WO1999009965A3 - Anti-inflammatory agent - Google Patents

Anti-inflammatory agent Download PDF

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Publication number
WO1999009965A3
WO1999009965A3 PCT/JP1998/003692 JP9803692W WO9909965A3 WO 1999009965 A3 WO1999009965 A3 WO 1999009965A3 JP 9803692 W JP9803692 W JP 9803692W WO 9909965 A3 WO9909965 A3 WO 9909965A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
group
inflammatory agent
formula
ring
Prior art date
Application number
PCT/JP1998/003692
Other languages
French (fr)
Other versions
WO1999009965A2 (en
Inventor
Hiroyuki Odaka
Yu Momose
Original Assignee
Takeda Chemical Industries Ltd
Hiroyuki Odaka
Yu Momose
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd, Hiroyuki Odaka, Yu Momose filed Critical Takeda Chemical Industries Ltd
Priority to CA002300813A priority Critical patent/CA2300813A1/en
Priority to EP98938913A priority patent/EP1007038A2/en
Priority to AU87479/98A priority patent/AU8747998A/en
Publication of WO1999009965A2 publication Critical patent/WO1999009965A2/en
Publication of WO1999009965A3 publication Critical patent/WO1999009965A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An anti-inflammatory agent which affects by way of a TNF-α inhibitory action and comprises a compound of formula (I) wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula -CO-, -CH(OH)-, or -NR3- where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond or a salt thereof.
PCT/JP1998/003692 1997-08-21 1998-08-20 Anti-inflammatory agent WO1999009965A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002300813A CA2300813A1 (en) 1997-08-21 1998-08-20 Anti-inflammatory agent
EP98938913A EP1007038A2 (en) 1997-08-21 1998-08-20 Anti-inflammatory agent
AU87479/98A AU8747998A (en) 1997-08-21 1998-08-20 Anti-inflammatory agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22530297 1997-08-21
JP9/225302 1997-08-21

Publications (2)

Publication Number Publication Date
WO1999009965A2 WO1999009965A2 (en) 1999-03-04
WO1999009965A3 true WO1999009965A3 (en) 1999-05-20

Family

ID=16827222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/003692 WO1999009965A2 (en) 1997-08-21 1998-08-20 Anti-inflammatory agent

Country Status (4)

Country Link
EP (1) EP1007038A2 (en)
AU (1) AU8747998A (en)
CA (1) CA2300813A1 (en)
WO (1) WO1999009965A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8950405B2 (en) 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US9060843B2 (en) 2005-07-18 2015-06-23 Tearscience, Inc. Method and apparatus for treating gland dysfunction employing heated medium
US9314369B2 (en) 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7349100A (en) 1999-08-31 2001-03-26 Maxia Pharmaceuticals, Inc. Benzylidene-thiazolidinediones and analogues and their use in the treatment of inflammation
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
WO2001058491A1 (en) * 2000-02-10 2001-08-16 Takeda Chemical Industries, Ltd. Drug comprising combination
WO2001062238A2 (en) * 2000-02-24 2001-08-30 San Diego State University Ppar gamma agonists for the treatment of liver inflammatory disorders
US7153875B2 (en) 2001-03-07 2006-12-26 Incyte San Diego Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
JP2004523571A (en) 2001-03-08 2004-08-05 マキシア・ファーマシューティカルズ・インコーポレイテッド RXR activating molecule
US7364736B2 (en) 2001-06-26 2008-04-29 Amgen Inc. Antibodies to OPGL
EP1456187A4 (en) 2001-11-15 2005-02-09 Incyte San Diego Inc N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases
GB0128138D0 (en) * 2001-11-23 2002-01-16 King S College London Pharmaceutical use
US7102000B2 (en) 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US7196108B2 (en) 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
WO2008027069A1 (en) 2006-08-21 2008-03-06 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid
EP2991729B8 (en) 2013-04-30 2018-09-05 Tear Film Innovations, Inc. Systems for the treatment of eye conditions
US9763827B2 (en) 2013-04-30 2017-09-19 Tear Film Innovations, Inc. Systems and methods for the treatment of eye conditions
US10974063B2 (en) 2016-06-30 2021-04-13 Alcon Inc. Light therapy for eyelash growth

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995035108A1 (en) * 1994-06-22 1995-12-28 The Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
WO1996024350A1 (en) * 1995-02-10 1996-08-15 Schering Aktiengesellschaft Pharmaceutical preparations for tumour necrosis factor (tnf) inhibition
WO1996034943A1 (en) * 1995-05-04 1996-11-07 City Of Hope Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
DE19540475A1 (en) * 1995-10-20 1997-04-24 Schering Ag Chiral methylphenyloxazolidinones
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity
WO1997045141A1 (en) * 1996-05-31 1997-12-04 Sankyo Company, Limited Remedy for autoimmune diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995035108A1 (en) * 1994-06-22 1995-12-28 The Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
WO1996024350A1 (en) * 1995-02-10 1996-08-15 Schering Aktiengesellschaft Pharmaceutical preparations for tumour necrosis factor (tnf) inhibition
WO1996034943A1 (en) * 1995-05-04 1996-11-07 City Of Hope Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
DE19540475A1 (en) * 1995-10-20 1997-04-24 Schering Ag Chiral methylphenyloxazolidinones
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity
WO1997045141A1 (en) * 1996-05-31 1997-12-04 Sankyo Company, Limited Remedy for autoimmune diseases

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
C. HOFMANN ET AL.: "Altered Gene Expression for Tumor Necrosis Factor-alpha and Its Receptors during Drug and Dietary Modulation of Insulin Resistance", ENDOCRINOLOGY, vol. 134, no. 1, January 1994 (1994-01-01), pages 264 - 270, XP002094464 *
D.SZALKOWSKI ET AL.: "Antidiabetic Thiazolidinediones Block the Inhibitory Effect of Tumor Necrosis Factor-alpha on Differentiation, Insulin-Stimulated Glucose Uptake, and Gene Expression in 3T3-L1 Cells", ENDOCRINOLOGY, vol. 136, no. 4, April 1995 (1995-04-01), pages 1474 - 1481, XP002094465 *
H.ODAKA ET AL.: "EFFECT OF PIOGLITAZONE ON SUCROSE-DETERIORATED DIABETIC STATES IN SPONTANEOUSLY DIABETIC GK RATS", DIALOG(R) FILE 5: BIOSIS PREVIEWS(R) ACCESSION NUMBER 07798952: J. JPN. DIABETES SOC., vol. 34, no. 6, 1991, pages 523 - 530, XP002094468 *
M. SUZUKI ET AL.: "Nephropathy in genetically obese-diabetic Wistar fatty rats - Characterization and prevention", DIALOG(R) FILE 73: EMBASE, ACCESSION NUMBER 07010090: JPN. PHARMACOL. THER., vol. 25, no. 2, 1997, pages 43 - 51, XP002094469 *
P. PERALDI ET AL.: "Thiazolidinediones Block Tumor Necrosis Factor-alpha.induced Inhibition of Insulin Signaling", J. CLIN.INVEST., vol. 100, no. 7, 1 October 1997 (1997-10-01), pages 1863 - 1869, XP002094470 *
R.W.STEVENSON ET AL.: "The thiazolidinedione drug series", THE DIABETES ANNUAL, vol. 9, 1995, pages 175 - 191, XP002094463 *
S.L. GROSSMAN ET AL.: "Mechanisms and clinical effects of thiazolidinediones", EXPERT OPIN. INVEST. DRUGS, vol. 6, no. 8, August 1997 (1997-08-01), pages 1025 - 1040, XP002094471 *
S.S.SOLOMON ET AL.: "Pioglitazone and Metformin Reverse Insulin Resistance Induced by Tumor Necrosis Factor-Alpha in Liver Cells", HORMON. METAB. RES., vol. 29, no. 8, August 1997 (1997-08-01), pages 379 - 382, XP002094467 *
T. YOSHIMOTO ET AL.: "Antihypertensive and vasculo- and renoprotective effects of pioglitazone in genetically obese diabetic rats", AM.J.PHYSIOL., vol. 272, no. 6 Part 1, June 1997 (1997-06-01), pages E989 - E996, XP002094466 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9060843B2 (en) 2005-07-18 2015-06-23 Tearscience, Inc. Method and apparatus for treating gland dysfunction employing heated medium
US8950405B2 (en) 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US9314369B2 (en) 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction

Also Published As

Publication number Publication date
EP1007038A2 (en) 2000-06-14
AU8747998A (en) 1999-03-16
CA2300813A1 (en) 1999-03-04
WO1999009965A2 (en) 1999-03-04

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