WO1999024036A1 - Skin penetration enhancing components - Google Patents
Skin penetration enhancing components Download PDFInfo
- Publication number
- WO1999024036A1 WO1999024036A1 PCT/GB1998/003317 GB9803317W WO9924036A1 WO 1999024036 A1 WO1999024036 A1 WO 1999024036A1 GB 9803317 W GB9803317 W GB 9803317W WO 9924036 A1 WO9924036 A1 WO 9924036A1
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- WO
- WIPO (PCT)
- Prior art keywords
- formulation according
- macrocyclic lactone
- derivative
- drug
- macrolide
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Definitions
- This present invention relates to an effective treatment for psoriasis and other dermatological conditions using a topically applied immunosuppressive agent.
- the preferred formulation does not allow the agent to appear in the blood or other circulatory system at any significant level.
- Dermatological conditions can be uncomfortable and embarrassing for the patient, so an effective safe treatment is required.
- Some dermatological conditions are caused by an overactive immune system, examples are psoriasis, alopecia, lichen planus, lupus erythematosus, pyoder a gangrenosum, vitiligo and graft versus host disease. Others can be due to bacterial or pustular skin infections.
- Dermatological conditions caused by an overactive immune system can be treated by immunosuppressive macrolides, for example sirolimus (rapamycin), FK-506 (tacrolimus) or SDZ ASM 981.
- immunosuppressive macrolides for example sirolimus (rapamycin), FK-506 (tacrolimus) or SDZ ASM 981.
- macrolide antibiotics for example erythromycin, azithromycin and clarithromycin.
- the above agents may be applied by means of topical creams and lotions or taken orally.
- Psoriasis affects 2.4% of the population and the current understanding of the pathogenesis of the disease is that it is driven initially by immunocytes. These and keratinocytes are mutually stimulated and activated through the production of cytokines, TGFa, IL-6 and IL-8 from lymphocytes. This leads to a hyperproliferative epidermis with rapid 36 hour cycling of the transient amplifying compartment of keratinocytes.
- FK506 is a macrolide antibiotic which shows part homology with sirolimus. Research in models has shown that it has some efficacy in the topical therapy of contact dermatitis, atopic eczema and to a lesser degree psoriasis. Cyclosporin is also known to be effective in treating a wide range of skin diseases. However the usefulness of these drugs is limited by their potential side effects resulting from systemic administration.
- Treatment of dermatological conditions may include using topical steroids but these have undesirable effects such as irreversible atrophy and purpura.
- any medicament shall as far as possible affect only the afflicted part. It is well known that amounts of circulating drug should be kept as low as possible to avoid unwanted mutations.
- the macrocyclic lactone antibiotic rapamycin for example as disclosed in EP-A-0533433 has already been used topically to treat such skin disorders as psoriasis and dermatitis. However no attempt has been made to reduce the amount of rapamycin translocated across the skin into the systemic system. Nor is there any discussion of the reduction of the levels of circulating rapamycin or other macrolide drug at the same time as providing therapeutically effective treatment for a variety of skin disorders.
- Permeation enhancers are well known as a class of drug translocation facilitors, but the purpose of these is to increase the drug flux across the skin.
- a permeation modulator however has the facility to allow the drug to penetrate the skin, and particularly the stratum corneum, without significantly passing through the epidermis into systemic systems (eg the blood or lymph systems) .
- immunosuppressive agents taken orally and steroids applied topically can be used to treat dermatological conditions, such as psoriasis or eczema.
- dermatological conditions such as psoriasis or eczema.
- they are often non-specific in their action which leads to undesirable side effects.
- a topical delivery formulation for an immunosuppressive agent which preferentially treats the diseased sites only and avoids significant systemic exposure; so reducing harmful side effects.
- Sirolimus is a macrocyclic lactone antibiotic produced by the organism Streptomyces hygroscopicus; it is known to have potent immunosuppressive activities. Sirolimus acts through specific binding of a family of cytosolic immunophilins called the FK binding proteins (FKBP) .
- FKBP FK binding proteins
- the sirolimus FKBP complex acts at least three sites. Firstly, by blocking the phosphorylation activation of p70 s ⁇ kinase, an enzyme acting on the 4OS ribosomal subunit s ⁇ protein, thereby reducing the efficiency of translation. Secondly by preventing activation of specific elongation factors required for protein synthesis.
- Sirolimus has an advantage over other immunosuppressive agents in the treatment of psoriasis as it has an inhibitory effect on keratinocyte proliferation. In vitro experiments have shown that this inhibitory effect takes place at concentrations ranging from 3-10 ⁇ g/ml. A broader range may be employed for example 1 to 20 ⁇ g/ml, but the more efficacious range is 5-8 ⁇ g/ml.
- a topical formulation for the treatment of a dermatological condition which comprises a macrocyclic lactone antibiotic or immunosuppressive macrolide or a pharmacologically active analogue, derivative or pro-drug thereof; characterised in that it further comprises a permeation modulator and the permeation modulator and the macrocyclic lactone antibiotic, immunosuppressive macrolide or pharmacologically active analogue, derivative or pro-drug are present in relative amounts such that when a therapeutic amount is applied to the skin, a minimal systemic effect is produced.
- minimal systemic effect is meant that the amount of active principal detectable in the blood stream is preferably less than 0.3 ng/nl over 4 to 24 hours after administration, more preferably below 0.1 ng/ml over the same period.
- the macrocyclic lactone antibiotic is selected from erythromycin, azithromycin or clarithromycin. These macrocyclic lactone antibiotics are effective for treating pustular and bacterial skin infections such as acne vulgaris.
- the immunosuppressive macrolide is selected from sirolimus, FK-506 or SDZ ASM 981.
- Sirolimus is a favoured alternative because it is also an effective antibiotic which is useful in the microbiological preservation of the formulation.
- the microbiological properties of sirolimus are also helpful in the treatment of scalp and flexural psoriasis, seborrhoeic dermatitis and in secondarily atopic eczema.
- the permeation modulator may be an alkanoic or alkenic acid, preferably having 6 to 20 carbon atoms such as capric acid, octanoic acid, oleic acid or acids or such acids of intermediate chain length.
- the permeation modulator aids the penetration of the immunosuppressive macrolide or macrocyclic antibiotic through the stratum corneum, the principle barrier to the penetration of drugs.
- the stratum corneum is an aggregate of the stacked, flattened skeletons of keratin filled cells interspersed with lipid monolayer structures and water.
- the addition of the permeation modulator to the formulation results in the partial disruption of the barrier components, particularly the lipid structures.
- a gradient of the drug can then be produced across the stratum corneum particularly, which facilitates the diffusion of the immunosuppressive macrolide or macrocyclic lactone antibiotic across the stratum corneum into the living epidermis.
- the relative concentrations of the macrolide or antibiotic and the permeation modulator are chosen so that only partial penetration of the skin occurs; the macrocyclic lactone antibiotics or immunosuppressive macrolides reach the areas which require treatment but significant absorption of the said drugs into the systemic circulation is avoided thus reducing the likelihood of any systemic side effects.
- the permeation modulator is used in conjunction with a solvent system which includes an aromatic alcohol such as phenyl-alkanol or a biologically acceptable benzene derivative, with or without an admixture of monoglycerides and/or a fatty acid ester (e.g. isopropyl myristate) .
- a solvent system which includes an aromatic alcohol such as phenyl-alkanol or a biologically acceptable benzene derivative, with or without an admixture of monoglycerides and/or a fatty acid ester (e.g. isopropyl myristate) .
- Other solvents used include benzaldehyde, benzyl benzoate and acetone.
- the combination of solvent and permeation modulator further optimises the passage of the immunosuppressive macrolide or the macrocyclic lactone antibiotic across the stratum corneum.
- the concentration of the macrocyclic lactone antibiotic or immunosuppressive macrolide is up to 10% by weight of the formulation. More preferably the concentration of the macrocyclic lactone antibiotic or immunosuppressive macrolide is either 0.5% to 5.9% or 6% to 12% by weight. Even more preferably the concentration of the macrocyclic antibiotic or immunosuppressive macrolide is either 1 to 5% or 6 to 8% by weight. A concentration of 0.05% to 2% is most preferable in the treatment of eczema.
- the term ⁇ % by weight" used herein refers to the "% by weight of the final formulation".
- the above ranges of macrocyclic lactone antibiotic or immunosuppressive macrolide or analogue derivative or pro- drug thereof are used in an agent comprising a permeation modulator; wherein the concentration of the permeation modulator is 0.1% to 60% by weight. More preferably the concentration of the permeation modulator is either 0.1% to 39.9% or 40% to 80% by weight. Even more preferably the concentration of the permeation modulator is either 0.1% to 19.9%, 20% to 39.9% or 40% to 60%.
- the above ranges of macrocyclic lactone antibiotic or immunosuppressive and permeation modulator are used in a formulation in conjunction with a solvent system; wherein the concentration of the solvent system is 5% to 90% by weight. More preferably the concentration of the solvent system is either 0.1% to 49.9% or 50% to 90% by weight. Even more preferably the concentration of the solvent system is either 0.1% to 19.9%, 20% to 39.9%, 40% to 69.9% or 70% to 90% by weight.
- a thickening agent is present in the formulation. If the formulation is to be used topically, it should be of an appropriate consistency. Therefore, thickening agents such as cetostearyl alcohol or commercially available medical grade white soft paraffin may be added. These can reduce the penetration of the immunosuppressive agent but they are required for effective application.
- the formulations of the invention are particularly suitable for treatment of conditions of the scalp.
- the formulations of the invention may additionally include one of the following:- flavouring agents, lubricants, solubilizers, suspending agents, filler and glidants.
- the formulation can also be dissolved or suspended in any pharmaceutically acceptable liquid carrier or vehicle such as water or a pharmaceutically acceptable oil or fat.
- a liquid carrier or vehicle can contain other pharmaceutically acceptable additives such as solubilizers, emulsifier, buffers, preservatives, suspending agents, thickening agents, colouring agents, viscosity regulators, stabilizers or osmo- regulators.
- Figure 1 is a graphical representation of the effect on the flux ( ⁇ g/hr/cm 2 ) of sirolimus (y) through the stratum corneum by varying the capric acid and benzyl alcohol ratio, where x is the percentage of capric acid in the benzyl alcohol.
- Figure 2 is a graphical representation of the effect on the flux ( ⁇ g/hr/cm 2 ) of sirolimus (y) through the stratum corneum by varying the octanoic acid and benzyl alcohol ratio, where x is the percentage of octanoic acid in the benzyl alcohol.
- Figure 3 is a graphical representation of the effect on the flux ( ⁇ g/hr/cm 2 ) of sirolimus (y) through the stratum corneum by varying the oleic acid and benzyl alcohol ratio, where x is the percentage of oleic acid in the benzyl alcohol.
- Figure 4 is a graphical representation of the effect on the flux ( ⁇ g/hr/cm 2 ) of sirolimus (y) through the stratum corneum by varying the sirolimus concentration (mg/ml) (x) while keeping the capric acid to benzyl acid ratio constant.
- Figure 5 is a graphical representation of the results of the clinical score (y) determined after application of the sirolimus formulation ( ) and the control ( . ; . ) in Example 3.
- Figure 6 is a graphical representation of the difference in the clinical score after application with sirolimus formulation in Example 3, where y is the number of subjects in each group.
- a positive score (x) shows improvement with use of the active formulation.
- Figures 1 to 4 were obtained by in vitro experimentation. The results were used to optimize the sirolimus concentration and the ratio of permeation enhancer and solvent used in in vivo experiments .
- Example 1 A formulation was formed of 8% sirolimus and 92% of a vehicle of capric acid (50%) with benzyl alcohol (50%) . This was tested in single application experiments on four individuals with normal skin. Venous blood samples were taken at 4, 7 and 24 hours after application and no significant levels of sirolimus were detected using MSGCMS, which is able to detect sirolimus levels down to O.lng/ml.
- Table 1 shows the tissue concentrations of sirolimus 7 hours after application of capric acid: benzyl alcohol (50:50) containing sirolimus at 8%.
- the horizontal skin sections were each 0.7mm. Accordingly, for example, the section of skin designated 2 was the horizontal layer of skin 0.7-1.4mm from the surface of the skin.
- sirolimus (2.2%) in a vehicle comprising isopropyl myristate 40%, benzyl alcohol 10% and capric acid 50% was tested in single application experiments on three individuals with normal skin. Venous blood samples were taken at 4, 7 and 24 hours after application and no significant levels of sirolimus were detected using MSGCMS. After 7 hours biopsy samples were taken from two of the individuals. These were bisected in parallel with the surface to give an upper and lower half, roughly corresponding to the epidermis and dermis. The skin was homogenised with acetonitrile and sirolimus concentration was determined by HPLC. The results are given in Table 2
- Table 2 shows the tissue concentrations of sirolimus 7 hours after application of capric acid: isopropyl myristate: benzyl alcohol (50:40:10) containing sirolimus at 2.2%.
- a double blind, left-right comparison of the effect of applying topical sirolimus in formulations as described in Examples 1 and 2, to 24 patients with chronic (over three months) plaque psoriasis was conducted. (22 out of the 24 patients were eventually analysed.)
- a single target plaque was treated for the first 6 weeks with the lower potency formulation of Example 2. After this the active treatment was increased to the higher potency formulation of Example 1 for 6 weeks unless a clear improvement on one side had already occurred.
- Treatment was randomised and double blind. Hands were thoroughly washed between the twice daily application of the test formulations.
- the active formulation was applied consistently to one plaque while a control comprising only the vehicle base was applied consistently to the plaque on the opposite side. Where possible the arms or elbows were selected as target areas as cross contamination is less likely at these sites .
- the lesions were also assessed at fortnightly intervals with subjective scoring on a scale of 0-8 for erythema, thickening, and scaling. Objective measures of improvement were performed on both lesions at the end of each treatment period (low and high formulations) . These included pulsed A scan ultrasound measurement of lesion thickness and erythema measured with a reflectance erythema metre, both were averaged over 5 areas in each psoriatic lesion and were validated using a previous study which was performed using betamethasome as a reference.
- sirolimus levels were performed every 2 weeks during therapy. Samples for sirolimus levels were stored at minus 80° C and shipped to a central reference laboratory for analysis by LC/MS/MS by Wyeth Ayerst Research.
- antibody Ki-67 was used to give a measure of hyperproliferation in the epidermis and CD4 helper lymphocytes were used to give a measure of auto-immune activity which drives psoriasis.
- the antibody tests with Ki-67 showed a significant reduction of proliferating cells from a mean of 83/mm 3 in control to 55/mm 3 with Sirolimus (rapamycin) to give a significance of P- 0.027 (T test).
- rapamycin rapamycin
- control values were 61/mm 3 against 32.7/mm 3 means values following rapamycin to give a significance of P-0.0026 (T-test) .
- the T-test were unpaired due to missing samples.
- Table 3 shows the clinical response to topical sirolimus. The clinical score is measured on a scale of 0-24 with higher values indicating a better result, ultrasound thickness in mm and erythema measurement in arbitrary units.
Abstract
Description
Claims
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA2000063310A UA73274C2 (en) | 1997-11-07 | 1998-05-11 | Components increasing skin permeability |
DE69835163T DE69835163T2 (en) | 1997-11-07 | 1998-11-05 | SKIN PENETRATION PROMOTERS |
EP98952860A EP1028727B1 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
SI9830848T SI1028727T1 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
NZ504076A NZ504076A (en) | 1997-11-07 | 1998-11-05 | A topical formulation which induces a minimal systemic effect when applied to the skin, the topical formulation comprising an immunosuppressive macrolide selected from sirolimus, FK506 and SDZ ASM 981 and a permeation modulator for the treatment of a dermatological condition |
EEP200000279A EE04390B1 (en) | 1997-11-07 | 1998-11-05 | Topical preparation for the treatment of dermatological conditions |
PL98340710A PL340710A1 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing agents |
AU10408/99A AU759326B2 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
KR1020007004806A KR20010031741A (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
IL13597898A IL135978A0 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
HU0003675A HUP0003675A3 (en) | 1997-11-07 | 1998-11-05 | Dermatologic composition containing skin penetration modulating component |
SK662-2000A SK6622000A3 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
EA200000461A EA003616B1 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
BR9815264-5A BR9815264A (en) | 1997-11-07 | 1998-11-05 | Components of increased penetration into the skin |
US09/530,375 US6958153B1 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
CA002309159A CA2309159C (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
JP2000520128A JP2001522801A (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancer |
NO20002078A NO20002078L (en) | 1997-11-07 | 2000-04-19 | Components for improved skin penetration |
HR20000233A HRP20000233A2 (en) | 1997-11-07 | 2000-04-20 | Skin penetration enhancing components |
BG104370A BG104370A (en) | 1997-11-07 | 2000-04-24 | Composition improving the penetration into the skin |
AU2003211175A AU2003211175B2 (en) | 1997-11-07 | 2003-07-08 | Skin penetration enhancing components |
US11/153,318 US20050239724A1 (en) | 1997-11-07 | 2005-06-16 | Skin penetration enhancing components |
CY20061101341T CY1105243T1 (en) | 1997-11-07 | 2006-09-20 | SKIN PENETRATION ENHANCING INGREDIENTS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9723669.9 | 1997-11-07 | ||
GBGB9723669.9A GB9723669D0 (en) | 1997-11-07 | 1997-11-07 | Skin penetration enhancing components |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/153,318 Continuation US20050239724A1 (en) | 1997-11-07 | 2005-06-16 | Skin penetration enhancing components |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999024036A1 true WO1999024036A1 (en) | 1999-05-20 |
Family
ID=10821813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/003317 WO1999024036A1 (en) | 1997-11-07 | 1998-11-05 | Skin penetration enhancing components |
Country Status (33)
Country | Link |
---|---|
US (2) | US6958153B1 (en) |
EP (2) | EP1632231A3 (en) |
JP (1) | JP2001522801A (en) |
KR (1) | KR20010031741A (en) |
CN (1) | CN1115148C (en) |
AR (1) | AR014011A1 (en) |
AT (1) | ATE332134T1 (en) |
AU (1) | AU759326B2 (en) |
BG (1) | BG104370A (en) |
BR (1) | BR9815264A (en) |
CA (1) | CA2309159C (en) |
CY (1) | CY1105243T1 (en) |
DE (1) | DE69835163T2 (en) |
DK (1) | DK1028727T3 (en) |
EA (1) | EA003616B1 (en) |
EE (1) | EE04390B1 (en) |
ES (1) | ES2268795T3 (en) |
GB (1) | GB9723669D0 (en) |
GE (2) | GEP20032884B (en) |
HR (1) | HRP20000233A2 (en) |
HU (1) | HUP0003675A3 (en) |
ID (1) | ID24662A (en) |
IL (1) | IL135978A0 (en) |
NO (1) | NO20002078L (en) |
NZ (3) | NZ530752A (en) |
PL (1) | PL340710A1 (en) |
PT (1) | PT1028727E (en) |
SK (1) | SK6622000A3 (en) |
TR (1) | TR200001238T2 (en) |
TW (1) | TW557218B (en) |
UA (1) | UA73274C2 (en) |
WO (1) | WO1999024036A1 (en) |
ZA (1) | ZA9810111B (en) |
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US8961588B2 (en) | 2002-03-27 | 2015-02-24 | Advanced Cardiovascular Systems, Inc. | Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin |
WO2004071398A3 (en) * | 2003-02-17 | 2005-01-20 | Cipla Ltd | Pharmaceutical patch |
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WO2004082681A1 (en) * | 2003-03-17 | 2004-09-30 | Novartis Ag | Pharmaceutical compositions comprising a combination of rapamycin or its derivative and pimecrolimus for the treatment of inflammation- and ummunologically-mediated diseases |
AU2004222563B2 (en) * | 2003-03-17 | 2006-11-02 | Novartis Ag | Pharmaceutical compositions comprising a combination of rapamycin or its derivative and pimecrolimus for the treatment of inflammation- and immunologically-mediated diseases |
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JP2006522058A (en) * | 2003-04-04 | 2006-09-28 | ノバルティス アクチエンゲゼルシャフト | Combination of macrolide T cell immunomodulator and calciferol for the treatment of skin disease or inflammatory bowel disease |
WO2004087144A1 (en) * | 2003-04-04 | 2004-10-14 | Novartis Ag | Combination of a macrolide and a local anesthetic for the treatment of dermatological diseases |
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