WO1999063834A1 - Cheese flavour - Google Patents
Cheese flavour Download PDFInfo
- Publication number
- WO1999063834A1 WO1999063834A1 PCT/EP1999/003933 EP9903933W WO9963834A1 WO 1999063834 A1 WO1999063834 A1 WO 1999063834A1 EP 9903933 W EP9903933 W EP 9903933W WO 9963834 A1 WO9963834 A1 WO 9963834A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cheese
- process according
- weight
- lipase
- flavour
- Prior art date
Links
- 235000013351 cheese Nutrition 0.000 title claims abstract description 53
- 239000000796 flavoring agent Substances 0.000 title claims abstract description 28
- 235000019634 flavors Nutrition 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 22
- 108091005804 Peptidases Proteins 0.000 claims abstract description 19
- 239000004365 Protease Substances 0.000 claims abstract description 15
- 102000004882 Lipase Human genes 0.000 claims abstract description 14
- 108090001060 Lipase Proteins 0.000 claims abstract description 14
- 239000004367 Lipase Substances 0.000 claims abstract description 14
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 14
- 235000019421 lipase Nutrition 0.000 claims abstract description 14
- 235000019419 proteases Nutrition 0.000 claims abstract description 14
- 230000005070 ripening Effects 0.000 claims abstract description 12
- 240000002605 Lactobacillus helveticus Species 0.000 claims abstract description 10
- 235000013967 Lactobacillus helveticus Nutrition 0.000 claims abstract description 10
- 229940054346 lactobacillus helveticus Drugs 0.000 claims abstract description 10
- 235000021116 parmesan Nutrition 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- 229940040461 lipase Drugs 0.000 claims description 13
- 241000194035 Lactococcus lactis Species 0.000 claims description 9
- 235000014897 Streptococcus lactis Nutrition 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 235000013305 food Nutrition 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 102000029813 Gastric triacylglycerol lipase Human genes 0.000 claims description 4
- 102000019280 Pancreatic lipases Human genes 0.000 claims description 4
- 108050006759 Pancreatic lipases Proteins 0.000 claims description 4
- 238000000855 fermentation Methods 0.000 claims description 4
- 230000004151 fermentation Effects 0.000 claims description 4
- 108010091264 gastric triacylglycerol lipase Proteins 0.000 claims description 4
- 229940116369 pancreatic lipase Drugs 0.000 claims description 4
- 108090000145 Bacillolysin Proteins 0.000 claims description 3
- 102000035092 Neutral proteases Human genes 0.000 claims description 3
- 108091005507 Neutral proteases Proteins 0.000 claims description 3
- 238000011534 incubation Methods 0.000 claims description 3
- 238000009928 pasteurization Methods 0.000 claims description 3
- 230000002538 fungal effect Effects 0.000 claims description 2
- 239000002002 slurry Substances 0.000 description 15
- 235000015067 sauces Nutrition 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 5
- 102000035195 Peptidases Human genes 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 108010009355 microbial metalloproteinases Proteins 0.000 description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 230000002366 lipolytic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 229940069338 potassium sorbate Drugs 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 235000011888 snacks Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 210000003165 abomasum Anatomy 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 108010007119 flavourzyme Proteins 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
- A23C19/063—Addition of, or treatment with, enzymes or cell-free extracts of microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
- A23C19/061—Addition of, or treatment with, microorganisms
- A23C19/062—Addition of, or treatment with, microorganisms using only lactic acid bacteria, e.g. pediococcus, leconostoc or bifidus sp., or propionic acid bacteria; Treatment with non-specified acidifying bacterial cultures
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/24—Synthetic spices, flavouring agents or condiments prepared by fermentation
- A23L27/25—Dairy flavours
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/157—Lactis
Definitions
- the present invention relates to the production of a cheese flavour more particularly to a natural intensified Parmesan or cheese flavour produced from cheese curds or cheese blocks.
- the product can be used to impart a cheese-like flavour to culinary products such as sauces, snacks, etc.
- Japanese Examined Patent No.54-24459 describes a method of producing a desirable cheese flavour in which cheese curd or crumbled green cheese is subjected to the action of proteolytic enzymes and lactic acid bacteria by accomplishing maturation in a short time.
- Japanese Patent Application No. 59-113869 describes a method for producing a strong cheese flavour by acting a proteolytic enzyme, a lipolytic enzyme and lactic acid bacteria on cheese curd or crumbled cheese, neutral protease produced by PeniciUium camemberti being used as the proteolytic enzyme and an esterase from the abomasum of a young mammal being used as the lipolytic enzyme.
- a strong cheese flavour is said to be produced without any unacceptable bitterness.
- the fermentation is stated to be carried out over a period of from 7-10 days.
- a strong flavour without bitterness may be produced in less than 6 days.
- a process for the preparation of a Parmesan or cheese flavour which comprises ripening cheese curds with a protease, lipase and Lactobacillus helveticus and/or Lactococcus lactis.
- the cheese curds are preferably cheddar cheese curds, or Cheddar or Parmesan cheese blocks.
- the protease is preferably a neutral protease, e.g. Protease P Amano 6 manufactured by the Amano Enzyme Co., or Neutrase or Flavourzyme manufactured by Novo Nordisk, Inc.
- a mixture of one or more proteases may be used if desired. Salt may be added, if desired.
- the lipase may be pancreatic lipase, pregastric esterase or a fungal lipase such as Palatase 20,000L manufactured by Novo Nordisk Inc. or any mixture thereof.
- pregastric esterase hydrolyses the cheese curds to give free fatty acids of low molecular weight such as caproic acid and butyric acid which generate a desirable intense cheese flavour.
- the temperature of the ripening may be from 20° to 45°C and preferably from 30° to 40°C.
- the duration of the ripening may conveniently from 2 to 5 days.
- the cheese curds are preferably slurried, for instance, in a liquefier with or without the addition of water.
- the protease and the lipase may be added to the curds, advantageously with agitation.
- the protease is added before the lipase.
- the Lactobacillus helveticus and/or Lactococcus lactis is added last.
- the mixture is then ripened in a fermentation vessel with agitation. After ripening, sodium chloride may be added, if desired.
- a preservative agent such as potassium sorbate may be added, if desired. Consistency of the product can be stabilized by the addition of xanthan gum, if desired.
- the slurry is advantageously pasteurized, e.g. at 95°C for from 5 to 20 minutes.
- the pH may be adjusted to 4.2 to 4.4, preferably with phosphoric acid.
- the product is conveniently cooled, e.g. to a temperature of from 4° to 10°C to give a product having the consistency of a paste.
- the amount of cheese curds used may be from 50 to 90% by weight, the amount of water may be from 5 to 50% by weight, the amount of protease may be from 0.1 to 1.0% by weight and preferably from 0.15 to 0.75% by weight, the amount of lipase may be from 0.1 to 1.0% by weight and preferably from 0.2 to 0.75% by weight, and the amount of Lactobacillus helveticus and/or Lactococcus lactis may be from 0.2 to 2.5 % by weight preferably from 0.4 to 2% by weight, all based on the total weight of the flavour.
- the product may be used as a paste or dried and used as a powder.
- the drying is preferably achieved by spray drying, using a carrier, for instance, maltodextrin in an amount of from 20 to 40% by weight based on the weight of the paste.
- the moisture content of the final powder is usually from about 2.0 to 4.0% by weight.
- the cheese flavor of the present invention may be incorporated in culinary food products, e.g. sauces, snacks, etc.
- the amount of cheese flavor used may be from 0.5 to 1.25%o by weight in the paste form and from 0.2 to 0.6% by weight in the powder form based on the total weight of the food product.
- the present invention therefore also provides a culinary food product containing a cheese flavor obtainable by the above described process according to the invention.
- the pH is 5.2 at 25°C and the moisture content is 51.7%.
- the product has a characteristic sharp Parmesan flavour.
- the slurry is incorporated into Alfredo sauce in an amount of from 0.8 to 1.2% by weight based on the total weight of the sauce. It was found that the flavor was just as good when the amount of Parmesan cheese was reduced to 6% by weight as an Alfredo sauce which normally contains about 12% by weight of Parmesan cheese.
- the slurry is incorporated into Cheddar cheese sauce in an amount of from 0.8 to 1.0%) by weight based on the total weight of the sauce. It was found that the flavor 5 was just as good when the amount of Cheddar cheese was reduced to 26% by weight as an Cheddar cheese sauce which normally contains about 33% by weight of Cheddar cheese.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
- Dairy Products (AREA)
- Seasonings (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69906730T DE69906730T2 (en) | 1998-06-11 | 1999-06-08 | Production of cheese flavor |
CA002332358A CA2332358A1 (en) | 1998-06-11 | 1999-06-08 | Cheese flavour |
AT99927910T ATE236533T1 (en) | 1998-06-11 | 1999-06-08 | PRODUCTION OF CHEESE FLAVOR |
AU45091/99A AU755761B2 (en) | 1998-06-11 | 1999-06-08 | Cheese flavour |
EP99927910A EP1085817B1 (en) | 1998-06-11 | 1999-06-08 | Production of cheese flavour |
HK01106128A HK1035469A1 (en) | 1998-06-11 | 2001-08-29 | Production of cheese flavour |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/096,069 US6054151A (en) | 1998-06-11 | 1998-06-11 | Cheese flavor |
US09/096,069 | 1998-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999063834A1 true WO1999063834A1 (en) | 1999-12-16 |
WO1999063834B1 WO1999063834B1 (en) | 2000-03-02 |
Family
ID=22255102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/003933 WO1999063834A1 (en) | 1998-06-11 | 1999-06-08 | Cheese flavour |
Country Status (12)
Country | Link |
---|---|
US (1) | US6054151A (en) |
EP (2) | EP1219176A3 (en) |
AR (1) | AR019658A1 (en) |
AT (1) | ATE236533T1 (en) |
AU (1) | AU755761B2 (en) |
CA (1) | CA2332358A1 (en) |
CO (1) | CO5050306A1 (en) |
DE (1) | DE69906730T2 (en) |
ES (1) | ES2194470T3 (en) |
HK (1) | HK1035469A1 (en) |
MY (1) | MY115488A (en) |
WO (1) | WO1999063834A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102144673A (en) * | 2011-03-03 | 2011-08-10 | 天津科技大学 | Method for preparing cheese flavor pulp by enzymatic method |
US8703217B2 (en) | 2006-03-31 | 2014-04-22 | Kraft Foods Group Brands Llc | Methods for rapid production and usage of biogenerated flavors |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG106572A1 (en) * | 1999-12-02 | 2004-10-29 | Nestle Sa | Production of hydrolysate seasoning |
US6406724B1 (en) | 2000-09-12 | 2002-06-18 | Kraft Foods Holdings, Inc. | Natural biogenerated cheese flavoring system |
NZ515881A (en) * | 2001-12-03 | 2004-09-24 | New Zealand Dairy Board | Cheese flavour ingredient and method of its production |
EP1492409A2 (en) * | 2002-04-03 | 2005-01-05 | Chr. Hansen A/S | Peptides with anti-hypertensive properties |
US6562383B1 (en) * | 2002-04-26 | 2003-05-13 | Kraft Foods Holdings, Inc. | Process for producing flavored cheese without curing |
US7718171B2 (en) * | 2003-04-07 | 2010-05-18 | Chr. Hansen A/S | Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus |
US7556833B2 (en) * | 2003-11-26 | 2009-07-07 | Kraft Foods Global Brands Llc | Cheese flavoring systems prepared with bacteriocins |
NZ534008A (en) * | 2004-07-09 | 2006-04-28 | Fonterra Co Operative Group | Dairy product and process |
US7091001B2 (en) * | 2004-07-30 | 2006-08-15 | Council Of Scientific & Industrial Research | Process for the preparation of high arginine peptides |
CN102742816A (en) * | 2011-04-21 | 2012-10-24 | 上海爱普植物科技有限公司 | Method for preparation of natural cheese essence with whey powder |
EP3434107A1 (en) | 2017-07-28 | 2019-01-30 | optiferm GmbH | Lipases from basidiomycetes for use in cheese dairy |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59113869A (en) * | 1982-12-21 | 1984-06-30 | Snow Brand Milk Prod Co Ltd | Formation of cheese flavor having strong taste |
US4595594A (en) * | 1983-09-19 | 1986-06-17 | Stauffer Chemical Company | Process for preparing intensified cheese flavor product |
US4707364A (en) * | 1984-01-27 | 1987-11-17 | Miles Laboratories, Inc. | Composition for accelerating cheese aging |
US4752483A (en) * | 1986-05-30 | 1988-06-21 | Campbell Soup Company | Method for producing a highly flavored cheese ingredient |
EP0777970A2 (en) * | 1995-12-05 | 1997-06-11 | Kraft Foods, Inc. | Manufacture of particulate natural cheese without block formation |
-
1998
- 1998-06-11 US US09/096,069 patent/US6054151A/en not_active Expired - Fee Related
-
1999
- 1999-05-10 MY MYPI99001845A patent/MY115488A/en unknown
- 1999-06-08 DE DE69906730T patent/DE69906730T2/en not_active Expired - Fee Related
- 1999-06-08 WO PCT/EP1999/003933 patent/WO1999063834A1/en active IP Right Grant
- 1999-06-08 CA CA002332358A patent/CA2332358A1/en not_active Abandoned
- 1999-06-08 AU AU45091/99A patent/AU755761B2/en not_active Ceased
- 1999-06-08 EP EP02076192A patent/EP1219176A3/en not_active Withdrawn
- 1999-06-08 EP EP99927910A patent/EP1085817B1/en not_active Expired - Lifetime
- 1999-06-08 AT AT99927910T patent/ATE236533T1/en not_active IP Right Cessation
- 1999-06-08 ES ES99927910T patent/ES2194470T3/en not_active Expired - Lifetime
- 1999-06-09 CO CO99036165A patent/CO5050306A1/en unknown
- 1999-06-11 AR ARP990102807A patent/AR019658A1/en unknown
-
2001
- 2001-08-29 HK HK01106128A patent/HK1035469A1/en not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59113869A (en) * | 1982-12-21 | 1984-06-30 | Snow Brand Milk Prod Co Ltd | Formation of cheese flavor having strong taste |
US4595594A (en) * | 1983-09-19 | 1986-06-17 | Stauffer Chemical Company | Process for preparing intensified cheese flavor product |
US4707364A (en) * | 1984-01-27 | 1987-11-17 | Miles Laboratories, Inc. | Composition for accelerating cheese aging |
US4752483A (en) * | 1986-05-30 | 1988-06-21 | Campbell Soup Company | Method for producing a highly flavored cheese ingredient |
EP0777970A2 (en) * | 1995-12-05 | 1997-06-11 | Kraft Foods, Inc. | Manufacture of particulate natural cheese without block formation |
Non-Patent Citations (3)
Title |
---|
CHEMICAL ABSTRACTS, vol. 107, no. 13, 1987, Columbus, Ohio, US; abstract no. 114460h, K. KATAOKA: "Accelerated cheese ripening by added enzymes with special reference to chemical properties" XP002118237 * |
NIPPON CHIKUSAN GAKKAIHO, vol. 58, no. 2, 1987, pages 107 - 115 * |
PATENT ABSTRACTS OF JAPAN vol. 008, no. 232 (C - 248) 25 October 1984 (1984-10-25) * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8703217B2 (en) | 2006-03-31 | 2014-04-22 | Kraft Foods Group Brands Llc | Methods for rapid production and usage of biogenerated flavors |
CN102144673A (en) * | 2011-03-03 | 2011-08-10 | 天津科技大学 | Method for preparing cheese flavor pulp by enzymatic method |
Also Published As
Publication number | Publication date |
---|---|
DE69906730T2 (en) | 2004-02-05 |
EP1219176A2 (en) | 2002-07-03 |
DE69906730D1 (en) | 2003-05-15 |
AU755761B2 (en) | 2002-12-19 |
EP1085817B1 (en) | 2003-04-09 |
HK1035469A1 (en) | 2001-11-30 |
MY115488A (en) | 2003-06-30 |
CO5050306A1 (en) | 2001-06-27 |
AU4509199A (en) | 1999-12-30 |
US6054151A (en) | 2000-04-25 |
EP1085817A1 (en) | 2001-03-28 |
ES2194470T3 (en) | 2003-11-16 |
CA2332358A1 (en) | 1999-12-16 |
WO1999063834B1 (en) | 2000-03-02 |
EP1219176A3 (en) | 2003-11-19 |
AR019658A1 (en) | 2002-03-13 |
ATE236533T1 (en) | 2003-04-15 |
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