WO1999034849A1 - Catheter sheath introducer for reducing friction - Google Patents

Catheter sheath introducer for reducing friction Download PDF

Info

Publication number
WO1999034849A1
WO1999034849A1 PCT/US1999/000505 US9900505W WO9934849A1 WO 1999034849 A1 WO1999034849 A1 WO 1999034849A1 US 9900505 W US9900505 W US 9900505W WO 9934849 A1 WO9934849 A1 WO 9934849A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
seal
introducer
recited
sealed state
tubular body
Prior art date
Application number
PCT/US1999/000505
Other languages
French (fr)
Inventor
Erp Wilhelmus Petrus Martinus Maria Van
Original Assignee
Cordis Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02Access sites
    • A61M39/06Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
    • A61M39/0693Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof including means for seal penetration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0097Catheters; Hollow probes characterised by the hub

Abstract

The invention relates to a catheter sheath introducer (10) for introducing one or more medical devices, such as guide wires or catheters which may include a tubular body (14) with distal ends, proximal ends, and a passage extending between the proximal and distal ends. The introducer also includes a housing (12) coupled to the proximal end of the tubular body, a seal (58) coupled to the housing tending to block the escape of fluids through the passage and the seal. The introducer may also include an opening mechanism for selectively causing the seal to open, thereby reducing friction resistance.

Description

CATHETER SHEATH INTRODUCER FOR REDUCING FRICTION

1. Technical Background:

The present invention relates generally to medical devices, and more particularly to devices and methods for reducing friction while introducing a medical device. 2. Discussion:

The present invention concerns apparatus for introducing various elongated medical devices into the body of a patient for treatment. Such medical devices include guidewires, optical fibers, ultrasound probes, and of course catheters of all types, including angioplasty, cryogenic, laser, diagnostic, thrombectomy or ablation catheters, or any combination of similar devices. Such medical devices are often introduced into the patient's body through a device specifically designed to do so, as in the present invention, which is generally known as a catheter sheath introducer. Of course, a catheter sheath introducer may be used for introducing any suitable devices, and not only catheters and accessories.

A catheter sheath introducer may be kept in place throughout a patient's hospital stay, yet each medical procedure often requires much less time. One of the main purposes of the catheter sheath introducer is to prevent fluids from escaping during the times between the medical procedures. Catheter sheath introducers generally may have a tubular basic body with distal and proximal ends and a passage or lumen extending between the ends, as well as a head having an openable seal near the proximal end. The seal tends to prevent the escape of liquids or other substances through the tubular body and outside the patient, and is usually formed by a membrane having one or more cuts that form several flaps. The membrane is generally made of pliable material, so that the flaps tend to resiliently give way to allow the introduction and withdrawal of a medical device. At the same time, the membrane material should be sufficiently firm, such that this seal tends to remain closed and block the passage effectively when the medical device is removed, despite internal pressure from inside the body. However, the seal membrane and its flaps tend to generate friction, resisting easy insertion or withdrawal of medical devices through the catheter sheath introducer. In addition, the medical device to be inserted through the catheter sheath introducer may not be entirely smooth. For example, a balloon catheter may be mounted with a stent, which is a metal mesh scaffold, crimped around the balloon. The stent, or any other surface features of the medical devices, may of course increase the friction present when advancing or withdrawing it through the catheter sheath introducer.

In addition, especially in the case of large diameter catheters and medical devices, the passage through the catheter sheath introducer must be very wide. Because it is desirable to ensure that the seal over such a wide passage remains closed when no medical device is inserted through it, the seal should preferably exert great resistance against pressure from inside the catheter sheath introducer. This increased resistance may for example be achieved by using a very thick seal membrane. Unfortunately, the friction caused by the seal against the introduction of a medical device through the seal will be greater, which is less desirable. An introducer device according to the present invention preferably incorporates a head defining a wide passage. Likewise, a seal gasket may be used which is sufficiently stiff to hold the wide passage closed against the internal pressures.

The novel arrangement of this present invention provides a unique mechanism for selectively forcing the seal gasket to open and remain open for some desired period of time, thus drastically reducing any friction that may resist introduction or withdrawal of any suitable medical device through the catheter sheath introducer. Of course, this opening mechanism is releasable whenever it is desirable to allow the seal to again close and block the passage.

Accordingly, by the way of the present invention, the catheter sheath introducer allows for the introduction of wider medical devices, with acceptable sealing when desired, yet minimizing friction when desired. In this way, the catheter sheath introducer of the present invention provides acceptable sealing during times between medical procedures, while allowing for low resistance to advancing and withdrawing medical devices during treatments.

The present invention thus preferably includes a system for enlarging the space available in the seal prior to the introduction of the medical device. This system for selectively holding the seal open can be incorporated in the same head of the catheter sheath introducer.

These and other various objects, advantages and features of the invention will become apparent from the following description and claims, when considered in conjunction with the appended drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1 is a perspective view of an introducer device according to the present invention; Figure 2 is an enlarged perspective view of the device illustrated in Figure 1; Figure 3 is a partial cross-sectional view of the introducer device according to the present invention;

Figure 4 is a cross-sectional view of the introducer device of Figure 3, in an opened configuration; Figure 5 is an exploded perspective view of an alternative embodiment of an introducer device according to the present invention;

Figure 6 is a top view of a seal gasket from an introducer device according to the present invention; and

Figure 7 is a partial cross-sectional view of another alternative embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The following description of the preferred embodiments of the present invention is merely illustrative in nature, and as such it does not limit in any way the present invention, its application or uses. Numerous modifications may be made by those skilled in the art without departing from the true spirit and scope of the invention.

Figure 1 shows a perspective view of a device according to the present invention, namely an introducer 10. The catheter sheath introducer 10 consists of a housing 12 and a tubular basic body 14 defining a chamber 38. A pair of connectors 16 and 18 couple the housing 12 to an auxiliary tube 20 and the tubular body 14, respectively. The auxiliary tube 20 terminates in a manual valve 22, adapted to allow the injection of medications directly into the chamber 38, through the tubular body 14, and out the tubular body distal end 24. The manual valve may include a medication port 26, a valve lever 28, and an aspiration port 30. The housing may be made of three main parts, a housing body 32, an intermediate collar 40, and an end cap 46. The housing body 32 defines chamber 38, has a port 34 for connection to the auxiliary tube 20, and a mounting hole 36 for stabilizing the position of the housing 12. The intermediate collar 40 has a snap coupling 42 to affix the intermediate collar 40 to the housing body 32, and threads 44. And the end cap 46 has finger knurls 48 for facilitating turning the end cap 46 in engagement with the threads 44, a vent 50 for equalizing pressures within an end chamber 56 defined by the end cap 46, and introduction port 52 for allowing the introduction and withdrawal of medical devices through the introducer, and a cylindrical plunger 54 for manually actuating the seal of the housing 12. The seal can be formed by a gasket 58 having slits 62, which is held in position by an annular anchor 60.

Figure 3 shows an introducer according to one embodiment of the present invention with the gasket seal 58 in a closed state, while Figure 4 shows the same introducer with the plunger actuated to force the gasket seal 58 into an open state. Figure 5 shows another embodiment of an introducer 64 arranged according to the present invention, having a body 66, a seal gasket 68, an intermediate collar 70, and an end cap 72.

Figure 6 shows one possible arrangement of a seal gasket 58 having a pair of slits 74 which are angled through the gasket 58 to attain a shifted position 76 on the opposing side of the gasket 58.

Figure 7 depicts another embodiment of an introducer 78 according to the present invention, having a housing body 80, a tubular body 86, an intermediate collar 88 with a fmger flange 90, and an end cap 92. The housing body 80 has an auxiliary port 82, and a connector 84. The end cap includes a cylindrical plunger 94 and a spring 96. Introducer 78 further includes a seal gasket 98 having one or more slits 100.

After reading the above, several embodiments of devices corresponding to those according to the present invention will force themselves on the expert in the field. Although these have not been described here explicitly, they are considered to fall within the scope of the attached claims. Many other forms of actively or passively operated aids integrated with the device may be designed so as to increase the ease of operation. Also, other seals than balloons, bodies made of solid pliable material and membranes may be employed and it is in particular possible to employ each of, and other seals than the ones described here in the configuration illustrated in figure 5 in an integrated aid for the opening hereof, etc.

Claims

1. An introducer for introducing medical devices into the body of a patient, comprising: a tubular body with distal and proximal ends, defining a passage extending between the proximal and distal ends; a housing affixed to the proximal end of the tubular body; a seal coupled to the housing having a sealed state and an open state, wherein the seal is adapted in the sealed state to close and tend to prevent the escape of material through the passage in a proximal direction, and wherein the seal in the open state is at least partially open to allow the introduction or withdrawal of a medical device through the seal and along the passage; such that the seal tends to resiliently at least partially open if a medical device is forcibly introduced through the seal, and tends to resiliently close and return to the sealed state upon removal of such medical device; and an opening mechanism for selectively causing the seal to shift from the sealed state and at least partially open to allow the introduction or withdrawal of a medical device and reduce friction resistance, the opening mechanism being adapted to override the tendency of the seal to resiliently close and return to the sealed state.
2. The introducer as recited in Claim 1, wherein the seal is formed as a gasket having one or more slits.
3. The introducer as recited in Claim 1, further comprising an auxiliary tube communicating between the tubular body passage and a manually actuatable valve, for allowing the injection of treatment fluids through the tubular body.
4. The introducer as recited in Claim 1, wherein the opening mechanism further comprises a plunger coupled to the housing, which can be selectively actuated to shift the seal to and from the sealed state and the open state.
5. The introducer as recited in Claim 4, further comprising a retracting mechanism causing the plunger to resiliently tend to retract and allow the seal to resume the sealed state.
6. The introducer as recited in Claim 5, wherein the retracting mechanism comprises a spring.
7. The introducer as recited in Claim 4, wherein the opening mechanism includes a screw cap coupled with the plunger.
PCT/US1999/000505 1998-01-09 1999-01-07 Catheter sheath introducer for reducing friction WO1999034849A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NL1007997A NL1007997C2 (en) 1998-01-09 1998-01-09 A device for the introduction of an elongated medical instrument.
NL1007997 1998-01-09

Publications (1)

Publication Number Publication Date
WO1999034849A1 true true WO1999034849A1 (en) 1999-07-15

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NL (1) NL1007997C2 (en)
WO (1) WO1999034849A1 (en)

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6322541B2 (en) 1999-09-10 2001-11-27 Scimed Life Systems, Inc. Vascular introducer sheath and hemostasis valve for use therewith
US6497681B1 (en) 2000-06-02 2002-12-24 Thomas Medical Products, Inc. Device and method for holding and maintaining the position of a medical device such as a cardiac pacing lead or other intravascular instrument and for facilitating removal of a peelable or splittable introducer sheath
US6520939B2 (en) 2001-02-13 2003-02-18 Scimed Life Systems, Inc. Hemostasis valve
WO2002005867A3 (en) * 2000-07-13 2003-09-25 Medamicus Inc Introducer having a movable valve assembly with removable side port
US6776774B2 (en) 2001-07-16 2004-08-17 Scimed Life Systems, Inc. Hemostasis gasket valve
WO2004110546A1 (en) * 2003-06-17 2004-12-23 Cube Medical A/S Haemostatic valve assembly with indicator
WO2005092427A2 (en) * 2004-03-15 2005-10-06 Applied Medical Resources Corporation Surgical guide valve
WO2008057666A2 (en) 2006-11-08 2008-05-15 Cardiac Pacemakers, Inc. Break-away hemostasis hub
JP2011115630A (en) * 2011-03-15 2011-06-16 Medikit Kk Indwelling catheter
US8357119B2 (en) 2010-07-15 2013-01-22 Becton, Dickinson And Company Catheter assembly and pierced septum valve
US8361038B2 (en) 2009-02-11 2013-01-29 Becton, Dickinson And Company Systems and methods for providing a flow control valve for a medical device
US8361020B2 (en) 2010-07-15 2013-01-29 Becton, Dickinson And Company Catheter assembly and pierced septum valve
US8366684B2 (en) 2008-05-12 2013-02-05 Becton, Dickinson And Company Intravenous catheter blood control device
US8388583B2 (en) 2009-08-20 2013-03-05 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US8469928B2 (en) 2009-02-11 2013-06-25 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US8574203B2 (en) 2009-02-11 2013-11-05 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US8636695B2 (en) 2010-09-08 2014-01-28 Becton, Dickinson And Company Assembly method for catheter with blood control
US8641675B2 (en) 2011-03-07 2014-02-04 Becton, Dickinson And Company Systems and methods for preventing septum damage in an intravascular device
US8679063B2 (en) 2009-02-11 2014-03-25 Becton, Dickinson And Company Systems and methods for providing a catheter assembly
JP2014533985A (en) * 2011-10-06 2014-12-18 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company Actuating member attachment for blood control catheter
US8932259B2 (en) 2010-09-13 2015-01-13 Becton, Dickinson And Company Catheter assembly
US9028425B2 (en) 2010-07-15 2015-05-12 Becton, Dickinson And Company Vented blood sampling device
US9089671B2 (en) 2011-10-06 2015-07-28 Becton, Dickinson And Company Systems and methods for sealing a septum within a catheter device
US9101748B2 (en) 2008-05-08 2015-08-11 Becton, Dickinson And Company Push-button blood control
US9126012B2 (en) 2011-10-06 2015-09-08 Becton, Dickinson And Company Intravenous catheter with duckbill valve
EP2805693B1 (en) 2010-02-03 2015-09-16 CircuLite, Inc. Vascular introducers having an expandable section
US9155863B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Multiple use stretching and non-penetrating blood control valves
US9155876B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Port valve of a blood control catheter
US9155864B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Multiple use blood control valve with center and circumferential slits
US9259554B2 (en) 2011-03-07 2016-02-16 Becton, Dickinson And Company Systems and methods to compensate for compression forces in an intravascular device
USRE45896E1 (en) 2009-02-11 2016-02-23 Becton, Dickinson And Company Systems and methods for providing a catheter assembly
CN105407953A (en) * 2014-04-28 2016-03-16 爱德华兹生命科学公司 Intravascular introducer devices
US20160114128A1 (en) * 2014-10-24 2016-04-28 Angiodynamics, Inc. Actuating Catheter Luer Devices
US20160114129A1 (en) * 2014-10-24 2016-04-28 Angiodynamics, Inc. Actuating catheter luer and hub devices
US9579486B2 (en) 2012-08-22 2017-02-28 Becton, Dickinson And Company Blood control IV catheter with antimicrobial properties
US9675793B2 (en) 2014-04-23 2017-06-13 Becton, Dickinson And Company Catheter tubing with extraluminal antimicrobial coating
US9695323B2 (en) 2013-02-13 2017-07-04 Becton, Dickinson And Company UV curable solventless antimicrobial compositions
US9750928B2 (en) 2013-02-13 2017-09-05 Becton, Dickinson And Company Blood control IV catheter with stationary septum activator
US9750925B2 (en) 2014-01-21 2017-09-05 Becton, Dickinson And Company Ported catheter adapter having combined port and blood control valve with venting
US9789279B2 (en) 2014-04-23 2017-10-17 Becton, Dickinson And Company Antimicrobial obturator for use with vascular access devices
USD819802S1 (en) 2016-10-05 2018-06-05 Becton, Dickinson And Company Catheter adapter

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US5456284A (en) * 1993-05-10 1995-10-10 Applied Medical Resources Corporation Elastomeric valve assembly
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US5545142A (en) * 1991-10-18 1996-08-13 Ethicon, Inc. Seal members for surgical trocars
US5657963A (en) * 1993-06-16 1997-08-19 United States Surgical Corporation Seal assembly for accommodating introduction of surgical instruments

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6322541B2 (en) 1999-09-10 2001-11-27 Scimed Life Systems, Inc. Vascular introducer sheath and hemostasis valve for use therewith
US6497681B1 (en) 2000-06-02 2002-12-24 Thomas Medical Products, Inc. Device and method for holding and maintaining the position of a medical device such as a cardiac pacing lead or other intravascular instrument and for facilitating removal of a peelable or splittable introducer sheath
WO2002005867A3 (en) * 2000-07-13 2003-09-25 Medamicus Inc Introducer having a movable valve assembly with removable side port
US6712789B1 (en) 2000-07-13 2004-03-30 Medamicus, Inc. Introducer having a movable valve assembly with removable side port
US6520939B2 (en) 2001-02-13 2003-02-18 Scimed Life Systems, Inc. Hemostasis valve
US6776774B2 (en) 2001-07-16 2004-08-17 Scimed Life Systems, Inc. Hemostasis gasket valve
WO2004110546A1 (en) * 2003-06-17 2004-12-23 Cube Medical A/S Haemostatic valve assembly with indicator
WO2005092427A3 (en) * 2004-03-15 2009-02-12 Applied Med Resources Surgical guide valve
WO2005092427A2 (en) * 2004-03-15 2005-10-06 Applied Medical Resources Corporation Surgical guide valve
US8105315B2 (en) 2006-11-08 2012-01-31 Cardiac Pacemakers, Inc. Break-away hemostasis hub
WO2008057666A3 (en) * 2006-11-08 2008-08-21 Cardiac Pacemakers Inc Break-away hemostasis hub
JP2010508905A (en) * 2006-11-08 2010-03-25 カーディアック ペースメイカーズ, インコーポレイテッド Separation hemostasis hub
WO2008057666A2 (en) 2006-11-08 2008-05-15 Cardiac Pacemakers, Inc. Break-away hemostasis hub
EP2404635A1 (en) * 2006-11-08 2012-01-11 Cardiac Pacemakers, Inc. Break-away hemostasis Hub
US9101748B2 (en) 2008-05-08 2015-08-11 Becton, Dickinson And Company Push-button blood control
US8366684B2 (en) 2008-05-12 2013-02-05 Becton, Dickinson And Company Intravenous catheter blood control device
US8679063B2 (en) 2009-02-11 2014-03-25 Becton, Dickinson And Company Systems and methods for providing a catheter assembly
US8361038B2 (en) 2009-02-11 2013-01-29 Becton, Dickinson And Company Systems and methods for providing a flow control valve for a medical device
US9101746B2 (en) 2009-02-11 2015-08-11 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
USRE45896E1 (en) 2009-02-11 2016-02-23 Becton, Dickinson And Company Systems and methods for providing a catheter assembly
US8469928B2 (en) 2009-02-11 2013-06-25 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US8574203B2 (en) 2009-02-11 2013-11-05 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US8740859B2 (en) 2009-02-11 2014-06-03 Becton, Dickinson And Company Systems and methods for providing a flow control valve for a medical device
US9114241B2 (en) 2009-02-11 2015-08-25 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US8388583B2 (en) 2009-08-20 2013-03-05 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
EP2805693B1 (en) 2010-02-03 2015-09-16 CircuLite, Inc. Vascular introducers having an expandable section
US8361020B2 (en) 2010-07-15 2013-01-29 Becton, Dickinson And Company Catheter assembly and pierced septum valve
US8357119B2 (en) 2010-07-15 2013-01-22 Becton, Dickinson And Company Catheter assembly and pierced septum valve
US9028425B2 (en) 2010-07-15 2015-05-12 Becton, Dickinson And Company Vented blood sampling device
US9895092B2 (en) 2010-07-15 2018-02-20 Becton, Dickinson And Company Vented blood sampling device
US8636695B2 (en) 2010-09-08 2014-01-28 Becton, Dickinson And Company Assembly method for catheter with blood control
US8864715B2 (en) 2010-09-08 2014-10-21 Becton, Dickinson And Company Assembly method for catheter with blood control
US8932259B2 (en) 2010-09-13 2015-01-13 Becton, Dickinson And Company Catheter assembly
US9579490B2 (en) 2011-03-07 2017-02-28 Becton, Dickinson And Company Systems and methods to compensate for compression forces in an intravascular device
US9259554B2 (en) 2011-03-07 2016-02-16 Becton, Dickinson And Company Systems and methods to compensate for compression forces in an intravascular device
US8641675B2 (en) 2011-03-07 2014-02-04 Becton, Dickinson And Company Systems and methods for preventing septum damage in an intravascular device
JP2011115630A (en) * 2011-03-15 2011-06-16 Medikit Kk Indwelling catheter
US9358364B2 (en) 2011-10-06 2016-06-07 Becton, Dickinson And Company Activator attachment for blood control catheters
US9155876B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Port valve of a blood control catheter
US9155864B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Multiple use blood control valve with center and circumferential slits
US9126012B2 (en) 2011-10-06 2015-09-08 Becton, Dickinson And Company Intravenous catheter with duckbill valve
US9089671B2 (en) 2011-10-06 2015-07-28 Becton, Dickinson And Company Systems and methods for sealing a septum within a catheter device
JP2014533985A (en) * 2011-10-06 2014-12-18 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company Actuating member attachment for blood control catheter
US9155863B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Multiple use stretching and non-penetrating blood control valves
US9579486B2 (en) 2012-08-22 2017-02-28 Becton, Dickinson And Company Blood control IV catheter with antimicrobial properties
US9695323B2 (en) 2013-02-13 2017-07-04 Becton, Dickinson And Company UV curable solventless antimicrobial compositions
US9750928B2 (en) 2013-02-13 2017-09-05 Becton, Dickinson And Company Blood control IV catheter with stationary septum activator
US9750925B2 (en) 2014-01-21 2017-09-05 Becton, Dickinson And Company Ported catheter adapter having combined port and blood control valve with venting
US9789279B2 (en) 2014-04-23 2017-10-17 Becton, Dickinson And Company Antimicrobial obturator for use with vascular access devices
US9675793B2 (en) 2014-04-23 2017-06-13 Becton, Dickinson And Company Catheter tubing with extraluminal antimicrobial coating
US9956379B2 (en) 2014-04-23 2018-05-01 Becton, Dickinson And Company Catheter tubing with extraluminal antimicrobial coating
CN105407953A (en) * 2014-04-28 2016-03-16 爱德华兹生命科学公司 Intravascular introducer devices
US20160114129A1 (en) * 2014-10-24 2016-04-28 Angiodynamics, Inc. Actuating catheter luer and hub devices
US20160114128A1 (en) * 2014-10-24 2016-04-28 Angiodynamics, Inc. Actuating Catheter Luer Devices
USD819802S1 (en) 2016-10-05 2018-06-05 Becton, Dickinson And Company Catheter adapter

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