WO1999066780A3 - Cinoxacin lanthanide chelates and their use as biomolecular probes - Google Patents

Cinoxacin lanthanide chelates and their use as biomolecular probes Download PDF

Info

Publication number
WO1999066780A3
WO1999066780A3 PCT/EP1999/004277 EP9904277W WO9966780A3 WO 1999066780 A3 WO1999066780 A3 WO 1999066780A3 EP 9904277 W EP9904277 W EP 9904277W WO 9966780 A3 WO9966780 A3 WO 9966780A3
Authority
WO
WIPO (PCT)
Prior art keywords
cinoxacin
lanthanide chelates
biomolecular probes
lanthanide
biomolecular
Prior art date
Application number
PCT/EP1999/004277
Other languages
French (fr)
Other versions
WO1999066780A2 (en
Inventor
Colin Andrew Leach
Keith James Millan Moore
Steven James Stanway
Original Assignee
Smithkline Beecham Plc
Colin Andrew Leach
Keith James Millan Moore
Steven James Stanway
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Colin Andrew Leach, Keith James Millan Moore, Steven James Stanway filed Critical Smithkline Beecham Plc
Priority to DE69929051T priority Critical patent/DE69929051T2/en
Priority to EP99931117A priority patent/EP1090007B1/en
Priority to US09/720,172 priority patent/US6441167B1/en
Priority to CA002335610A priority patent/CA2335610A1/en
Priority to JP2000555481A priority patent/JP2002518413A/en
Publication of WO1999066780A2 publication Critical patent/WO1999066780A2/en
Publication of WO1999066780A3 publication Critical patent/WO1999066780A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Abstract

This invention relates to novel compounds that can complex with lanthanide cations, processes for their preparation and the use of the resulting lanthanide chelates as biomolecular probes.
PCT/EP1999/004277 1998-06-25 1999-06-18 Cinoxacin lanthanide chelates and their use as biomolecular probes WO1999066780A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69929051T DE69929051T2 (en) 1998-06-25 1999-06-18 LANTHANIDECHELATE OF CINOXACIN AND ITS USE AS BIOMOLECULAR SAMPLE
EP99931117A EP1090007B1 (en) 1998-06-25 1999-06-18 Cinoxacin lanthanide chelates and their use as biomolecular probes
US09/720,172 US6441167B1 (en) 1998-06-25 1999-06-18 Cinoxacin lanthanide chelates and their use as biomolecular probes
CA002335610A CA2335610A1 (en) 1998-06-25 1999-06-18 Novel compounds
JP2000555481A JP2002518413A (en) 1998-06-25 1999-06-18 New compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813776.3A GB9813776D0 (en) 1998-06-25 1998-06-25 Novel compounds
GB9813776.3 1998-06-25

Publications (2)

Publication Number Publication Date
WO1999066780A2 WO1999066780A2 (en) 1999-12-29
WO1999066780A3 true WO1999066780A3 (en) 2000-02-03

Family

ID=10834399

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/004277 WO1999066780A2 (en) 1998-06-25 1999-06-18 Cinoxacin lanthanide chelates and their use as biomolecular probes

Country Status (8)

Country Link
US (1) US6441167B1 (en)
EP (1) EP1090007B1 (en)
JP (1) JP2002518413A (en)
CA (1) CA2335610A1 (en)
DE (1) DE69929051T2 (en)
ES (1) ES2253899T3 (en)
GB (1) GB9813776D0 (en)
WO (1) WO1999066780A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740756B1 (en) 1998-07-07 2004-05-25 Smithkline Beecham Corporation Fluorescent lanthanide chelates
EP1095011A4 (en) * 1998-07-07 2003-01-08 Smithkline Beecham Corp Novel fluorescent lanthanide chelates
AUPP856399A0 (en) * 1999-02-08 1999-03-04 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
JP2006022123A (en) * 2002-06-27 2006-01-26 Ajinomoto Co Inc Chelating agent
CN107954893A (en) * 2017-11-28 2018-04-24 兰州纬寰生物科技有限公司 Anthranilamide derivatives and preparation method and purposes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2065719A1 (en) * 1969-02-04 1975-03-20 Lilly Co Eli 1-LOWER ALKYL OR ALKENYL SUBSTITUTED 6,7-METHYLENE DIOXY-4 (1H) -OXOCINNOLIN-3-CARBONITRILE
DD207098A3 (en) * 1981-12-22 1984-02-15 Schmidt Hans Joerg PROCESS FOR THE PREPARATION OF 1-ALKYL-6,7-METHYLENDIOXY-4 (1H) -OXO-CINNOLINE-3-CARBONSAEURES
WO1996000901A1 (en) * 1994-06-29 1996-01-11 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
US5571897A (en) * 1991-12-05 1996-11-05 Wallac Oy Luminescent lanthanide chelates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE207098C (en) 1908-03-06 1909-02-16 Koppers Gmbh Heinrich Process for producing luminous gas by distilling hard coal and adding a cheaper gas to the hard coal gas.
US4379929A (en) * 1981-03-19 1983-04-12 Eli Lilly And Company 4(1H)-Oxocinnoline-3-carboxylic acid derivatives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2065719A1 (en) * 1969-02-04 1975-03-20 Lilly Co Eli 1-LOWER ALKYL OR ALKENYL SUBSTITUTED 6,7-METHYLENE DIOXY-4 (1H) -OXOCINNOLIN-3-CARBONITRILE
DD207098A3 (en) * 1981-12-22 1984-02-15 Schmidt Hans Joerg PROCESS FOR THE PREPARATION OF 1-ALKYL-6,7-METHYLENDIOXY-4 (1H) -OXO-CINNOLINE-3-CARBONSAEURES
US5571897A (en) * 1991-12-05 1996-11-05 Wallac Oy Luminescent lanthanide chelates
WO1996000901A1 (en) * 1994-06-29 1996-01-11 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
US5639615A (en) * 1994-06-29 1997-06-17 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
US5656433A (en) * 1994-06-29 1997-08-12 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TARO IZUMI ET AL.: "Protein Binding of Quinolonecarboxylic Acids. II", CHEM PHARM. BULL., vol. 37, no. 3, 1989, Japan, pages 746 - 752, XP002124240 *

Also Published As

Publication number Publication date
GB9813776D0 (en) 1998-08-26
CA2335610A1 (en) 1999-12-29
US6441167B1 (en) 2002-08-27
WO1999066780A2 (en) 1999-12-29
DE69929051T2 (en) 2006-07-13
JP2002518413A (en) 2002-06-25
ES2253899T3 (en) 2006-06-01
EP1090007A2 (en) 2001-04-11
EP1090007B1 (en) 2005-12-21
DE69929051D1 (en) 2006-01-26

Similar Documents

Publication Publication Date Title
WO1999054326A8 (en) Dihydropyrimidines
MXPA03007983A (en) Process for the preparation of middle distillates.
EP0978282A3 (en) Sublingual composition containing apomorphine for diagnosing functional impotence
CA2352505A1 (en) Epothilone derivatives and their use as antitumor agents
WO2002041889A3 (en) Indolsulfonyl compounds useful in the treatment of cns disorders
YU28199A (en) A novel compound form
CA2278201A1 (en) Novel modifications to 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonyl-aminobenzene, and processes for their preparation
CA2378148A1 (en) Nematicidal trifluorobutenes
IN2012DE00109A (en)
WO2002085843A3 (en) Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds
HUP0303487A3 (en) Compositions containing 3,7-diazabicyclo [3,3,1] compounds as anthiarhythmic agents and process for preparation of the compounds
CA2362698A1 (en) Resorcinol derivatives
HK1068329A1 (en) Process for the preparation of 2,6-naphthalenedicarboxylic acid
IL157709A0 (en) Process for the preparation of 1,2-benzisoxazole-3-acetic acid
WO1999066780A3 (en) Cinoxacin lanthanide chelates and their use as biomolecular probes
WO2002024867A3 (en) Novel compositions and methods for lymphoma and leukemia
CA2270301A1 (en) Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for their preparation
WO2000059862A3 (en) Processes for preparing pesticidal intermediates
GB2343892B (en) Process for the preparation of d,l-menthol
WO1999048851A3 (en) Processes for preparing intermediates
HUP0303486A3 (en) Compositions containing 3,7-diazabicyclo [3,3,1] compounds as anti-arrythmic compounds agents
HUP0402475A3 (en) Process for the preparation of [1,4,5]-oxadiazepine derivatives
ZA968550B (en) Novel processes for the preparation of anti-malarial compounds.
WO2000006575A3 (en) Azabicyclic compounds
WO1998048844A3 (en) Ion paris, method for the production and use thereof as contrast agents

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2335610

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1999931117

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09720172

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999931117

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: CA

WWG Wipo information: grant in national office

Ref document number: 1999931117

Country of ref document: EP