WO1999023466A3 - Apparatus and methods for measuring fluorescence polarization - Google Patents

Apparatus and methods for measuring fluorescence polarization Download PDF

Info

Publication number
WO1999023466A3
WO1999023466A3 PCT/US1998/023095 US9823095W WO9923466A3 WO 1999023466 A3 WO1999023466 A3 WO 1999023466A3 US 9823095 W US9823095 W US 9823095W WO 9923466 A3 WO9923466 A3 WO 9923466A3
Authority
WO
WIPO (PCT)
Prior art keywords
apparatus
composition
methods
fluorescence polarization
measuring fluorescence
Prior art date
Application number
PCT/US1998/023095
Other languages
French (fr)
Other versions
WO1999023466A2 (en
Inventor
Douglas N Modlin
John C Owicki
Original Assignee
Ljl Biosystems Inc
Douglas N Modlin
John C Owicki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US6381197P priority Critical
Priority to US60/063,811 priority
Priority to US7249998P priority
Priority to US7278098P priority
Priority to US7541498P priority
Priority to US7580698P priority
Priority to US8225398P priority
Priority to US09/062,472 priority patent/US6071748A/en
Priority to US8416798P priority
Priority to US60/085,335 priority
Priority to US8533598P priority
Priority to US60/085,500 priority
Priority to US8550098P priority
Priority to US60/089,848 priority
Priority to US8984898P priority
Priority to US60/092,203 priority
Priority to US9220398P priority
Priority to US60/094,275 priority
Priority to US9427598P priority
Priority to US9427698P priority
Priority to US60/094,276 priority
Priority to US60/100,817 priority
Priority to US10081798P priority
Priority to US10095198P priority
Priority to US09/156,318 priority patent/US6258326B1/en
Priority to US09/156,318 priority
Priority to US09/160,533 priority patent/US6097025A/en
Priority to US10496498P priority
Priority to US60/104,964 priority
Application filed by Ljl Biosystems Inc, Douglas N Modlin, John C Owicki filed Critical Ljl Biosystems Inc
Priority to US60/072,499 priority
Priority to US60/084,167 priority
Priority to US60/072,780 priority
Priority to US60/075,806 priority
Priority claimed from IL13567198A external-priority patent/IL135671D0/en
Priority to US60/082,253 priority
Priority to US09/160,533 priority
Priority claimed from IL13748599A external-priority patent/IL137485D0/en
Priority to US60/075,414 priority
Priority claimed from JP2000528201A external-priority patent/JP2003526077A/en
Priority to US09/062,472 priority
Priority to US60/100,951 priority
Priority claimed from AU27758/99A external-priority patent/AU2775899A/en
Priority claimed from IL13777799A external-priority patent/IL137777D0/en
Publication of WO1999023466A2 publication Critical patent/WO1999023466A2/en
Publication of WO1999023466A3 publication Critical patent/WO1999023466A3/en
Priority claimed from US09/643,221 external-priority patent/US6326605B1/en
Priority claimed from US10/012,255 external-priority patent/US20020158212A1/en
Priority claimed from US10/445,292 external-priority patent/US6992761B2/en
Priority claimed from US10/746,797 external-priority patent/US7745142B2/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6445Measuring fluorescence polarisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00691Automatic using robots
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00707Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • G01N2021/6419Excitation at two or more wavelengths
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • G01N2021/6421Measuring at two or more wavelengths
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • G01N2021/6471Special filters, filter wheel
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/40Rare earth chelates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Abstract

An apparatus (90) for measuring polarized light emitted from a composition that includes a stage configured to hold a microplate (124) having an array of sample wells (126), a continuous high color temperature light source (100), and a detector (144). An excitation optical relay structure directs light from the light source (100) through an excitation polarizer (114) toward a composition in one of the sample wells (126). An emission optical relay structure directs light emitted from the composition through an emission polarizer (132) toward the detector (144).
PCT/US1998/023095 1997-07-16 1998-10-30 Apparatus and methods for measuring fluorescence polarization WO1999023466A2 (en)

Priority Applications (38)

Application Number Priority Date Filing Date Title
US6381197P true 1997-10-31 1997-10-31
US60/063,811 1997-10-31
US7249998P true 1998-01-26 1998-01-26
US7278098P true 1998-01-27 1998-01-27
US7541498P true 1998-02-20 1998-02-20
US7580698P true 1998-02-24 1998-02-24
US8225398P true 1998-04-17 1998-04-17
US09/062,472 US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US8416798P true 1998-05-04 1998-05-04
US8533598P true 1998-05-13 1998-05-13
US60/085,335 1998-05-13
US8550098P true 1998-05-14 1998-05-14
US60/085,500 1998-05-14
US8984898P true 1998-06-19 1998-06-19
US60/089,848 1998-06-19
US9220398P true 1998-07-09 1998-07-09
US60/092,203 1998-07-09
US9427598P true 1998-07-27 1998-07-27
US9427698P true 1998-07-27 1998-07-27
US60/094,276 1998-07-27
US60/094,275 1998-07-27
US10081798P true 1998-09-18 1998-09-18
US10095198P true 1998-09-18 1998-09-18
US09/156,318 US6258326B1 (en) 1997-09-20 1998-09-18 Sample holders with reference fiducials
US09/156,318 1998-09-18
US60/100,817 1998-09-18
US09/160,533 US6097025A (en) 1997-10-31 1998-09-24 Light detection device having an optical-path switching mechanism
US10496498P true 1998-10-20 1998-10-20
US60/104,964 1998-10-20
US60/072,499 1998-10-30
US60/084,167 1998-10-30
US60/072,780 1998-10-30
US60/075,806 1998-10-30
US60/075,414 1999-01-25
US60/082,253 1999-01-25
US09/160,533 1999-01-25
US60/100,951 1999-01-25
US09/062,472 1999-01-25

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
IL13567198A IL135671D0 (en) 1997-10-31 1998-10-30 Apparatus and methods for measuring fluorescence polarization
AU15184/99A AU1518499A (en) 1997-10-31 1998-10-30 Apparatus and methods for measuring fluorescence polarization
JP2000519281A JP2003521670A (en) 1997-10-31 1998-10-30 Apparatus and method for measuring the fluorescence polarization
EP98959374A EP1032813A2 (en) 1997-10-31 1998-10-30 Apparatus and methods for measuring fluorescence polarization
JP2000528201A JP2003526077A (en) 1998-01-26 1999-01-25 Apparatus and method for improving the signal resolution in spectroscopy
IL13748599A IL137485D0 (en) 1998-01-26 1999-01-25 Apparatus and method for improving signal resolution in optical spectroscopy
AU23448/99A AU2344899A (en) 1998-01-26 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
PCT/US1999/001656 WO1999037203A2 (en) 1998-01-26 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
AU27758/99A AU2775899A (en) 1998-02-20 1999-02-19 Broad range light detection system
IL13777799A IL137777D0 (en) 1998-02-20 1999-02-19 Broad range light detection system
JP2000532708A JP2003526767A (en) 1998-02-20 1999-02-19 Broad light detection system
PCT/US1999/003678 WO1999042817A1 (en) 1998-02-20 1999-02-19 Broad range light detection system
EP99908291A EP1060384A1 (en) 1998-02-20 1999-02-19 Broad range light detection system
US09/643,221 US6326605B1 (en) 1998-02-20 2000-08-18 Broad range light detection system
US10/012,255 US20020158212A1 (en) 1998-04-17 2001-11-12 Apparatus and methods for time-resolved optical spectroscopy
US10/004,647 US6498335B2 (en) 1998-02-20 2001-12-03 Broad range light detection system
US10/445,292 US6992761B2 (en) 1997-09-20 2003-05-22 Broad range light detection system
US10/746,797 US7745142B2 (en) 1997-09-15 2003-12-23 Molecular modification assays

Related Parent Applications (4)

Application Number Title Priority Date Filing Date
US09/062,472 Continuation US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US09/160,533 Continuation-In-Part US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
PCT/US1999/001656 Continuation WO1999037203A2 (en) 1997-07-16 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
PCT/US1999/001656 Continuation-In-Part WO1999037203A2 (en) 1997-07-16 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
PCT/US1999/001656 Continuation WO1999037203A2 (en) 1997-07-16 1999-01-25 Apparatus and methods for improving signal resolution in optical spectroscopy
PCT/US1999/003678 Continuation WO1999042817A1 (en) 1997-07-16 1999-02-19 Broad range light detection system
US34973399A Continuation 1999-07-08 1999-07-08

Publications (2)

Publication Number Publication Date
WO1999023466A2 WO1999023466A2 (en) 1999-05-14
WO1999023466A3 true WO1999023466A3 (en) 1999-08-19

Family

ID=56289869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023095 WO1999023466A2 (en) 1997-07-16 1998-10-30 Apparatus and methods for measuring fluorescence polarization

Country Status (4)

Country Link
EP (1) EP1032813A2 (en)
JP (1) JP2003521670A (en)
AU (1) AU1518499A (en)
WO (1) WO1999023466A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287774B1 (en) 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
US6472141B2 (en) 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
US8264680B2 (en) 1999-05-28 2012-09-11 Yokogawa Electric Corporation Biochip reader and electrophoresis system
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
EP1261621B1 (en) 1999-06-09 2011-01-26 Molecular Devices, Inc Phosphorylation assays
DE20214868U1 (en) * 2002-07-31 2003-03-13 Tecan Trading Ag Maennedorf Device for measuring the lifetime of fluorescence from fluorophores in samples
EP1546723A4 (en) * 2002-08-16 2007-03-07 Decision Biomarkers Inc Reading of fluorescent arrays
EP2208054B1 (en) 2007-10-31 2019-01-02 PerkinElmer Singapore Pte. Ltd. Sample measurement system
CA2859951A1 (en) * 2011-12-19 2013-06-27 Opticul Diagnostics Inc. Spectroscopic means and methods for identifying microorganisms in culture
FR2994264B1 (en) * 2012-08-02 2014-09-12 Centre Nat Rech Scient Process for analyzing the crystalline structure of a poly-crystalline semiconductor material

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203670A (en) * 1977-04-21 1980-05-20 Bromberg Nathan S System and method of fluorescence polarimetry
US4451149A (en) * 1980-07-28 1984-05-29 Noeller Hans Guenter Polarization fluoroimmunoassay apparatus
US4699512A (en) * 1984-07-13 1987-10-13 Hitachi, Ltd. Device for measuring fluorescence polarization

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203670A (en) * 1977-04-21 1980-05-20 Bromberg Nathan S System and method of fluorescence polarimetry
US4451149A (en) * 1980-07-28 1984-05-29 Noeller Hans Guenter Polarization fluoroimmunoassay apparatus
US4699512A (en) * 1984-07-13 1987-10-13 Hitachi, Ltd. Device for measuring fluorescence polarization

Also Published As

Publication number Publication date
AU1518499A (en) 1999-05-24
JP2003521670A (en) 2003-07-15
EP1032813A2 (en) 2000-09-06
WO1999023466A2 (en) 1999-05-14

Similar Documents

Publication Publication Date Title
Weber et al. Construction and performance of a fluorescence polarization spectrophotometer
KR100647317B1 (en) Optical system for multi-channel fluorescence measurement of microfluidic chip and multi-channel fluorescence sample analyzer
US4626684A (en) Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US20010046050A1 (en) Instantaneous dual band fluorescence detection systems
CA2186241C (en) High-speed multiple wavelength illumination source in quantitative luminescence ratio microscopy
FI96452C (en) A method for tuning the color substances
CN101166966B (en) Fluorescence detection system
US4771629A (en) System for chemical analysis
Netzel et al. Picosecond kinetics of reaction centers containing bacteriochlorophyll
TW398029B (en) Exposure device, method of manufacturing the same and the electric circuit
US6404495B1 (en) System and method for molecular sample measurement
Bykov et al. Steady-state and transient ultraviolet resonance Raman spectrometer for the 193–270 nm spectral region
KR870007476A (en) Device to minimize the ambient light reflected by the display
JPH03162612A (en) Apparatus and operational method for monitoring and/or measuring parameter of travelling thread-like or wire-like test piece
GB2386945A (en) Ink level sensing device and method therefor
WO1998028655A3 (en) Light modulated confocal optical instruments and method
US6683735B2 (en) Rapidly changing dichroic beamsplitter in epifluorescent microscopes
KR970703541A (en) Image projection apparatus including a high-efficiency lighting device, and such devices (High- efficiency illumination device and image projection apparatus comprising such a device)
AU7850298A (en) Monochromatic R,G,B laser light source display system and method
US4395126A (en) Apparatus for reflectance measurement of fluorescent radiation and composite useful therein
JPH034151A (en) Method for photothermal inspection and apparatus for performing the method
EP0841685A3 (en) High efficiency lamp apparatus for producing a beam of polarized light
AU3872699A (en) Eye examination apparatus employing polarized light probe
WO1998048221A3 (en) Laser ignition
EP1420244A3 (en) Video inspection system employing multiple spectrum LED illumination

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 135671

Country of ref document: IL

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase in:

Ref country code: KR

ENP Entry into the national phase in:

Ref country code: JP

Ref document number: 2000 519281

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1998959374

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1998959374

Country of ref document: EP

NENP Non-entry into the national phase in:

Ref country code: CA

WWW Wipo information: withdrawn in national office

Ref document number: 1998959374

Country of ref document: EP