WO1999063050A3 - Method for preparation and in vivo administration of antigen presenting cell composition - Google Patents

Method for preparation and in vivo administration of antigen presenting cell composition Download PDF

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Publication number
WO1999063050A3
WO1999063050A3 PCT/US1999/012142 US9912142W WO9963050A3 WO 1999063050 A3 WO1999063050 A3 WO 1999063050A3 US 9912142 W US9912142 W US 9912142W WO 9963050 A3 WO9963050 A3 WO 9963050A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
antigen presenting
method
preparation
presenting cell
Prior art date
Application number
PCT/US1999/012142
Other languages
French (fr)
Other versions
WO1999063050A2 (en
Inventor
Vlasselaer Peter Van
Original Assignee
Dendreon Corp
Vlasselaer Peter Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US8776498P priority Critical
Priority to US60/087,764 priority
Application filed by Dendreon Corp, Vlasselaer Peter Van filed Critical Dendreon Corp
Publication of WO1999063050A2 publication Critical patent/WO1999063050A2/en
Publication of WO1999063050A3 publication Critical patent/WO1999063050A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0639Dendritic cells, e.g. Langherhans cells in the epidermis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells, macrophages

Abstract

A method of obtaining a blood-cell fraction enriched for antigen presenting cells is disclosed. The method includes treating a patient with an agent effective to mobilize stem cells, obtaining a blood sample from a patient, subjecting it to density centrifugation over a medium with a defined density, harvesting the cell fractions enriched in precursor antigen-presenting cells, and culturing the harvested cells under conditions effective to induce cells having the morphology, phenotype, and function of dendritic cells. A method of using such antigen presenting cell for in vivo therapy and pharmaceutical compositions comprising such antigen presenting cells are also disclosed.
PCT/US1999/012142 1998-06-02 1999-06-01 Method for preparation and in vivo administration of antigen presenting cell composition WO1999063050A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US8776498P true 1998-06-02 1998-06-02
US60/087,764 1998-06-02

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NZ50893699A NZ508936A (en) 1998-06-02 1999-06-01 Method for preparation and in vivo administration of antigen presenting cell composition
AU42269/99A AU4226999A (en) 1998-06-02 1999-06-01 Method for preparation and (in vivo) administration of antigen presenting cell composition
JP2000552246A JP2002517409A (en) 1998-06-02 1999-06-01 Methods for preparation and in vivo administration of the antigen presenting cell composition
EP19990926111 EP1082411A2 (en) 1998-06-02 1999-06-01 Method for preparation and in vivo administration of antigen presenting cell composition
CA 2330027 CA2330027A1 (en) 1998-06-02 1999-06-01 Method for preparation and in vivo administration of antigen presenting cell composition

Publications (2)

Publication Number Publication Date
WO1999063050A2 WO1999063050A2 (en) 1999-12-09
WO1999063050A3 true WO1999063050A3 (en) 2000-01-27

Family

ID=22207115

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012142 WO1999063050A2 (en) 1998-06-02 1999-06-01 Method for preparation and in vivo administration of antigen presenting cell composition

Country Status (6)

Country Link
EP (1) EP1082411A2 (en)
JP (1) JP2002517409A (en)
AU (1) AU4226999A (en)
CA (1) CA2330027A1 (en)
NZ (1) NZ508936A (en)
WO (1) WO1999063050A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
JP2002509716A (en) 1998-03-31 2002-04-02 ユニバーシティ テクノロジー コーポレイション The methods and compositions for eliciting an immune response against telomerase antigen
US7030228B1 (en) 1999-11-15 2006-04-18 Miltenyi Biotec Gmbh Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028479A1 (en) * 1994-04-14 1995-10-26 KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITäT FREIBURG Process for producing dendritic cells, cells thus produced and container for carrying out this process
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
WO1995034638A1 (en) * 1994-06-14 1995-12-21 The Board Of Trustees Of Leland Stanford Junior University Methods for in vivo t cell activation by antigen-pulsed dendritic cells
WO1997003186A2 (en) * 1995-07-12 1997-01-30 Activated Cell Therapy, Inc. Method for in vitro proliferation of dentritic cells, composition containing the cells entrapped in a three-dimensional matrix and use for immunization

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028479A1 (en) * 1994-04-14 1995-10-26 KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITäT FREIBURG Process for producing dendritic cells, cells thus produced and container for carrying out this process
WO1995034638A1 (en) * 1994-06-14 1995-12-21 The Board Of Trustees Of Leland Stanford Junior University Methods for in vivo t cell activation by antigen-pulsed dendritic cells
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
WO1997003186A2 (en) * 1995-07-12 1997-01-30 Activated Cell Therapy, Inc. Method for in vitro proliferation of dentritic cells, composition containing the cells entrapped in a three-dimensional matrix and use for immunization

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HSU F J ET AL: "VACCINATION OF PATIENTS WITH B-CELL LYMPHOMA USING AUTOLOGOUS ANTIGEN-PULSED DENTRITIC CELLS", NATURE MEDICINE,US,NATURE PUBLISHING, CO, vol. 2, no. 1, January 1996 (1996-01-01), pages 52-58, XP000605401, ISSN: 1078-8956 *
SIENA S ET AL: "MASSIVE EX VIVO GENERATION OF FUNCTIONAL DENDRITIC CELLS FROM MOBILIZED CD34+ BLOOD PROGENITORS FOR ANTICANCER THERAPY", EXPERIMENTAL HEMATOLOGY,US,NEW YORK, NY, vol. 23, no. 14, 1995, pages 1463-1471, XP000198738, ISSN: 0301-472X *

Also Published As

Publication number Publication date
JP2002517409A (en) 2002-06-18
WO1999063050A2 (en) 1999-12-09
EP1082411A2 (en) 2001-03-14
CA2330027A1 (en) 1999-12-09
AU4226999A (en) 1999-12-20
NZ508936A (en) 2005-01-28

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