WO1999043815A3 - Human monoclonal antibodies capable of oligospecifically recognizing the major tumor-associated gangliosides and methods of use thereof - Google Patents

Human monoclonal antibodies capable of oligospecifically recognizing the major tumor-associated gangliosides and methods of use thereof Download PDF

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Publication number
WO1999043815A3
WO1999043815A3 PCT/CA1999/000178 CA9900178W WO9943815A3 WO 1999043815 A3 WO1999043815 A3 WO 1999043815A3 CA 9900178 W CA9900178 W CA 9900178W WO 9943815 A3 WO9943815 A3 WO 9943815A3
Authority
WO
WIPO (PCT)
Prior art keywords
human monoclonal
recognizing
oligospecifically
methods
monoclonal antibodies
Prior art date
Application number
PCT/CA1999/000178
Other languages
French (fr)
Other versions
WO1999043815A2 (en
Inventor
Michael E Mcknight
Mark C Glassy
Original Assignee
Novopharm Biotech Inc
Michael E Mcknight
Mark C Glassy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novopharm Biotech Inc, Michael E Mcknight, Mark C Glassy filed Critical Novopharm Biotech Inc
Priority to CA002322003A priority Critical patent/CA2322003A1/en
Priority to AU32427/99A priority patent/AU3242799A/en
Priority to EP99936093A priority patent/EP1056861A2/en
Publication of WO1999043815A2 publication Critical patent/WO1999043815A2/en
Publication of WO1999043815A3 publication Critical patent/WO1999043815A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Abstract

A human monoclonal antibody capable of recognizing major tumor-associated gangliosides was isolated, sequenced and characterized. The human monoclonal antibody and antigen binding fragments therein are useful for detecting tumor associated antigens, diagnosis of cancer cells expressing the antigens, and for therapeutic treatment of cancers.
PCT/CA1999/000178 1998-02-27 1999-02-26 Human monoclonal antibodies capable of oligospecifically recognizing the major tumor-associated gangliosides and methods of use thereof WO1999043815A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002322003A CA2322003A1 (en) 1998-02-27 1999-02-26 Human monoclonal antibodies capable of oligospecifically recognizing the major tumor-associated gangliosides and methods of use thereof
AU32427/99A AU3242799A (en) 1998-02-27 1999-02-26 Human monoclonal antibodies capable of oligospecifically recognizing the major tumor-associated gangliosides and methods of use thereof
EP99936093A EP1056861A2 (en) 1998-02-27 1999-02-26 Human monoclonal antibodies capable of oligospecifically recognizing the major tumor-associated gangliosides and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7620098P 1998-02-27 1998-02-27
US60/076,200 1998-02-27

Publications (2)

Publication Number Publication Date
WO1999043815A2 WO1999043815A2 (en) 1999-09-02
WO1999043815A3 true WO1999043815A3 (en) 1999-11-25

Family

ID=22130549

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000178 WO1999043815A2 (en) 1998-02-27 1999-02-26 Human monoclonal antibodies capable of oligospecifically recognizing the major tumor-associated gangliosides and methods of use thereof

Country Status (4)

Country Link
EP (1) EP1056861A2 (en)
AU (1) AU3242799A (en)
CA (1) CA2322003A1 (en)
WO (1) WO1999043815A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2441863A1 (en) * 2001-03-29 2002-10-10 Kenya Shitara Drugs containing genetically modified antibody against ganglioside gd3
CA2498778A1 (en) 2002-09-11 2004-03-25 Shantha West, Inc. Antibodies that recognize hyperproliferative cells and methods of making and using same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480440A1 (en) * 1990-10-11 1992-04-15 Roche Diagnostics GmbH Monoclonal antibody against melanoma
EP0492409A1 (en) * 1990-12-18 1992-07-01 Ishihara Sangyo Kaisha, Ltd. Human monoclonal antibody
WO1994019457A1 (en) * 1993-02-26 1994-09-01 The Regents Of The University Of California Human b-lymphoblastoid cell line secreting anti-ganglioside antibody

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480440A1 (en) * 1990-10-11 1992-04-15 Roche Diagnostics GmbH Monoclonal antibody against melanoma
EP0492409A1 (en) * 1990-12-18 1992-07-01 Ishihara Sangyo Kaisha, Ltd. Human monoclonal antibody
WO1994019457A1 (en) * 1993-02-26 1994-09-01 The Regents Of The University Of California Human b-lymphoblastoid cell line secreting anti-ganglioside antibody

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
H. YAMAGUCHI ET AL.: "Human monoclonal antibody with dual GM2/GD2 specificity derived from an immunized melanoma patient.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE U.S.A., vol. 87, no. 9, May 1990 (1990-05-01), Washington, DC, USA, pages 3333 - 3337, XP002116959 *
K. FURUKAWA ET AL.: "Two human monoclonal antibodies reacting with the major gangliosides of human melanomas and comparison with corresponding mouse monoclonal antibodies.", CANCER RESEARCH, vol. 49, no. 1, 1 January 1989 (1989-01-01), Baltimore, MD, USA, pages 191 - 196, XP000608629 *
M. ALFONSO ET AL.: "Generation of human monoclonal antibodies against ganglioside antigens and their applications in the diagnosis and therapy of cancer.", ACTA ONCOLOGICA, vol. 35, no. 3, 1996, Stockholm, Sweden, pages 287 - 295, XP002116960 *
S. MUKERJEE ET AL.: "Characterization of human IgG1 monoclonal antibody against gangliosides expressed on tumor cells.", HYBRIDOMA, vol. 17, no. 2, April 1998 (1998-04-01), New York, NY, USA, pages 133 - 142, XP002116961 *
Z. ABDEL-WAHAB ET AL.: "Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides.", MELANOMA RESEARCH, vol. 3, no. 6, December 1993 (1993-12-01), Oxford, GB, pages 415 - 423, XP000608631 *

Also Published As

Publication number Publication date
WO1999043815A2 (en) 1999-09-02
CA2322003A1 (en) 1999-09-02
EP1056861A2 (en) 2000-12-06
AU3242799A (en) 1999-09-15

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