WO1999017671A1 - Transmyocardial revascularization using radiofrequency energy - Google Patents
Transmyocardial revascularization using radiofrequency energy Download PDFInfo
- Publication number
- WO1999017671A1 WO1999017671A1 PCT/US1998/020799 US9820799W WO9917671A1 WO 1999017671 A1 WO1999017671 A1 WO 1999017671A1 US 9820799 W US9820799 W US 9820799W WO 9917671 A1 WO9917671 A1 WO 9917671A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- energy
- patient
- heart
- distal tip
- elongated
- Prior art date
Links
- 0 C[*+](CC*1)CC1N Chemical compound C[*+](CC*1)CC1N 0.000 description 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
- A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00392—Transmyocardial revascularisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00738—Depth, e.g. depth of ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00839—Bioelectrical parameters, e.g. ECG, EEG
Definitions
- This invention is directed to the ablation or disruption of tissue in the wall of a
- TMR transmyocardial revascularization
- diagnostic agents to various locations in the patient's heart wall or for a variety of
- TMR involves forming a plurality of channels in a
- Patent 4,658,817 (Hardy). These early references describe intraoperative TMR
- peripheral arterial system e.g., the femoral artery
- the distal end of the optical fiber Within the left ventricle, the distal end of the optical fiber
- the device is directed toward a desired location on the patient's endocardium and urged
- the laser based revascularization procedure has been shown to be clinically
- the present invention is directed to a method and system for the
- said region with emissions of radiofrequency (RF) energy and is particularly
- One method includes the step of inserting an elongated shaft having an RF
- the RF energy emitter is guided to the interior of the left
- ventricle and positioned against a desired portion of the ventricle's inner wall.
- the RF energy emitter is activated to remove or otherwise injure tissue.
- RF energy emitter may be advanced so as to remove tissue until a channel or
- channel formation include fluoroscopic or ultrasonic visualization or advancing the
- revascularization means a fixed distance.
- penetration limitation can be
- the RF energy emitter is repositioned against another portion of the heart wall and the process is repeated until enough channels or regions of ablated
- tissue are formed to provide the desired revascularization.
- tissue is ablated within
- intervals of about one to about 500 msec and preferably about 30 to about 130
- a radiofrequency burst may comprise a continuous emission or
- discontinuous emission i.e. be pulsatile, and, if pulsatile, may involve a plurality or
- train of pulses which may or may not be of the same width (duration), frequency or
- the RF emissions are preferably controlled so that heart tissue is exposed to
- the RF energy source generally should have
- the channel formation or tissue disruption may be performed
- the remainder of the procedure may be performed at a lower energy
- RF energy transmitting member which has a proximal end, and an uninsulated distal tip configured to emit RF energy.
- the channel formed in the heart wall preferably has an aspect ratio
- the RF energy emitter includes
- lumens for perfusion and aspiration to remove the particles from the patient's body are provided.
- the RF energy emitter is configured to produce particles small enough
- a flexible RF energy emitter is advanced through the patient's vasculature until a
- a heart chamber such as the left ventricle.
- RF energy transmitting member is advanced so that the uninsulated distal tip which
- At least one burst of RF energy is emitted from the uninsulated
- Another embodiment of the invention involves a minimally invasive approach where a small incision is made in the patient's chest and with or without the benefit
- an elongated RF energy transmitting member is advanced into
- the RF energy emitter preferably includes an RF energy transmitting
- uninsulated distal tip can have a diameter of about 0.025 to about 0.2 inch (0.64-5.1
- the distal tip may be solid or
- the frequency of the RF current should not be less than 100 kHz and preferably is
- the method and system of the invention effectively ablates or disturbs tissue within the patient's heart wall to revascularize the ablated region and particularly can
- FIG. 1 is a schematic illustration of a system for revascularizing heart tissue
- FIG. 2 is a transverse cross-section of the RF energy transmitting member of
- FIG. 3 is a schematic illustration of the one shot shown in FIG. 1.
- FIG. 4 is a schematic illustration of a system for generating trigger signals
- FIG. 5 is an elevational view of a delivery system for the RF energy emitter
- FIG. 6 is a schematic elevational view, partially in cross-section, of a human
- FIG. 7 is a schematic longitudinal cross-sectional view of the distal portion of
- FIGS. 8 and 9 are schematic longitudinal cross-sectional views of RF
- FIGS. 1 and 2 depict an RF system 10 embodying features of the invention
- the RF energy transmitting member The RF
- energy transmitting member 11 includes an electrical conductor 14 which may be
- a suitable insulating polymeric material is the
- the output from the RF energy source 12 is pulsed by pulse-trigger system
- the pulsed output signal 20 from the one-shot 17 actuates the transistor 21 for the
- the output of the transistor 21 is connected to reed
- the output of the reed relay 22 is connected in series to the foot switch 23.
- FIG. 3 illustrates in more detail the one-shot shown in FIG. 1 which has 14
- pins identified as pins a-n in FIG. 3.
- the one-shot shown in FIG. 3 has the pins
- the one-shot model number CD4047 has these pins numbered 1-14.
- trigger signal 18 from an ECG unit is received by pin h and upon receipt of the
- pin j is controlled by the resistance R and capacitance C from the RC circuit
- the resistance R can typically range from about
- the capacitance can typically range from about 0.08 to
- FIG. 4 schematically illustrates a system of generating trigger signals 18
- the signals from the patient's heart 31 are based upon the patient's heart cycle 30.
- the signals from the patient's heart 31 are
- trigger generating system 32 which may also be contained in the ECG unit.
- trigger signal generating system 32 is preprogrammed to emit one or more trigger
- FIG. 5 illustrates a system for the percutaneous
- an RF system which has an outer catheter 40, a shaped distal end 41 , a
- This system also includes an inner catheter
- catheter 44 which is slidably and rotatably disposed within the inner lumen of the
- outer catheter 40 which has a shaped distal section 45, a distal end 46, a port
- An RF energy emitter 50 is slidably disposed within the
- the distal section 45 of the inner catheter 44 is at an angle with respect to the main shaft section 51 of the inner catheter to orient the
- the present invention also comprises a method for
- An RF system 10 including
- an elongated shaft 60 with an RF energy emitter 50 disposed at the distal end is
- the RF energy emitter 50 is
- the RF energy emitter 50 is activated and urged against the muscle 62 to
- tissue forming the revascularization channel 64.
- region disturbed or ablated should extend a desired distance through the
- the RF energy emitter 50 is deactivated, withdrawn from channel 64 and
- RF energy emitter 50 on the distal end is introduced through a small opening in the patient's chest wall. RF system 10 is advanced until the RF energy emitter 50 is
- emitter 50 is activated and urged towards the muscle 62. Tissue is removed
- channels 64 or similar revascularization sites are formed in muscle 62 to
- the RF energy emitter 50 may be maintained in position on the RF energy emitter 50
- the RF energy emitter 50 can be maintained in place by applying a vacuum at the
- the operation may be synchronized
- the RF energy emitter 50 is subject to
- the RF energy emitter 50 may operate at two or more energy
- the initial tissue removal to penetrate the endocardium 66 is
- the remainder of the tissue removal may be performed at a lower energy level to
- control lines 70 are
- Adhesive bonding may utilize any of a variety of adhesives, including
- control lines 70 are thus axially,
- a mechanism such as a ring or knob may
- control lines 70 may be attached to the proximal ends of control lines 70 to allow manipulation of control
- Control lines 70 are preferably approximately 3-mil stainless steel wire,
- an outer tubular member 74 preferably encloses control lines 70
- Outer tubular member 74 is secured at
- control lines 70 are
- Channels 76 are preferably constructed of 30 gauge polyamide tubing.
- Control lines 70 are thus guided to remain both separated and within well controlled
- the positioning of the device may be viewed by esophageal ultrasound
- trans-thoracic ultrasound imaging and trans-thoracic fluoroscopic imaging.
- RF energy emitter 50 may
- FIG. 8 illustrates the distal portion of an RF system
- the thermal ablator 78 has an electrode 80
- the diameter of probe 82 should be from about 1.0 to 5.0 mm.
- proximal ends of the electrode 80 is are connected to a radiofrequency generating
- Radiofrequency energy may also provide inductive heating as shown in
- FIG. 9 The distal portion of an RF system 10 has a ferrite probe 84 on the end.
- radiofrequency generating means (not shown) irradiates the patient's body with
- Radiofrequency energy at a frequency to which body tissue is relatively transparent but the ferrite Radiofrequency energy may also provide inductive heating as shown in FIG. 9.
- distal portion of an RF system 10 has a ferrite probe 84 on the end.
- radiofrequency generating means (not shown) irradiates the patient's body with
- Eighteen channels were made in the heart of a live, anesthetized medium
- distal tip of the RF delivery system were varied to determine the nature of the
- the revascularization may be performed from
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Medical Informatics (AREA)
- Otolaryngology (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU96803/98A AU9680398A (en) | 1997-10-02 | 1998-10-02 | Transmyocardial revascularization using radiofrequency energy |
EP98950873A EP1018961A1 (en) | 1997-10-02 | 1998-10-02 | Transmyocardial revascularization using radiofrequency energy |
JP2000514573A JP2001518345A (en) | 1997-10-02 | 1998-10-02 | Myocardial revascularization using high frequency energy |
CA002305333A CA2305333A1 (en) | 1997-10-02 | 1998-10-02 | Transmyocardial revascularization using radiofrequency energy |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/942,874 US6267757B1 (en) | 1995-08-09 | 1997-10-02 | Revascularization with RF ablation |
US08/942,874 | 1997-10-02 | ||
US94729097A | 1997-10-07 | 1997-10-07 | |
US08/947,290 | 1997-10-07 | ||
US09/107,077 US6156031A (en) | 1995-08-09 | 1998-06-29 | Transmyocardial revascularization using radiofrequency energy |
US09/107,077 | 1998-06-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999017671A1 true WO1999017671A1 (en) | 1999-04-15 |
WO1999017671A9 WO1999017671A9 (en) | 1999-06-17 |
Family
ID=27380246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/020799 WO1999017671A1 (en) | 1997-10-02 | 1998-10-02 | Transmyocardial revascularization using radiofrequency energy |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1018961A1 (en) |
JP (1) | JP2001518345A (en) |
AU (1) | AU9680398A (en) |
CA (1) | CA2305333A1 (en) |
WO (1) | WO1999017671A1 (en) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1218801A2 (en) * | 1999-09-08 | 2002-07-03 | Curon Medical, Inc. | Systems and methods for monitoring and controlling use of medical devices |
WO2003013641A2 (en) | 2001-08-10 | 2003-02-20 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Side-exit catheter and method for its use |
US7704222B2 (en) | 1998-09-10 | 2010-04-27 | Jenavalve Technology, Inc. | Methods and conduits for flowing blood from a heart chamber to a blood vessel |
US9292152B2 (en) | 2009-09-22 | 2016-03-22 | Mederi Therapeutics, Inc. | Systems and methods for controlling use and operation of a family of different treatment devices |
US9675404B2 (en) | 2009-09-22 | 2017-06-13 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
US9675403B2 (en) | 2000-05-18 | 2017-06-13 | Mederi Therapeutics, Inc. | Graphical user interface for monitoring and controlling use of medical devices |
US9750563B2 (en) | 2009-09-22 | 2017-09-05 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
US9775664B2 (en) | 2009-09-22 | 2017-10-03 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
US9925000B2 (en) | 1999-09-08 | 2018-03-27 | Mederi Therapeutics, Inc. | Systems and methods for monitoring and controlling use of medical devices |
US10386990B2 (en) | 2009-09-22 | 2019-08-20 | Mederi Rf, Llc | Systems and methods for treating tissue with radiofrequency energy |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7480200A (en) | 1999-09-08 | 2001-04-10 | Curon Medical, Inc. | System for controlling a family of treatment devices |
WO2012013243A1 (en) * | 2010-07-30 | 2012-02-02 | Umc Utrecht Holding B.V. | Generator, combination of a generator and a catheter, and method for providing an electrical pulse |
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US4658817A (en) | 1985-04-01 | 1987-04-21 | Children's Hospital Medical Center | Method and apparatus for transmyocardial revascularization using a laser |
EP0553576A1 (en) * | 1990-09-24 | 1993-08-04 | Plc Medical Systems, Inc. | Heart-synchronized pulsed laser system |
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WO1996035469A1 (en) * | 1995-05-10 | 1996-11-14 | Cardiogenesis Corporation | System for treating or diagnosing heart tissue |
WO1996039967A1 (en) * | 1995-06-07 | 1996-12-19 | Ep Technologies, Inc. | Tissue heating and ablation systems and methods which predict maximum tissue temperature |
WO1997027897A1 (en) * | 1996-02-02 | 1997-08-07 | Transvascular, Inc. | A device, system and method for interstitial transvascular intervention |
US5672170A (en) * | 1996-06-20 | 1997-09-30 | Cynosure, Inc. | Laser transmyocardial revascularization arrangement |
EP0858779A1 (en) * | 1997-02-03 | 1998-08-19 | Eclipse Surgical Technologies, Inc. | Transmyocardial revascularisation device |
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-
1998
- 1998-10-02 AU AU96803/98A patent/AU9680398A/en not_active Abandoned
- 1998-10-02 CA CA002305333A patent/CA2305333A1/en not_active Abandoned
- 1998-10-02 WO PCT/US1998/020799 patent/WO1999017671A1/en not_active Application Discontinuation
- 1998-10-02 EP EP98950873A patent/EP1018961A1/en not_active Withdrawn
- 1998-10-02 JP JP2000514573A patent/JP2001518345A/en active Pending
Patent Citations (10)
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US4658817A (en) | 1985-04-01 | 1987-04-21 | Children's Hospital Medical Center | Method and apparatus for transmyocardial revascularization using a laser |
EP0553576A1 (en) * | 1990-09-24 | 1993-08-04 | Plc Medical Systems, Inc. | Heart-synchronized pulsed laser system |
US5389096A (en) | 1990-12-18 | 1995-02-14 | Advanced Cardiovascular Systems | System and method for percutaneous myocardial revascularization |
US5554152A (en) | 1990-12-18 | 1996-09-10 | Cardiogenesis Corporation | Method for intra-operative myocardial revascularization |
WO1996035469A1 (en) * | 1995-05-10 | 1996-11-14 | Cardiogenesis Corporation | System for treating or diagnosing heart tissue |
WO1996039967A1 (en) * | 1995-06-07 | 1996-12-19 | Ep Technologies, Inc. | Tissue heating and ablation systems and methods which predict maximum tissue temperature |
WO1997027897A1 (en) * | 1996-02-02 | 1997-08-07 | Transvascular, Inc. | A device, system and method for interstitial transvascular intervention |
US5672170A (en) * | 1996-06-20 | 1997-09-30 | Cynosure, Inc. | Laser transmyocardial revascularization arrangement |
EP0858779A1 (en) * | 1997-02-03 | 1998-08-19 | Eclipse Surgical Technologies, Inc. | Transmyocardial revascularisation device |
US7844393B2 (en) | 2003-05-15 | 2010-11-30 | Alpine Electronics, Inc. | Vehicle navigation system and method |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7736327B2 (en) | 1998-09-10 | 2010-06-15 | Jenavalve Technology, Inc. | Methods and conduits for flowing blood from a heart chamber to a blood vessel |
US8597226B2 (en) | 1998-09-10 | 2013-12-03 | Jenavalve Technology, Inc. | Methods and conduits for flowing blood from a heart chamber to a blood vessel |
US8216174B2 (en) | 1998-09-10 | 2012-07-10 | Jenavalve Technology, Inc. | Methods and conduits for flowing blood from a heart chamber to a blood vessel |
US7704222B2 (en) | 1998-09-10 | 2010-04-27 | Jenavalve Technology, Inc. | Methods and conduits for flowing blood from a heart chamber to a blood vessel |
EP1218801A2 (en) * | 1999-09-08 | 2002-07-03 | Curon Medical, Inc. | Systems and methods for monitoring and controlling use of medical devices |
EP1218801A4 (en) * | 1999-09-08 | 2009-07-01 | Mederi Therapeutics Inc | Systems and methods for monitoring and controlling use of medical devices |
US8449529B2 (en) | 1999-09-08 | 2013-05-28 | Mederi Therapeutics, Inc. | Systems and methods for monitoring and controlling use of medical devices |
US9925000B2 (en) | 1999-09-08 | 2018-03-27 | Mederi Therapeutics, Inc. | Systems and methods for monitoring and controlling use of medical devices |
US9750559B2 (en) | 1999-09-08 | 2017-09-05 | Mederi Therapeutics Inc | System and methods for monitoring and controlling use of medical devices |
US9675403B2 (en) | 2000-05-18 | 2017-06-13 | Mederi Therapeutics, Inc. | Graphical user interface for monitoring and controlling use of medical devices |
WO2003013641A2 (en) | 2001-08-10 | 2003-02-20 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Side-exit catheter and method for its use |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11154398B2 (en) | 2008-02-26 | 2021-10-26 | JenaValve Technology. Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US9292152B2 (en) | 2009-09-22 | 2016-03-22 | Mederi Therapeutics, Inc. | Systems and methods for controlling use and operation of a family of different treatment devices |
US9495059B2 (en) | 2009-09-22 | 2016-11-15 | Mederi Therapeutics, Inc. | Systems and methods for controlling use and operation of a family of different treatment devices |
US9750563B2 (en) | 2009-09-22 | 2017-09-05 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
US10292756B2 (en) | 2009-09-22 | 2019-05-21 | Mederi Rf, Llc | Systems and methods for treating tissue with radiofrequency energy |
US10363089B2 (en) | 2009-09-22 | 2019-07-30 | Mederi Rf, Llc | Systems and methods for treating tissue with radiofrequency energy |
US10386990B2 (en) | 2009-09-22 | 2019-08-20 | Mederi Rf, Llc | Systems and methods for treating tissue with radiofrequency energy |
US10624690B2 (en) | 2009-09-22 | 2020-04-21 | Mederi Rf, Llc | Systems and methods for controlling use and operation of a family of different treatment devices |
US10639090B2 (en) | 2009-09-22 | 2020-05-05 | Mederi Rf, Llc | Systems and methods for controlling use and operation of a treatment device |
US9675404B2 (en) | 2009-09-22 | 2017-06-13 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
US9310956B2 (en) | 2009-09-22 | 2016-04-12 | Mederi Therapeutics, Inc. | Systems and methods for controlling use and operation of a family of different treatment devices |
US9513761B2 (en) | 2009-09-22 | 2016-12-06 | Mederi Therapeutics, Inc. | Systems and methods for controlling use of treatment devices |
US9448681B2 (en) | 2009-09-22 | 2016-09-20 | Mederi Therapeutics, Inc. | Systems and methods for controlling use and operation of a family of different treatment devices |
US11507247B2 (en) | 2009-09-22 | 2022-11-22 | Mederi Rf, Llc | Systems and methods for treating tissue with radiofrequency energy |
US9775664B2 (en) | 2009-09-22 | 2017-10-03 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
US11471214B2 (en) | 2009-09-22 | 2022-10-18 | Mederi Rf, Llc | Systems and methods for treating tissue with radiofrequency energy |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
Also Published As
Publication number | Publication date |
---|---|
CA2305333A1 (en) | 1999-04-15 |
JP2001518345A (en) | 2001-10-16 |
EP1018961A1 (en) | 2000-07-19 |
AU9680398A (en) | 1999-04-27 |
WO1999017671A9 (en) | 1999-06-17 |
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