WO2000010543A2 - Arzneimittel enthaltend platinkomplexverbindungen sowie deren verwendung - Google Patents
Arzneimittel enthaltend platinkomplexverbindungen sowie deren verwendung Download PDFInfo
- Publication number
- WO2000010543A2 WO2000010543A2 PCT/DE1999/002656 DE9902656W WO0010543A2 WO 2000010543 A2 WO2000010543 A2 WO 2000010543A2 DE 9902656 W DE9902656 W DE 9902656W WO 0010543 A2 WO0010543 A2 WO 0010543A2
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- WO
- WIPO (PCT)
- Prior art keywords
- carbon atoms
- platinum
- medicament according
- radical
- compound
- Prior art date
Links
- 0 C[N-][N+](N*([N-]1)N[N+]1O*)OC Chemical compound C[N-][N+](N*([N-]1)N[N+]1O*)OC 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Definitions
- the invention relates to medicines containing platinum complexes and their use for the therapy of tumor diseases.
- cancer is usually treated with drug therapy or radiotherapy before and / or after surgery.
- chemotherapy compounds are used in which cancer growth is influenced in different ways.
- side effects e.g. Hair loss, nausea, vomiting, fatigue, damage to the bone marrow and white blood cells.
- Secondary infections are often more or less severe.
- not all types of tumors respond to chemotherapy, e.g. renal cell carcinoma or tumors of the gastrointestinal tract.
- the invention is therefore based on the object of providing an effective medicament for the treatment of cancer.
- the drug is said to be effective in low doses, to be as little toxic as possible to healthy cells and to have few side effects.
- the drug is also said to be suitable for regional chemotherapy and to be administered on an outpatient basis.
- the drug is also said to reduce the risk of relapse.
- the Medicament can be stored for a long time without loss of effectiveness.
- the invention therefore relates to medicaments which contain platinum complexes of the general formula (I)
- R 1 and R 2 each independently of one another a straight or branched alkyl radical having 1 to 30 carbon atoms, a straight or branched alkenyl radical having 2 to 30 carbon atoms, a mono- or polycyclic alkyl radical having 3 to 30 carbon atoms, a mono- or polycyclic Alkenyl radical having 4 to 30 carbon atoms, or a mono- or polycyclic aromatic radical having 6 to 30 carbon atoms, which radicals can optionally be substituted by one or more substituents.
- R 1 and R 2 may be the same or different.
- R 1 and R 2 are preferably straight C 1-4 alkyl radicals or C 3.14 cycloalkyl radicals.
- R and R 2 are particularly preferably CH 3 CH 2 .
- Any straight or branched C 1-4 alkyl radical can be used. Examples include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, n-butyl, n-hexyl, 2-methylpentyl, 2,3-dimethylbutyl, n -Heptyl-, 2-methylhexyl-, 2,2-dimethylpentyl-, 3,3-dimethylpentyl-, 3-ethylpentyl-, n-octyl-, 2,2-dimethylhexyl-, 3,3-dimethylhexyl-, 3rd -Methyl-3-ethylpenti groups.
- Short alkyl chains such as methyl,
- Any straight or branched C 2.30 alkenyl radical can be used.
- examples of these are vinyl, propenyl, isopropenyl, allyl, 2-methylallyl, butenyl or isobutenyl, hexenyl or isohexenyl, heptenyl or isoheptenyl, octenyl or isooctenyi groups.
- Vinyl, propenyl and isopropenyl are preferred.
- the cycloalkyl radical having 3 to 30 carbon atoms can be any cycloalkyl radical. Examples include a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl or cyclodecyl group. Cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl,
- the cycloalkenyl radical having 4 to 30 carbon atoms can be any cycloalkenyl radical. Examples include a cyclobutenyl, cyclopentenyl or cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclononenyl or cyclodecenyl groups. Cyclobutenyl, cyclopentenyl or cyclohexenyl are preferred. Examples of polycyclic alkyl or alkenyl radicals include norbornane, adamantane or benzvalene. R 1 and R 2 can also be any mono- or polycyclic C6-30 aryl radicals.
- Examples of these are a carbocyclic, monocyclic radical, for example the phenylene group, a heterocyclic, monocyclic radical, for example the groups thienyl, furyl, pyranyl, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, furazannyl, pyrrol Imidazolinyl, pyrazolinyl, thiazolinyl, triazolyl, tetrazolyl, and the positional isomers of the hetero atom or atoms which these groups can comprise, a radical consisting of carbocyclic fused rings, for example the naphthyl group or the phenanthrenyl group, a radical consisting of fused heterocyclic rings, for example benzofuranyl Benzothienyl, Benzimidazolyl, Benzothi
- Halogen fluorine, chlorine, bromine, iodine
- dialkylamino such as dimethylamino, diethylamino, methylethylamino, each of these dialkylamino residues optionally being in oxide form,
- Aminoalkyl such as aminomethyl or aminoethyl
- Dialkylaminoalkyl such as dimethylaminomethyl or ethyl
- Dialkylaminoalkyloxy such as dimethylaminoethyloxy
- esterified carboxyl group such as alkoxycarbonyl, for example methoxycarbonyl or ethoxycarbonyl, or converted into a salt, for example by a sodium or potassium atom,
- Alkyl having 1 to 8 carbon atoms such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, optionally substituted by one or more halogen atoms, for example by fluorine, such as trifluoromethyl,
- Alkoxy such as methoxy, ethoxy, propyloxy, isopropyloxy, butyloxy,
- Alkylthio such as methylthio, ethylthio, propylthio, isopropylthio, butylthio,
- Alkenyl such as vinyl, propenyl,
- alkynyl such as ethynyl, propynyl and
- Aryl such as phenyl, furyl, thienyl.
- substituted radicals are an alkyl radical substituted by one or more halogen atoms, such as the trifluoromethyl, trifluorobutyl, pentafluoropropyl, pentafluorobutyl, pentafluoropentyl, heptafluorobutyl or nonafluorobutyl group or 2-chloroethyl.
- the compounds of the formula (I) are preferably prepared by a process which is characterized in that a ligand exchange reaction from a platinum complex, such as e.g. Cischlorodiamminplatin (ll), with the corresponding xanthate.
- a ligand exchange reaction from a platinum complex such as e.g. Cischlorodiamminplatin (ll)
- ll Cischlorodiamminplatin
- Me stands for an alkali or alkaline earth metal
- R has the definition given for R 1 and R 2 , reacted with a platinum complex, such as cis-dichlorodiammine platinum (II), and isolated the new platinum complex obtained.
- a platinum complex such as cis-dichlorodiammine platinum (II)
- the compounds of formula (I) are suitable for the treatment of various cancers, such as testicular tumors, ovarian, bladder, colon, prostate cancers, small and non-small cell bronchial cancers, carcinomas of the Head and neck area, carcinoma of the thorax and abdomen area, cervical and endometrial carcinoma, sarcoma and melanoma as well as leukemia.
- cancers such as testicular tumors, ovarian, bladder, colon, prostate cancers, small and non-small cell bronchial cancers, carcinomas of the Head and neck area, carcinoma of the thorax and abdomen area, cervical and endometrial carcinoma, sarcoma and melanoma as well as leukemia.
- Therapy of small cell bronchial carcinoma or colorectal carcinoma is preferred.
- the therapy can also be given as an accompanying therapy to radiotherapy or before or after a surgical intervention.
- the compounds of formula (I) are well tolerated.
- the L 50 value is lower by a factor of 3 than for the cis-platinum known in tumor therapy.
- the nephrotoxicity known and feared for cis-platinum has not previously occurred in this way in the case of the thioplati ⁇ compounds.
- Another advantage of the compounds according to the invention is that they have a broad spectrum of action against a wide variety of tumors and in particular also against tumors which have hitherto resisted therapy with platinum compounds (for example cisplatin).
- Thioplatin is particularly suitable for solid tumors.
- Another advantage is that the compounds according to the invention have a higher activity in the slightly acidic than in the alkaline pH range, since many tumor tissues have a rather acidic environment.
- the inventors carried out studies on bis [0-ethyldithiocarbonato] platinum (II), a platinum coordination complex according to formula (I) in which platinum is complexed with sulfur atoms. After protonation, two sulfur ligations open reversibly (so that an "aqua complex” is formed), which can initiate cross-linking of DNA. After increasing the pH, the protons dissociate from the sulfur atoms and the inert molecule becomes restored. The following pH-dependent reaction equation is set up for this:
- the medicament according to the invention can be administered in various ways, e.g. oral, parenteral, cutaneous, subcutaneous, intravenous, intramuscular, rectal or intratumoral.
- intravenous or intratumoral administration i.e. administration to certain diseased organs or regions of the body.
- the medicine is given to a patient for a period of time to be determined by the doctor.
- the medicine can be administered to both humans and mammals.
- the dosage of the compound according to the invention is determined by the doctor on the basis of the patient-specific parameters such as age, weight, gender, severity of the disease, etc.
- the dosage is preferably between 0.001 and 1000 mg / kg body weight.
- the medicinal product is formulated in a suitable manner, for example in the form of simple or coated tablets, hard or soft gelatin capsules, powder for reconstitution before use, granules, suppositories, ovules, injection preparations, infusion solutions, pomades, creams, gels, microspheres , Implants that are manufactured according to standard galenic processes.
- the compounds of formula (I) can optionally be formulated together with further active ingredients and with excipients customary in pharmaceutical compositions, e.g. Depending on the preparation to be made, talc, gum arabic, lactose, starch, magnesium stearate, cocoa butter, aqueous and non-aqueous carriers, fatty substances with animal or vegetable origin, paraffin derivatives, glycols (especially polyethylene glycol), various plasticizers, dispersants or emulsifiers, preservatives.
- excipients customary in pharmaceutical compositions, e.g. Depending on the preparation to be made, talc, gum arabic, lactose, starch, magnesium stearate, cocoa butter, aqueous and non-aqueous carriers, fatty substances with animal or vegetable origin, paraffin derivatives, glycols (especially polyethylene glycol), various plasticizers, dispersants or emulsifiers, preservatives.
- Additives such as sodium chloride solution, ethanol, sorbitol, glycerin, olive oil, almond oil, propylene glycol or ethylene glycol can be used to produce liquid preparations.
- Infusion or injection solutions are preferably prepared. These are preferably aqueous solutions or suspensions, it being possible to prepare them before use, for example from lyophilized preparations which contain the active ingredient alone or together with a carrier such as mannitol, lactose, glucose, albumin and the like.
- the ready-to-use solutions are sterilized and, if necessary, mixed with auxiliaries, for example with preserving agents. Detergents, stabilizers, emulsifiers, solubilizers, buffers and / or salts for regulating the osmotic pressure. Sterilization can be achieved by sterile filtration through filters with a small pore size, after which the composition can optionally be lyophilized. Small amounts of antibiotics can also be added to help maintain sterility.
- the invention also relates to pharmaceuticals or pharmaceutical compositions which contain a therapeutically effective amount of the active ingredient (compound of the formula (I) according to the invention) together with organic or inorganic inert solid or liquid pharmaceutically acceptable carriers or diluents which are suitable for the intended administration , and which do not interact adversely with the active ingredients.
- the invention also relates to a process for the production of a pharmaceutical composition, which is characterized in that the compound of the formula (I) is mixed with a pharmaceutically acceptable carrier.
- medicaments according to the invention in particular the compounds described in the experimental part and very particularly the compounds in which in the above formula (I) R1 and / or R2 which are the same or can be different, is a methyl, ethyl, propyl or isoproyl group.
- the pharmaceuticals or pharmaceutical compositions according to the invention comprise as active ingredient at least one active ingredient as defined above. If necessary, further pharmaceutical active ingredients can be included in the composition, such as e.g. Immunosuppressants, e.g. Cyclosporin, rapamycin, 15-deoxyspergualin, OKT3, azathioprine; Cytokines (eg TNF), interferon etc.
- Immunosuppressants e.g. Cyclosporin, rapamycin, 15-deoxyspergualin, OKT3, azathioprine
- Cytokines eg TNF
- interferon interferon etc.
- composition according to the invention can additionally contain a steroid or other cytostatics (eg cisplatin, methotrexate, aminopterin, dacarbazine, nitrosourea compounds, fluorouracil, bleomycin, daunomycin, daunorubicin, doxorubicin, mithramycin, mitomycin C, etc.) contain.
- cytostatics eg cisplatin, methotrexate, aminopterin, dacarbazine, nitrosourea compounds, fluorouracil, bleomycin, daunomycin, daunorubicin, doxorubicin, mithramycin, mitomycin C, etc.
- Fig. 2 Antitumor effect of a compound according to the invention on a human colon carcinoma in the nude mouse
- Fig. 3 pH-dependent effectiveness of cytostatics
- Fig. 4 Anti-tumor effect of thioplatin on human xenotransplates
- Fig. 5 Histopathology of the kidney and small intestine after thioplatin and cis-platinum treatment
- Excipients aqueous dispersion solution: benzyl alcohol, polyethylene glycol 900, carboxymethyl cellulose (sodium salt), sodium chloride, water for an injection for an ampoule of 1 ml
- PEG is added except for a 5% solution to stabilize the solution.
- NCLC Bronchial carcinoma cells
- mice were implanted under the skin of six-week-old Nu / Nu mice, strain NMRI (5x106 cells in 0.1 ml saline). After two weeks the tumors had reached a size of about 8 mm. Five animals were then treated either with 0.2 ml saline / 0.1% BSA / 1% acetone (control group) or with 10 mg / kg compound according to Example 1 in saline / 1% BSA / 1% acetone (treatment group) treated iv. The tumor growth was checked daily. The values are in the attached figure 1 shown.
- Colon cancer cells (SW707) were implanted under the skin of 6-week-old Nu / Nu mice, NMRI strain (5 x 10 ⁇ cells in saline). After 10 days when the tumors had reached a size of approx. 10 mm, six animals each were treated either with 0.2 ml saline / 1% BSA / 1% acetone (control group), with 7.5 mg / kg compound according to Example 1 treated in saline / 1% BSA / 1% acetone iv (treatment group I) or with 10 mg / kg cisplatin iv (treatment group II). The tumor growth was checked daily and entered in the graph shown in FIG. 2.
- Fig. 2 shows that the tumor growth was slowed down in treatment group I, while in the control group and treatment group II steady tumor growth was observed. From this it can be seen that the compounds according to the invention are far superior to cisplatin and are also effective in tumors which have hitherto not responded to platinum compounds (cisplatin). The thioplatin compounds therefore have a broader spectrum of activity than previous cytostatics.
- Example 4
- Heia cells were sown in Linbro plates (10 5 ) and after 6 hours with different concentrations of cisplatin or a compound according to Example 1 in basal medium according to Eagle, which either 2.2 g (pH 7.4) or 0, Contained 85 g (pH 6.8) sodium bicarbonate and 10% fetal calf serum, incubated for 24 hours at 37 ° C in a 5% C0 2 atmosphere. The number of living cells was determined after vital staining with trypan blue in the Neubauer counting chamber. The result can be seen in FIG. 3.
- the compound according to Example 1 has an active maximum in the slightly acidic range, while the conventional cytostatic cisplatin has a better effect in the alkaline range. Since tumor tissue often has a slightly acidic pH, it is clear that the compound according to Example 1 has a higher activity than conventional cytostatics due to this property.
- the samples and platinum standards were irradiated with neutrons (5 x 10 12 n cm “2 sec " 1 ) for 30 minutes. A week later, the ⁇ radiation of 158.4 keV and 208.2 keV was determined and the platinum concentration was determined using standards. The limit of detection was 2 ng.
- the DNA was isolated 16 hours after incubation by phenol / chloroform extraction followed by ethanol precipitation.
- the platinum content of 100 ⁇ g in each case was determined using the neutron activation method as described above.
- Cells were plated in Linbroschalen and 4 hours later the cells were fed with a medium containing either 2.2 g / l (pH 7.4) or 0.85 g / l (pH 6.8) NaHC0 3 . After adjustment to a 5% CO 2 atmosphere, cis-platinum or thioplatin were added at concentrations between 5 and 150 ⁇ M in each case. The number of living cells was determined 24 hours later and the IC 5 ⁇ and IC gg values were calculated from the dose response curves (standard deviations below 10% in all cases).
- the tumor sizes were determined in two directions and the relative tumor growth was calculated. The mean values are given in FIG. 4.
- cis-platinum was effective in H10 cells, whereas in colorectal cancer (SW707) there was no effect even at a dose of 10 mg / kg.
- thioplatin was effective in both types of cancer.
- the mean tumor size of the thioplatin-treated group was smaller than that of the cis-platinum-treated group.
- the tumor size in small cell lung cancer decreased to 23% of the control group (ie a reduction to about 1/4 of the control), while with cis-platinum only halved the tumor size could be achieved in comparison to the control (FIG. 4A).
- cis-platinum had no effect, while tumor growth could be prevented by thioplatin (Fig. 4B).
- Weight loss is a rough estimate of the toxic side effects. While the cis-platinum-treated animals had a loss of 12% and 13% on days 3 and 6 after treatment, no weight loss was found in the thioplatin group (FIG. 4C).
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- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0103262A HUP0103262A3 (en) | 1998-08-25 | 1999-08-25 | Medicament containing platinum complex compounds and the use thereof |
JP2000565865A JP2002523361A (ja) | 1998-08-25 | 1999-08-25 | 白金錯化合物含有医薬並びにその使用 |
DE59905863T DE59905863D1 (de) | 1998-08-25 | 1999-08-25 | Arzneimittel enthaltend platinkomplexverbindungen sowie deren verwendung |
EP99953589A EP1107751B1 (de) | 1998-08-25 | 1999-08-25 | Arzneimittel enthaltend platinkomplexverbindungen sowie deren verwendung |
AT99953589T ATE241975T1 (de) | 1998-08-25 | 1999-08-25 | Arzneimittel enthaltend platinkomplexverbindungen sowie deren verwendung |
NZ509529A NZ509529A (en) | 1998-08-25 | 1999-08-25 | A pharmaceutical preparation containing platinum complex compounds and the use thereof for treating tumoral diseases |
KR1020017002273A KR20010079680A (ko) | 1998-08-25 | 1999-08-25 | 플라티늄 복합 화합물을 함유하는 약제 및 그 사용 |
DK99953589T DK1107751T3 (da) | 1998-08-25 | 1999-08-25 | Lægemiddel indeholdende platinkompleksforbindelser samt anvendelse deraf |
CA002341701A CA2341701A1 (en) | 1998-08-25 | 1999-08-25 | Medicament containing platinum complex compounds and the use thereof |
PL99346643A PL346643A1 (en) | 1998-08-25 | 1999-08-25 | Medicament containing platinum complex compounds and the use thereof |
MXPA01001999A MXPA01001999A (es) | 1998-08-25 | 1999-08-25 | Medicamento que contiene compuestos complejos de platino asi como su empleo. |
AU10286/00A AU769882C (en) | 1998-08-25 | 1999-08-25 | Medicament containing platinum complex compounds and the use thereof |
BR9913321-0A BR9913321A (pt) | 1998-08-25 | 1999-08-25 | Medicamento contendo compostos de complexos de platina, assim como sua aplicação |
IL14157599A IL141575A0 (en) | 1998-08-25 | 1999-10-25 | Medicament containing platinum complex compounds and the use thereof |
US09/784,618 US6881751B2 (en) | 1998-08-25 | 2001-02-15 | Medicament containing platinum complex compounds and the use thereof |
NO20010907A NO20010907L (no) | 1998-08-25 | 2001-02-22 | Medikament inneholdende platinakompleksforbindelser og anvendelse derav |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19838547 | 1998-08-25 | ||
DE19838547.1 | 1998-08-25 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/784,618 Continuation US6881751B2 (en) | 1998-08-25 | 2001-02-15 | Medicament containing platinum complex compounds and the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000010543A2 true WO2000010543A2 (de) | 2000-03-02 |
WO2000010543A3 WO2000010543A3 (de) | 2000-08-10 |
Family
ID=7878626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1999/002656 WO2000010543A2 (de) | 1998-08-25 | 1999-08-25 | Arzneimittel enthaltend platinkomplexverbindungen sowie deren verwendung |
Country Status (21)
Country | Link |
---|---|
US (1) | US6881751B2 (de) |
EP (1) | EP1107751B1 (de) |
JP (1) | JP2002523361A (de) |
KR (1) | KR20010079680A (de) |
CN (1) | CN1224385C (de) |
AT (1) | ATE241975T1 (de) |
AU (1) | AU769882C (de) |
BR (1) | BR9913321A (de) |
CA (1) | CA2341701A1 (de) |
CZ (1) | CZ293449B6 (de) |
DE (2) | DE19940407A1 (de) |
DK (1) | DK1107751T3 (de) |
ES (1) | ES2201792T3 (de) |
HU (1) | HUP0103262A3 (de) |
IL (1) | IL141575A0 (de) |
MX (1) | MXPA01001999A (de) |
NO (1) | NO20010907L (de) |
NZ (1) | NZ509529A (de) |
PL (1) | PL346643A1 (de) |
PT (1) | PT1107751E (de) |
WO (1) | WO2000010543A2 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1391221A1 (de) * | 2002-08-23 | 2004-02-25 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Pharmazeutische Zubereitung enthaltend Palladiumkomplexverbindungen und deren Verwendung zur Behandlung von Krebs und Autoimmunerkrankungen |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1541142A1 (de) * | 2003-12-10 | 2005-06-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Pharmazeutische Zubereitungen enthaltend einen Platin Komplex mit einem zweiwertigen Xanthat und die therapeutische Verwendung der Zubereitungen |
WO2006039293A2 (en) * | 2004-09-29 | 2006-04-13 | University Of Virginia Patent Foundation | Localized control of thermal properties on microdevices and applications thereof |
US8056881B2 (en) * | 2004-10-13 | 2011-11-15 | University Of Virginia Patent Foundation | Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof |
EP1859797A4 (de) * | 2005-02-28 | 2011-04-13 | Eisai R&D Man Co Ltd | Neue gleichzeitige verwendung einer sulfonamid-verbindung und eines mittels gegen krebs |
US8916375B2 (en) * | 2005-10-12 | 2014-12-23 | University Of Virginia Patent Foundation | Integrated microfluidic analysis systems |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4843161A (en) | 1984-06-01 | 1989-06-27 | Massachusetts Institute Of Technology | Platinum-intercalative complexes for the treatment of cancer |
US4885376A (en) | 1987-10-13 | 1989-12-05 | Iowa State University Research Foundation, Inc. | New types of organometallic reagents and catalysts for asymmetric synthesis |
US5068375A (en) | 1990-10-01 | 1991-11-26 | Exxon Research & Engineering Company | Substituted noble metal xanthates |
US5844001A (en) | 1993-02-26 | 1998-12-01 | Research Development Foundation | Combination platinum chemotherapeutic/antiestrogen therapy for human cancers |
ZA941290B (en) | 1993-02-26 | 1995-08-25 | Res Dev Foundation | Combination cisplatin/tamoxifen therapy for human cancers |
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1999
- 1999-08-25 NZ NZ509529A patent/NZ509529A/en unknown
- 1999-08-25 PL PL99346643A patent/PL346643A1/xx unknown
- 1999-08-25 CA CA002341701A patent/CA2341701A1/en not_active Abandoned
- 1999-08-25 ES ES99953589T patent/ES2201792T3/es not_active Expired - Lifetime
- 1999-08-25 CZ CZ2001569A patent/CZ293449B6/cs not_active IP Right Cessation
- 1999-08-25 BR BR9913321-0A patent/BR9913321A/pt not_active IP Right Cessation
- 1999-08-25 DE DE19940407A patent/DE19940407A1/de not_active Withdrawn
- 1999-08-25 KR KR1020017002273A patent/KR20010079680A/ko not_active Application Discontinuation
- 1999-08-25 MX MXPA01001999A patent/MXPA01001999A/es not_active IP Right Cessation
- 1999-08-25 WO PCT/DE1999/002656 patent/WO2000010543A2/de not_active Application Discontinuation
- 1999-08-25 HU HU0103262A patent/HUP0103262A3/hu unknown
- 1999-08-25 EP EP99953589A patent/EP1107751B1/de not_active Expired - Lifetime
- 1999-08-25 DE DE59905863T patent/DE59905863D1/de not_active Expired - Lifetime
- 1999-08-25 AT AT99953589T patent/ATE241975T1/de not_active IP Right Cessation
- 1999-08-25 DK DK99953589T patent/DK1107751T3/da active
- 1999-08-25 PT PT99953589T patent/PT1107751E/pt unknown
- 1999-08-25 CN CNB998101141A patent/CN1224385C/zh not_active Expired - Fee Related
- 1999-08-25 JP JP2000565865A patent/JP2002523361A/ja active Pending
- 1999-08-25 AU AU10286/00A patent/AU769882C/en not_active Ceased
- 1999-10-25 IL IL14157599A patent/IL141575A0/xx unknown
-
2001
- 2001-02-15 US US09/784,618 patent/US6881751B2/en not_active Expired - Fee Related
- 2001-02-22 NO NO20010907A patent/NO20010907L/no not_active Application Discontinuation
Non-Patent Citations (5)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1391221A1 (de) * | 2002-08-23 | 2004-02-25 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Pharmazeutische Zubereitung enthaltend Palladiumkomplexverbindungen und deren Verwendung zur Behandlung von Krebs und Autoimmunerkrankungen |
WO2004018043A1 (en) * | 2002-08-23 | 2004-03-04 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | A pharmaceutical preparation containing palladium complex compounds and the uses thereof for treating cancer and autoimmune disease |
Also Published As
Publication number | Publication date |
---|---|
DE19940407A1 (de) | 2000-03-09 |
CN1398183A (zh) | 2003-02-19 |
ES2201792T3 (es) | 2004-03-16 |
NO20010907L (no) | 2001-04-25 |
ATE241975T1 (de) | 2003-06-15 |
NZ509529A (en) | 2003-07-25 |
HUP0103262A2 (hu) | 2001-12-28 |
BR9913321A (pt) | 2001-05-15 |
AU1028600A (en) | 2000-03-14 |
CN1224385C (zh) | 2005-10-26 |
EP1107751B1 (de) | 2003-06-04 |
CZ2001569A3 (cs) | 2001-09-12 |
AU769882C (en) | 2004-10-07 |
EP1107751A2 (de) | 2001-06-20 |
KR20010079680A (ko) | 2001-08-22 |
HUP0103262A3 (en) | 2004-03-01 |
NO20010907D0 (no) | 2001-02-22 |
JP2002523361A (ja) | 2002-07-30 |
CA2341701A1 (en) | 2000-03-02 |
IL141575A0 (en) | 2002-03-10 |
PL346643A1 (en) | 2002-02-25 |
PT1107751E (pt) | 2003-10-31 |
MXPA01001999A (es) | 2002-04-24 |
DK1107751T3 (da) | 2003-09-29 |
AU769882B2 (en) | 2004-02-05 |
WO2000010543A3 (de) | 2000-08-10 |
US6881751B2 (en) | 2005-04-19 |
US20020004526A1 (en) | 2002-01-10 |
CZ293449B6 (cs) | 2004-04-14 |
DE59905863D1 (de) | 2003-07-10 |
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