WO2000027871A3 - New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs - Google Patents

New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs Download PDF

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Publication number
WO2000027871A3
WO2000027871A3 PCT/IB1999/001886 IB9901886W WO0027871A3 WO 2000027871 A3 WO2000027871 A3 WO 2000027871A3 IB 9901886 W IB9901886 W IB 9901886W WO 0027871 A3 WO0027871 A3 WO 0027871A3
Authority
WO
WIPO (PCT)
Prior art keywords
task2
screening
cloning
drugs
potassium channels
Prior art date
Application number
PCT/IB1999/001886
Other languages
French (fr)
Other versions
WO2000027871A2 (en
Inventor
Fabrice Duprat
Florian Lesage
Michel Lazdunski
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Priority to DE69938667T priority Critical patent/DE69938667D1/en
Priority to EP99956260A priority patent/EP1129187B1/en
Priority to CA2350334A priority patent/CA2350334C/en
Publication of WO2000027871A2 publication Critical patent/WO2000027871A2/en
Publication of WO2000027871A3 publication Critical patent/WO2000027871A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention relates to a new member of a recently recognized TWIK potassium transport channels, herein designated as TASK2. TASK2 is a unique potassium transport channel which is regulated by external pH and predominantly expressed in kidney and epithelial tissues. The invention relates to various constructs of TASK2 for the production of TASK2 and their uses for diagnostic tests and screening methods to identify compounds that modulate potassium transport.
PCT/IB1999/001886 1998-11-09 1999-11-09 New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs WO2000027871A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE69938667T DE69938667D1 (en) 1998-11-09 1999-11-09 NEW FAMILY OF MAMMALIAN CALIUM CHANNELS, THEIR CLONING AND THEIR USE, ESPECIALLY FOR DRUG SCREENING
EP99956260A EP1129187B1 (en) 1998-11-09 1999-11-09 New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs
CA2350334A CA2350334C (en) 1998-11-09 1999-11-09 New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10769298P 1998-11-09 1998-11-09
US60/107,692 1998-11-09
US43626599A 1999-11-08 1999-11-08
US09/436,265 1999-11-08

Publications (2)

Publication Number Publication Date
WO2000027871A2 WO2000027871A2 (en) 2000-05-18
WO2000027871A3 true WO2000027871A3 (en) 2000-11-30

Family

ID=26805049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/001886 WO2000027871A2 (en) 1998-11-09 1999-11-09 New family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs

Country Status (6)

Country Link
EP (1) EP1129187B1 (en)
AT (1) ATE394486T1 (en)
CA (1) CA2350334C (en)
DE (1) DE69938667D1 (en)
ES (1) ES2307343T3 (en)
WO (1) WO2000027871A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001250794B2 (en) 2000-03-03 2006-03-02 Amgen Inc. Kcnb: a novel potassium channel protein
JP2004513618A (en) * 2000-07-07 2004-05-13 インサイト・ゲノミックス・インコーポレイテッド Transporters and ion channels
NZ513755A (en) * 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
WO2005054867A2 (en) * 2003-11-25 2005-06-16 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with potassium channel, subfamily k, member 5 (kcnk5)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0799889A1 (en) * 1996-02-08 1997-10-08 Centre National De La Recherche Scientifique (Cnrs) Mammalian potassium channel family, their cloning and their use for drug screening
WO2000005367A2 (en) * 1998-07-24 2000-02-03 Sagami Chemical Research Center Human proteins having hydrophobic domains and dnas encoding these proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0799889A1 (en) * 1996-02-08 1997-10-08 Centre National De La Recherche Scientifique (Cnrs) Mammalian potassium channel family, their cloning and their use for drug screening
WO2000005367A2 (en) * 1998-07-24 2000-02-03 Sagami Chemical Research Center Human proteins having hydrophobic domains and dnas encoding these proteins

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DUPRAT F. ET AL: "TASK, a *human* background K+ channel to sense external pH variations near physiological pH", EMBO JOURNAL(EMBO J.), 16/17 (5464-5471), 1997, United Kingdom, XP000919218 *
FINK M ET AL: "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 17, no. 12, 15 June 1998 (1998-06-15), pages 3297 - 3308, XP002085600, ISSN: 0261-4189 *
FINK M ET AL: "Cloning, functional expression an brain localization of a novel unconventional outward rectifier K+ channel", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 15, no. 24, 16 December 1996 (1996-12-16), pages 6854 - 6862, XP002085602, ISSN: 0261-4189 *
LESAGE F ET AL: "TWIK-1, A UBIQUITOUS HUMAN WEAKLY INWARD RECTIFYING K+ CHANNEL WITH A NOVEL STRUCTURE", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 15, no. 5, 1996, pages 1004 - 1011, XP002017569, ISSN: 0261-4189 *
PATEL A J ET AL: "A mammalian two pore domain mechano-gated S-like K+ channel", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 17, no. 15, 3 August 1998 (1998-08-03), pages 4283 - 4290, XP002085601, ISSN: 0261-4189 *
REYES ROBERTO ET AL: "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 47, 20 November 1998 (1998-11-20), pages 30863 - 30869, XP000919229, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
EP1129187B1 (en) 2008-05-07
EP1129187A2 (en) 2001-09-05
DE69938667D1 (en) 2008-06-19
ES2307343T3 (en) 2008-11-16
CA2350334C (en) 2013-07-16
ATE394486T1 (en) 2008-05-15
WO2000027871A2 (en) 2000-05-18
CA2350334A1 (en) 2000-05-18

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