WO1999050286A3 - Antioxidant peptides derived from apolipoprotein a-iv - Google Patents

Antioxidant peptides derived from apolipoprotein a-iv Download PDF

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Publication number
WO1999050286A3
WO1999050286A3 PCT/US1999/006580 US9906580W WO9950286A3 WO 1999050286 A3 WO1999050286 A3 WO 1999050286A3 US 9906580 W US9906580 W US 9906580W WO 9950286 A3 WO9950286 A3 WO 9950286A3
Authority
WO
WIPO (PCT)
Prior art keywords
apolipoprotein
lipid oxidation
peptides
peptides derived
present
Prior art date
Application number
PCT/US1999/006580
Other languages
French (fr)
Other versions
WO1999050286A2 (en
Inventor
David Y Hui
Patrick Tso
Original Assignee
Univ Cincinnati
David Y Hui
Patrick Tso
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cincinnati, David Y Hui, Patrick Tso filed Critical Univ Cincinnati
Priority to EP99914142A priority Critical patent/EP1068239A2/en
Publication of WO1999050286A2 publication Critical patent/WO1999050286A2/en
Publication of WO1999050286A3 publication Critical patent/WO1999050286A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a method and means for inhibiting lipid oxidation. In accordance with the present invention, a number of novel lipid oxidation suppressant peptides, derived from apolipoprotein A-IV, have been made. These peptides possess lipid oxidation inhibiting properties which when administered orally or intravenously, can be used to decrease atherosclerosis. Since the peptides comprise specific portions of the native apo A-IV protein, there should be no immunogenicity problems associated with their administration to humans.
PCT/US1999/006580 1998-03-31 1999-03-25 Antioxidant peptides derived from apolipoprotein a-iv WO1999050286A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP99914142A EP1068239A2 (en) 1998-03-31 1999-03-25 Antioxidant peptides derived from apolipoprotein a-iv

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8013198P 1998-03-31 1998-03-31
US60/080,131 1998-03-31

Publications (2)

Publication Number Publication Date
WO1999050286A2 WO1999050286A2 (en) 1999-10-07
WO1999050286A3 true WO1999050286A3 (en) 1999-11-18

Family

ID=22155452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/006580 WO1999050286A2 (en) 1998-03-31 1999-03-25 Antioxidant peptides derived from apolipoprotein a-iv

Country Status (2)

Country Link
EP (1) EP1068239A2 (en)
WO (1) WO1999050286A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001278864A1 (en) * 2000-06-30 2002-01-30 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
GB2368339B (en) 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
AU2002350409A1 (en) * 2001-10-26 2003-05-06 Uffe Holmskov Surfactant protein-d and atherosclerosis
EP3720415A4 (en) 2017-12-06 2021-11-24 Steven W. Bailey Peptide compositions for slowing degradation of vitamin-mineral supplements, foods, pharmaceuticals, and cosmetics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686605A1 (en) * 1992-01-27 1993-07-30 Rhone Poulenc Rorer Sa NOVEL POLYPEPTIDES, THEIR PREPARATION AND THEIR USE.
WO1995025749A2 (en) * 1994-03-22 1995-09-28 Research Corporation Technologies, Inc. Eating suppressant peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686605A1 (en) * 1992-01-27 1993-07-30 Rhone Poulenc Rorer Sa NOVEL POLYPEPTIDES, THEIR PREPARATION AND THEIR USE.
WO1995025749A2 (en) * 1994-03-22 1995-09-28 Research Corporation Technologies, Inc. Eating suppressant peptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAREW ET AL.: "Antiatherogenic effect of probucol...", PROC. NAT. ACAD. SCI. USA, vol. 84, November 1987 (1987-11-01), pages 7725 - 7729, XP000651844 *
COHEN ET AL.: "Reduced aortic lesions and elevated high density lipoprotein levels...", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 99, no. 8, April 1997 (1997-04-01), pages 1906 - 1916, XP002115082 *
DUVERGER ET AL.: "Protection against atherogenesis in mice mediated by human apolipoprotein A-IV", SCIENCE, vol. 273, 16 August 1996 (1996-08-16), pages 966- - 968, XP002115081 *
QIN ET AL.: "Apolipoprotein AIV: a potent endogenous inhibitor of lipid oxidation", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 43, no. 5, May 1998 (1998-05-01), pages H1836 - H1840, XP002115083 *

Also Published As

Publication number Publication date
WO1999050286A2 (en) 1999-10-07
EP1068239A2 (en) 2001-01-17

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