WO2000024931A3 - Detection of analytes - Google Patents

Detection of analytes Download PDF

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Publication number
WO2000024931A3
WO2000024931A3 PCT/IL1999/000557 IL9900557W WO0024931A3 WO 2000024931 A3 WO2000024931 A3 WO 2000024931A3 IL 9900557 W IL9900557 W IL 9900557W WO 0024931 A3 WO0024931 A3 WO 0024931A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid sequence
catalytic
analytes
detection
Prior art date
Application number
PCT/IL1999/000557
Other languages
French (fr)
Other versions
WO2000024931A2 (en
Inventor
Andy Ellington
Asher Nathan
Original Assignee
Asher Nathan
Andy Ellington
Intelligene Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL12673198A priority Critical patent/IL126731D0/en
Priority to IL126731 priority
Application filed by Asher Nathan, Andy Ellington, Intelligene Ltd filed Critical Asher Nathan
Publication of WO2000024931A2 publication Critical patent/WO2000024931A2/en
Publication of WO2000024931A3 publication Critical patent/WO2000024931A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6862Ligase chain reaction [LCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]

Abstract

The invention concerns a method where catalytic nucleic acid sequence in the presence of an analyte (which may be a nucleic acid sequence or a non-nucleic acid sequence) converts a substrate to a catalytic product. The catalytic product may then be amplified by state of the art amplification methods such as PCR, LCR, 3SR and NASBA.
PCT/IL1999/000557 1998-10-23 1999-10-22 Detection of analytes WO2000024931A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL12673198A IL126731D0 (en) 1998-10-23 1998-10-23 A method of detection
IL126731 1998-10-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU63646/99A AU6364699A (en) 1998-10-23 1999-10-22 Detection of analytes

Publications (2)

Publication Number Publication Date
WO2000024931A2 WO2000024931A2 (en) 2000-05-04
WO2000024931A3 true WO2000024931A3 (en) 2000-08-17

Family

ID=11072060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000557 WO2000024931A2 (en) 1998-10-23 1999-10-22 Detection of analytes

Country Status (3)

Country Link
AU (1) AU6364699A (en)
IL (1) IL126731D0 (en)
WO (1) WO2000024931A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034009B2 (en) 1995-10-26 2006-04-25 Sirna Therapeutics, Inc. Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
US6617438B1 (en) 1997-11-05 2003-09-09 Sirna Therapeutics, Inc. Oligoribonucleotides with enzymatic activity
US6482932B1 (en) 1997-11-05 2002-11-19 Ribozyme Pharmaceuticals, Incorporated Nucleoside triphosphates and their incorporation into oligonucleotides
US6995259B1 (en) 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
IL130606D0 (en) * 1999-06-23 2000-06-01 Intelligene Ltd An array of nucleic acid sequence
US6506887B1 (en) 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
EP1386004A4 (en) 2001-04-05 2005-02-16 Ribozyme Pharm Inc Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
US7833992B2 (en) 2001-05-18 2010-11-16 Merck Sharpe & Dohme Conjugates and compositions for cellular delivery
US7109165B2 (en) 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2005041859A2 (en) 2003-04-30 2005-05-12 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery.
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
EP2415486B1 (en) 2001-05-18 2017-02-22 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US7491805B2 (en) 2001-05-18 2009-02-17 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7205399B1 (en) 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
US7071311B2 (en) 2002-02-13 2006-07-04 Sirna Therapeutics, Inc. Antibodies having specificity for 2′-C-allyl nucleic acids
WO2004011680A1 (en) 2002-07-25 2004-02-05 Archemix Corp. Regulated aptamer therapeutics
US7981866B2 (en) 2006-07-11 2011-07-19 University Of Medicine And Dentistry Of New Jersey MG53 compositions and methods of use
CA2785492C (en) 2009-12-23 2018-07-24 Novartis Ag Lipids, lipid compositions, and methods of using them
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc Rna interference-mediated inhibition of gene expression using short interferring nucleic acids (sina)
MX2015011955A (en) 2013-03-08 2016-04-07 Novartis Ag Lipids and lipid compositions for the delivery of active agents.
US10426737B2 (en) 2013-12-19 2019-10-01 Novartis Ag Lipids and lipid compositions for the delivery of active agents
US10059655B2 (en) 2013-12-19 2018-08-28 Novartis Ag Lipids and lipid compositions for the delivery of active agents
WO2016010840A1 (en) 2014-07-16 2016-01-21 Novartis Ag Method of encapsulating a nucleic acid in a lipid nanoparticle host
JP2017532302A (en) 2014-09-05 2017-11-02 ノバルティス アーゲー Lipids and lipid compositions for delivery of active agents

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013833A1 (en) * 1992-12-04 1994-06-23 Innovir Laboratories, Inc. Ribozyme amplified diagnostics
US5652107A (en) * 1993-01-15 1997-07-29 The Public Health Research Institute Of The City Of New York, Inc. Diagnostic assays and kits for RNA using RNA binary probes and a ribozyme ligase
WO1998008974A2 (en) * 1996-08-26 1998-03-05 Intelligene Ltd. Catalytic nucleic acid and its medical use
WO1998027104A1 (en) * 1996-12-19 1998-06-25 Yale University Bioreactive allosteric polynucleotides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013833A1 (en) * 1992-12-04 1994-06-23 Innovir Laboratories, Inc. Ribozyme amplified diagnostics
US5652107A (en) * 1993-01-15 1997-07-29 The Public Health Research Institute Of The City Of New York, Inc. Diagnostic assays and kits for RNA using RNA binary probes and a ribozyme ligase
WO1998008974A2 (en) * 1996-08-26 1998-03-05 Intelligene Ltd. Catalytic nucleic acid and its medical use
WO1998027104A1 (en) * 1996-12-19 1998-06-25 Yale University Bioreactive allosteric polynucleotides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARTEL ET AL: "Isolation of new ribozymes from a large pool of random sequences", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 261, no. 261, 10 September 1993 (1993-09-10), pages 1411 - 1418-1418, XP002115117, ISSN: 0036-8075 *
ROBERTSON M P ET AL: "In vitro selection of an allosteric ribozyme that transduces analytes to amplicons.", NATURE BIOTECHNOLOGY, (1999 JAN) 17 (1) 62-6., XP002138120 *

Also Published As

Publication number Publication date
IL126731D0 (en) 1999-08-17
AU6364699A (en) 2000-05-15
WO2000024931A2 (en) 2000-05-04

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