 99.5%.
- the present process allows diastereo ericallly pure salts to be isolated in high yield after a single cystallisation from solution. It is surprising that what may be regarded as a small structural difference between O,0-dibenzoyltartaric acid and O,0-di-p-toluoyltartaric acid, i.e. aromatic hydrogen atoms, remote at positions from the chiral centres, replaced by methyl groups, results in such a dramatic improvement in the efficiency of the resolution process.
- Any suitable solvent may be used to effect the process of the present invention.
- Preferred solvents are C ⁇ _ 4 alkanols, of which ethanol is especially preferred.
- both enantiomers of the resolving agent are readily available in quantity, either can be used to effect resolution, depending on the which enantiomer of tramadol is required.
- O,0-di-p-toluoyl-l/-tartaric acid gives initial crystallisation of a diastereomeric salt enriched in (-) -tramadol, whereas with 0,0-di-p-toluoyl-D- tartaric acid a diastereomeric salt enriched in (+)- tramadol is obtained.
- the O,0-di-p-toluoyltartaric acid resolving agent can be easily recovered in a state of high purity, such that it can be re-used in one or more subsequent resolution processes.
- 1 molar equivalent of the 0,0-di-p- toluoyltartaric acid is used relative to racemic tramadol free base.
- less than 1 molar equivalent may be used, e.g. as little as 0.50 molar equivalent, preferably around 0.5-0.6 molar equivalents, such that the yield of diastereomeric salt obtained on initial crystallisation is comparable to that achieved with 1 equivalent of resolving agent, leaving an excess of tramadol free base in solution.
- Isolated diastereomeric salts obtained by either method have a 1:1 stoichiometry of resolving agent:tramadol.
- a substantially single enantiomer typically we mean that one of the enantiomers is present in an excess of at least 70%, preferably at least 90%, and more preferably at least 95%, with respect to its opposite enantiomer, including an optically-pure enantiomer.
- the present invention is further illustrated by the following examples. Examples
- Example 1 Resolution of (+/-) -Tramadol with Di-p-toluo ⁇ l- -tartaric acid in ethanol.
- 57 g of racemic Tramadol hydrochloride (0.190 mol) was taken up in 110 mis of distilled water.
- To this yellow coloured solution is added 120 ml of dichloromethane, and the reaction mixture stirred at 10°C in a jacketed vessel.
- a solution of 36% sodium hydroxide 22 ml is added dropwise to the tramadol hydrochloride. After 10 minutes stirring the layers are allowed to separate, and the bottom organic layer removed. The basic aqueous layer is re-extracted with 35 ml of dichloromethane and combined with the first organic layer.
- (+)-Tramadol-containing salt from Example 1 was cracked using 2.1 equivalents of sodium hydroxide as follows.
- the (+) -Tramadol. (£)-(-) -DTTA salt 131 g (0.202 mol) in 1 volume of ethanol was taken up in 150 ml of dichloromethane and placed in a jacketed vessel at 10°C.
- TBME tert-butyl ethylether
- the white solid was collected by filtration to give 58.3 g (75.4%) of (L) -(-) -DTTA which compared to an authentic sample.
- 77.3 g of Di-p-toluoyl- -tartaric acid ((£»)-(+) -DTTA) was taken up in 550 ml of ethanol at 70°C in a jacketed vessel.
- To this solution was added the Tramadol free base in 200 ml of ethanol. A precipitate formed almost immediately.
- the vessel was gradually cooled to 25°C over several hours to give a fine white solid. Stirring at 25°C was maintained overnight.
- the resulting copious white solid was collected at the pump, washing with 500 ml of ethanol.
- Example 5 (+) -Tramadol Hydrochloride preparation from (+) -Tramadol. Di-p-toluyl-D-Tartaric acid salt.
- Example 6 (-) -Tramadol Hydrochloride preparation from (-) -Tramadol.Di-p-toluoyl- -tartaric acid salt.
- (+/-) -Tramadol hydrochloride 60 g were suspended in 96 ml of water and treated with 32 g of crushed ice. To this suspension was added 26 ml of 36% sodium hydroxide solution. The mixture was then extracted with dichloromethane 140 ml, followed by re-extraction with a further 40 ml of dichloromethane. The organic layers were combined and dried over magnesium sulphate. The solvent was then removed under vacuum to give the (+/-)- Tramadol free base quantitatively as a yellow oil.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fertilizers (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT99973014T ATE253037T1 (en) | 1998-12-02 | 1999-11-18 | METHOD FOR THE RACEMAT CLEAVING OF TRAMADOL |
DE69912474T DE69912474D1 (en) | 1998-12-02 | 1999-11-18 | PROCESS FOR RACEMATING OF TRAMADOL |
KR1020017006815A KR20010112223A (en) | 1998-12-02 | 1999-11-18 | Process for the Resolution of Tramadol |
AU11708/00A AU747431B2 (en) | 1998-12-02 | 1999-11-18 | Process for the resolution of tramadol |
BR9915868-0A BR9915868A (en) | 1998-12-02 | 1999-11-18 | Process for the decomposition of tramadol |
JP2000585196A JP2002531429A (en) | 1998-12-02 | 1999-11-18 | Methods for Tramadol Splitting |
CA002353549A CA2353549A1 (en) | 1998-12-02 | 1999-11-18 | Process for the resolution of tramadol |
EP99973014A EP1135357B1 (en) | 1998-12-02 | 1999-11-18 | Process for the resolution of tramadol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9826540.8A GB9826540D0 (en) | 1998-12-02 | 1998-12-02 | Process |
GB9826540.8 | 1998-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000032554A1 true WO2000032554A1 (en) | 2000-06-08 |
Family
ID=10843543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1999/003843 WO2000032554A1 (en) | 1998-12-02 | 1999-11-18 | Process for the resolution of tramadol |
Country Status (12)
Country | Link |
---|---|
US (1) | US6323368B1 (en) |
EP (1) | EP1135357B1 (en) |
JP (1) | JP2002531429A (en) |
KR (1) | KR20010112223A (en) |
CN (1) | CN1329587A (en) |
AT (1) | ATE253037T1 (en) |
AU (1) | AU747431B2 (en) |
BR (1) | BR9915868A (en) |
CA (1) | CA2353549A1 (en) |
DE (1) | DE69912474D1 (en) |
GB (1) | GB9826540D0 (en) |
WO (1) | WO2000032554A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001083422A1 (en) * | 2000-04-28 | 2001-11-08 | Darwin Discovery Limited | Process for the separation of the cis trans diastereoisomers of tramadol |
US6780891B2 (en) | 2001-11-30 | 2004-08-24 | Sepracor Inc. | Tramadol analogs and uses thereof |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4357848B2 (en) | 2003-02-12 | 2009-11-04 | 株式会社リコー | SQUARYLIUM METAL CHEL COMPOUND AND OPTICAL RECORDING MEDIUM |
JP2007509856A (en) * | 2003-10-27 | 2007-04-19 | スミスクライン ビーチャム コーポレーション | Enzyme-catalyzed dynamic kinetic resolution method for preparing (+)-(2S, 3S) -2- (3-chlorophenyl) -3,5,5-trimethyl-2-morpholinol, its salts and solvates |
GB0325051D0 (en) * | 2003-10-27 | 2003-12-03 | Smithkline Beecham Corp | New process |
WO2006006071A1 (en) * | 2004-07-07 | 2006-01-19 | Pfizer Products Inc. | Resolution of an aryl-fused azapolycyclic compound |
RU2440993C2 (en) * | 2004-10-07 | 2012-01-27 | Вайти Фармасьютикл, Инк. | Aspartic protease diaminoalkane inhibitors |
EP1785412A1 (en) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
TWI411607B (en) * | 2005-11-14 | 2013-10-11 | Vitae Pharmaceuticals Inc | Aspartic protease inhibitors |
CL2007002689A1 (en) * | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | COMPOUNDS DERIVED FROM PIPERIDIN-1-CARBOXAMIDA, INHIBITORS OF THE RENINE; INTERMEDIARY COMPOUNDS; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DISEASES SUCH AS HYPERTENSION, CARDIAC INSUFFICIENCY, CARDIAC FIBROSIS, AMONG OTHERS. |
WO2008036216A1 (en) * | 2006-09-18 | 2008-03-27 | Vitae Pharmaceuticals, Inc. | Piperidine derivatives as renin inhibitors |
EP2167609A1 (en) * | 2007-06-20 | 2010-03-31 | Vitae Pharmaceuticals, Inc. | Renin inhibitors |
CN101434552B (en) * | 2007-11-16 | 2012-05-23 | 江苏恒瑞医药股份有限公司 | Method for splitting 4,5- dimethoxy-1-(methyl amino methyl)-benzocyclobutane |
AR077692A1 (en) * | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | SALTS OF 2 - ((R) - (3-CHLOROPHENYL) ((R) -1 - ((S) -2- (METHYLAMINE) -3 - ((R) -TETRAHYDRO-2H-PIRAN-3-IL) PROPILCARBAMOIL ) PIPERIDIN -3-IL) METOXI) METHYL ETILCARBAMATE |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3830934A (en) | 1967-07-27 | 1974-08-20 | Gruenenthal Chemie | Analgesic and antitussive compositions and methods |
DE19601745C1 (en) | 1996-01-19 | 1997-10-09 | Gruenenthal Gmbh | Process for racemate resolution of tramadol |
-
1998
- 1998-12-02 GB GBGB9826540.8A patent/GB9826540D0/en not_active Ceased
-
1999
- 1999-11-18 BR BR9915868-0A patent/BR9915868A/en not_active IP Right Cessation
- 1999-11-18 EP EP99973014A patent/EP1135357B1/en not_active Expired - Lifetime
- 1999-11-18 CN CN99813993A patent/CN1329587A/en active Pending
- 1999-11-18 AT AT99973014T patent/ATE253037T1/en not_active IP Right Cessation
- 1999-11-18 AU AU11708/00A patent/AU747431B2/en not_active Ceased
- 1999-11-18 JP JP2000585196A patent/JP2002531429A/en active Pending
- 1999-11-18 DE DE69912474T patent/DE69912474D1/en not_active Expired - Lifetime
- 1999-11-18 WO PCT/GB1999/003843 patent/WO2000032554A1/en not_active Application Discontinuation
- 1999-11-18 CA CA002353549A patent/CA2353549A1/en not_active Abandoned
- 1999-11-18 KR KR1020017006815A patent/KR20010112223A/en not_active Application Discontinuation
- 1999-11-30 US US09/452,012 patent/US6323368B1/en not_active Expired - Fee Related
Non-Patent Citations (2)
Title |
---|
FRANKUS, E. ET AL: "Über die Isomerentrennung, Strukturaufklärung und pharmakologische Charakterisierung von 1-(m-Methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol", ARZNEIM.-FORSCH. (1978), 28(1A), 114-21 CODEN: ARZNAD;ISSN: 0004-4172, 1978, XP000644506 * |
J. JACQUES ET AL.: "Enantiomers, racemates and resolutions", 1991, KRIEGER PUBLISHING COMPANY, MALABAR, FLORIDA (U.S.A), XP002030514, 20422 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001083422A1 (en) * | 2000-04-28 | 2001-11-08 | Darwin Discovery Limited | Process for the separation of the cis trans diastereoisomers of tramadol |
US6780891B2 (en) | 2001-11-30 | 2004-08-24 | Sepracor Inc. | Tramadol analogs and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
AU1170800A (en) | 2000-06-19 |
EP1135357A1 (en) | 2001-09-26 |
CA2353549A1 (en) | 2000-06-08 |
KR20010112223A (en) | 2001-12-20 |
AU747431B2 (en) | 2002-05-16 |
CN1329587A (en) | 2002-01-02 |
GB9826540D0 (en) | 1999-01-27 |
EP1135357B1 (en) | 2003-10-29 |
DE69912474D1 (en) | 2003-12-04 |
JP2002531429A (en) | 2002-09-24 |
ATE253037T1 (en) | 2003-11-15 |
US6323368B1 (en) | 2001-11-27 |
BR9915868A (en) | 2001-08-21 |
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