WO2000021658A3 - Porous device - Google Patents

Porous device Download PDF

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Publication number
WO2000021658A3
WO2000021658A3 PCT/GB1999/003406 GB9903406W WO0021658A3 WO 2000021658 A3 WO2000021658 A3 WO 2000021658A3 GB 9903406 W GB9903406 W GB 9903406W WO 0021658 A3 WO0021658 A3 WO 0021658A3
Authority
WO
WIPO (PCT)
Prior art keywords
porous device
porous
internal region
entrapped
synthesis
Prior art date
Application number
PCT/GB1999/003406
Other languages
French (fr)
Other versions
WO2000021658A2 (en
Inventor
Ryszard Kobylecki
Original Assignee
Cambridge Discovery Chemistry
Ryszard Kobylecki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Discovery Chemistry, Ryszard Kobylecki filed Critical Cambridge Discovery Chemistry
Priority to CA002347171A priority Critical patent/CA2347171A1/en
Priority to EP99949229A priority patent/EP1121196A2/en
Priority to JP2000575617A priority patent/JP2002527412A/en
Priority to AU62203/99A priority patent/AU764377B2/en
Priority to NZ511066A priority patent/NZ511066A/en
Publication of WO2000021658A2 publication Critical patent/WO2000021658A2/en
Publication of WO2000021658A3 publication Critical patent/WO2000021658A3/en
Priority to US11/240,386 priority patent/US20060046245A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00502—Particles of irregular geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
  • Manipulator (AREA)
  • Catalysts (AREA)

Abstract

A porous device for use in a method of synthesis comprising a body having an internal region which is porous wherein an active material, for example a solid support resin, is entrapped within the internal region.
PCT/GB1999/003406 1998-10-14 1999-10-14 Porous device WO2000021658A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002347171A CA2347171A1 (en) 1998-10-14 1999-10-14 Porous device
EP99949229A EP1121196A2 (en) 1998-10-14 1999-10-14 Porous device
JP2000575617A JP2002527412A (en) 1998-10-14 1999-10-14 Porous element
AU62203/99A AU764377B2 (en) 1998-10-14 1999-10-14 Porous device
NZ511066A NZ511066A (en) 1998-10-14 1999-10-14 Porous device useful as a support for reagents used in a synthesis
US11/240,386 US20060046245A1 (en) 1998-10-14 2005-10-03 Porous device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9822436.3 1998-10-14
GBGB9822436.3A GB9822436D0 (en) 1998-10-14 1998-10-14 Sintered/co-sintered materials

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/240,386 Continuation US20060046245A1 (en) 1998-10-14 2005-10-03 Porous device

Publications (2)

Publication Number Publication Date
WO2000021658A2 WO2000021658A2 (en) 2000-04-20
WO2000021658A3 true WO2000021658A3 (en) 2001-02-01

Family

ID=10840576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/003406 WO2000021658A2 (en) 1998-10-14 1999-10-14 Porous device

Country Status (8)

Country Link
US (1) US20060046245A1 (en)
EP (1) EP1121196A2 (en)
JP (1) JP2002527412A (en)
AU (1) AU764377B2 (en)
CA (1) CA2347171A1 (en)
GB (1) GB9822436D0 (en)
NZ (1) NZ511066A (en)
WO (1) WO2000021658A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6579725B1 (en) 1999-03-05 2003-06-17 Massachusetts Institute Of Technology Linkers for synthesis of oligosaccharides on solid supports
DE10042871A1 (en) * 2000-08-31 2002-05-16 Hte Ag The High Throughput Exp Three-dimensional material library and method for producing a three-dimensional material library
DE10059890A1 (en) * 2000-12-01 2002-06-20 Hte Ag Method for producing a large number of building blocks of a material library
AU2003266932B2 (en) * 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
EP1569987B1 (en) 2002-10-29 2013-12-18 Porvair Filtration Group Limited Process
US8022013B2 (en) 2003-08-29 2011-09-20 Illumina, Inc. Method of forming and using solid-phase support
US7691316B2 (en) 2004-02-12 2010-04-06 Chemistry & Technology For Genes, Inc. Devices and methods for the synthesis of nucleic acids
CA2570802A1 (en) * 2004-06-28 2006-01-05 H. Lundbeck A/S Porous article for delivering chemical substances
KR100682862B1 (en) * 2005-01-11 2007-02-15 삼성에스디아이 주식회사 Electrode for electrochemical cell, manufacturing method thereof, and electrochemical cell containing the electrode
WO2007112491A1 (en) * 2006-03-31 2007-10-11 The University Of Tasmania Microreactor
US8129517B1 (en) 2006-05-23 2012-03-06 Integrated Dna Technologies, Inc. Labeled solid supports for organic synthesis
US9073033B2 (en) 2010-01-19 2015-07-07 Illumina, Inc. Methods and compositions for processing chemical reactions

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1281364A (en) * 1968-10-25 1972-07-12 Rohm & Haas Polypeptide synthesis
US4061701A (en) * 1972-12-20 1977-12-06 Basf Aktiengesellschaft Manufacture of soft and resilient foams
EP0175195A2 (en) * 1984-09-13 1986-03-26 BEHRINGWERKE Aktiengesellschaft Device comprising membrane-structured polymers with solid particles incorporated there-in
US4774058A (en) * 1985-09-26 1988-09-27 Mehl Ehrenfried L Apparatus for, and methods of, operating upon a fluid
WO1989008705A1 (en) * 1988-03-19 1989-09-21 Eric Robinson Supports for proteins and amino acids
WO1992000799A1 (en) * 1990-07-09 1992-01-23 Upfront Chromatography A/S Substance carrying conglomerate
US5177023A (en) * 1987-08-03 1993-01-05 Eastman Kodak Company Water-insoluble reagent elements containing same and methods of use
US5459079A (en) * 1988-10-21 1995-10-17 Rhone-Poulenc Chimie Support for biologically active molecules which itself may be biologically active, process for its preparation and its biological applications
WO1997012680A2 (en) * 1995-10-03 1997-04-10 Irori Matrices with memories, sensors with memories and uses thereof
US5688370A (en) * 1993-12-22 1997-11-18 Minnesota Mining And Manufacturing Company Sheet materials for solid phase extractions and solid phase reactions
WO1998041534A2 (en) * 1997-03-19 1998-09-24 Biosepra Inc. Multifunctional ceramic particles as supports for solid phase and combinatorial synthesis
WO1999032508A1 (en) * 1997-12-22 1999-07-01 Avecia Limited Process for the preparation of solid polymer composites

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218363A (en) * 1978-10-16 1980-08-19 Uop Inc. Preparation of support matrices for immobilized enzymes
AU669489B2 (en) * 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
GB2295152A (en) * 1994-11-18 1996-05-22 Pfizer Ltd Preparation of a library of compounds by solid-phase synthesis
US5684130A (en) * 1995-06-05 1997-11-04 Solid Phase Sciences Corporation Process for synthesis of organic compounds using magnetic particles
US5834121A (en) * 1996-01-16 1998-11-10 Solid Phase Sciences Corp. Composite magnetic beads
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
US6147159A (en) * 1998-09-30 2000-11-14 Argonaut Technologies Compositions for organic synthesis on solid phase and methods of using the same

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1281364A (en) * 1968-10-25 1972-07-12 Rohm & Haas Polypeptide synthesis
US4061701A (en) * 1972-12-20 1977-12-06 Basf Aktiengesellschaft Manufacture of soft and resilient foams
EP0175195A2 (en) * 1984-09-13 1986-03-26 BEHRINGWERKE Aktiengesellschaft Device comprising membrane-structured polymers with solid particles incorporated there-in
US4774058A (en) * 1985-09-26 1988-09-27 Mehl Ehrenfried L Apparatus for, and methods of, operating upon a fluid
US5177023A (en) * 1987-08-03 1993-01-05 Eastman Kodak Company Water-insoluble reagent elements containing same and methods of use
WO1989008705A1 (en) * 1988-03-19 1989-09-21 Eric Robinson Supports for proteins and amino acids
US5459079A (en) * 1988-10-21 1995-10-17 Rhone-Poulenc Chimie Support for biologically active molecules which itself may be biologically active, process for its preparation and its biological applications
WO1992000799A1 (en) * 1990-07-09 1992-01-23 Upfront Chromatography A/S Substance carrying conglomerate
US5688370A (en) * 1993-12-22 1997-11-18 Minnesota Mining And Manufacturing Company Sheet materials for solid phase extractions and solid phase reactions
WO1997012680A2 (en) * 1995-10-03 1997-04-10 Irori Matrices with memories, sensors with memories and uses thereof
WO1998041534A2 (en) * 1997-03-19 1998-09-24 Biosepra Inc. Multifunctional ceramic particles as supports for solid phase and combinatorial synthesis
WO1999032508A1 (en) * 1997-12-22 1999-07-01 Avecia Limited Process for the preparation of solid polymer composites

Also Published As

Publication number Publication date
CA2347171A1 (en) 2000-04-20
NZ511066A (en) 2003-08-29
WO2000021658A2 (en) 2000-04-20
EP1121196A2 (en) 2001-08-08
US20060046245A1 (en) 2006-03-02
GB9822436D0 (en) 1998-12-09
AU764377B2 (en) 2003-08-14
AU6220399A (en) 2000-05-01
JP2002527412A (en) 2002-08-27

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