WO1999026604A3 - Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood - Google Patents

Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood Download PDF

Info

Publication number
WO1999026604A3
WO1999026604A3 PCT/US1998/024632 US9824632W WO9926604A3 WO 1999026604 A3 WO1999026604 A3 WO 1999026604A3 US 9824632 W US9824632 W US 9824632W WO 9926604 A3 WO9926604 A3 WO 9926604A3
Authority
WO
WIPO (PCT)
Prior art keywords
artificial blood
liquid ventilation
perfluorinated hydrocarbons
mediums
perfluorinated
Prior art date
Application number
PCT/US1998/024632
Other languages
French (fr)
Other versions
WO1999026604A2 (en
Inventor
Leland C Clark
Richard E Hoffmann
Original Assignee
Synthetic Blood International
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthetic Blood International filed Critical Synthetic Blood International
Priority to EP19980958073 priority Critical patent/EP1037619A4/en
Priority to CA002311122A priority patent/CA2311122C/en
Priority to JP2000521806A priority patent/JP2003522094A/en
Priority to AU14184/99A priority patent/AU759557B2/en
Publication of WO1999026604A2 publication Critical patent/WO1999026604A2/en
Publication of WO1999026604A3 publication Critical patent/WO1999026604A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Perfluorinated alkylcyclohexane and alkyl cyclopentane derivatives of the empirical formula C10F20 boil at atmospheric pressure in the range of 144-146 °C and are utilized as mediums for gas transport in liquid ventilation and in artificial blood. Compounds of the C10F20 formula which can exist only as a single stereoisomer are preferred as mediums for gas transport.
PCT/US1998/024632 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood WO1999026604A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP19980958073 EP1037619A4 (en) 1997-11-21 1998-11-18 Selected c 10? perfluorinated hydrocarbons for liquid ventilation and artificial blood
CA002311122A CA2311122C (en) 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood
JP2000521806A JP2003522094A (en) 1997-11-20 1998-11-18 Selected C10 perfluorohydrocarbons for liquid ventilation and artificial blood
AU14184/99A AU759557B2 (en) 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/975,743 1997-11-20
US08/975,743 US6167887B1 (en) 1997-11-21 1997-11-21 Selected C-10 perfluorinated hydrocarbons for liquid ventilation and artificial blood

Publications (2)

Publication Number Publication Date
WO1999026604A2 WO1999026604A2 (en) 1999-06-03
WO1999026604A3 true WO1999026604A3 (en) 1999-10-14

Family

ID=25523336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/024632 WO1999026604A2 (en) 1997-11-20 1998-11-18 Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood

Country Status (6)

Country Link
US (1) US6167887B1 (en)
EP (1) EP1037619A4 (en)
JP (1) JP2003522094A (en)
AU (1) AU759557B2 (en)
CA (1) CA2311122C (en)
WO (1) WO1999026604A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081008A1 (en) * 2006-01-16 2007-07-19 Asahi Glass Company, Limited Novel fluorine surface active agent and novel fluorine-containing compound
MX337857B (en) * 2006-05-15 2016-03-16 Univ Virginia Commonwealth Methods and compositions for controlled and sustained production and delivery of peroxides.
CN101646442B (en) 2007-02-23 2013-09-04 21世纪国际新技术株式会社 Therapeutic or prophylactic agent for vasoconstriction
EP2252333A4 (en) * 2008-02-13 2013-07-10 Oxygen Biotherapeutics Inc Gas based wound and tissue therapeutics
WO2010008594A1 (en) * 2008-07-18 2010-01-21 Oxygen Biotherapeutics, Inc. Method of treating traumatic brain injury
US8343515B2 (en) 2008-11-25 2013-01-01 Oxygen Biotherapeutics, Inc. Perfluorocarbon gel formulations
CN102223877A (en) * 2008-11-25 2011-10-19 奥斯金生医公司 Perfluorocarbon gel formulations
US20100144597A1 (en) * 2008-12-10 2010-06-10 Ward Kevin R Novel combinatorial approaches to enhancing oxygen transport to tissues
WO2011014247A1 (en) * 2009-07-28 2011-02-03 Oxygen Biotherapeutics, Inc. Method to increase oxygen in male and female sexual organs through the topical use of perfluorocarbons
US20120128589A1 (en) * 2009-07-31 2012-05-24 Koninklijke Philips Electronics N.V. Perfluoro Compounds For Use In Imaging
WO2011116277A1 (en) * 2010-03-19 2011-09-22 Oxygen Biotherapeutics, Inc. Perfluorocarbon eye cream formulations
WO2012044963A2 (en) 2010-10-01 2012-04-05 Oxygen Biotherapeutics, Inc. Perfluorocarbons for use in treating pruritus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453028A (en) * 1982-03-29 1984-06-05 Lagow Richard J Perfluorinated compounds with cyclohexyl groups
EP0521492A2 (en) * 1991-07-02 1993-01-07 Air Products And Chemicals, Inc. Perfluoro (ethyldimethylcyclohexane)
WO1995031191A1 (en) * 1994-05-13 1995-11-23 Synthetic Blood International, Inc. Use of perfluorocarbons for assisting normal breathing in mammals having lung disorders
WO1997019678A1 (en) * 1995-12-01 1997-06-05 Synthetic Blood International, Inc. Improved perfluorocarbons for biological gas exchange and method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911138B1 (en) 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
USRE33451E (en) 1982-04-12 1990-11-20 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4686024A (en) 1985-02-01 1987-08-11 The Green Cross Corporation Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same
US5437272A (en) 1991-05-01 1995-08-01 Alliance Pharmaceutical Corp. Perfluorocarbon associated gas exchange
EP0583358B1 (en) 1991-05-03 1998-12-02 Alliance Pharmaceutical Corporation Partial liquid breathing of fluorocarbons
JP4289499B2 (en) * 2004-09-06 2009-07-01 城南鋼鉄工業株式会社 Door lock mechanism

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453028A (en) * 1982-03-29 1984-06-05 Lagow Richard J Perfluorinated compounds with cyclohexyl groups
EP0521492A2 (en) * 1991-07-02 1993-01-07 Air Products And Chemicals, Inc. Perfluoro (ethyldimethylcyclohexane)
WO1995031191A1 (en) * 1994-05-13 1995-11-23 Synthetic Blood International, Inc. Use of perfluorocarbons for assisting normal breathing in mammals having lung disorders
WO1997019678A1 (en) * 1995-12-01 1997-06-05 Synthetic Blood International, Inc. Improved perfluorocarbons for biological gas exchange and method

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 3, 16 January 1984, Columbus, Ohio, US; abstract no. 17149, OKAMOTO H. ET AL: "Fate of perfluorochemical impurities contained in both perfluorodecaline (FDC) and perfluorotripropylamine (FTPA) in rats following intravenous injection of their emulsions" XP002097459 *
CHEMICAL ABSTRACTS, vol. 96, no. 9, 1 March 1982, Columbus, Ohio, US; abstract no. 68466, MAKAROV, K. N. ET AL: "Synthesis and physicochemical properties of perfluoroalkyl- and 1,4-dialkyl-substituted cyclohexanes" XP002110502 *
CLARK L. ET AL: "a NEW LOOK AT THE VAPOR PRESSURE PROBLEM IN RED CELL SUBSTITUTES", INT. CONGR. SER. - EXCERPTA MED. (1979), 486 (PROC. INT. SYMP. PERFLUOROCHEM. BLOOD SUBSTITUTES, 4TH, 1978 ), 1979, pages 55 - 67, XP002097458 *
LIN, WEN HUEY ET AL: "The synthesis of highly fluorinated alkylcyclohexanes for use as oxygen carriers and the fluorine-19 and carbon-13 NMR spectra of alkycyclohexane", J. FLUORINE CHEM. (1990), 50(3), 345-58, XP002110499 *
MOORE R E ET AL: "SYNTHESIS AND PHYSICAL PROPERTIES OF PERFLUOROCOMPOUNDS USEFUL AS SYNTHETIC BLOOD CANDIDATES", OXYGEN CARRYING COLLOIDAL BLOOD SUBSTITUTES. INTERNATIONAL SYMPOSIUM PERFLUOROCHEM. BLOOD SUBSTITUTES, 1982, pages 50 - 60, XP000646210 *
OKAMOTO H. ET AL, YAKURI TO CHIRYO, vol. 10, no. 7, 1983, pages 3801 - 3806 *
PERFTORIROVAN, UGLERODY V BIOL. I MED., PUSHCHINO (1980) 21-30 FROM: REF. ZH., KHIM. 1981, ABSTR. NO. 20B358 *
QUINTEL M ET AL: "[Liquid ventilation with perfluorocarbons (see comments)]. Flussigkeitsventilation mit Perfluorcarbonen.", ANASTHESIOLOGIE, INTENSIVMEDIZIN, NOTFALLMEDIZIN, SCHMERZTHERAPIE, (1996 OCT) 31 (8) 461-9. REF: 72, XP002110501 *
VARUSHCHENKO, RAISA M. ET AL: "Thermodynamics of vaporization of some cyclic perfluorocarbons", FLUID PHASE EQUILIB. (1996), 126(1), 93-104, XP002110500 *

Also Published As

Publication number Publication date
EP1037619A2 (en) 2000-09-27
AU759557B2 (en) 2003-04-17
US6167887B1 (en) 2001-01-02
WO1999026604A2 (en) 1999-06-03
AU1418499A (en) 1999-06-15
JP2003522094A (en) 2003-07-22
CA2311122C (en) 2004-04-13
EP1037619A4 (en) 2001-08-13
CA2311122A1 (en) 1999-06-03

Similar Documents

Publication Publication Date Title
WO1999026604A3 (en) Selected c10 perfluorinated hydrocarbons for liquid ventilation and artificial blood
AU2001228325A1 (en) Use of compounds for the regulation of food intake
AU2003235671A1 (en) Adsorbents for low vapor pressure fluid storage and delivery
AU6059000A (en) Pressure balanced gas valve
AU7309200A (en) Membrane support for drip chamber
AU2002258848A1 (en) Self contained anti-blowout seal for fluids or gases
UA85715C2 (en) packed insulation product and method of packing of insulation product
AU2002218348A1 (en) Cask for drawing off liquids under the effect of pressure
AU2003254235A1 (en) System and process for the vaporization of liquified natural gas
AU3003300A (en) Processes for the rapid preparation of foam materials from high internal phase emulsions at high temperatures and pressures
AU2002255936A1 (en) Media isolation seal system
AU2002239637A1 (en) Sealing valve assembly for medical products
AU1196701A (en) Automatic-locking shut-off valve for liquid suction systems
WO2007067469A3 (en) Method for expelling gas positioned between a substrate and a mold
AU2003213942A1 (en) Storage tank for cryogenic liquids
AU2002309773A1 (en) Improved vapor plug for cryogenic storage vessels
MXPA03000437A (en) Bonnet securement for gas pressure regulators.
AU2003271215A1 (en) Vector for anti-hpv vaccine and transformed microorganism by the vector
AU2002317612A1 (en) Tank support system of gas grill
AU2426100A (en) Low supply pressure alarm for gas supply
AU2003210351A1 (en) Preservation of liquids
HU0002221D0 (en) Portable, combined packing from cardboard, corrugated cardboard or the same
AU2003282077A1 (en) Pressure container, particularly for frozen substances
AU2003291182A1 (en) Permeable gas assembly for gas delivery
AU2003290266A1 (en) Vapour permeable heat-reflective membranes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1998958073

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2311122

Country of ref document: CA

Ref country code: CA

Ref document number: 2311122

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 14184/99

Country of ref document: AU

NENP Non-entry into the national phase

Ref country code: KR

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 521806

Kind code of ref document: A

Format of ref document f/p: F

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1998958073

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 14184/99

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1998958073

Country of ref document: EP