WO1999021971A3 - Thermostable alcohol dehydrogenases - Google Patents

Thermostable alcohol dehydrogenases Download PDF

Info

Publication number
WO1999021971A3
WO1999021971A3 PCT/US1998/022607 US9822607W WO9921971A3 WO 1999021971 A3 WO1999021971 A3 WO 1999021971A3 US 9822607 W US9822607 W US 9822607W WO 9921971 A3 WO9921971 A3 WO 9921971A3
Authority
WO
WIPO (PCT)
Prior art keywords
alcohol dehydrogenases
thermostable
proteins
dehydrogenase activity
alcohol dehydrogenase
Prior art date
Application number
PCT/US1998/022607
Other languages
French (fr)
Other versions
WO1999021971A2 (en
WO1999021971A9 (en
Inventor
Larry Allen
Igor Brikun
John H Alkens
David C Demirjian
Ramesh Matur
Yuri Nikolsky
David Rozzell
Original Assignee
Thermogen Inc
Larry Allen
Igor Brikun
John H Alkens
David C Demirjian
Ramesh Matur
Yuri Nikolsky
David Rozzell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermogen Inc, Larry Allen, Igor Brikun, John H Alkens, David C Demirjian, Ramesh Matur, Yuri Nikolsky, David Rozzell filed Critical Thermogen Inc
Priority to EP98957372A priority Critical patent/EP1027427A2/en
Priority to CA002308095A priority patent/CA2308095A1/en
Priority to AU13648/99A priority patent/AU1364899A/en
Publication of WO1999021971A2 publication Critical patent/WO1999021971A2/en
Publication of WO1999021971A9 publication Critical patent/WO1999021971A9/en
Publication of WO1999021971A3 publication Critical patent/WO1999021971A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides proteins having alcohol dehydrogenase activity. In a particular embodiment, proteins having chiral alcohol selective alcohol dehydrogenase activity. In another embodiment, proteins having thermostable alcohol dehydrogenase activity are provided.
PCT/US1998/022607 1997-10-27 1998-10-26 Thermostable alcohol dehydrogenases WO1999021971A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98957372A EP1027427A2 (en) 1997-10-27 1998-10-26 Thermostable alcohol dehydrogenases
CA002308095A CA2308095A1 (en) 1997-10-27 1998-10-26 Thermostable alcohol dehydrogenases
AU13648/99A AU1364899A (en) 1997-10-27 1998-10-26 Thermostable alcohol dehydrogenases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6351797P 1997-10-27 1997-10-27
US60/063,517 1997-10-27

Publications (3)

Publication Number Publication Date
WO1999021971A2 WO1999021971A2 (en) 1999-05-06
WO1999021971A9 WO1999021971A9 (en) 1999-08-19
WO1999021971A3 true WO1999021971A3 (en) 1999-10-28

Family

ID=22049741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/022607 WO1999021971A2 (en) 1997-10-27 1998-10-26 Thermostable alcohol dehydrogenases

Country Status (4)

Country Link
EP (1) EP1027427A2 (en)
AU (1) AU1364899A (en)
CA (1) CA2308095A1 (en)
WO (1) WO1999021971A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2346992A4 (en) 2008-09-26 2012-06-06 Kesen Ma Thermostable alcohol dehydrogenase derived from thermococcus guaymasensis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352885A (en) * 1980-05-09 1982-10-05 Wisconsin Alumni Research Foundation Preparation of a novel NADP linked alcohol-aldehyde/ketone oxidoreductase from thermophilic anaerobic bacteria for analytical and commercial use
FR2706906A1 (en) * 1993-06-21 1994-12-30 Ifremer Alcohol dehydrogenase, microorganism producing it and its uses
WO1997032012A1 (en) * 1996-02-27 1997-09-04 Michigan State University Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization
EP0796914A2 (en) * 1996-03-21 1997-09-24 Roche Diagnostics GmbH Alcohol dehydrogenase and its use in the enzymatic production of chiral hydroxy-compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352885A (en) * 1980-05-09 1982-10-05 Wisconsin Alumni Research Foundation Preparation of a novel NADP linked alcohol-aldehyde/ketone oxidoreductase from thermophilic anaerobic bacteria for analytical and commercial use
FR2706906A1 (en) * 1993-06-21 1994-12-30 Ifremer Alcohol dehydrogenase, microorganism producing it and its uses
WO1997032012A1 (en) * 1996-02-27 1997-09-04 Michigan State University Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization
EP0796914A2 (en) * 1996-03-21 1997-09-24 Roche Diagnostics GmbH Alcohol dehydrogenase and its use in the enzymatic production of chiral hydroxy-compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RELLOS P ET AL: "Polymerase chain reaction-based random mutagenesis: production and characterization of thermostable mutants of Zymomonas mobilis alcohol dehydrogenase-2", PROTEIN EXPRESSION AND PURIFICATION, vol. 5, 1994, pages 270 - 277, XP002076286 *

Also Published As

Publication number Publication date
WO1999021971A2 (en) 1999-05-06
EP1027427A2 (en) 2000-08-16
CA2308095A1 (en) 1999-05-06
WO1999021971A9 (en) 1999-08-19
AU1364899A (en) 1999-05-17

Similar Documents

Publication Publication Date Title
HK1024191A1 (en) Electrochemical pump, in particular for medicamentdelivery.
ZA982187B (en) Adsorbent construction; and, method.
WO1997043387A3 (en) Detergent composition
ZA983670B (en) Cutting tool assembly.
AU6321498A (en) Electrochemical analyte sensors using thermostable soybean peroxidase
AU1664595A (en) Fat blends, based on diglycerides
AU4680599A (en) Thermostable polymerase
ZA991975B (en) Enzyme inhibitors.
AU7908298A (en) Endo-beta-1,4-glucanases from (saccharothrix)
AU6758798A (en) Dna glycosylase inhibitors, and uses related thereto
AU5906699A (en) (neisseria spp.) polypeptide, nucleic acid sequence and uses thereof
IT1286143B1 (en) HUB-WHEEL GROUP, IN PARTICULAR FOR A VEHICLE.
AU7903998A (en) Coffee machine, especially for mobile use
AU7683998A (en) Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof
AU2002213452A1 (en) Applicator, e.g. for shaving preparations and the like
AU1874899A (en) Catalyst based on zeolite, use and epoxidation method in the presence of said catalyst
WO1999021971A3 (en) Thermostable alcohol dehydrogenases
AU2002221966A1 (en) Enzyme with proteolytic activity
AU2002214198A1 (en) Sealing, trimming and finishing strips
WO2001060986A3 (en) Esterase enzymes having selective activity
AU7625298A (en) M. tuberculosis RNA polymerase alpha subunit
IT246281Y1 (en) CRANKSET FOR FURNITURE, IN PARTICULAR CONNECTION CRANKSET.
ZA986160B (en) 2,4,4-trisubstituted-1,3-dioxolone antifungals.
IT1299133B1 (en) EARRING ACCESSORY, IN PARTICULAR EARRING.
AU1906599A (en) Pancreatic-derived factors, and uses related thereto

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/10-10/10, DRAWINGS, REPLACED BY NEW PAGES 1/17-17/17; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2308095

Country of ref document: CA

Ref country code: CA

Ref document number: 2308095

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 1998957372

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1998957372

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1998957372

Country of ref document: EP