WO1999021533A3 - Delivery vehicles for bioactive agents and uses thereof - Google Patents

Delivery vehicles for bioactive agents and uses thereof Download PDF

Info

Publication number
WO1999021533A3
WO1999021533A3 PCT/US1998/022552 US9822552W WO9921533A3 WO 1999021533 A3 WO1999021533 A3 WO 1999021533A3 US 9822552 W US9822552 W US 9822552W WO 9921533 A3 WO9921533 A3 WO 9921533A3
Authority
WO
WIPO (PCT)
Prior art keywords
oil
agent
compositions
nucleic acid
surface active
Prior art date
Application number
PCT/US1998/022552
Other languages
French (fr)
Other versions
WO1999021533A2 (en
Inventor
Lawrence L Kunz
Thomas R Tice
Randell T Libby
Christopher W Mcdaniel
Original Assignee
Neorx Corp
Southern Res Inst
Lawrence L Kunz
Thomas R Tice
Randell T Libby
Christopher W Mcdaniel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neorx Corp, Southern Res Inst, Lawrence L Kunz, Thomas R Tice, Randell T Libby, Christopher W Mcdaniel filed Critical Neorx Corp
Priority to EP98955098A priority Critical patent/EP1023045A2/en
Priority to AU11985/99A priority patent/AU1198599A/en
Priority to CA002306090A priority patent/CA2306090A1/en
Publication of WO1999021533A2 publication Critical patent/WO1999021533A2/en
Publication of WO1999021533A3 publication Critical patent/WO1999021533A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically-modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agent.
PCT/US1998/022552 1997-10-24 1998-10-23 Delivery vehicles for bioactive agents and uses thereof WO1999021533A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98955098A EP1023045A2 (en) 1997-10-24 1998-10-23 Delivery vehicles for bioactive agents and uses thereof
AU11985/99A AU1198599A (en) 1997-10-24 1998-10-23 Delivery vehicles for bioactive agents and uses thereof
CA002306090A CA2306090A1 (en) 1997-10-24 1998-10-23 Delivery vehicles for bioactive agents and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6311497P 1997-10-24 1997-10-24
US95669497A 1997-10-24 1997-10-24
US60/063,114 1997-10-24
US08/956,694 1997-10-24

Publications (2)

Publication Number Publication Date
WO1999021533A2 WO1999021533A2 (en) 1999-05-06
WO1999021533A3 true WO1999021533A3 (en) 1999-07-08

Family

ID=26743057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/022552 WO1999021533A2 (en) 1997-10-24 1998-10-23 Delivery vehicles for bioactive agents and uses thereof

Country Status (4)

Country Link
EP (1) EP1023045A2 (en)
AU (1) AU1198599A (en)
CA (1) CA2306090A1 (en)
WO (1) WO1999021533A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200957B1 (en) * 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
IT1318539B1 (en) 2000-05-26 2003-08-27 Italfarmaco Spa PROLONGED RELEASE PHARMACEUTICAL COMPOSITIONS FOR THE PARENTERAL ADMINISTRATION OF BIOLOGICALLY HYDROPHILE SUBSTANCES
US20020155084A1 (en) * 2000-06-02 2002-10-24 The Regents Of The University Of The Michigan Nanoemulsion formulations
US20030165545A1 (en) * 2002-01-30 2003-09-04 Allergan, Inc. Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same
PL1787658T3 (en) * 2005-11-10 2012-08-31 Italfarmaco Spa Sustained release formulations of somatostatin analogue inhibitors of growth hormone
AU2014209218B2 (en) 2013-01-25 2018-06-07 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
CN111394444A (en) * 2013-09-13 2020-07-10 生命技术公司 Device preparation using condensed nucleic acid particles
WO2017223199A1 (en) * 2016-06-22 2017-12-28 Xcell Biosciences, Inc. Methods for increasing cell culture transfection efficiency and cellular reprogramming

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3384544A (en) * 1966-06-08 1968-05-21 Glaxo Lab Ltd Injectable solutions or suspensions of antigens in optically clear colloidal solutions
EP0399843A2 (en) * 1989-05-25 1990-11-28 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
WO1995011700A1 (en) * 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants
EP0682942A1 (en) * 1993-01-21 1995-11-22 Yamanouchi Pharmaceutical Co. Ltd. Novel, percutaneously absorbable preparation
WO1997011682A2 (en) * 1995-09-26 1997-04-03 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3384544A (en) * 1966-06-08 1968-05-21 Glaxo Lab Ltd Injectable solutions or suspensions of antigens in optically clear colloidal solutions
EP0399843A2 (en) * 1989-05-25 1990-11-28 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
EP0682942A1 (en) * 1993-01-21 1995-11-22 Yamanouchi Pharmaceutical Co. Ltd. Novel, percutaneously absorbable preparation
WO1995011700A1 (en) * 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants
WO1997011682A2 (en) * 1995-09-26 1997-04-03 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells

Also Published As

Publication number Publication date
EP1023045A2 (en) 2000-08-02
AU1198599A (en) 1999-05-17
WO1999021533A2 (en) 1999-05-06
CA2306090A1 (en) 1999-05-06

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