WO1999009381A1 - Calibration system for a photomultiplier tube - Google Patents
Calibration system for a photomultiplier tube Download PDFInfo
- Publication number
- WO1999009381A1 WO1999009381A1 PCT/US1998/017047 US9817047W WO9909381A1 WO 1999009381 A1 WO1999009381 A1 WO 1999009381A1 US 9817047 W US9817047 W US 9817047W WO 9909381 A1 WO9909381 A1 WO 9909381A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- check
- signal
- optical system
- light signal
- Prior art date
Links
- 230000003287 optical effect Effects 0.000 claims abstract description 54
- 239000011521 glass Substances 0.000 description 18
- 230000004044 response Effects 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 8
- 230000003595 spectral effect Effects 0.000 description 7
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 6
- 229910052710 silicon Inorganic materials 0.000 description 6
- 239000010703 silicon Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 230000001052 transient effect Effects 0.000 description 4
- DZBUGLKDJFMEHC-UHFFFAOYSA-O acridine;hydron Chemical compound C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-O 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 229910002601 GaN Inorganic materials 0.000 description 2
- JMASRVWKEDWRBT-UHFFFAOYSA-N Gallium nitride Chemical compound [Ga]#N JMASRVWKEDWRBT-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GONFBOIJNUKKST-UHFFFAOYSA-N 5-ethylsulfanyl-2h-tetrazole Chemical compound CCSC=1N=NNN=1 GONFBOIJNUKKST-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- -1 acridinium amide Chemical class 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 239000005337 ground glass Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000011022 opal Substances 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measurement Of Radiation (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP51351499A JP3255647B2 (en) | 1997-08-20 | 1998-08-17 | Calibration system for photomultiplier tubes |
AT98939971T ATE270426T1 (en) | 1997-08-20 | 1998-08-17 | CALIBRATION SYSTEM FOR A PHOTO MULTIPLIER TUBE |
EP98939971A EP1005630B1 (en) | 1997-08-20 | 1998-08-17 | Calibration system for a photomultiplier tube |
CA002294188A CA2294188C (en) | 1997-08-20 | 1998-08-17 | Calibration system for a photomultiplier tube |
DE69824858T DE69824858T2 (en) | 1997-08-20 | 1998-08-17 | CALIBRATION SYSTEM FOR A PHOTOVERFUL TUBE TUBE |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/915,029 US5859429A (en) | 1997-08-20 | 1997-08-20 | Optical system with test/calibration |
US08/915,029 | 1997-08-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999009381A1 true WO1999009381A1 (en) | 1999-02-25 |
Family
ID=25435100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/017047 WO1999009381A1 (en) | 1997-08-20 | 1998-08-17 | Calibration system for a photomultiplier tube |
Country Status (8)
Country | Link |
---|---|
US (1) | US5859429A (en) |
EP (1) | EP1005630B1 (en) |
JP (1) | JP3255647B2 (en) |
AT (1) | ATE270426T1 (en) |
CA (1) | CA2294188C (en) |
DE (1) | DE69824858T2 (en) |
ES (1) | ES2232008T3 (en) |
WO (1) | WO1999009381A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2348949A (en) * | 1999-04-16 | 2000-10-18 | Lre Technology Partner Gmbh | Optical analytical instrument |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7005646B1 (en) * | 2002-07-24 | 2006-02-28 | Canberra Industries, Inc. | Stabilized scintillation detector for radiation spectroscopy and method |
US7157681B1 (en) | 2003-12-16 | 2007-01-02 | Wolfgang Tetzlaff | Photomultiplier tube gain stabilization for radiation dosimetry system |
US8112229B2 (en) * | 2007-05-31 | 2012-02-07 | Abbott Laboratories | Method for determining the order of execution of assays of a sample in a laboratory automation system |
US11754504B2 (en) | 2017-09-19 | 2023-09-12 | Beckman Coulter, Inc. | System for analog light measuring and photon counting in chemiluminescence measurements |
CN108444917A (en) * | 2018-06-05 | 2018-08-24 | 深圳迎凯生物科技有限公司 | Self-alignment Dim light measurement device |
EP3779412A4 (en) * | 2018-06-05 | 2021-05-26 | Shenzhen Increcare Biotech Co. Ltd | Self-calibrating weak light detection device and use thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03262931A (en) * | 1990-03-13 | 1991-11-22 | Aloka Co Ltd | Light source unit for calibrating sensitivity of photomultiplier tube |
DE4422580C1 (en) * | 1994-06-28 | 1995-12-14 | Boehringer Mannheim Gmbh | Calibration of light sensitivity for optical measurement receiver with long-term instability e.g. photomultiplier |
US5715048A (en) * | 1995-11-22 | 1998-02-03 | Dynex Technologies, Inc. | Calibration system for a photo multiplier tube |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USB283761I5 (en) * | 1971-05-26 | |||
US3754866A (en) * | 1971-07-30 | 1973-08-28 | Sherwood Medical Ind Inc | Optical detecting system |
FR2286393A1 (en) * | 1974-09-27 | 1976-04-23 | Labo Electronique Physique | AUTOMATIC PERMANENT CALIBRATION SYSTEM FOR SCINTILLATION CAMERA |
US4160165A (en) * | 1976-11-26 | 1979-07-03 | American Science And Engineering, Inc. | X-ray detecting system having negative feedback for gain stabilization |
US4256960A (en) * | 1979-07-25 | 1981-03-17 | General Electric Company | Instrument and method for calibrating nuclear cameras |
NL8103058A (en) * | 1981-06-24 | 1983-01-17 | Philips Nv | METHOD FOR CALIBRATING A GAMMA CAMERA AND GAMMA CAMERA WITH A CALIBRATION DEVICE |
JPS58103625A (en) * | 1981-12-15 | 1983-06-20 | Hitachi Ltd | Photometer |
US4437762A (en) * | 1981-12-28 | 1984-03-20 | Beckman Instruments, Inc. | Control of detector gain hysteresis in a single beam spectrophotometer |
JPS5981969A (en) * | 1982-11-02 | 1984-05-11 | Fuji Photo Film Co Ltd | Photodetector |
US4802768A (en) * | 1986-04-11 | 1989-02-07 | Sclavo, Inc. | Two light source reference system for a fluorometer |
JPS62299171A (en) * | 1986-06-18 | 1987-12-26 | Fuji Photo Film Co Ltd | Light beam scanning device |
US5004904A (en) * | 1988-06-17 | 1991-04-02 | Kabushiki Kaisha Toshiba | Method and system for controlling gain and offset in radiation measurement apparatus |
JP2602287B2 (en) * | 1988-07-01 | 1997-04-23 | 株式会社日立製作所 | X-ray mask defect inspection method and apparatus |
JPH0254688A (en) * | 1988-08-19 | 1990-02-23 | Toshiba Corp | Color television receiver with built-in teletext receiver |
JPH02240588A (en) * | 1989-03-14 | 1990-09-25 | Toshiba Corp | Scintillation camera |
WO1993003347A1 (en) * | 1991-07-26 | 1993-02-18 | Cirrus Diagnostics, Inc. | Automated immunoassay analyzer |
US5315375A (en) * | 1992-02-11 | 1994-05-24 | Acrogen, Inc. | Sensitive light detection system |
US5376335A (en) * | 1993-04-30 | 1994-12-27 | Gleaves; John T. | Apparatus for study and analysis of products of catalytic reaction |
US5453610A (en) * | 1994-05-20 | 1995-09-26 | Summit World Trade Corporation | Electronic gain control for photomultiplier used in gamma camera |
US5559324A (en) * | 1995-03-23 | 1996-09-24 | In/Us Systems, Inc. | Continuous sample detector with standard |
US5561290A (en) * | 1995-06-09 | 1996-10-01 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Optical detector calibrator system |
-
1997
- 1997-08-20 US US08/915,029 patent/US5859429A/en not_active Expired - Lifetime
-
1998
- 1998-08-17 WO PCT/US1998/017047 patent/WO1999009381A1/en active IP Right Grant
- 1998-08-17 AT AT98939971T patent/ATE270426T1/en not_active IP Right Cessation
- 1998-08-17 JP JP51351499A patent/JP3255647B2/en not_active Expired - Fee Related
- 1998-08-17 ES ES98939971T patent/ES2232008T3/en not_active Expired - Lifetime
- 1998-08-17 EP EP98939971A patent/EP1005630B1/en not_active Expired - Lifetime
- 1998-08-17 CA CA002294188A patent/CA2294188C/en not_active Expired - Fee Related
- 1998-08-17 DE DE69824858T patent/DE69824858T2/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03262931A (en) * | 1990-03-13 | 1991-11-22 | Aloka Co Ltd | Light source unit for calibrating sensitivity of photomultiplier tube |
DE4422580C1 (en) * | 1994-06-28 | 1995-12-14 | Boehringer Mannheim Gmbh | Calibration of light sensitivity for optical measurement receiver with long-term instability e.g. photomultiplier |
US5715048A (en) * | 1995-11-22 | 1998-02-03 | Dynex Technologies, Inc. | Calibration system for a photo multiplier tube |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 016, no. 070 (P - 1315) 20 February 1992 (1992-02-20) * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2348949A (en) * | 1999-04-16 | 2000-10-18 | Lre Technology Partner Gmbh | Optical analytical instrument |
GB2348949B (en) * | 1999-04-16 | 2003-12-17 | Lre Technology Partner Gmbh | Optical analytical instrument |
Also Published As
Publication number | Publication date |
---|---|
EP1005630B1 (en) | 2004-06-30 |
JP3255647B2 (en) | 2002-02-12 |
CA2294188A1 (en) | 1999-02-25 |
CA2294188C (en) | 2007-05-22 |
DE69824858D1 (en) | 2004-08-05 |
ES2232008T3 (en) | 2005-05-16 |
EP1005630A1 (en) | 2000-06-07 |
DE69824858T2 (en) | 2005-08-25 |
US5859429A (en) | 1999-01-12 |
JP2000513823A (en) | 2000-10-17 |
ATE270426T1 (en) | 2004-07-15 |
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