WO2000015767A3 - Antigen-presenting cells and their use in therapy - Google Patents

Antigen-presenting cells and their use in therapy Download PDF

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Publication number
WO2000015767A3
WO2000015767A3 PCT/NL1999/000575 NL9900575W WO0015767A3 WO 2000015767 A3 WO2000015767 A3 WO 2000015767A3 NL 9900575 W NL9900575 W NL 9900575W WO 0015767 A3 WO0015767 A3 WO 0015767A3
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WO
WIPO (PCT)
Prior art keywords
presenting cells
measurement
tolerogenic
antigen
antigen presenting
Prior art date
Application number
PCT/NL1999/000575
Other languages
French (fr)
Other versions
WO2000015767A2 (en
Inventor
Marc Henriette Michaela Wauben
Eden Willem Van
Original Assignee
Upither B V
Marc Henriette Michaela Wauben
Eden Willem Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upither B V, Marc Henriette Michaela Wauben, Eden Willem Van filed Critical Upither B V
Priority to AU57643/99A priority Critical patent/AU5764399A/en
Publication of WO2000015767A2 publication Critical patent/WO2000015767A2/en
Publication of WO2000015767A3 publication Critical patent/WO2000015767A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0648—Splenocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4612—B-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4614—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464476—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4648—Bacterial antigens
    • A61K39/464817—Mycobacterium, e.g. Mycobacterium tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

Abstract

A method for ex vivo treatment of antigen presenting cells, wherein said method consists of in vitro culture of antigen presenting cells under conditions resulting in development of tolerogenic antigen presenting cells, such tolerogenic cells being characterised by: a) reduced induction of T cell activation upon T-cell receptor ligation as can be determined by any of the measurements selected from the group measurement of proliferation, measurement of cytokine production, measurement of cytotoxicity and measurement of expression of activation cell surface markers, b) a dominant tolerogenic effect. Also part of the invention are such tolerogenic antigen-presenting cells and artificial analogues, compositions containing them and their use in immunotherapy.
PCT/NL1999/000575 1998-09-15 1999-09-15 Antigen-presenting cells and their use in therapy WO2000015767A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57643/99A AU5764399A (en) 1998-09-15 1999-09-15 Antigen-presenting cells and their use in therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98203083 1998-09-15
EP98203083.5 1998-09-15

Publications (2)

Publication Number Publication Date
WO2000015767A2 WO2000015767A2 (en) 2000-03-23
WO2000015767A3 true WO2000015767A3 (en) 2000-07-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1999/000575 WO2000015767A2 (en) 1998-09-15 1999-09-15 Antigen-presenting cells and their use in therapy

Country Status (2)

Country Link
AU (1) AU5764399A (en)
WO (1) WO2000015767A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9528088B2 (en) 2002-06-28 2016-12-27 Life Technologies Corporation Methods for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190359939A1 (en) * 2015-08-23 2019-11-28 Diamyd Medical Ab New use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005323A1 (en) * 1992-09-04 1994-03-17 The Johns Hopkins University School Of Medicine Method for induction of antigen-specific immune tolerance
US5623056A (en) * 1989-03-15 1997-04-22 Tkb Associates Limited Partnership CDS derivatives and methods of use for cellular modulation and enhancement of cellular engraftment
EP0856314A1 (en) * 1995-04-07 1998-08-05 Chugai Seiyaku Kabushiki Kaisha Immunosuppressant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5623056A (en) * 1989-03-15 1997-04-22 Tkb Associates Limited Partnership CDS derivatives and methods of use for cellular modulation and enhancement of cellular engraftment
WO1994005323A1 (en) * 1992-09-04 1994-03-17 The Johns Hopkins University School Of Medicine Method for induction of antigen-specific immune tolerance
EP0856314A1 (en) * 1995-04-07 1998-08-05 Chugai Seiyaku Kabushiki Kaisha Immunosuppressant

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MANNIE M D ET AL: "Anergy-associated T cell antigen presentation. A mechanism of infectious tolerance in experimental autoimmune encephalomyelitis.", JOURNAL OF IMMUNOLOGY, (1996 AUG 1) 157 (3) 1062-70., XP002133088 *
TAAMS LEONIE S ET AL: "Anergic T cells actively suppress T cell responses via the antigen-presenting cell.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, no. 9, September 1998 (1998-09-01), pages 2902 - 2912, XP000877447, ISSN: 0014-2980 *
VAN RENSEN ANNEMIEK J M L ET AL: "Specific T cell activation and induction of T cell unresponsiveness by MHC II/peptide liposomes.", JOURNAL OF LIPOSOME RESEARCH, vol. 8, no. 1, February 1998 (1998-02-01), pages 117, XP000877083, ISSN: 0898-2104 *
WAUBEN M H M ET AL: "Anergic T cells down-regulate the T cell activating capacity of APC.", 2ND INTERNATIONAL CONGRESS ON AUTOIMMUNITY; MARCH 7-11, 1999, no. SUPPL., 1999, Journal of Autoimmunity, pages 50, XP000877448, ISSN: 0896-8411 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9528088B2 (en) 2002-06-28 2016-12-27 Life Technologies Corporation Methods for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation

Also Published As

Publication number Publication date
WO2000015767A2 (en) 2000-03-23
AU5764399A (en) 2000-04-03

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