WO1999055885A3 - Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein - Google Patents

Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein Download PDF

Info

Publication number
WO1999055885A3
WO1999055885A3 PCT/US1999/009224 US9909224W WO9955885A3 WO 1999055885 A3 WO1999055885 A3 WO 1999055885A3 US 9909224 W US9909224 W US 9909224W WO 9955885 A3 WO9955885 A3 WO 9955885A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
growth factor
binding protein
serine protease
factor binding
Prior art date
Application number
PCT/US1999/009224
Other languages
French (fr)
Other versions
WO1999055885A2 (en
Inventor
Steven P Smeekens
Jinzhao Hou
Original Assignee
Axys Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharm Inc filed Critical Axys Pharm Inc
Priority to CA002327352A priority Critical patent/CA2327352A1/en
Priority to AU36694/99A priority patent/AU3669499A/en
Priority to IL13930999A priority patent/IL139309A0/en
Priority to JP2000546028A priority patent/JP2003517269A/en
Priority to KR1020007012020A priority patent/KR20010043127A/en
Priority to EP99918882A priority patent/EP1073755A2/en
Publication of WO1999055885A2 publication Critical patent/WO1999055885A2/en
Publication of WO1999055885A3 publication Critical patent/WO1999055885A3/en
Priority to NO20005455A priority patent/NO20005455D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4743—Insulin-like growth factor binding protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention is directed to novel nucleic acids and proteins which have sequence identity to an ASP05 protease, and the use of such compositions in assays, as well as in the diagnosis and treatment of disease.
PCT/US1999/009224 1998-04-28 1999-04-28 Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein WO1999055885A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002327352A CA2327352A1 (en) 1998-04-28 1999-04-28 Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein
AU36694/99A AU3669499A (en) 1998-04-28 1999-04-28 Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein
IL13930999A IL139309A0 (en) 1998-04-28 1999-04-28 Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein
JP2000546028A JP2003517269A (en) 1998-04-28 1999-04-28 A novel serine protease capable of selectively cleaving insulin-like growth factor binding protein
KR1020007012020A KR20010043127A (en) 1998-04-28 1999-04-28 Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein
EP99918882A EP1073755A2 (en) 1998-04-28 1999-04-28 Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein
NO20005455A NO20005455D0 (en) 1998-04-28 2000-10-27 New serine protease capable of selectively cutting insulin-like growth factor binding protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8332198P 1998-04-28 1998-04-28
US60/083,321 1998-04-28

Publications (2)

Publication Number Publication Date
WO1999055885A2 WO1999055885A2 (en) 1999-11-04
WO1999055885A3 true WO1999055885A3 (en) 2000-02-24

Family

ID=22177579

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/009224 WO1999055885A2 (en) 1998-04-28 1999-04-28 Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein

Country Status (3)

Country Link
EP (1) EP1073755A2 (en)
AU (1) AU3669499A (en)
WO (1) WO1999055885A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100166743A1 (en) * 2006-10-06 2010-07-01 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
EP2913341A1 (en) * 2006-12-22 2015-09-02 University of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
BR112014008862A2 (en) 2011-10-14 2018-08-07 Genentech Inc isolated antibody that binds to htra1, isolated nucleic acid, host cell, immunoconjugate, pharmaceutical formulation, methods and uses
EP3368578B1 (en) 2015-10-30 2021-03-17 H. Hoffnabb-La Roche Ag Anti-htra1 antibodies and methods of use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464922A1 (en) * 1990-07-06 1992-01-08 Unilever N.V. Production of active pseudomonas glumae lipase in homologous or heterologous hosts
WO1997012979A1 (en) * 1995-10-05 1997-04-10 G.D Searle & Co. Interleuken-3 (il-3) receptor agonists
JPH09107980A (en) * 1995-08-17 1997-04-28 Japan Tobacco Inc New physiologically active protein
EP0778348A1 (en) * 1989-07-07 1997-06-11 Unilever N.V. Process for preparing a protein by a fungus transformed by multicopy integration of an expression vector
EP0828003A2 (en) * 1996-09-06 1998-03-11 Smithkline Beecham Plc Human serine protease
WO1998042827A2 (en) * 1997-03-21 1998-10-01 Pioneer Hi-Bred International, Inc. Gene encoding oxalate decarboxylase from aspergillus phoenicis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0778348A1 (en) * 1989-07-07 1997-06-11 Unilever N.V. Process for preparing a protein by a fungus transformed by multicopy integration of an expression vector
EP0464922A1 (en) * 1990-07-06 1992-01-08 Unilever N.V. Production of active pseudomonas glumae lipase in homologous or heterologous hosts
JPH09107980A (en) * 1995-08-17 1997-04-28 Japan Tobacco Inc New physiologically active protein
WO1997012979A1 (en) * 1995-10-05 1997-04-10 G.D Searle & Co. Interleuken-3 (il-3) receptor agonists
EP0828003A2 (en) * 1996-09-06 1998-03-11 Smithkline Beecham Plc Human serine protease
WO1998042827A2 (en) * 1997-03-21 1998-10-01 Pioneer Hi-Bred International, Inc. Gene encoding oxalate decarboxylase from aspergillus phoenicis

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002124455, Database accession no. D87258 *
DATABASE GENESEQ PATENT SEQUE 1 January 1900 (1900-01-01), XP002124454, Database accession no. W22849 *
DATABASE WPI Section Ch Week 199727, Derwent World Patents Index; Class B04, AN 1997-292469, XP002124456 *
HOCULI E ET AL: "GENETIC APPROACH TO FACILITATE PURIFICATION OF RECOMBINANT PROTEINS WITH A NOVEL METAL CHELATE ADSORBENT", BIO/TECHNOLOGY,US,NATURE PUBLISHING CO. NEW YORK, pages 1321-1325, XP002916185, ISSN: 0733-222X *
HU S-I ET AL: "Human HtrA, an evolutionary conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 51, 18 December 1998 (1998-12-18), MD US, pages 34406 - 34412, XP002124453 *
ZUMBRUNN J AND TRUEB B: "Primary structure of putative serine protease specific for IGF binding protein", FEBS LETTERS., vol. 398, 1996, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 187 - 192, XP002124452, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
WO1999055885A2 (en) 1999-11-04
AU3669499A (en) 1999-11-16
EP1073755A2 (en) 2001-02-07

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