WO1999051218A1 - Biocidal compositions comprising lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid - Google Patents
Biocidal compositions comprising lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid Download PDFInfo
- Publication number
- WO1999051218A1 WO1999051218A1 PCT/EP1999/002182 EP9902182W WO9951218A1 WO 1999051218 A1 WO1999051218 A1 WO 1999051218A1 EP 9902182 W EP9902182 W EP 9902182W WO 9951218 A1 WO9951218 A1 WO 9951218A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- composition according
- biocidal
- lactic acid
- animal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
Definitions
- This invention relates to the use of biocidal compositions comprising a blend of acids for use as a medicament for animals, especially pigs, at the same time promoting growth thereof and improving the digestibility of amino acids fed to such animals. 5 It is known from prior published patents that antibiotics can be administered to animals to protect them from infection such as eg E. coli. However, antibiotics are relatively expensive and they have to be administered in vary controlled amounts. In order to avoid such an expensive method of protecting animals, a composition comprising benzoic acid or a derivative of
- WO 96/24248 (corresponding to EP-A- 808101) refers to the use of a combination of benzoic ester (0.2-30 % w/w) and 50-99.8% w/w of an unsubstituted or substituted C1-C4 monocarboxylic acid which is preferably formic, acetic, propionic or lactic acids or mixtures thereof and
- 15 is most preferably formic acid or a mixture of formic acid and propionic acid (page 3, lines 1-8) in antimicrobial compositions in order to enable penetration of microbial cells by benzoic acid.
- benzoic acid has relatively low solubility in aqueous systems. Therefore, an attempt has been made to find an antibiotic composition having greater solubility in water than benzoic acid and yet is just as 0 inexpensive and effective as benzoic acid.
- the present invention is a biocidal, antibiotic composition substantially free of any ester of unsubstituted or substituted benzoic acid and comprising a mixture of lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid said mixture being used as a medicament for animals.
- a biocidal, antibiotic composition comprising (1) lactic acid or a derivative thereof capable of giving rise to lactic acid in vivo and (2) formic acid, acetic acid and/or propionic acid or a derivative of any capable of giving rise to formic acid, acetic acid and/or propionic acid respectively in vivo may be administered to the animals as a component of a conventional animal feed composition which is fed to animals.
- the biocidal composition comprising (1) and (2) may be suitably administered to the animals as a component of the animal feed or in their drinking water.
- Specific examples of derivatives of lactic acid which can give rise to lactic acid in vivo include salts of lactic acid such as eg the alkali metal-, the alkaline earth metal- and ammonium-lactates. The same applies to formic acid, acetic acid and propionic acid.
- the amount of lactic acid and formic acid present in such a composition may vary within a wide range. Lactic acid and formic acid are usually sold commercially as aqueous solutions. For instance, lactic acid is sold as a 70% by weight solution whereas formic acid is sold as an 85% by weight aqueous solution.
- the weight ratio of lactic acid to formic acid in such a biocidal composition is suitably in the range from 99 : 1 to 1 : 99, preferably from 90 : 10 to 10 : 90 and more preferably from 80 : 20 to 20 : 80.
- the amount of the biocidal composition comprising (1) and (2) administered to the animal is suitably such that it is sufficient to prevent/cure any infection in the animal in its capacity as a biocide.
- Such an amount is suitably in the range from 0.001 - 5% based on the total weight of each feed fed to the animal.
- This amount may, however, be higher if the function of the biocidal composition or a derivative thereof is not only to act as a biocide but also to control the pH of the animal excreta fed on such a diet in order to suppress the emission of ammonia from the excreta.
- Such higher amounts are suitably limited to a maximum of about 10% based on the total animal feed composition.
- the biocidal composition functions inter alia as an antibiotic, promotes growth, decreases feed conversion and improves digestibility of amino acids administered in animal feeds.
- a typical formulation for an animal feed composition is shown in the Tables below in which all the amounts shown in % w/w were fed to pigs:
- Soybean oil meal 17.25
- Component Amount (g/kg)
- the biocidal, antibiotic composition of the present invention may be used in combination with additional ingredients selected from calcium carbonates, electrolytes such as eg ammonium chloride, proteins such as soya bean meal, wheat, starch, sunflower meal, corn, meat and bone meal, amino acids, animal fat, vitamins and trace minerals.
- the ratio of the electrolyte to the biocidal composition is suitably in the range from 0.5 : 1 to 5 : 1 w/w, preferably from 1.5 : 1 to 3 : 1 w/w.
- the biocidal composition is particularly effective as a medicament for animals such as poultry, pigs or cattle, especially pigs.
- animals such as poultry, pigs or cattle, especially pigs.
- the present invention is further illustrated with reference to the following
- Vitamin/Minerals Premix 2.0 2.0 2.0 2.0 2.0 2.0
- Lactic acid (70%) 0 1.0 0 0
- Component Amount (g/kg)
Abstract
This invention relates to a biocidal, antibiotic composition substantially free of esters of benzoic acid and comprising a mixture of lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid said mixture being used as a medicament for animals. The biocidal composition can be administered as such with the animal feed or admixed with the drinking water used by the animals.
Description
BIOCIDAL COMPOSITIONS COMPRISING LACTIC ACID AND AT LEAST ONE OTHER ACID SELECTED FROM FORMIC ACID, ACETIC ACID AND PROPIONIC ACID
This invention relates to the use of biocidal compositions comprising a blend of acids for use as a medicament for animals, especially pigs, at the same time promoting growth thereof and improving the digestibility of amino acids fed to such animals. 5 It is known from prior published patents that antibiotics can be administered to animals to protect them from infection such as eg E. coli. However, antibiotics are relatively expensive and they have to be administered in vary controlled amounts. In order to avoid such an expensive method of protecting animals, a composition comprising benzoic acid or a derivative of
10 benzoic acid capable of giving rise to free benzoic acid in vivo has been proposed for use as a medicament for animals. WO 96/24248 (corresponding to EP-A- 808101) refers to the use of a combination of benzoic ester (0.2-30 % w/w) and 50-99.8% w/w of an unsubstituted or substituted C1-C4 monocarboxylic acid which is preferably formic, acetic, propionic or lactic acids or mixtures thereof and
15 is most preferably formic acid or a mixture of formic acid and propionic acid (page 3, lines 1-8) in antimicrobial compositions in order to enable penetration of microbial cells by benzoic acid. However, benzoic acid has relatively low solubility in aqueous systems. Therefore, an attempt has been made to find an antibiotic composition having greater solubility in water than benzoic acid and yet is just as 0 inexpensive and effective as benzoic acid.
It has now been found that a biocidal composition comprising a blend of acids substantially free of benzoic acid or a derivative thereof can be used instead of relatively expensive antibiotics for such animals and furthermore, such acid/salts have the advantage of being able to promote growth, decrease feed conversion and 5 improve digestibility of amino acids in animal feeds.
Accordingly, the present invention is a biocidal, antibiotic composition substantially free of any ester of unsubstituted or substituted benzoic acid and comprising a mixture of lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid said mixture being used as a medicament for animals.
A biocidal, antibiotic composition comprising (1) lactic acid or a derivative thereof capable of giving rise to lactic acid in vivo and (2) formic acid, acetic acid and/or propionic acid or a derivative of any capable of giving rise to formic acid, acetic acid and/or propionic acid respectively in vivo may be administered to the animals as a component of a conventional animal feed composition which is fed to animals. Thus, the biocidal composition comprising (1) and (2) may be suitably administered to the animals as a component of the animal feed or in their drinking water. Specific examples of derivatives of lactic acid which can give rise to lactic acid in vivo include salts of lactic acid such as eg the alkali metal-, the alkaline earth metal- and ammonium-lactates. The same applies to formic acid, acetic acid and propionic acid.
The amount of lactic acid and formic acid present in such a composition may vary within a wide range. Lactic acid and formic acid are usually sold commercially as aqueous solutions. For instance, lactic acid is sold as a 70% by weight solution whereas formic acid is sold as an 85% by weight aqueous solution. The weight ratio of lactic acid to formic acid in such a biocidal composition is suitably in the range from 99 : 1 to 1 : 99, preferably from 90 : 10 to 10 : 90 and more preferably from 80 : 20 to 20 : 80.
The amount of the biocidal composition comprising (1) and (2) administered to the animal is suitably such that it is sufficient to prevent/cure any infection in the animal in its capacity as a biocide. Such an amount is suitably in the range from 0.001 - 5% based on the total weight of each feed fed to the animal. This amount may, however, be higher if the function of the biocidal composition or a derivative thereof is not only to act as a biocide but also to control the pH of the animal excreta fed on such a diet in order to suppress the emission of ammonia from the excreta. Such higher amounts are suitably limited to a maximum of about 10% based on the total animal feed composition. The biocidal composition functions inter alia as an antibiotic, promotes growth, decreases feed conversion and improves digestibility of amino acids administered in animal feeds. A typical formulation for an animal feed composition is shown in the
Tables below in which all the amounts shown in % w/w were fed to pigs:
TABLE 1
Components of Starter Feed Control - Amount
Barley 31.5
Maize Gluten Feed 10.00
Wheat 10.00
Maize 18.75
Soybean oil meal 17.25
Tapioca 5.0
Wheat middlings 5.75
Animal fat 0.5
Limestone 0.80
Vitamin Premix 1.00
Salt 0.30
Monocalciumphosphate 0.40
The calculated chemical composition of this control feed in g/kg can be tabulated as follows:
TABLE 2
Component Amount (g/kg)
Crude Protein 160.61
Crude Fat 29.21
Crude Fibre 43.24
Water 145.35
Ash 47.01
Starch 404.32
Calcium 6.13
Phosphorus 5.94
Lysine 8.73
Methionine 3.29
Energy Value* 102.29
Sodium 1.42
Potassium 7.41
Chloride 2.63
Qlaqindox® - Antibiotic 0.05
'Energy value = 8.8 MJ net available energy for pigs for production and maintenance Thus, the biocidal, antibiotic composition of the present invention may be used in combination with additional ingredients selected from calcium carbonates, electrolytes such as eg ammonium chloride, proteins such as soya bean meal, wheat, starch, sunflower meal, corn, meat and bone meal, amino acids, animal fat, vitamins and trace minerals. In such a composition, the ratio of the electrolyte to the biocidal composition is suitably in the range from 0.5 : 1 to 5 : 1 w/w, preferably from 1.5 : 1 to 3 : 1 w/w.
The biocidal composition is particularly effective as a medicament for animals such as poultry, pigs or cattle, especially pigs. The present invention is further illustrated with reference to the following
Examples: EXAMPLES:
The following feed compositions (shown in Table 2 below) in which all the amounts shown in % by weight were fed to pigs. The amounts and concentrations
4
of formic acid, lactic acid and mixtures thereof shown are all in aqueous solution.
TABLE 3
Component Control* Ex I* Ex π Ex m*
DL-Methionine 0.020 0.020 0.020 0.020
TYLAN® - Tylosine 0.002 0 0 0
Fat 1.5 1.5 1.5 1.5
Vitamin/Minerals Premix 2.0 2.0 2.0 2.0
Molasses 2.7 2.7 2.7 2.7
Citrus pulp 5.0 5.0 5.0 5.0
Wheat 7.5 7.5 7.5 7.5
Maize gluten feed 16.05 16.05 16.05 16.05
Soybean oil meal 25.05 25.05 25.05 25.05
Tapioca 39.98 39.98 39.98 39.98
Lactic acid (70%) 0 1.0 0 0
50% Formic acid (85%) + 0 0 1.0 0 50% Lactic Acid (70%)
Formic acid (85%) 0 0 0 1.0
* - Comparative Feeds not according to the invention.
The calculated chemical composition (g/kg) of the Control feed used in the Control/Examples summarised in Table 3 above are shown in Table 4 below:
TABLE 4
Component Amount (g/kg)
Crude Protein 156.00
Crude fat 31.35
Crude fibre 49.97
Water 124.87
Ash 63.16
Starch 369.73
Calcium 5.66
Phosphorus 4.29
Lysine 8.85
Methionine 2.74
Energy value* 104.76
Sodium 1.74
Potassium 1 1.39
Chloride 2.49
Tylosine 20.00 mg
♦Energy value = 8.8 MJ net available energy for pigs for production and maintenance
In three pens pigs were fed with the control feed, and in the other three pens pigs were fed with the experimental feeds. The effect of the experimental feeds containing no acids (control), lactic acid alone (Ex I Feed), formic acid alone (Exp II Feed) and a mixture of lactic acid and formic acid (Ex II Feed, according to the present invention) on the performance of the pigs was compared. The performance of the above compositions on pigs fed therewith are summarised in Table 5 below:
TABLE 5
Control Ex I Feed* Ex π Feed E m Feed* Feed*
No. of Pigs 80 80 80 80
Initial Live weight (kg) 23.2 23.4 23.2 23.6
Final Live weight (kg) 110.2 111.8 112.8 109.6
Growth rate (g/day) 790 803 820 785
Feed intake (kg/day) 2.13 2.16 2.15 2.19
Feed conversion rate 2.70 2.69 2.62 2.67
No. of pigs dead 3 2 1 2
* Comparative Experiments not according to the invention.
The above results show that pigs fed with a diet comprising lactic acid/formic acid mixtures have a much lower feed conversion (calculated as a ratio of feed intake over growth per pig per day) than those fed on a diet which is:
(a) free of either (1) or (2) or
(b) contained either (1) or (2) alone.
These results also show that pigs fed on a feed comprising the acid mixture now claimed have are healthier and have a higher survival rate. These results also signify that pigs fed on a feed containing the acid mixture of the present invention is being used more efficiently.
Claims
1. A biocidal, antibiotic composition substantially free of any ester of an unsubstituted or substituted benzoic acid and comprising a mixture of lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid said mixture being used as a medicament for animals.
2. A biocidal composition according to Claim 1 comprising (1) lactic acid or a derivative thereof capable of giving rise to lactic acid in vivo and (2) formic acid, acetic acid and/or propionic acid or a derivative of any of these acids capable of giving rise to formic acid, acetic acid and/or propionic acid respectively in vivo when administered to the animals as a component of a conventional animal feed composition.
3. A biocidal composition according to Claim 2 wherein said composition comprising (1) and (2) is administered to the animals as a component of the animal feed and/or in their drinking water.
4. A biocidal composition according to Claim 2 wherein the derivative of lactic acid capable of giving rise to lactic acid in vivo is a salt of lactic acid selected from the alkali metal, alkaline earth metal and ammonium lactates.
5. A biocidal composition according to the preceding Claims 2 or 3 wherein the derivative of formic acid, acetic acid and propionic acid capable of giving rise to the respective acids in vivo is a salt of the respective acid selected from the alkali metal, alkaline earth metal and ammonium salts.
6. A biocidal composition according to any one of the preceding Claims wherein the amount of lactic acid and formic acid present in such a composition is in a weight ratio in the range from 99 : 1 to 1 : 99 respectively.
7. A biocidal composition according to any one of the preceding Claims wherein the amount of lactic acid and formic acid present in such a composition is in a weight ratio in the range from 90 : 10 to 10 : 90 respectively.
8. A biocidal composition according to any one of the preceding Claims wherein said composition is administered to the animal in an amount sufficient to prevent/cure any infection in the animal in its capacity as a biocide.
9. A biocidal composition according to Claim 8 wherein said composition is administered to the animal in an amount in the range from 0.001 - 5% based on the total weight of each feed fed to the animal.
10. A biocidal composition according to any one of the preceding Claims wherein said composition comprises in addition, one or more ingredients selected from calcium carbonates, electrolytes, proteins, wheat, starch, sunflower meal, corn, meat and bone meal, amino acids, animal fat, vitamins and trace minerals.
11. A biocidal composition according to Claim 10 wherein the ratio of the added electrolyte to the biocidal composition is in the range from 0.5 : 1 to 5 : 1 w/w, preferably from 1.5 : 1 to 3 : 1 w/w.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU36028/99A AU3602899A (en) | 1998-04-03 | 1999-03-26 | Biocidal compositions comprising lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9807287.9A GB9807287D0 (en) | 1998-04-03 | 1998-04-03 | Biocidal compositions |
| GB9807287.9 | 1998-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1999051218A1 true WO1999051218A1 (en) | 1999-10-14 |
Family
ID=10829880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1999/002182 WO1999051218A1 (en) | 1998-04-03 | 1999-03-26 | Biocidal compositions comprising lactic acid and at least one other acid selected from formic acid, acetic acid and propionic acid |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU3602899A (en) |
| GB (1) | GB9807287D0 (en) |
| WO (1) | WO1999051218A1 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1450771A2 (en) * | 2001-10-03 | 2004-09-01 | Innovative Pharmaceutical Concepts (IPC) Inc. | Pharmaceutical preparations useful for treating tumors and lesions of the skin and the mucous membranes and methods and kits using same |
| FR2874324A1 (en) * | 2004-08-20 | 2006-02-24 | Ceva Sante Animale Sa | Composition, useful as a veterinary antibacterial product, comprises lactic acid and formic acid in an excipient |
| JP2008029359A (en) * | 2007-10-22 | 2008-02-14 | Marubeni Nisshin Feed Co Ltd | Cattle growth improving agent |
| US7727568B2 (en) | 2003-06-05 | 2010-06-01 | Purac Biochem B.V. | Antimicrobial composition comprising a mixture of lactic acid or a derivative thereof and an inorganic acid |
| WO2013101019A1 (en) * | 2011-12-29 | 2013-07-04 | Hill's Pet Nutrition, Inc. | Compositions and methods for modifying gastrointestinal flora |
| JP2017002053A (en) * | 2016-06-30 | 2017-01-05 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | Compositions and methods for modifying gastrointestinal flora |
| JP2018509464A (en) * | 2015-01-23 | 2018-04-05 | バイオシディウム バイオファーマスーティカルズ インコーポレイテッド | Antibacterial composition |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1048724A (en) * | 1964-03-06 | 1966-11-16 | Feed Serv Livestock | Feeds for ruminants |
| BE749193A (en) * | 1969-04-19 | 1970-10-01 | Steindler Milos | FORAGE ADDITIVE |
| EP0116484A1 (en) * | 1983-01-12 | 1984-08-22 | Institut National De La Recherche Agronomique | Rehydrating composition for treatment of young animals unable to digest normally the milk |
| GB2159388A (en) * | 1984-06-01 | 1985-12-04 | Pan Britannica Ind Ltd | Preservation of silage |
| EP0275946A2 (en) * | 1987-01-19 | 1988-07-27 | Nisshin Flour Milling Co., Ltd. | Veterinary composition for preventing diarrhoea in animals |
| WO1993016611A1 (en) * | 1992-02-27 | 1993-09-02 | Kemira Oy | Preservative compositions for a plant material |
| WO1996024248A1 (en) * | 1995-02-06 | 1996-08-15 | Kemira Chemicals Oy | Antimicrobic composition and its use |
| WO1997029645A1 (en) * | 1996-02-14 | 1997-08-21 | Biofeed (Thailand) Co., Ltd. | Animal feed |
| WO1997033488A1 (en) * | 1996-03-13 | 1997-09-18 | Don J. Pestell Limited | Animal feed supplement |
| GB2313287A (en) * | 1996-05-20 | 1997-11-26 | Guildali Sa | Delayed-action acidifying additive for animal feed |
| WO1998020749A1 (en) * | 1996-11-11 | 1998-05-22 | Minotara Corporation N.V. | Aqueous nutritive preparation comprising lactic acid, organic acid and chelated trace elements |
-
1998
- 1998-04-03 GB GBGB9807287.9A patent/GB9807287D0/en not_active Ceased
-
1999
- 1999-03-26 WO PCT/EP1999/002182 patent/WO1999051218A1/en active Application Filing
- 1999-03-26 AU AU36028/99A patent/AU3602899A/en not_active Abandoned
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1048724A (en) * | 1964-03-06 | 1966-11-16 | Feed Serv Livestock | Feeds for ruminants |
| BE749193A (en) * | 1969-04-19 | 1970-10-01 | Steindler Milos | FORAGE ADDITIVE |
| EP0116484A1 (en) * | 1983-01-12 | 1984-08-22 | Institut National De La Recherche Agronomique | Rehydrating composition for treatment of young animals unable to digest normally the milk |
| GB2159388A (en) * | 1984-06-01 | 1985-12-04 | Pan Britannica Ind Ltd | Preservation of silage |
| EP0275946A2 (en) * | 1987-01-19 | 1988-07-27 | Nisshin Flour Milling Co., Ltd. | Veterinary composition for preventing diarrhoea in animals |
| WO1993016611A1 (en) * | 1992-02-27 | 1993-09-02 | Kemira Oy | Preservative compositions for a plant material |
| WO1996024248A1 (en) * | 1995-02-06 | 1996-08-15 | Kemira Chemicals Oy | Antimicrobic composition and its use |
| WO1997029645A1 (en) * | 1996-02-14 | 1997-08-21 | Biofeed (Thailand) Co., Ltd. | Animal feed |
| WO1997033488A1 (en) * | 1996-03-13 | 1997-09-18 | Don J. Pestell Limited | Animal feed supplement |
| GB2313287A (en) * | 1996-05-20 | 1997-11-26 | Guildali Sa | Delayed-action acidifying additive for animal feed |
| WO1998020749A1 (en) * | 1996-11-11 | 1998-05-22 | Minotara Corporation N.V. | Aqueous nutritive preparation comprising lactic acid, organic acid and chelated trace elements |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1450771A2 (en) * | 2001-10-03 | 2004-09-01 | Innovative Pharmaceutical Concepts (IPC) Inc. | Pharmaceutical preparations useful for treating tumors and lesions of the skin and the mucous membranes and methods and kits using same |
| EP1450771B1 (en) * | 2001-10-03 | 2008-06-25 | Innovative Pharmaceutical Concepts (IPC) Inc. | Pharmaceutical preparations useful for treating lesions of the skin and the mucous membranes and methods and kits using same |
| US7727568B2 (en) | 2003-06-05 | 2010-06-01 | Purac Biochem B.V. | Antimicrobial composition comprising a mixture of lactic acid or a derivative thereof and an inorganic acid |
| FR2874324A1 (en) * | 2004-08-20 | 2006-02-24 | Ceva Sante Animale Sa | Composition, useful as a veterinary antibacterial product, comprises lactic acid and formic acid in an excipient |
| JP2008029359A (en) * | 2007-10-22 | 2008-02-14 | Marubeni Nisshin Feed Co Ltd | Cattle growth improving agent |
| CN103997903A (en) * | 2011-12-29 | 2014-08-20 | 希尔氏宠物营养品公司 | Compositions and methods for modifying gastrointestinal flora |
| WO2013101019A1 (en) * | 2011-12-29 | 2013-07-04 | Hill's Pet Nutrition, Inc. | Compositions and methods for modifying gastrointestinal flora |
| AU2011385194B2 (en) * | 2011-12-29 | 2015-03-05 | Hill's Pet Nutrition, Inc. | Compositions and methods for modifying gastrointestinal flora |
| JP2015507629A (en) * | 2011-12-29 | 2015-03-12 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | Compositions and methods for improving gastrointestinal flora |
| JP2018509464A (en) * | 2015-01-23 | 2018-04-05 | バイオシディウム バイオファーマスーティカルズ インコーポレイテッド | Antibacterial composition |
| US10716305B2 (en) | 2015-01-23 | 2020-07-21 | Biocidium Biopharmaceuticals Inc. | Anti-bacterial compositions |
| US11363814B2 (en) | 2015-01-23 | 2022-06-21 | Biocidium Ip Holdco, Co. | Anti-bacterial compositions |
| JP2017002053A (en) * | 2016-06-30 | 2017-01-05 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | Compositions and methods for modifying gastrointestinal flora |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3602899A (en) | 1999-10-25 |
| GB9807287D0 (en) | 1998-06-03 |
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