WO2000001399A1 - Companion animal therapeutic treat - Google Patents
Companion animal therapeutic treat Download PDFInfo
- Publication number
- WO2000001399A1 WO2000001399A1 PCT/US1999/015168 US9915168W WO0001399A1 WO 2000001399 A1 WO2000001399 A1 WO 2000001399A1 US 9915168 W US9915168 W US 9915168W WO 0001399 A1 WO0001399 A1 WO 0001399A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sea cucumber
- jerky
- glucosamine
- green tea
- fractions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/616—Echinodermata, e.g. starfish, sea cucumbers or sea urchins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention involves the use of sea cucumber tissue fractions, in combination with kelp, and/or green tea extracts, for the inhibition of inflammation.
- These therapeutic fractions are incorporated with ingredients which provide palatability into a delivery system as a user- convenient and pet acceptable "jerky stick” or similar animal “treat” format.
- Dogs and other companion animals suffering from various forms of arthritis are in need of supplements which deliver active forms of anti-inflammatory agents in a palatable manner.
- Glucosamine sulfate and glucosamine HCL and related products are described in various patents such as those by Henderson, et al, which teach the incorporation of glucosamines with other sulfated polysaccharides, vitamin C and manganese in products aimed at cartilage health. It is believed that glucosamine, or similar products, provide one or more of the biochemical components which make up the matrix of mammalian cartilage.
- Glucosamine is a chondroprotective agent which acts as a competitive inhibitor of inflammatory agents produced by the body which attack the cartilage and/or joint fluid in the joints . Green tea extracts have been shown to be potent inhibitors of inflammation and collagen-induced arthritis in mice.
- EGCg epigallocatechin-3- gallate
- EGCg The inhibition of both the basal and stimulated protcoglycan degradation by EGCg was measured using a colorimetric assay for sulfated glycosaminoglycans . See, Farndale, et al., Biochem . Biophys . Acta , 4:883 (1986). The results showed that EGCg was a potent inhibitor of cartilage breakdown at the sub-cellular level.
- Jerky sticks as are known in the dog treat industry, are often combinations of meat or fish byproducts, gelatin, grains, vitamins, minerals, animal fat, preservatives such as BHT and BHA or mixed tocopherols that are mixed and extruded into various shapes, weights, and sizes which can vary widely. See, U.S. patent No. 5 ,773 , 076 for a general description of the art. Jerky sticks are given to pets as rewards or for added nutrition, or both. Both extracts from the sea cucumber and from green tea are known to have beneficial therapeutic effects in mammals. These beneficial effects could not be utilized by veterinarians and others skilled in the art of animal care because they were not available in a palatable form.
- the present invention relates to a mode of delivery for biologically active fractions of sea cucumber and green tea.
- the present invention describes a "jerky stick” or “dog bone” as is known in the art, being combined with the palatability factors of meat and meat by-products, garlic, smoke flavor or cheese, and the additional co-factors of glucosamine sulfate, glucosamine hydrochloride and/or green tea extracts or derivatives thereof for therapeutic treatment of inflammation and arthritis.
- the present invention addresses the problem of administration of anti-inflammatory treatments, specifically; sea cucumber products, glucosamines, kelps and green tea extracts by incorporating them into jerky treats with co-factors addressing the need to make the total product palatable to the animal in need.
- the sea cucumber fraction delivery system for animals of the present invention includes the combination of glucosamines and/or kelp, and/or green tea extracts in the form, of a jerky stick, or "treat", as is popular in the dog-treat industry.
- the "jerky stick" of the present invention combines certain ingredients and is made palatable by certain co-factors such as meats or flavorings known to those skilled in the art and include glucosamines or glucosamine derivatives.
- Sea cucumber body wall finely divided, including the epithelial layer, muscle layer and collagen layer as an ingredient in a formed dog jerky stick is also an aspect of the present invention.
- These total sea cucumber skin fractions are also incorporated with glucosamines described above and formed in various percentages of incorporation into jerky sticks with palatability factors such as beef, meat meal and meat by-products or other flavor-bearing compounds.
- a suitable range of glucosamine concentration is between 1% and 50% of the final product (by weight) .
- These jerky sticks or manufactured “treats" are administered to dogs, cats and other animals and provide increased attractiveness to those animals in need of the therapeutic ingredients .
- the term “B1000” refers to the isolated epithelial layer of the sea cucumber, substantially free of the flower portion, muscle, collagenous tissues and viscera;
- T2000 refers to the isolated flower portion of the sea cucumber, substantially free of other portions of the sea cucumber body;
- derivative refers to any compound, fraction or combination thereof, derived from a sea cucumber or green tea fraction that has biological activity or nutritional properties;
- inflammation disorder refers to any condition or disease in a warm-blooded animal having inflammation as a symptom or proximate cause.
- the delivery form "jerky treat” material contains the sea cucumber fractions as disclosed in U.S. patent No. 5,770,205.
- Active anti-inflammatory compositions can be obtained from sea cucumber in a variety of ways. For example, sea cucumbers can first be cleaned of muscle bands and viscera, boiled (but not salted) , preferably for about ⁇ hour, and then dried, preferably in low-heat mechanical driers such as those employing "heat pump” technology. The dried tissue can further be ground or divided as needed for ultimate use. This process decreases the sodium content of the tissue and helps protect various active ingredients from degradation.
- This fraction can be formulated and used directly as an anti-inflammatory composition.
- Another active fraction can be obtained from the flower portion of the sea cucumber.
- the anterior portion ("flower") of the sea cucumber is cut away from the viscera and body wall.
- the isolated flower is then heated, preferably for about ⁇ hour, dried at low temperatures (e.g. between about 140°F and about 180°F using conventional drying apparatus and per se known techniques) .
- This dried fraction designated "T2000" by the inventor, can then be ground or divided as needed for formulation and use directly as an anti- inflammatory composition.
- Still another anti-inflammatory fraction can be obtained from the epithelial layer of the sea cucumber body wall.
- Muscle, viscera and flower are removed as described above, followed by isolation of the epithelial layer of the sea cucumber body wall from the harder collagenous layers beneath, preferably by one or more of the following means: - heating the body-wall in water at temperatures from about 140°F to about 180°F, preferably at about 170°F, followed by mechanical separation by hand or machine (e.g. , using machines known in the art as mincers or de-boners, which detect tissue density and separate harder tissues from softer tissues) ;
- - enzymatic hydrolytic separation using, e.g., organism's own digestive tract enzymes, proteases from mammalian sources, proteases from non- mammalian sources or acidic hydrolazes, preferably Alcalase (NOVO Nordisk Bio Chem, North Carolina) , the enzyme preferably being in a solution of about 1% to about 10% enzyme, most preferably in a solution of about 10% enzyme; - scouring/scrubbing or de-boning processes known to those skilled in the potato or chicken processing arts. Heating in water, followed by mechanical separation using a de-boner is most preferred.
- the epithelial fraction so obtained (designated "B1000” by the inventor) is a dark, moist, viscous, carbohydrate-rich matter. B1000 can be dried as described above, formulated and used directly as an anti-inflammatory composition.
- the B1000 and/or T2000 fractions, other sea cucumber tissues, and kelp are incorporated into the mixture for the preparation of the "jerky treats" in amounts between 1% and 80% by weight.
- These therapeutic constituents are then added to the combinations of meat or fish by-products, gelatin, grains, vitamins, minerals, animal fat, preservatives such as BHT and BHA or mixed tocopherols and palatability factors such as beef, meat meal and meat by-products or other flavor-bearing compounds that are mixed and extruded into various shapes, weights, and sizes which can vary widely.
- green tea or green tea extracts are added to the formulation.
- Green tea is known to contain potent inhibitors of cartilage degradation, for example EGCg, and is a useful adjunct for treating individuals with inflammatory diseases, such as arthritis, that can lead to cartilage degradation.
- Green tea can be water and alcohol extracted by methods known in the art whereby the phenolic fraction is between 30% and 70%.
- Green tea extracts having 30%, 50%, 60% and 100% enriched polyphenolics, or specifically green tea catechins, are available commercially and are suitable for use in the present invention. Extracts are incorporated into the "jerky stick" of the present invention at percentages of weight between 1% and 80% of the total "jerky stick” delivery form.
- the pure compound EGCg can be added directly to the "jerky stick" formulation in amounts ranging up to 60% by weight or more, limited by factors such as LD 50 and the physical considerations of maintaining a palatable consistency to the product.
- Jerky sticks were prepared using T2000 from the Sea Cucumber, Cucumaria frondosa, as described above.
- T2000 together with various palatability factors including, but not limited to, meat, meat by-products and "Norwegian" kelp, Ascophylum nodosum, were added to vitamin E, garlic, lecithin, gelatin, glucosamine (as a hydrochloride salt, although the sulfate salt or any other suitable form) and flax seeds.
- the T2000 was added at about 8% of the final treat product by weight.
- the glucosamine constituent was added at 2% of the final treat product by weight.
- the ingredient mix was then extruded and molded into a jerky stick shape 5 inches long, 1.25 inches wide and approximately 0.25 inches thick, with final weight of 14 grams.
- Example 2 Example 2
- the jerky stick was produced as in Example 1, with the addition of a green tea extract containing 30% polyphenolics.
- the green tea extract purchased from Indena USA. Seattle WA, USA, Product 36TVD0090-"THE VERT" AQ-ATO-HF, was added to the above recipe at 2% by weight, but can be added at any percentage of the jerky stick weight between 1% and 30% (limited by palatability) .
- the epigallocatechin- 3-gallate (EGCg) is absorbed systemically in mammals, and is effective in inhibiting degradation of cartilage in arthritic joints.
- EGCg is thought to provide added synergy to the anti-inflammatory activity of the sea cucumber and the sea cucumber plus glucosamine compounds.
- Jerky sticks with added green tea extracts were administered to 4 dogs of unknown breeds at Westside Animal Clinic in Richmond, IN and were found to be palatable.
- Example 1 Six arthritic dogs in various conditions of lameness were administered jerky sticks as prepared in Example 1. After two weeks of administration at one stick per day per 50 pounds of weight, these dogs showed increased mobility as determined by both their owners and veterinarians. In every instance, palatability was not a problem in administration of the jerky.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000557845A JP2002519384A (en) | 1998-07-07 | 1999-07-06 | Pet remedies |
AU49694/99A AU770392B2 (en) | 1998-07-07 | 1999-07-06 | Companion animal therapeutic treat |
US09/743,449 US6428817B1 (en) | 1999-07-06 | 1999-07-06 | Companion animal therapeutic treat |
GB0100640A GB2355196B (en) | 1998-07-07 | 1999-07-06 | Companion animal therapeutic treat |
CA2336602A CA2336602C (en) | 1998-07-07 | 1999-07-06 | Companion animal therapeutic treat |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9441898P | 1998-07-07 | 1998-07-07 | |
US60/094,418 | 1998-07-07 | ||
US13769999P | 1999-06-07 | 1999-06-07 | |
US60/137,699 | 1999-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000001399A1 true WO2000001399A1 (en) | 2000-01-13 |
Family
ID=26788849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/015168 WO2000001399A1 (en) | 1998-07-07 | 1999-07-06 | Companion animal therapeutic treat |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2002519384A (en) |
AU (1) | AU770392B2 (en) |
CA (1) | CA2336602C (en) |
GB (1) | GB2355196B (en) |
WO (1) | WO2000001399A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000044375A1 (en) * | 1999-01-29 | 2000-08-03 | Mars Uk Limited | Antioxidant compositions and methods for companion animals |
WO2001082719A1 (en) * | 2000-05-01 | 2001-11-08 | The Iams Company | Process for enhancing immune response in canines using a dietary composition including garlic |
GB2367489A (en) * | 2000-07-31 | 2002-04-10 | Mars Inc | Anti-oxidant compositions for companion animals |
JP2003082152A (en) * | 2001-09-11 | 2003-03-19 | Koken Co Ltd | Sponge composed of collagen of sea cucumbers or starfishes and its manufacturing method |
EP1308095A1 (en) * | 2001-10-31 | 2003-05-07 | Earl Moulin du Chatel | Feed for laying hens which produces eggs enriched in iodine and polyunsaturated fatty acids and corresponding feeding method |
US6689391B2 (en) | 2001-03-30 | 2004-02-10 | Council Of Scientific & Industrial Research | Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses |
JP2004532212A (en) * | 2001-04-05 | 2004-10-21 | ニュー・チャプター・インコーポレーテッド | Improved anti-inflammatory herbal compositions and methods of use |
US6916492B2 (en) | 2001-03-30 | 2005-07-12 | Council Of Scientific & Industrial Research | Natural nontoxic multicolor fluorescent protein dye from a marine invertebrate, compositions containing the said dye and its uses |
CN102934819A (en) * | 2012-10-26 | 2013-02-20 | 青岛佳日隆海洋食品有限公司 | Trepang capsule and preparation process thereof |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050108423A (en) * | 2003-04-11 | 2005-11-16 | 교와 핫꼬 고교 가부시끼가이샤 | Preventive or remedy for arthritis |
GB201414910D0 (en) * | 2014-05-23 | 2014-10-08 | Mars Inc | Composition |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3683076A (en) * | 1968-10-26 | 1972-08-08 | Luigi Rovati | Pharmaceutically active glucosamine salts useful in the treatment of osteoarthritis and rheumatoid arthritis |
US5681569A (en) * | 1994-06-03 | 1997-10-28 | The Procter & Gamble Company | Beverage compositions containing green tea solids, electrolytes and carbohydrates to provide improved cellular hydration and drinkability |
US5770205A (en) * | 1996-08-05 | 1998-06-23 | Coastside Bio Resources | Tissue fractions of sea cucumber for the treatment of inflammation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975270A (en) * | 1987-04-21 | 1990-12-04 | Nabisco Brands, Inc. | Elastomer encased active ingredients |
JPH0491027A (en) * | 1990-08-02 | 1992-03-24 | Taiho Yakuhin Kogyo Kk | Therapeutic agent of human immune deficiency virus |
JPH04117329A (en) * | 1990-09-05 | 1992-04-17 | Shiseido Co Ltd | Composition showing activity related to dissolution of thrombosis |
CN1050680A (en) * | 1990-10-05 | 1991-04-17 | 刘辉明 | The manufacture method of Haicibao liquid |
CN1045538C (en) * | 1993-08-04 | 1999-10-13 | 成都市疑难病研究所 | Natural composition oral medicine for treating male sterility |
US5474033A (en) * | 1994-05-05 | 1995-12-12 | Mitchell, Jr.; Robert K. | Animal teaching/amusement device |
FR2745978B1 (en) * | 1996-03-18 | 1998-07-17 | ORAL TREATMENT PRODUCT FOR ANIMALS | |
US5888514A (en) * | 1997-05-23 | 1999-03-30 | Weisman; Bernard | Natural composition for treating bone or joint inflammation |
-
1999
- 1999-07-06 JP JP2000557845A patent/JP2002519384A/en not_active Withdrawn
- 1999-07-06 CA CA2336602A patent/CA2336602C/en not_active Expired - Fee Related
- 1999-07-06 GB GB0100640A patent/GB2355196B/en not_active Expired - Fee Related
- 1999-07-06 WO PCT/US1999/015168 patent/WO2000001399A1/en active IP Right Grant
- 1999-07-06 AU AU49694/99A patent/AU770392B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3683076A (en) * | 1968-10-26 | 1972-08-08 | Luigi Rovati | Pharmaceutically active glucosamine salts useful in the treatment of osteoarthritis and rheumatoid arthritis |
US5681569A (en) * | 1994-06-03 | 1997-10-28 | The Procter & Gamble Company | Beverage compositions containing green tea solids, electrolytes and carbohydrates to provide improved cellular hydration and drinkability |
US5770205A (en) * | 1996-08-05 | 1998-06-23 | Coastside Bio Resources | Tissue fractions of sea cucumber for the treatment of inflammation |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000044375A1 (en) * | 1999-01-29 | 2000-08-03 | Mars Uk Limited | Antioxidant compositions and methods for companion animals |
GB2366179A (en) * | 1999-01-29 | 2002-03-06 | Mars Uk Ltd | Antioxidant compositions and methods for companion animals |
GB2366179B (en) * | 1999-01-29 | 2003-04-16 | Mars Uk Ltd | Antioxidant compositions and methods for companion animals |
WO2001082719A1 (en) * | 2000-05-01 | 2001-11-08 | The Iams Company | Process for enhancing immune response in canines using a dietary composition including garlic |
US6641836B2 (en) | 2000-05-01 | 2003-11-04 | The Procter & Gamble Company | Process for enhancing immune response in canines using a dietary composition including garlic |
GB2367489A (en) * | 2000-07-31 | 2002-04-10 | Mars Inc | Anti-oxidant compositions for companion animals |
GB2367489B (en) * | 2000-07-31 | 2005-02-09 | Mars Inc | Use of antioxidants |
US6916492B2 (en) | 2001-03-30 | 2005-07-12 | Council Of Scientific & Industrial Research | Natural nontoxic multicolor fluorescent protein dye from a marine invertebrate, compositions containing the said dye and its uses |
US6689391B2 (en) | 2001-03-30 | 2004-02-10 | Council Of Scientific & Industrial Research | Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses |
JP2004532212A (en) * | 2001-04-05 | 2004-10-21 | ニュー・チャプター・インコーポレーテッド | Improved anti-inflammatory herbal compositions and methods of use |
JP2003082152A (en) * | 2001-09-11 | 2003-03-19 | Koken Co Ltd | Sponge composed of collagen of sea cucumbers or starfishes and its manufacturing method |
EP1308095A1 (en) * | 2001-10-31 | 2003-05-07 | Earl Moulin du Chatel | Feed for laying hens which produces eggs enriched in iodine and polyunsaturated fatty acids and corresponding feeding method |
CN102934819A (en) * | 2012-10-26 | 2013-02-20 | 青岛佳日隆海洋食品有限公司 | Trepang capsule and preparation process thereof |
Also Published As
Publication number | Publication date |
---|---|
GB2355196A (en) | 2001-04-18 |
CA2336602A1 (en) | 2000-01-13 |
AU4969499A (en) | 2000-01-24 |
JP2002519384A (en) | 2002-07-02 |
AU770392C (en) | 2000-01-24 |
GB0100640D0 (en) | 2001-02-21 |
CA2336602C (en) | 2010-11-02 |
GB2355196B (en) | 2004-06-09 |
AU770392B2 (en) | 2004-02-19 |
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