WO2000002874A3 - Integrin dependent cell adhesion inhibitors - Google Patents

Integrin dependent cell adhesion inhibitors Download PDF

Info

Publication number
WO2000002874A3
WO2000002874A3 PCT/GB1999/002219 GB9902219W WO0002874A3 WO 2000002874 A3 WO2000002874 A3 WO 2000002874A3 GB 9902219 W GB9902219 W GB 9902219W WO 0002874 A3 WO0002874 A3 WO 0002874A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell adhesion
dependent cell
adhesion inhibitors
integrin dependent
integrin
Prior art date
Application number
PCT/GB1999/002219
Other languages
French (fr)
Other versions
WO2000002874A2 (en
Inventor
Solomon Habtemariam
Original Assignee
Univ Strathclyde
Solomon Habtemariam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Strathclyde, Solomon Habtemariam filed Critical Univ Strathclyde
Publication of WO2000002874A2 publication Critical patent/WO2000002874A2/en
Publication of WO2000002874A3 publication Critical patent/WO2000002874A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to euparin derivatives having broad spectrum integrin receptor inhibition activity and utility in the treatment of integrin mediated disease.
PCT/GB1999/002219 1998-07-09 1999-07-09 Integrin dependent cell adhesion inhibitors WO2000002874A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9814801.8A GB9814801D0 (en) 1998-07-09 1998-07-09 Integrin dependent cell adhesion inhibitors
GB9814801.8 1998-07-09

Publications (2)

Publication Number Publication Date
WO2000002874A2 WO2000002874A2 (en) 2000-01-20
WO2000002874A3 true WO2000002874A3 (en) 2000-02-24

Family

ID=10835162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002219 WO2000002874A2 (en) 1998-07-09 1999-07-09 Integrin dependent cell adhesion inhibitors

Country Status (2)

Country Link
GB (1) GB9814801D0 (en)
WO (1) WO2000002874A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002243692B2 (en) 2001-01-29 2006-06-08 3-Dimensional Pharmaceuticals, Inc. Substituted indoles and their use as integrin antagonists
US6872730B2 (en) 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
CN104095840B (en) * 2014-06-23 2016-04-27 西安交通大学 The application of euparin in preparation treatment ischemic cardio cerebrovascular diseases medicine
CN105919991B (en) * 2016-05-18 2019-01-15 西安交通大学 Application of the euparin in preparation medicament for treatment of depression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0132130A2 (en) * 1983-07-14 1985-01-23 Syntex (U.S.A.) Inc. Aroyl benzofuran and benzothiophene acetic and propionic acids processes for their production and pharmaceutical compositions containing them
WO1998009956A1 (en) * 1996-09-09 1998-03-12 Dainippon Pharmaceutical Co., Ltd. 2,3-dihydrobenzofuran derivative and hepatopathy remedy comprising the same as active ingredient
WO1998014440A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0132130A2 (en) * 1983-07-14 1985-01-23 Syntex (U.S.A.) Inc. Aroyl benzofuran and benzothiophene acetic and propionic acids processes for their production and pharmaceutical compositions containing them
WO1998009956A1 (en) * 1996-09-09 1998-03-12 Dainippon Pharmaceutical Co., Ltd. 2,3-dihydrobenzofuran derivative and hepatopathy remedy comprising the same as active ingredient
WO1998014440A1 (en) * 1996-10-04 1998-04-09 Eli Lilly And Company Antitumor compositions and methods of treatment

Also Published As

Publication number Publication date
GB9814801D0 (en) 1998-09-09
WO2000002874A2 (en) 2000-01-20

Similar Documents

Publication Publication Date Title
HK1044545A1 (en) Human beta-secretase enzyme, inhibitors and their compositions and uses
AU2018301A (en) Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
AU2687301A (en) Novel glycosidase inhibitors and their pharmacological uses, in particular for treating diabetes
AU7620200A (en) Compositions and methods relating to the inhibition of casomorphin and gluteomorphin
MY135732A (en) 5,6-trimethylenepyrimidin - 4 - one compounds
EP1115389A4 (en) Fructosamine oxidase: antagonists and inhibitors
AU3478100A (en) Rapid determination of present and potential battery capacity
AU5264599A (en) Thiocarboxamide derivatives and their use as inhibitors of alpha-4 integrins
WO2000071703A3 (en) Inhibition of histone deacetylase
AU1853600A (en) Method for the detection of gene transcripts in blood and uses thereof
HUP9800634A3 (en) P-amidino-benzylamide derivatives as thrombin inhibitors, intermediates and use thereof
AU6909300A (en) Substituted ureas as cell adhesion inhibitors
AU2002223647A1 (en) Aryl-substituted indirubin derivatives, the production thereof and use of the same
AU2208401A (en) Inhibitors of complement activation, their preparation and use
HK1022419A1 (en) Agent for inhibition of cytokine production and agent for inhibition of cell adhesion.
AU3716499A (en) Substituted diamines and their use as cell adhesion inhibitors
HK1041006A1 (en) Derivatives of monosaccharides as cell adhesion inhibitors.
EP1185555A4 (en) Compositions isolated from skin cells and methods for their use
AU1028601A (en) Isoquinoline and quinazoline derivatives having a combined 5ht1a, 5ht1b and 5ht1d receptor activity
AU4501199A (en) 8-phenylxanthine derivatives and their use as phosphodiesterase inhibitors
DE60005300D1 (en) 2,3-O-ISOPROYLIDENE DERIVATIVES OF MONOSACCHARIDES AND USE AS CELL ADHESION INHIBITORS
PL353214A1 (en) Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-ones and their use as lipase inhibitors
WO2000002874A3 (en) Integrin dependent cell adhesion inhibitors
AU6500600A (en) Methods and compositions for determining enzymatic activity
AU5680900A (en) Combination of mtp inhibitors and hmg-coa reductase inhibitors and the use thereof in medicaments

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase