WO1999029670A3 - Aminocarbonyltetralin- und -dihydronapthalinderivate als thrombinhemmer - Google Patents

Aminocarbonyltetralin- und -dihydronapthalinderivate als thrombinhemmer Download PDF

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Publication number
WO1999029670A3
WO1999029670A3 PCT/EP1998/007958 EP9807958W WO9929670A3 WO 1999029670 A3 WO1999029670 A3 WO 1999029670A3 EP 9807958 W EP9807958 W EP 9807958W WO 9929670 A3 WO9929670 A3 WO 9929670A3
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WIPO (PCT)
Prior art keywords
general formula
compounds
aminocarbonyltetralin
dihydronaphtalene
derivates
Prior art date
Application number
PCT/EP1998/007958
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English (en)
French (fr)
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WO1999029670A2 (de
Inventor
Rainer Soyka
Armin Heckel
Thorsten Lehmann-Lintz
Rainer Walter
Wolfgang Wienen
Jean-Marie Stassen
Original Assignee
Boehringer Ingelheim Pharma
Rainer Soyka
Armin Heckel
Lehmann Lintz Thorsten
Rainer Walter
Wolfgang Wienen
Stassen Jean Marie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Rainer Soyka, Armin Heckel, Lehmann Lintz Thorsten, Rainer Walter, Wolfgang Wienen, Stassen Jean Marie filed Critical Boehringer Ingelheim Pharma
Priority to AU18773/99A priority Critical patent/AU1877399A/en
Publication of WO1999029670A2 publication Critical patent/WO1999029670A2/de
Publication of WO1999029670A3 publication Critical patent/WO1999029670A3/de

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft durch einen Aminocarbonylrest substituierte Bicyclen der allgemeinen Formel (I), in der R1 bis R6, X1 bis X3, Y1 und Y2 wie im Anspruch 1 definiert sind, deren Tautomere, deren Stereoisomere, deren Gemische und deren Salze, welche wertvolle Eigenschaften aufweisen. So stellen die Verbindungen der allgemeinen Formel (I), in denen X3 eine Cyanogruppe darstellt, wertvolle Zwischenprodukte zur Herstellung der übrigen Verbindungen der allgemeinen Formel (I) dar, und die Verbindungen der allgemeinen Formel (I), in denen X3 eine Amino-, 2-Amino-1H-imidazolyl- oder RaNH-C(=NH)-Gruppe darstellt, sowie deren Tautomere und deren Stereoisomere weisen wertvolle pharmakologische Eigenschaften auf, insbesondere eine antithrombotische Wirkung, welche auf einer Thrombin-hemmenden Wirkung beruht.
PCT/EP1998/007958 1997-12-09 1998-12-08 Aminocarbonyltetralin- und -dihydronapthalinderivate als thrombinhemmer WO1999029670A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18773/99A AU1877399A (en) 1997-12-09 1998-12-08 Bicyclene substituted by an aminocarbonyl radical, the production and use thereof as a medicament

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19754490.8 1997-12-09
DE1997154490 DE19754490A1 (de) 1997-12-09 1997-12-09 Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
WO1999029670A2 WO1999029670A2 (de) 1999-06-17
WO1999029670A3 true WO1999029670A3 (de) 1999-09-10

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PCT/EP1998/007958 WO1999029670A2 (de) 1997-12-09 1998-12-08 Aminocarbonyltetralin- und -dihydronapthalinderivate als thrombinhemmer

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AU (1) AU1877399A (de)
DE (1) DE19754490A1 (de)
WO (1) WO1999029670A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
TW200510311A (en) * 2002-12-23 2005-03-16 Millennium Pharm Inc CCr8 inhibitors
US7491827B2 (en) 2002-12-23 2009-02-17 Millennium Pharmaceuticals, Inc. Aryl sulfonamides useful as inhibitors of chemokine receptor activity
US7378525B2 (en) 2002-12-23 2008-05-27 Millennium Pharmaceuticals, Inc. CCR8 inhibitors
AU2005281934A1 (en) * 2004-09-06 2006-03-16 F. Hoffmann-La Roche Ag 4-aminomethyl benzamidine derivatives and their use as factor VIIA inhibitors
WO2007147762A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonamidyl tetralin derivatives and uses thereof
DE102008019838A1 (de) * 2008-04-19 2009-12-10 Boehringer Ingelheim International Gmbh Neue Arylsulfonylglycin-Derivate, deren Herstellung und deren Verwendung als Arzneimittel

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284359A1 (de) * 1987-03-24 1988-09-28 Takeda Chemical Industries, Ltd. 1,4-Disubstituierte Piperazin-Verbindungen, ihre Herstellung und ihre Verwendung
EP0542203A2 (de) * 1991-11-11 1993-05-19 Ono Pharmaceutical Co., Ltd. Kondensierte Benzenoxyessigsäurederivate als PGI2-Rezeptoragonisten
WO1996016940A1 (fr) * 1994-12-02 1996-06-06 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive d'amidinonaphtyle ou sel de celui-ci
WO1998006691A2 (en) * 1996-08-14 1998-02-19 Warner-Lambert Company Low molecular weight dendritic compounds as pharmaceutical agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284359A1 (de) * 1987-03-24 1988-09-28 Takeda Chemical Industries, Ltd. 1,4-Disubstituierte Piperazin-Verbindungen, ihre Herstellung und ihre Verwendung
EP0542203A2 (de) * 1991-11-11 1993-05-19 Ono Pharmaceutical Co., Ltd. Kondensierte Benzenoxyessigsäurederivate als PGI2-Rezeptoragonisten
WO1996016940A1 (fr) * 1994-12-02 1996-06-06 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive d'amidinonaphtyle ou sel de celui-ci
WO1998006691A2 (en) * 1996-08-14 1998-02-19 Warner-Lambert Company Low molecular weight dendritic compounds as pharmaceutical agents

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WO1999029670A2 (de) 1999-06-17
AU1877399A (en) 1999-06-28
DE19754490A1 (de) 1999-06-10

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