WO1999045972A3 - Skin substitute and a topical composition for skin wounds - Google Patents

Skin substitute and a topical composition for skin wounds

Info

Publication number
WO1999045972A3
WO1999045972A3 PCT/NL1999/000124 NL9900124W WO1999045972A3 WO 1999045972 A3 WO1999045972 A3 WO 1999045972A3 NL 9900124 W NL9900124 W NL 9900124W WO 1999045972 A3 WO1999045972 A3 WO 1999045972A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
skin
substitute
matrix
protease
composition
Prior art date
Application number
PCT/NL1999/000124
Other languages
French (fr)
Other versions
WO1999045972A2 (en )
Inventor
Leeuwen Reinier Theodorus Van
Esther Middelkoop
Original Assignee
Stichting Tech Wetenschapp
Leeuwen Reinier Theodorus Jaco
Esther Middelkoop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60Materials for use in artificial skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432Inhibitors, antagonists
    • A61L2300/434Inhibitors, antagonists of enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64Animal cells

Abstract

The invention relates to a skin substitute which is suitable for the promotion of the healing of skin wounds. The skin substitute according to the present invention comprises a degradable, hydrophilic matrix, which matrix is permeable for cells, contituted by a collagen and elastin comprising biocompatible matrix material, wherein the matrix of the skin substitute comprises an inhibitor of a protease. Furthermore, the invention relates to a composition showing a protease inhibiting action for the topical application on skin wounds, which composition comprises a protease inhibitor and a pharmaceutically acceptable carrier.
PCT/NL1999/000124 1998-03-09 1999-03-08 Skin substitute and a topical composition for skin wounds WO1999045972A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NL1008531A NL1008531C2 (en) 1998-03-09 1998-03-09 Skin substitute and a topical formulation for skin wounds.
NL1008531 1998-03-09

Publications (2)

Publication Number Publication Date
WO1999045972A2 true WO1999045972A2 (en) 1999-09-16
WO1999045972A3 true true WO1999045972A3 (en) 1999-10-14

Family

ID=19766695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1999/000124 WO1999045972A3 (en) 1998-03-09 1999-03-08 Skin substitute and a topical composition for skin wounds

Country Status (2)

Country Link
NL (1) NL1008531C2 (en)
WO (1) WO1999045972A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
KR20050086949A (en) * 2002-12-27 2005-08-30 안지오테크 인터내셔날 아게 Compositions and methods of using collajolie
US20050048105A1 (en) * 2003-08-29 2005-03-03 Mcnulty Amy K. Protease inhibitor compositions for prevention and treatment of skin conditions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344924A2 (en) * 1988-06-02 1989-12-06 Organogenesis Inc. Fibrin-Collagen Tissue Equivalents and methods of preparation thereof
US5196196A (en) * 1986-06-03 1993-03-23 Incyte Pharmaceuticals, Inc. Use of protease nexin-I in wound dressings
GB2272645A (en) * 1992-11-23 1994-05-25 Johnson & Johnson Medical Wound Dressing
WO1995024921A1 (en) * 1994-03-16 1995-09-21 Institute Of Ophthalmology A medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
WO1998014222A1 (en) * 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196196A (en) * 1986-06-03 1993-03-23 Incyte Pharmaceuticals, Inc. Use of protease nexin-I in wound dressings
EP0344924A2 (en) * 1988-06-02 1989-12-06 Organogenesis Inc. Fibrin-Collagen Tissue Equivalents and methods of preparation thereof
GB2272645A (en) * 1992-11-23 1994-05-25 Johnson & Johnson Medical Wound Dressing
WO1995024921A1 (en) * 1994-03-16 1995-09-21 Institute Of Ophthalmology A medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
WO1998014222A1 (en) * 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue

Also Published As

Publication number Publication date Type
WO1999045972A2 (en) 1999-09-16 application
NL1008531C2 (en) 1999-09-10 grant

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DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase