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WO1999045972A3 - Skin substitute and a topical composition for skin wounds - Google Patents

Skin substitute and a topical composition for skin wounds

Info

Publication number
WO1999045972A3
WO1999045972A3 PCT/NL1999/000124 NL9900124W WO1999045972A3 WO 1999045972 A3 WO1999045972 A3 WO 1999045972A3 NL 9900124 W NL9900124 W NL 9900124W WO 1999045972 A3 WO1999045972 A3 WO 1999045972A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
skin
substitute
matrix
protease
composition
Prior art date
Application number
PCT/NL1999/000124
Other languages
French (fr)
Other versions
WO1999045972A2 (en )
Inventor
Leeuwen Reinier Theodorus Van
Esther Middelkoop
Original Assignee
Stichting Tech Wetenschapp
Leeuwen Reinier Theodorus Jaco
Esther Middelkoop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60Materials for use in artificial skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432Inhibitors, antagonists
    • A61L2300/434Inhibitors, antagonists of enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64Animal cells

Abstract

The invention relates to a skin substitute which is suitable for the promotion of the healing of skin wounds. The skin substitute according to the present invention comprises a degradable, hydrophilic matrix, which matrix is permeable for cells, contituted by a collagen and elastin comprising biocompatible matrix material, wherein the matrix of the skin substitute comprises an inhibitor of a protease. Furthermore, the invention relates to a composition showing a protease inhibiting action for the topical application on skin wounds, which composition comprises a protease inhibitor and a pharmaceutically acceptable carrier.
PCT/NL1999/000124 1998-03-09 1999-03-08 Skin substitute and a topical composition for skin wounds WO1999045972A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NL1008531A NL1008531C2 (en) 1998-03-09 1998-03-09 Skin substitute and a topical formulation for skin wounds.
NL1008531 1998-03-09

Publications (2)

Publication Number Publication Date
WO1999045972A2 true WO1999045972A2 (en) 1999-09-16
WO1999045972A3 true true WO1999045972A3 (en) 1999-10-14

Family

ID=19766695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1999/000124 WO1999045972A3 (en) 1998-03-09 1999-03-08 Skin substitute and a topical composition for skin wounds

Country Status (2)

Country Link
NL (1) NL1008531C2 (en)
WO (1) WO1999045972A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
KR20050086949A (en) * 2002-12-27 2005-08-30 안지오테크 인터내셔날 아게 Compositions and methods of using collajolie
US20050048105A1 (en) * 2003-08-29 2005-03-03 Mcnulty Amy K. Protease inhibitor compositions for prevention and treatment of skin conditions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344924A2 (en) * 1988-06-02 1989-12-06 Organogenesis Inc. Fibrin-Collagen Tissue Equivalents and methods of preparation thereof
US5196196A (en) * 1986-06-03 1993-03-23 Incyte Pharmaceuticals, Inc. Use of protease nexin-I in wound dressings
GB2272645A (en) * 1992-11-23 1994-05-25 Johnson & Johnson Medical Wound Dressing
WO1995024921A1 (en) * 1994-03-16 1995-09-21 Institute Of Ophthalmology A medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
WO1998014222A1 (en) * 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196196A (en) * 1986-06-03 1993-03-23 Incyte Pharmaceuticals, Inc. Use of protease nexin-I in wound dressings
EP0344924A2 (en) * 1988-06-02 1989-12-06 Organogenesis Inc. Fibrin-Collagen Tissue Equivalents and methods of preparation thereof
GB2272645A (en) * 1992-11-23 1994-05-25 Johnson & Johnson Medical Wound Dressing
WO1995024921A1 (en) * 1994-03-16 1995-09-21 Institute Of Ophthalmology A medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
WO1998014222A1 (en) * 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue

Also Published As

Publication number Publication date Type
WO1999045972A2 (en) 1999-09-16 application
NL1008531C2 (en) 1999-09-10 grant

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121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase